Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5E8_LEIDO

TriTrypDb:

LdBPK_041130.1 , LdCL_040016900 , LDHU3_04.1380

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5E8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.460
CLV_C14_Caspase3-7	412	416	PF00656	0.579
CLV_C14_Caspase3-7	435	439	PF00656	0.562
CLV_C14_Caspase3-7	475	479	PF00656	0.716
CLV_C14_Caspase3-7	561	565	PF00656	0.677
CLV_C14_Caspase3-7	579	583	PF00656	0.684
CLV_NRD_NRD_1	164	166	PF00675	0.652
CLV_NRD_NRD_1	24	26	PF00675	0.608
CLV_NRD_NRD_1	283	285	PF00675	0.461
CLV_NRD_NRD_1	364	366	PF00675	0.466
CLV_NRD_NRD_1	379	381	PF00675	0.458
CLV_NRD_NRD_1	533	535	PF00675	0.819
CLV_NRD_NRD_1	585	587	PF00675	0.682
CLV_NRD_NRD_1	635	637	PF00675	0.557
CLV_NRD_NRD_1	651	653	PF00675	0.338
CLV_NRD_NRD_1	692	694	PF00675	0.673
CLV_NRD_NRD_1	90	92	PF00675	0.691
CLV_PCSK_KEX2_1	164	166	PF00082	0.652
CLV_PCSK_KEX2_1	237	239	PF00082	0.477
CLV_PCSK_KEX2_1	24	26	PF00082	0.604
CLV_PCSK_KEX2_1	244	246	PF00082	0.503
CLV_PCSK_KEX2_1	368	370	PF00082	0.483
CLV_PCSK_KEX2_1	379	381	PF00082	0.507
CLV_PCSK_KEX2_1	533	535	PF00082	0.809
CLV_PCSK_KEX2_1	585	587	PF00082	0.682
CLV_PCSK_KEX2_1	600	602	PF00082	0.575
CLV_PCSK_KEX2_1	634	636	PF00082	0.576
CLV_PCSK_KEX2_1	649	651	PF00082	0.473
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.477
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.503
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.469
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.659
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.473
CLV_PCSK_PC7_1	160	166	PF00082	0.650
CLV_PCSK_SKI1_1	241	245	PF00082	0.485
CLV_PCSK_SKI1_1	269	273	PF00082	0.428
CLV_PCSK_SKI1_1	305	309	PF00082	0.493
CLV_PCSK_SKI1_1	404	408	PF00082	0.450
CLV_PCSK_SKI1_1	533	537	PF00082	0.699
CLV_PCSK_SKI1_1	694	698	PF00082	0.676
CLV_PCSK_SKI1_1	722	726	PF00082	0.635
DEG_APCC_KENBOX_2	667	671	PF00400	0.679
DEG_SIAH_1	550	558	PF03145	0.620
DOC_CKS1_1	19	24	PF01111	0.678
DOC_CKS1_1	724	729	PF01111	0.628
DOC_MAPK_DCC_7	550	560	PF00069	0.693
DOC_MAPK_gen_1	654	662	PF00069	0.588
DOC_PP1_RVXF_1	633	640	PF00149	0.543
DOC_USP7_MATH_1	128	132	PF00917	0.658
DOC_USP7_MATH_1	139	143	PF00917	0.766
DOC_USP7_MATH_1	163	167	PF00917	0.609
DOC_USP7_MATH_1	17	21	PF00917	0.629
DOC_USP7_MATH_1	172	176	PF00917	0.617
DOC_USP7_MATH_1	353	357	PF00917	0.386
DOC_USP7_MATH_1	489	493	PF00917	0.657
DOC_USP7_MATH_1	52	56	PF00917	0.497
