LeishMANIAdb
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Acyltransferase-like protein, copy 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Acyltransferase-like protein, copy 1
Gene product:
acyltransferase-like protein, copy 1
Species:
Leishmania donovani
UniProt:
A0A3S5H5E4_LEIDO
TriTrypDb:
LdBPK_041040.1 * , LdCL_040016100 , LDHU3_04.1280
Length:
432

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 18
GO:0110165 cellular anatomical entity 1 18
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Expansion

Sequence features

A0A3S5H5E4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5E4

Function

Biological processes
TermNameLevelCount
GO:0006629 lipid metabolic process 3 4
GO:0006644 phospholipid metabolic process 4 4
GO:0006650 glycerophospholipid metabolic process 5 4
GO:0006654 phosphatidic acid biosynthetic process 6 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0008152 metabolic process 1 4
GO:0008610 lipid biosynthetic process 4 4
GO:0008654 phospholipid biosynthetic process 5 4
GO:0009058 biosynthetic process 2 4
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 22
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7 4
GO:0008374 O-acyltransferase activity 5 4
GO:0016411 acylglycerol O-acyltransferase activity 6 4
GO:0016740 transferase activity 2 22
GO:0016746 acyltransferase activity 3 22
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 4
GO:0042171 lysophosphatidic acid acyltransferase activity 6 4
GO:0071617 lysophospholipid acyltransferase activity 5 4
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 420 424 PF00656 0.330
CLV_MEL_PAP_1 280 286 PF00089 0.552
CLV_NRD_NRD_1 122 124 PF00675 0.321
CLV_NRD_NRD_1 271 273 PF00675 0.563
CLV_NRD_NRD_1 4 6 PF00675 0.359
CLV_NRD_NRD_1 402 404 PF00675 0.546
CLV_NRD_NRD_1 79 81 PF00675 0.379
CLV_PCSK_FUR_1 119 123 PF00082 0.324
CLV_PCSK_KEX2_1 121 123 PF00082 0.325
CLV_PCSK_KEX2_1 4 6 PF00082 0.359
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HTP4 Leptomonas seymouri 66% 100%
A0A0S4JRB2 Bodo saltans 31% 100%
A0A3R7NKA0 Trypanosoma rangeli 33% 100%
A0A3S5H7L8 Leishmania donovani 34% 100%
A0A3S7WNW6 Leishmania donovani 50% 100%
A4H419 Leishmania braziliensis 66% 100%
A4H420 Leishmania braziliensis 54% 100%
A4HHM7 Leishmania braziliensis 32% 100%
A4HSA1 Leishmania infantum 99% 100%
A4HSA2 Leishmania infantum 52% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS