Acyltransferase-like protein, copy 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase-like protein, copy 1

Species:

Leishmania donovani

UniProt:

A0A3S5H5E4_LEIDO

TriTrypDb:

LdBPK_041040.1 , LdCL_040016100 , LDHU3_04.1280

Length:

432

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

A0A3S5H5E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5E4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006654	phosphatidic acid biosynthetic process	6	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0019637	organophosphate metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046473	phosphatidic acid metabolic process	6	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0016740	transferase activity	2	22
GO:0016746	acyltransferase activity	3	22
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	4
GO:0008374	O-acyltransferase activity	5	4
GO:0016411	acylglycerol O-acyltransferase activity	6	4
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	4
GO:0042171	lysophosphatidic acid acyltransferase activity	6	4
GO:0071617	lysophospholipid acyltransferase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.330
CLV_MEL_PAP_1	280	286	PF00089	0.552
CLV_NRD_NRD_1	122	124	PF00675	0.321
CLV_NRD_NRD_1	271	273	PF00675	0.563
CLV_NRD_NRD_1	4	6	PF00675	0.359
CLV_NRD_NRD_1	402	404	PF00675	0.546
CLV_NRD_NRD_1	79	81	PF00675	0.379
CLV_PCSK_FUR_1	119	123	PF00082	0.324
CLV_PCSK_KEX2_1	121	123	PF00082	0.325
CLV_PCSK_KEX2_1	4	6	PF00082	0.359
CLV_PCSK_KEX2_1	402	404	PF00082	0.577
CLV_PCSK_KEX2_1	79	81	PF00082	0.379
CLV_PCSK_PC7_1	75	81	PF00082	0.384
CLV_PCSK_SKI1_1	258	262	PF00082	0.481
DEG_APCC_DBOX_1	144	152	PF00400	0.296
DOC_CYCLIN_RxL_1	255	265	PF00134	0.289
DOC_MAPK_DCC_7	145	153	PF00069	0.331
DOC_MAPK_DCC_7	191	199	PF00069	0.371
DOC_MAPK_gen_1	145	153	PF00069	0.309
DOC_MAPK_MEF2A_6	145	153	PF00069	0.334
DOC_MAPK_MEF2A_6	155	163	PF00069	0.271
DOC_MAPK_MEF2A_6	191	199	PF00069	0.401
DOC_PP1_RVXF_1	200	207	PF00149	0.324
DOC_PP1_RVXF_1	223	229	PF00149	0.426
DOC_PP2B_LxvP_1	16	19	PF13499	0.541
DOC_PP2B_LxvP_1	182	185	PF13499	0.616
DOC_USP7_MATH_1	126	130	PF00917	0.483
DOC_USP7_MATH_1	45	49	PF00917	0.548
DOC_USP7_MATH_1	59	63	PF00917	0.552
DOC_WW_Pin1_4	252	257	PF00397	0.352
DOC_WW_Pin1_4	49	54	PF00397	0.548
DOC_WW_Pin1_4	82	87	PF00397	0.570
LIG_14-3-3_CanoR_1	225	229	PF00244	0.372
LIG_14-3-3_CanoR_1	4	9	PF00244	0.565
LIG_14-3-3_CanoR_1	46	50	PF00244	0.550
LIG_14-3-3_CanoR_1	69	77	PF00244	0.578
LIG_14-3-3_CanoR_1	79	88	PF00244	0.573
LIG_APCC_ABBA_1	323	328	PF00400	0.277
LIG_BRCT_BRCA1_1	128	132	PF00533	0.563
LIG_deltaCOP1_diTrp_1	365	371	PF00928	0.306
LIG_EH1_1	157	165	PF00400	0.234
LIG_FHA_1	171	177	PF00498	0.419
LIG_FHA_1	184	190	PF00498	0.504
LIG_FHA_1	97	103	PF00498	0.539
LIG_GBD_Chelix_1	135	143	PF00786	0.433
LIG_LIR_Gen_1	129	139	PF02991	0.499
LIG_LIR_Gen_1	247	257	PF02991	0.302
LIG_LIR_Gen_1	345	354	PF02991	0.291
LIG_LIR_LC3C_4	173	177	PF02991	0.356
LIG_LIR_Nem_3	129	135	PF02991	0.507
LIG_LIR_Nem_3	21	26	PF02991	0.576
LIG_LIR_Nem_3	227	231	PF02991	0.328
LIG_LIR_Nem_3	244	249	PF02991	0.342
LIG_LIR_Nem_3	255	260	PF02991	0.296
LIG_LIR_Nem_3	345	349	PF02991	0.306
LIG_LIR_Nem_3	355	360	PF02991	0.310
LIG_MYND_1	14	18	PF01753	0.549
LIG_Pex14_2	201	205	PF04695	0.430