DOC_USP7_MATH_1	523	527	PF00917	0.615
DOC_USP7_MATH_1	559	563	PF00917	0.816
DOC_USP7_MATH_1	609	613	PF00917	0.667
DOC_USP7_MATH_1	617	621	PF00917	0.585
DOC_USP7_MATH_1	66	70	PF00917	0.667
DOC_USP7_MATH_1	685	689	PF00917	0.604
DOC_USP7_UBL2_3	668	672	PF12436	0.684
DOC_WW_Pin1_4	130	135	PF00397	0.625
DOC_WW_Pin1_4	159	164	PF00397	0.613
DOC_WW_Pin1_4	168	173	PF00397	0.635
DOC_WW_Pin1_4	18	23	PF00397	0.600
DOC_WW_Pin1_4	446	451	PF00397	0.633
DOC_WW_Pin1_4	496	501	PF00397	0.700
DOC_WW_Pin1_4	50	55	PF00397	0.495
DOC_WW_Pin1_4	58	63	PF00397	0.555
DOC_WW_Pin1_4	723	728	PF00397	0.630
LIG_14-3-3_CanoR_1	141	149	PF00244	0.632
LIG_14-3-3_CanoR_1	164	172	PF00244	0.601
LIG_14-3-3_CanoR_1	44	50	PF00244	0.659
LIG_14-3-3_CanoR_1	504	514	PF00244	0.651
LIG_BIR_III_2	51	55	PF00653	0.502
LIG_BRCT_BRCA1_1	235	239	PF00533	0.419
LIG_FHA_1	450	456	PF00498	0.799
LIG_FHA_1	508	514	PF00498	0.662
LIG_FHA_2	229	235	PF00498	0.429
LIG_FHA_2	27	33	PF00498	0.578
LIG_FHA_2	372	378	PF00498	0.511
LIG_FHA_2	473	479	PF00498	0.691
LIG_FHA_2	506	512	PF00498	0.618
LIG_FHA_2	559	565	PF00498	0.675
LIG_FHA_2	588	594	PF00498	0.651
LIG_FHA_2	74	80	PF00498	0.578
LIG_GSK3_LRP6_1	450	455	PF00069	0.624
LIG_LIR_Apic_2	478	484	PF02991	0.714
LIG_LIR_Apic_2	517	523	PF02991	0.629
LIG_LIR_Gen_1	12	23	PF02991	0.631
LIG_LIR_Gen_1	183	190	PF02991	0.473
LIG_LIR_Gen_1	214	224	PF02991	0.405
LIG_LIR_Gen_1	283	290	PF02991	0.483
LIG_LIR_Gen_1	334	341	PF02991	0.424
LIG_LIR_Nem_3	12	18	PF02991	0.633
LIG_LIR_Nem_3	183	187	PF02991	0.496
LIG_LIR_Nem_3	214	219	PF02991	0.405
LIG_LIR_Nem_3	283	289	PF02991	0.482
LIG_LIR_Nem_3	334	340	PF02991	0.424
LIG_MYND_1	717	721	PF01753	0.610
LIG_NRBOX	321	327	PF00104	0.487
LIG_PCNA_yPIPBox_3	220	232	PF02747	0.435
LIG_SH2_CRK	216	220	PF00017	0.429
LIG_SH2_CRK	481	485	PF00017	0.710
LIG_SH2_NCK_1	481	485	PF00017	0.710
LIG_SH2_PTP2	520	523	PF00017	0.621
LIG_SH2_STAP1	194	198	PF00017	0.533
LIG_SH2_STAP1	205	209	PF00017	0.447
LIG_SH2_STAP1	275	279	PF00017	0.430
LIG_SH2_STAP1	286	290	PF00017	0.440
LIG_SH2_STAP1	78	82	PF00017	0.643
LIG_SH2_STAT3	198	201	PF00017	0.457
LIG_SH2_STAT3	574	577	PF00017	0.597
LIG_SH2_STAT5	520	523	PF00017	0.621
LIG_SH2_STAT5	82	85	PF00017	0.658
LIG_SH3_2	19	24	PF14604	0.678
LIG_SH3_2	673	678	PF14604	0.685
LIG_SH3_3	16	22	PF00018	0.677
LIG_SH3_3	174	180	PF00018	0.643
LIG_SH3_3	448	454	PF00018	0.675
LIG_SH3_3	526	532	PF00018	0.805
LIG_SH3_3	551	557	PF00018	0.620
LIG_SH3_3	670	676	PF00018	0.685
LIG_SH3_3	721	727	PF00018	0.681
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.574
LIG_SUMO_SIM_par_1	225	231	PF11976	0.436
LIG_TRAF2_1	261	264	PF00917	0.447
LIG_UBA3_1	336	345	PF00899	0.494
LIG_WW_2	556	559	PF00397	0.603
MOD_CDC14_SPxK_1	499	502	PF00782	0.704
MOD_CDK_SPK_2	159	164	PF00069	0.601
MOD_CDK_SPK_2	723	728	PF00069	0.582
MOD_CDK_SPxK_1	159	165	PF00069	0.651
MOD_CDK_SPxK_1	18	24	PF00069	0.601
MOD_CDK_SPxK_1	496	502	PF00069	0.703
MOD_CDK_SPxxK_3	130	137	PF00069	0.624
MOD_CDK_SPxxK_3	18	25	PF00069	0.601
MOD_CK1_1	126	132	PF00069	0.636
MOD_CK1_1	144	150	PF00069	0.515
MOD_CK1_1	153	159	PF00069	0.595
MOD_CK1_1	3	9	PF00069	0.627
MOD_CK1_1	331	337	PF00069	0.454
MOD_CK1_1	441	447	PF00069	0.636
MOD_CK1_1	449	455	PF00069	0.624
MOD_CK1_1	515	521	PF00069	0.806
MOD_CK1_1	540	546	PF00069	0.599
MOD_CK1_1	671	677	PF00069	0.800
MOD_CK1_1	688	694	PF00069	0.570
MOD_CK1_1	99	105	PF00069	0.751
MOD_CK2_1	228	234	PF00069	0.430
MOD_CK2_1	371	377	PF00069	0.517
MOD_CK2_1	505	511	PF00069	0.625
MOD_CK2_1	663	669	PF00069	0.615
MOD_CK2_1	723	729	PF00069	0.631
MOD_GlcNHglycan	126	129	PF01048	0.770
MOD_GlcNHglycan	268	272	PF01048	0.511
MOD_GlcNHglycan	491	494	PF01048	0.778
MOD_GlcNHglycan	5	8	PF01048	0.595
MOD_GlcNHglycan	514	517	PF01048	0.743
MOD_GlcNHglycan	54	57	PF01048	0.532
MOD_GlcNHglycan	579	582	PF01048	0.774
MOD_GlcNHglycan	607	610	PF01048	0.680
MOD_GlcNHglycan	613	616	PF01048	0.576
MOD_GlcNHglycan	619	622	PF01048	0.510
MOD_GlcNHglycan	68	71	PF01048	0.671
MOD_GlcNHglycan	86	89	PF01048	0.533
MOD_GlcNHglycan	92	95	PF01048	0.709
MOD_GlcNHglycan	98	101	PF01048	0.637
MOD_GSK3_1	124	131	PF00069	0.720
MOD_GSK3_1	144	151	PF00069	0.544
MOD_GSK3_1	154	161	PF00069	0.703
MOD_GSK3_1	164	171	PF00069	0.561
MOD_GSK3_1	245	252	PF00069	0.468
MOD_GSK3_1	3	10	PF00069	0.611
MOD_GSK3_1	313	320	PF00069	0.536
MOD_GSK3_1	331	338	PF00069	0.478
MOD_GSK3_1	434	441	PF00069	0.651
MOD_GSK3_1	442	449	PF00069	0.597
MOD_GSK3_1	503	510	PF00069	0.661
MOD_GSK3_1	533	540	PF00069	0.661
MOD_GSK3_1	559	566	PF00069	0.699
MOD_GSK3_1	601	608	PF00069	0.688
MOD_GSK3_1	626	633	PF00069	0.620
MOD_GSK3_1	78	85	PF00069	0.579
MOD_GSK3_1	86	93	PF00069	0.659
MOD_GSK3_1	95	102	PF00069	0.776
MOD_N-GLC_1	116	121	PF02516	0.603
MOD_N-GLC_1	123	128	PF02516	0.615
MOD_N-GLC_1	438	443	PF02516	0.646
MOD_NEK2_1	118	123	PF00069	0.596
MOD_NEK2_1	158	163	PF00069	0.625
MOD_NEK2_1	247	252	PF00069	0.478
MOD_NEK2_1	267	272	PF00069	0.303
