LeishMANIAdb
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Acyltransferase-like protein, copy 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Acyltransferase-like protein, copy 1
Gene product:
acyltransferase-like protein, copy 1
Species:
Leishmania donovani
UniProt:
A0A3S5H5E4_LEIDO
TriTrypDb:
LdBPK_041040.1 * , LdCL_040016100 , LDHU3_04.1280
Length:
432

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0016020 membrane 2 18
GO:0110165 cellular anatomical entity 1 18

Expansion

Sequence features

A0A3S5H5E4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5E4

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 4
GO:0006644 phospholipid metabolic process 4 4
GO:0006650 glycerophospholipid metabolic process 5 4
GO:0006654 phosphatidic acid biosynthetic process 6 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0008152 metabolic process 1 4
GO:0008610 lipid biosynthetic process 4 4
GO:0008654 phospholipid biosynthetic process 5 4
GO:0009058 biosynthetic process 2 4
GO:0009987 cellular process 1 4
GO:0019637 organophosphate metabolic process 3 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044249 cellular biosynthetic process 3 4
GO:0044255 cellular lipid metabolic process 3 4
GO:0045017 glycerolipid biosynthetic process 4 4
GO:0046473 phosphatidic acid metabolic process 6 4
GO:0046474 glycerophospholipid biosynthetic process 5 4
GO:0046486 glycerolipid metabolic process 4 4
GO:0071704 organic substance metabolic process 2 4
GO:0090407 organophosphate biosynthetic process 4 4
GO:1901576 organic substance biosynthetic process 3 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 22
GO:0016740 transferase activity 2 22
GO:0016746 acyltransferase activity 3 22
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7 4
GO:0008374 O-acyltransferase activity 5 4
GO:0016411 acylglycerol O-acyltransferase activity 6 4
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 4
GO:0042171 lysophosphatidic acid acyltransferase activity 6 4
GO:0071617 lysophospholipid acyltransferase activity 5 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 420 424 PF00656 0.330
CLV_MEL_PAP_1 280 286 PF00089 0.552
CLV_NRD_NRD_1 122 124 PF00675 0.321
CLV_NRD_NRD_1 271 273 PF00675 0.563
CLV_NRD_NRD_1 4 6 PF00675 0.359
CLV_NRD_NRD_1 402 404 PF00675 0.546
CLV_NRD_NRD_1 79 81 PF00675 0.379
CLV_PCSK_FUR_1 119 123 PF00082 0.324
CLV_PCSK_KEX2_1 121 123 PF00082 0.325
CLV_PCSK_KEX2_1 4 6 PF00082 0.359
CLV_PCSK_KEX2_1 402 404 PF00082 0.577
CLV_PCSK_KEX2_1 79 81 PF00082 0.379
CLV_PCSK_PC7_1 75 81 PF00082 0.384
CLV_PCSK_SKI1_1 258 262 PF00082 0.481
DEG_APCC_DBOX_1 144 152 PF00400 0.296
DOC_CYCLIN_RxL_1 255 265 PF00134 0.289
DOC_MAPK_DCC_7 145 153 PF00069 0.331
DOC_MAPK_DCC_7 191 199 PF00069 0.371
DOC_MAPK_gen_1 145 153 PF00069 0.309
DOC_MAPK_MEF2A_6 145 153 PF00069 0.334
DOC_MAPK_MEF2A_6 155 163 PF00069 0.271
DOC_MAPK_MEF2A_6 191 199 PF00069 0.401
DOC_PP1_RVXF_1 200 207 PF00149 0.324
DOC_PP1_RVXF_1 223 229 PF00149 0.426
DOC_PP2B_LxvP_1 16 19 PF13499 0.541
DOC_PP2B_LxvP_1 182 185 PF13499 0.616
DOC_USP7_MATH_1 126 130 PF00917 0.483
DOC_USP7_MATH_1 45 49 PF00917 0.548
DOC_USP7_MATH_1 59 63 PF00917 0.552
DOC_WW_Pin1_4 252 257 PF00397 0.352
DOC_WW_Pin1_4 49 54 PF00397 0.548
DOC_WW_Pin1_4 82 87 PF00397 0.570
LIG_14-3-3_CanoR_1 225 229 PF00244 0.372
LIG_14-3-3_CanoR_1 4 9 PF00244 0.565
LIG_14-3-3_CanoR_1 46 50 PF00244 0.550
LIG_14-3-3_CanoR_1 69 77 PF00244 0.578
LIG_14-3-3_CanoR_1 79 88 PF00244 0.573
LIG_APCC_ABBA_1 323 328 PF00400 0.277
LIG_BRCT_BRCA1_1 128 132 PF00533 0.563
LIG_deltaCOP1_diTrp_1 365 371 PF00928 0.306
LIG_EH1_1 157 165 PF00400 0.234
LIG_FHA_1 171 177 PF00498 0.419
LIG_FHA_1 184 190 PF00498 0.504
LIG_FHA_1 97 103 PF00498 0.539
LIG_GBD_Chelix_1 135 143 PF00786 0.433
LIG_LIR_Gen_1 129 139 PF02991 0.499