LIG_Pex14_2	277	281	PF04695	0.350
LIG_Pex14_2	287	291	PF04695	0.347
LIG_Pex14_2	346	350	PF04695	0.289
LIG_SH2_CRK	23	27	PF00017	0.581
LIG_SH2_CRK	249	253	PF00017	0.360
LIG_SH2_PTP2	141	144	PF00017	0.276
LIG_SH2_STAT3	187	190	PF00017	0.234
LIG_SH2_STAT5	141	144	PF00017	0.347
LIG_SH2_STAT5	188	191	PF00017	0.282
LIG_SH2_STAT5	238	241	PF00017	0.242
LIG_SH2_STAT5	290	293	PF00017	0.270
LIG_SH3_3	334	340	PF00018	0.216
LIG_SH3_3	89	95	PF00018	0.559
LIG_TYR_ITIM	139	144	PF00017	0.419
LIG_WRC_WIRS_1	343	348	PF05994	0.336
MOD_CDK_SPxK_1	252	258	PF00069	0.362
MOD_CK1_1	170	176	PF00069	0.369
MOD_CK1_1	62	68	PF00069	0.419
MOD_CK1_1	82	88	PF00069	0.447
MOD_CK2_1	108	114	PF00069	0.359
MOD_CMANNOS	368	371	PF00535	0.428
MOD_Cter_Amidation	119	122	PF01082	0.384
MOD_Cter_Amidation	2	5	PF01082	0.433
MOD_GlcNHglycan	169	172	PF01048	0.409
MOD_GlcNHglycan	292	295	PF01048	0.328
MOD_GlcNHglycan	318	321	PF01048	0.250
MOD_GlcNHglycan	425	428	PF01048	0.426
MOD_GSK3_1	262	269	PF00069	0.448
MOD_GSK3_1	394	401	PF00069	0.429
MOD_GSK3_1	45	52	PF00069	0.417
MOD_GSK3_1	82	89	PF00069	0.427
MOD_N-GLC_1	108	113	PF02516	0.368
MOD_NEK2_1	260	265	PF00069	0.308
MOD_NEK2_1	266	271	PF00069	0.404
MOD_NEK2_1	38	43	PF00069	0.455
MOD_NEK2_1	88	93	PF00069	0.425
MOD_NMyristoyl	1	7	PF02799	0.439
MOD_PIKK_1	229	235	PF00454	0.321
MOD_PIKK_1	96	102	PF00454	0.411
MOD_PK_1	108	114	PF00069	0.359
MOD_PK_1	4	10	PF00069	0.444
MOD_PKA_1	4	10	PF00069	0.444
MOD_PKA_1	79	85	PF00069	0.456
MOD_PKA_2	224	230	PF00069	0.435
MOD_PKA_2	4	10	PF00069	0.444
MOD_PKA_2	45	51	PF00069	0.418
MOD_PKA_2	62	68	PF00069	0.418
MOD_PKA_2	79	85	PF00069	0.452
MOD_Plk_1	108	114	PF00069	0.371
MOD_Plk_1	364	370	PF00069	0.481
MOD_Plk_4	126	132	PF00069	0.462
MOD_Plk_4	162	168	PF00069	0.315
MOD_Plk_4	183	189	PF00069	0.303
MOD_Plk_4	241	247	PF00069	0.345
MOD_Plk_4	345	351	PF00069	0.462
MOD_Plk_4	353	359	PF00069	0.462
MOD_ProDKin_1	252	258	PF00069	0.423
MOD_ProDKin_1	49	55	PF00069	0.419
MOD_ProDKin_1	82	88	PF00069	0.450
MOD_SUMO_for_1	107	110	PF00179	0.365
MOD_SUMO_rev_2	391	400	PF00179	0.445
MOD_SUMO_rev_2	414	424	PF00179	0.366
MOD_SUMO_rev_2	426	432	PF00179	0.466
TRG_ENDOCYTIC_2	141	144	PF00928	0.428
TRG_ENDOCYTIC_2	23	26	PF00928	0.465
TRG_ENDOCYTIC_2	249	252	PF00928	0.464
TRG_ENDOCYTIC_2	343	346	PF00928	0.407
TRG_ENDOCYTIC_2	357	360	PF00928	0.393
TRG_ENDOCYTIC_2	412	415	PF00928	0.432
TRG_ER_diArg_1	119	122	PF00400	0.384
TRG_ER_diArg_1	144	147	PF00400	0.469
TRG_ER_diArg_1	402	404	PF00400	0.439
TRG_NES_CRM1_1	380	393	PF08389	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTP4	Leptomonas seymouri	66%	100%
A0A0S4JRB2	Bodo saltans	31%	100%
A0A3R7NKA0	Trypanosoma rangeli	33%	100%
A0A3S5H7L8	Leishmania donovani	34%	100%
A0A3S7WNW6	Leishmania donovani	50%	100%
A4H419	Leishmania braziliensis	66%	100%
A4H420	Leishmania braziliensis	54%	100%
A4HHM7	Leishmania braziliensis	32%	100%
A4HSA1	Leishmania infantum	99%	100%
A4HSA2	Leishmania infantum	52%	100%
A4I4U1	Leishmania infantum	30%	100%
A4I4U2	Leishmania infantum	34%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AE89	Leishmania major	31%	100%
E9AE90	Leishmania major	33%	100%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q9NF90	Leishmania major	52%	100%
Q9NF91	Leishmania major	89%	100%
V5C201	Trypanosoma cruzi	32%	100%