MOD_NEK2_1	418	423	PF00069	0.684
MOD_NEK2_1	546	551	PF00069	0.649
MOD_NEK2_1	637	642	PF00069	0.512
MOD_NEK2_1	86	91	PF00069	0.604
MOD_NEK2_2	565	570	PF00069	0.631
MOD_PIKK_1	317	323	PF00454	0.478
MOD_PIKK_1	537	543	PF00454	0.663
MOD_PKA_1	164	170	PF00069	0.651
MOD_PKA_1	533	539	PF00069	0.655
MOD_PKA_2	102	108	PF00069	0.572
MOD_PKA_2	163	169	PF00069	0.600
MOD_PKA_2	43	49	PF00069	0.496
MOD_PKA_2	503	509	PF00069	0.597
MOD_PKA_2	533	539	PF00069	0.701
MOD_PKA_2	577	583	PF00069	0.593
MOD_PKA_2	90	96	PF00069	0.720
MOD_PKB_1	502	510	PF00069	0.656
MOD_Plk_1	116	122	PF00069	0.636
MOD_Plk_1	305	311	PF00069	0.555
MOD_Plk_1	371	377	PF00069	0.544
MOD_Plk_1	38	44	PF00069	0.555
MOD_Plk_1	78	84	PF00069	0.587
MOD_Plk_4	299	305	PF00069	0.443
MOD_Plk_4	321	327	PF00069	0.453
MOD_Plk_4	396	402	PF00069	0.443
MOD_Plk_4	525	531	PF00069	0.644
MOD_Plk_4	78	84	PF00069	0.668
MOD_ProDKin_1	130	136	PF00069	0.622
MOD_ProDKin_1	159	165	PF00069	0.615
MOD_ProDKin_1	168	174	PF00069	0.634
MOD_ProDKin_1	18	24	PF00069	0.601
MOD_ProDKin_1	446	452	PF00069	0.633
MOD_ProDKin_1	496	502	PF00069	0.703
MOD_ProDKin_1	50	56	PF00069	0.492
MOD_ProDKin_1	58	64	PF00069	0.562
MOD_ProDKin_1	723	729	PF00069	0.631
MOD_SUMO_for_1	243	246	PF00179	0.450
MOD_SUMO_for_1	265	268	PF00179	0.434
MOD_SUMO_rev_2	230	239	PF00179	0.434
MOD_SUMO_rev_2	263	267	PF00179	0.436
MOD_SUMO_rev_2	291	298	PF00179	0.443
MOD_SUMO_rev_2	348	356	PF00179	0.509
TRG_DiLeu_BaEn_3	234	240	PF01217	0.439
TRG_ENDOCYTIC_2	15	18	PF00928	0.682
TRG_ENDOCYTIC_2	184	187	PF00928	0.490
TRG_ENDOCYTIC_2	194	197	PF00928	0.512
TRG_ENDOCYTIC_2	205	208	PF00928	0.483
TRG_ENDOCYTIC_2	216	219	PF00928	0.465
TRG_ENDOCYTIC_2	275	278	PF00928	0.444
TRG_ENDOCYTIC_2	286	289	PF00928	0.440
TRG_ER_diArg_1	163	165	PF00400	0.651
TRG_ER_diArg_1	191	194	PF00400	0.469
TRG_ER_diArg_1	23	25	PF00400	0.604
TRG_ER_diArg_1	251	254	PF00400	0.460
TRG_ER_diArg_1	501	504	PF00400	0.673
TRG_ER_diArg_1	532	534	PF00400	0.805
TRG_ER_diArg_1	548	551	PF00400	0.542
TRG_ER_diArg_1	585	587	PF00400	0.539
TRG_ER_diArg_1	634	636	PF00400	0.576
TRG_ER_diArg_1	650	652	PF00400	0.347
TRG_NES_CRM1_1	398	412	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	654	658	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I386	Leptomonas seymouri	52%	89%
A4H426	Leishmania braziliensis	76%	98%
A4HSB0	Leishmania infantum	99%	100%
E9AK93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O97197	Leishmania major	92%	100%