LIG_LIR_Gen_1 247 257 PF02991 0.302
LIG_LIR_Gen_1 345 354 PF02991 0.291
LIG_LIR_LC3C_4 173 177 PF02991 0.356
LIG_LIR_Nem_3 129 135 PF02991 0.507
LIG_LIR_Nem_3 21 26 PF02991 0.576
LIG_LIR_Nem_3 227 231 PF02991 0.328
LIG_LIR_Nem_3 244 249 PF02991 0.342
LIG_LIR_Nem_3 255 260 PF02991 0.296
LIG_LIR_Nem_3 345 349 PF02991 0.306
LIG_LIR_Nem_3 355 360 PF02991 0.310
LIG_MYND_1 14 18 PF01753 0.549
LIG_Pex14_2 201 205 PF04695 0.430
LIG_Pex14_2 277 281 PF04695 0.350
LIG_Pex14_2 287 291 PF04695 0.347
LIG_Pex14_2 346 350 PF04695 0.289
LIG_SH2_CRK 23 27 PF00017 0.581
LIG_SH2_CRK 249 253 PF00017 0.360
LIG_SH2_PTP2 141 144 PF00017 0.276
LIG_SH2_STAT3 187 190 PF00017 0.234
LIG_SH2_STAT5 141 144 PF00017 0.347
LIG_SH2_STAT5 188 191 PF00017 0.282
LIG_SH2_STAT5 238 241 PF00017 0.242
LIG_SH2_STAT5 290 293 PF00017 0.270
LIG_SH3_3 334 340 PF00018 0.216
LIG_SH3_3 89 95 PF00018 0.559
LIG_TYR_ITIM 139 144 PF00017 0.419
LIG_WRC_WIRS_1 343 348 PF05994 0.336
MOD_CDK_SPxK_1 252 258 PF00069 0.362
MOD_CK1_1 170 176 PF00069 0.369
MOD_CK1_1 62 68 PF00069 0.419
MOD_CK1_1 82 88 PF00069 0.447
MOD_CK2_1 108 114 PF00069 0.359
MOD_CMANNOS 368 371 PF00535 0.428
MOD_Cter_Amidation 119 122 PF01082 0.384
MOD_Cter_Amidation 2 5 PF01082 0.433
MOD_GlcNHglycan 169 172 PF01048 0.409
MOD_GlcNHglycan 292 295 PF01048 0.328
MOD_GlcNHglycan 318 321 PF01048 0.250
MOD_GlcNHglycan 425 428 PF01048 0.426
MOD_GSK3_1 262 269 PF00069 0.448
MOD_GSK3_1 394 401 PF00069 0.429
MOD_GSK3_1 45 52 PF00069 0.417
MOD_GSK3_1 82 89 PF00069 0.427
MOD_N-GLC_1 108 113 PF02516 0.368
MOD_NEK2_1 260 265 PF00069 0.308
MOD_NEK2_1 266 271 PF00069 0.404
MOD_NEK2_1 38 43 PF00069 0.455
MOD_NEK2_1 88 93 PF00069 0.425
MOD_NMyristoyl 1 7 PF02799 0.439
MOD_PIKK_1 229 235 PF00454 0.321
MOD_PIKK_1 96 102 PF00454 0.411
MOD_PK_1 108 114 PF00069 0.359
MOD_PK_1 4 10 PF00069 0.444
MOD_PKA_1 4 10 PF00069 0.444
MOD_PKA_1 79 85 PF00069 0.456
MOD_PKA_2 224 230 PF00069 0.435
MOD_PKA_2 4 10 PF00069 0.444
MOD_PKA_2 45 51 PF00069 0.418
MOD_PKA_2 62 68 PF00069 0.418
MOD_PKA_2 79 85 PF00069 0.452
MOD_Plk_1 108 114 PF00069 0.371
MOD_Plk_1 364 370 PF00069 0.481
MOD_Plk_4 126 132 PF00069 0.462
MOD_Plk_4 162 168 PF00069 0.315
MOD_Plk_4 183 189 PF00069 0.303
MOD_Plk_4 241 247 PF00069 0.345
MOD_Plk_4 345 351 PF00069 0.462
MOD_Plk_4 353 359 PF00069 0.462
MOD_ProDKin_1 252 258 PF00069 0.423
MOD_ProDKin_1 49 55 PF00069 0.419
MOD_ProDKin_1 82 88 PF00069 0.450
MOD_SUMO_for_1 107 110 PF00179 0.365
MOD_SUMO_rev_2 391 400 PF00179 0.445
MOD_SUMO_rev_2 414 424 PF00179 0.366
MOD_SUMO_rev_2 426 432 PF00179 0.466
TRG_ENDOCYTIC_2 141 144 PF00928 0.428
TRG_ENDOCYTIC_2 23 26 PF00928 0.465
TRG_ENDOCYTIC_2 249 252 PF00928 0.464
TRG_ENDOCYTIC_2 343 346 PF00928 0.407
TRG_ENDOCYTIC_2 357 360 PF00928 0.393
TRG_ENDOCYTIC_2 412 415 PF00928 0.432
TRG_ER_diArg_1 119 122 PF00400 0.384
TRG_ER_diArg_1 144 147 PF00400 0.469
TRG_ER_diArg_1 402 404 PF00400 0.439
TRG_NES_CRM1_1 380 393 PF08389 0.366

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTP4 Leptomonas seymouri 66% 100%
A0A0S4JRB2 Bodo saltans 31% 100%
A0A3R7NKA0 Trypanosoma rangeli 33% 100%
A0A3S5H7L8 Leishmania donovani 34% 100%
A0A3S7WNW6 Leishmania donovani 50% 100%
A4H419 Leishmania braziliensis 66% 100%
A4H420 Leishmania braziliensis 54% 100%
A4HHM7 Leishmania braziliensis 32% 100%
A4HSA1 Leishmania infantum 99% 100%
A4HSA2 Leishmania infantum 52% 100%
A4I4U1 Leishmania infantum 30% 100%
A4I4U2 Leishmania infantum 34% 100%
C9ZLI8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AE89 Leishmania major 31% 100%
E9AE90 Leishmania major 33% 100%
E9AK86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9ALJ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
Q9NF90 Leishmania major 52% 100%
Q9NF91 Leishmania major 89% 100%
V5C201 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS