Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5F3_LEIDO

TriTrypDb:

LdBPK_041220.1 , LdCL_040017800 , LDHU3_04.1470

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	13
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H5F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5F3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.366
CLV_NRD_NRD_1	15	17	PF00675	0.738
CLV_PCSK_KEX2_1	172	174	PF00082	0.569
CLV_PCSK_KEX2_1	4	6	PF00082	0.730
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.569
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.755
DEG_APCC_DBOX_1	161	169	PF00400	0.404
DOC_CYCLIN_RxL_1	22	32	PF00134	0.569
DOC_MAPK_gen_1	178	186	PF00069	0.503
DOC_MAPK_gen_1	22	30	PF00069	0.627
DOC_USP7_MATH_1	48	52	PF00917	0.534
DOC_USP7_UBL2_3	13	17	PF12436	0.651
DOC_USP7_UBL2_3	4	8	PF12436	0.680
LIG_14-3-3_CanoR_1	26	31	PF00244	0.614
LIG_14-3-3_CanoR_1	44	53	PF00244	0.467
LIG_BRCT_BRCA1_1	124	128	PF00533	0.489
LIG_FHA_1	63	69	PF00498	0.515
LIG_LIR_Gen_1	120	129	PF02991	0.450
LIG_LIR_Gen_1	47	53	PF02991	0.496
LIG_LIR_Nem_3	120	124	PF02991	0.448
LIG_LIR_Nem_3	47	52	PF02991	0.534
LIG_MYND_3	116	120	PF01753	0.494
LIG_PTB_Apo_2	115	122	PF02174	0.444
LIG_SH2_STAT5	34	37	PF00017	0.434
LIG_SH2_STAT5	72	75	PF00017	0.395
LIG_SH3_2	3	8	PF14604	0.701
LIG_SH3_3	12	18	PF00018	0.684
LIG_SH3_3	3	9	PF00018	0.684
LIG_SUMO_SIM_par_1	63	69	PF11976	0.533
LIG_TRAF2_1	29	32	PF00917	0.535
LIG_UBA3_1	165	172	PF00899	0.545
LIG_UBA3_1	81	87	PF00899	0.507
LIG_WRC_WIRS_1	49	54	PF05994	0.436
MOD_CK1_1	171	177	PF00069	0.496
MOD_CK2_1	26	32	PF00069	0.505
MOD_CK2_1	34	40	PF00069	0.443
MOD_GlcNHglycan	111	114	PF01048	0.414
MOD_GlcNHglycan	46	49	PF01048	0.422
MOD_GSK3_1	168	175	PF00069	0.481
MOD_GSK3_1	180	187	PF00069	0.575
MOD_GSK3_1	20	27	PF00069	0.645
MOD_GSK3_1	44	51	PF00069	0.467
MOD_GSK3_1	62	69	PF00069	0.485
MOD_N-GLC_1	20	25	PF02516	0.737
MOD_NEK2_1	109	114	PF00069	0.376
MOD_NEK2_1	152	157	PF00069	0.508
MOD_NEK2_1	168	173	PF00069	0.570
MOD_NEK2_1	180	185	PF00069	0.406
MOD_NEK2_2	11	16	PF00069	0.773
MOD_PKA_1	172	178	PF00069	0.578
MOD_PKA_1	4	10	PF00069	0.763
MOD_PKA_2	172	178	PF00069	0.578
MOD_PKA_2	180	186	PF00069	0.598
MOD_PKA_2	4	10	PF00069	0.698
MOD_Plk_1	62	68	PF00069	0.587
MOD_Plk_4	180	186	PF00069	0.640
MOD_Plk_4	48	54	PF00069	0.475
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.429
TRG_ER_diArg_1	101	104	PF00400	0.472
TRG_NES_CRM1_1	86	98	PF08389	0.439
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I143	Leptomonas seymouri	67%	92%
A0A0S4IYV0	Bodo saltans	44%	97%
A0A0S4JTE7	Bodo saltans	44%	97%
A0A1X0NKZ2	Trypanosomatidae	47%	100%
A0A422NNV2	Trypanosoma rangeli	46%	100%
A4H435	Leishmania braziliensis	81%	100%
A4HSB9	Leishmania infantum	99%	100%
C9ZYB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O97000	Leishmania major	94%	100%
V5DEE3	Trypanosoma cruzi	46%	75%