Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5F4_LEIDO

TriTrypDb:

LdBPK_050010.1 , LdCL_050005000 , LDHU3_05.0040

Length:

915

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0000922	spindle pole	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.524
CLV_C14_Caspase3-7	73	77	PF00656	0.484
CLV_NRD_NRD_1	322	324	PF00675	0.475
CLV_NRD_NRD_1	363	365	PF00675	0.514
CLV_NRD_NRD_1	45	47	PF00675	0.434
CLV_NRD_NRD_1	620	622	PF00675	0.490
CLV_NRD_NRD_1	741	743	PF00675	0.609
CLV_NRD_NRD_1	756	758	PF00675	0.384
CLV_NRD_NRD_1	782	784	PF00675	0.481
CLV_NRD_NRD_1	802	804	PF00675	0.338
CLV_NRD_NRD_1	825	827	PF00675	0.480
CLV_NRD_NRD_1	97	99	PF00675	0.493
CLV_PCSK_FUR_1	780	784	PF00082	0.472
CLV_PCSK_KEX2_1	283	285	PF00082	0.453
CLV_PCSK_KEX2_1	322	324	PF00082	0.509
CLV_PCSK_KEX2_1	45	47	PF00082	0.434
CLV_PCSK_KEX2_1	741	743	PF00082	0.609
CLV_PCSK_KEX2_1	756	758	PF00082	0.384
CLV_PCSK_KEX2_1	769	771	PF00082	0.499
CLV_PCSK_KEX2_1	782	784	PF00082	0.376
CLV_PCSK_KEX2_1	802	804	PF00082	0.474
CLV_PCSK_KEX2_1	825	827	PF00082	0.480
CLV_PCSK_KEX2_1	904	906	PF00082	0.583
CLV_PCSK_KEX2_1	97	99	PF00082	0.576
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.510
CLV_PCSK_PC1ET2_1	769	771	PF00082	0.461
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.485
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.583
CLV_PCSK_SKI1_1	17	21	PF00082	0.409
CLV_PCSK_SKI1_1	360	364	PF00082	0.541
CLV_PCSK_SKI1_1	388	392	PF00082	0.467
CLV_PCSK_SKI1_1	421	425	PF00082	0.447
CLV_PCSK_SKI1_1	48	52	PF00082	0.474
CLV_PCSK_SKI1_1	588	592	PF00082	0.635
CLV_PCSK_SKI1_1	623	627	PF00082	0.394
CLV_PCSK_SKI1_1	684	688	PF00082	0.485
CLV_PCSK_SKI1_1	706	710	PF00082	0.521
CLV_PCSK_SKI1_1	729	733	PF00082	0.542
CLV_PCSK_SKI1_1	770	774	PF00082	0.461
CLV_PCSK_SKI1_1	808	812	PF00082	0.432
CLV_PCSK_SKI1_1	83	87	PF00082	0.478
CLV_Separin_Metazoa	618	622	PF03568	0.427
DEG_Nend_UBRbox_2	1	3	PF02207	0.584
DOC_CDC14_PxL_1	897	905	PF14671	0.617
DOC_CYCLIN_RxL_1	679	690	PF00134	0.400
DOC_MAPK_gen_1	204	211	PF00069	0.523
DOC_MAPK_gen_1	269	277	PF00069	0.459
DOC_MAPK_gen_1	322	328	PF00069	0.465
DOC_MAPK_gen_1	45	51	PF00069	0.439
DOC_MAPK_gen_1	56	67	PF00069	0.433
DOC_MAPK_gen_1	663	671	PF00069	0.456
DOC_MAPK_gen_1	741	751	PF00069	0.457
DOC_MAPK_MEF2A_6	167	174	PF00069	0.485
DOC_MAPK_MEF2A_6	665	673	PF00069	0.471
DOC_PP1_RVXF_1	5	12	PF00149	0.483
DOC_USP7_MATH_1	100	104	PF00917	0.426
DOC_USP7_MATH_1	694	698	PF00917	0.487
DOC_USP7_MATH_1	725	729	PF00917	0.457
DOC_USP7_MATH_1	896	900	PF00917	0.562
DOC_USP7_UBL2_3	17	21	PF12436	0.321
DOC_USP7_UBL2_3	183	187	PF12436	0.511
DOC_USP7_UBL2_3	3	7	PF12436	0.522
DOC_USP7_UBL2_3	56	60	PF12436	0.429
DOC_USP7_UBL2_3	769	773	PF12436	0.647
DOC_USP7_UBL2_3	788	792	PF12436	0.373
DOC_USP7_UBL2_3	804	808	PF12436	0.357
DOC_WW_Pin1_4	883	888	PF00397	0.571
LIG_14-3-3_CanoR_1	162	170	PF00244	0.613
