Acyltransferase-like protein, copy 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase-like protein, copy 1

Species:

Leishmania donovani

UniProt:

A0A3S5H5E4_LEIDO

TriTrypDb:

LdBPK_041040.1 , LdCL_040016100 , LDHU3_04.1280

Length:

432

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

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Expansion

Sequence features

A0A3S5H5E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5E4

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006654	phosphatidic acid biosynthetic process	6	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	4
GO:0008374	O-acyltransferase activity	5	4
GO:0016411	acylglycerol O-acyltransferase activity	6	4
GO:0016740	transferase activity	2	22
GO:0016746	acyltransferase activity	3	22
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	4
GO:0042171	lysophosphatidic acid acyltransferase activity	6	4
GO:0071617	lysophospholipid acyltransferase activity	5	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.330
CLV_MEL_PAP_1	280	286	PF00089	0.552
CLV_NRD_NRD_1	122	124	PF00675	0.321
CLV_NRD_NRD_1	271	273	PF00675	0.563
CLV_NRD_NRD_1	4	6	PF00675	0.359
CLV_NRD_NRD_1	402	404	PF00675	0.546
CLV_NRD_NRD_1	79	81	PF00675	0.379
CLV_PCSK_FUR_1	119	123	PF00082	0.324
CLV_PCSK_KEX2_1	121	123	PF00082	0.325
CLV_PCSK_KEX2_1	4	6	PF00082	0.359

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTP4	Leptomonas seymouri	66%	100%
A0A0S4JRB2	Bodo saltans	31%	100%
A0A3R7NKA0	Trypanosoma rangeli	33%	100%
A0A3S5H7L8	Leishmania donovani	34%	100%
A0A3S7WNW6	Leishmania donovani	50%	100%
A4H419	Leishmania braziliensis	66%	100%
A4H420	Leishmania braziliensis	54%	100%
A4HHM7	Leishmania braziliensis	32%	100%
A4HSA1	Leishmania infantum	99%	100%
A4HSA2	Leishmania infantum	52%	100%

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