LIG_14-3-3_CanoR_1	364	373	PF00244	0.499
LIG_14-3-3_CanoR_1	569	573	PF00244	0.502
LIG_14-3-3_CanoR_1	762	766	PF00244	0.609
LIG_Actin_WH2_2	349	366	PF00022	0.479
LIG_Actin_WH2_2	633	651	PF00022	0.396
LIG_Actin_WH2_2	810	827	PF00022	0.513
LIG_Actin_WH2_2	890	906	PF00022	0.617
LIG_deltaCOP1_diTrp_1	344	347	PF00928	0.540
LIG_FHA_1	18	24	PF00498	0.489
LIG_FHA_1	519	525	PF00498	0.582
LIG_FHA_1	537	543	PF00498	0.394
LIG_FHA_1	56	62	PF00498	0.451
LIG_FHA_1	600	606	PF00498	0.506
LIG_FHA_1	672	678	PF00498	0.451
LIG_FHA_1	870	876	PF00498	0.510
LIG_FHA_2	106	112	PF00498	0.493
LIG_FHA_2	153	159	PF00498	0.478
LIG_FHA_2	391	397	PF00498	0.592
LIG_FHA_2	773	779	PF00498	0.484
LIG_LIR_Gen_1	346	356	PF02991	0.528
LIG_LIR_Gen_1	489	500	PF02991	0.507
LIG_LIR_Gen_1	764	772	PF02991	0.494
LIG_LIR_Nem_3	346	352	PF02991	0.532
LIG_LIR_Nem_3	489	495	PF02991	0.503
LIG_LIR_Nem_3	764	768	PF02991	0.487
LIG_NRBOX	750	756	PF00104	0.486
LIG_PCNA_PIPBox_1	655	664	PF02747	0.454
LIG_Pex14_1	345	349	PF04695	0.539
LIG_Pex14_1	846	850	PF04695	0.421
LIG_Pex14_2	495	499	PF04695	0.599
LIG_SH2_NCK_1	650	654	PF00017	0.373
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.447
LIG_SUMO_SIM_par_1	395	403	PF11976	0.712
LIG_TRAF2_1	109	112	PF00917	0.490
LIG_TRAF2_1	393	396	PF00917	0.592
LIG_TRAF2_1	775	778	PF00917	0.472
LIG_UBA3_1	249	255	PF00899	0.556
LIG_WRC_WIRS_1	492	497	PF05994	0.454
LIG_WRC_WIRS_1	765	770	PF05994	0.471
MOD_CK1_1	176	182	PF00069	0.435
MOD_CK1_1	292	298	PF00069	0.538
MOD_CK1_1	366	372	PF00069	0.505
MOD_CK1_1	532	538	PF00069	0.433
MOD_CK1_1	571	577	PF00069	0.562
MOD_CK1_1	600	606	PF00069	0.593
MOD_CK1_1	675	681	PF00069	0.514
MOD_CK1_1	764	770	PF00069	0.491
MOD_CK1_1	860	866	PF00069	0.545
MOD_CK1_1	869	875	PF00069	0.534
MOD_CK2_1	105	111	PF00069	0.493
MOD_CK2_1	152	158	PF00069	0.492
MOD_CK2_1	176	182	PF00069	0.500
MOD_CK2_1	347	353	PF00069	0.464
MOD_CK2_1	390	396	PF00069	0.560
MOD_CK2_1	436	442	PF00069	0.505
MOD_CK2_1	577	583	PF00069	0.642
MOD_CK2_1	591	597	PF00069	0.502
MOD_CK2_1	638	644	PF00069	0.406
MOD_CK2_1	694	700	PF00069	0.443
MOD_CK2_1	772	778	PF00069	0.452
MOD_CK2_1	816	822	PF00069	0.563
MOD_GlcNHglycan	30	33	PF01048	0.533
MOD_GlcNHglycan	366	369	PF01048	0.540
MOD_GlcNHglycan	438	441	PF01048	0.488
MOD_GlcNHglycan	602	605	PF01048	0.481
MOD_GlcNHglycan	700	704	PF01048	0.513
MOD_GlcNHglycan	908	913	PF01048	0.532
MOD_GSK3_1	112	119	PF00069	0.459
MOD_GSK3_1	157	164	PF00069	0.510
MOD_GSK3_1	211	218	PF00069	0.521
MOD_GSK3_1	283	290	PF00069	0.554
MOD_GSK3_1	343	350	PF00069	0.531
MOD_GSK3_1	532	539	PF00069	0.566
MOD_GSK3_1	624	631	PF00069	0.476
MOD_GSK3_1	634	641	PF00069	0.409
MOD_GSK3_1	671	678	PF00069	0.569
MOD_GSK3_1	708	715	PF00069	0.621
MOD_GSK3_1	908	915	PF00069	0.560
MOD_N-GLC_1	100	105	PF02516	0.486
MOD_N-GLC_1	597	602	PF02516	0.494
MOD_N-GLC_1	712	717	PF02516	0.501
MOD_NEK2_1	191	196	PF00069	0.510
MOD_NEK2_1	219	224	PF00069	0.572
MOD_NEK2_1	233	238	PF00069	0.445
MOD_NEK2_1	289	294	PF00069	0.539
MOD_NEK2_1	326	331	PF00069	0.464
MOD_NEK2_1	347	352	PF00069	0.525
MOD_NEK2_1	363	368	PF00069	0.544
MOD_NEK2_1	537	542	PF00069	0.425
MOD_NEK2_1	591	596	PF00069	0.439
MOD_NEK2_1	599	604	PF00069	0.587
MOD_NEK2_1	626	631	PF00069	0.380
MOD_NEK2_1	671	676	PF00069	0.532
MOD_NEK2_2	694	699	PF00069	0.451
MOD_PIKK_1	127	133	PF00454	0.447
MOD_PIKK_1	161	167	PF00454	0.625
MOD_PIKK_1	176	182	PF00454	0.437
MOD_PIKK_1	287	293	PF00454	0.469
MOD_PIKK_1	326	332	PF00454	0.465
MOD_PIKK_1	400	406	PF00454	0.552
MOD_PIKK_1	537	543	PF00454	0.431
MOD_PIKK_1	626	632	PF00454	0.361
MOD_PIKK_1	83	89	PF00454	0.458
MOD_PK_1	866	872	PF00069	0.557
MOD_PKA_1	283	289	PF00069	0.540
MOD_PKA_1	364	370	PF00069	0.500
MOD_PKA_1	56	62	PF00069	0.489
MOD_PKA_2	161	167	PF00069	0.532
MOD_PKA_2	283	289	PF00069	0.540
MOD_PKA_2	363	369	PF00069	0.504
MOD_PKA_2	532	538	PF00069	0.411
MOD_PKA_2	568	574	PF00069	0.510
MOD_PKA_2	761	767	PF00069	0.440
MOD_Plk_1	100	106	PF00069	0.488
MOD_Plk_1	116	122	PF00069	0.492
MOD_Plk_1	191	197	PF00069	0.486
MOD_Plk_1	219	225	PF00069	0.624
MOD_Plk_1	233	239	PF00069	0.481
MOD_Plk_1	324	330	PF00069	0.483
MOD_Plk_1	343	349	PF00069	0.473
MOD_Plk_1	597	603	PF00069	0.598
MOD_Plk_1	699	705	PF00069	0.474
MOD_Plk_2-3	112	118	PF00069	0.370
MOD_Plk_2-3	215	221	PF00069	0.463
MOD_Plk_2-3	761	767	PF00069	0.536
MOD_Plk_4	191	197	PF00069	0.443
MOD_Plk_4	369	375	PF00069	0.529
MOD_Plk_4	491	497	PF00069	0.492
MOD_Plk_4	568	574	PF00069	0.403
MOD_Plk_4	672	678	PF00069	0.592
MOD_Plk_4	750	756	PF00069	0.490
MOD_ProDKin_1	883	889	PF00069	0.573
MOD_SUMO_for_1	135	138	PF00179	0.521
MOD_SUMO_for_1	268	271	PF00179	0.514
MOD_SUMO_for_1	768	771	PF00179	0.474
MOD_SUMO_rev_2	168	177	PF00179	0.534
MOD_SUMO_rev_2	213	219	PF00179	0.551
MOD_SUMO_rev_2	329	338	PF00179	0.533
MOD_SUMO_rev_2	382	390	PF00179	0.611
MOD_SUMO_rev_2	53	58	PF00179	0.425
MOD_SUMO_rev_2	702	711	PF00179	0.520
MOD_SUMO_rev_2	766	775	PF00179	0.483
MOD_SUMO_rev_2	800	810	PF00179	0.422
TRG_DiLeu_BaEn_1	376	381	PF01217	0.540
TRG_DiLeu_BaEn_1	501	506	PF01217	0.375
TRG_DiLeu_BaEn_2	553	559	PF01217	0.429
TRG_DiLeu_BaEn_4	396	402	PF01217	0.587
TRG_DiLeu_BaEn_4	656	662	PF01217	0.452
TRG_ENDOCYTIC_2	349	352	PF00928	0.528
TRG_ER_diArg_1	321	323	PF00400	0.534
TRG_ER_diArg_1	44	46	PF00400	0.433
TRG_ER_diArg_1	755	757	PF00400	0.489
TRG_ER_diArg_1	824	826	PF00400	0.531
TRG_ER_diArg_1	96	98	PF00400	0.497
TRG_NES_CRM1_1	131	144	PF08389	0.432
TRG_NES_CRM1_1	190	203	PF08389	0.500
TRG_NLS_Bipartite_1	802	819	PF00514	0.500
TRG_NLS_MonoExtC_3	814	820	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P634	Leptomonas seymouri	51%	100%
A0A3R7LAM9	Trypanosoma rangeli	33%	99%
A4H447	Leishmania braziliensis	75%	100%
A4HSC4	Leishmania infantum	99%	100%
E9AKA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QJK2	Leishmania major	91%	100%