rRNA biogenesis protein RRP36

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF947), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5E2_LEIDO

TriTrypDb:

LdBPK_041020.1 , LdCL_040015800 , LDHU3_04.1260

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1

Expansion

Sequence features

A0A3S5H5E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5E2

Function

Biological processes
Term	Name	Level	Count
GO:0000469	cleavage involved in rRNA processing	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.328
CLV_NRD_NRD_1	168	170	PF00675	0.349
CLV_NRD_NRD_1	17	19	PF00675	0.300
CLV_NRD_NRD_1	178	180	PF00675	0.353
CLV_NRD_NRD_1	217	219	PF00675	0.321
CLV_NRD_NRD_1	42	44	PF00675	0.349
CLV_NRD_NRD_1	78	80	PF00675	0.279
CLV_NRD_NRD_1	90	92	PF00675	0.261
CLV_PCSK_FUR_1	15	19	PF00082	0.323
CLV_PCSK_KEX2_1	14	16	PF00082	0.594
CLV_PCSK_KEX2_1	159	161	PF00082	0.372
CLV_PCSK_KEX2_1	164	166	PF00082	0.328
CLV_PCSK_KEX2_1	17	19	PF00082	0.302
CLV_PCSK_KEX2_1	187	189	PF00082	0.355
CLV_PCSK_KEX2_1	192	194	PF00082	0.212
CLV_PCSK_KEX2_1	219	221	PF00082	0.363
CLV_PCSK_KEX2_1	42	44	PF00082	0.305
CLV_PCSK_KEX2_1	57	59	PF00082	0.381
CLV_PCSK_KEX2_1	78	80	PF00082	0.276
CLV_PCSK_KEX2_1	90	92	PF00082	0.272
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.600
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.297
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.365
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.216
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.364
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.463
CLV_PCSK_PC7_1	160	166	PF00082	0.441
CLV_PCSK_PC7_1	188	194	PF00082	0.318
CLV_PCSK_PC7_1	86	92	PF00082	0.437
CLV_PCSK_SKI1_1	123	127	PF00082	0.378
CLV_PCSK_SKI1_1	165	169	PF00082	0.323
CLV_PCSK_SKI1_1	193	197	PF00082	0.310
CLV_PCSK_SKI1_1	23	27	PF00082	0.391
CLV_PCSK_SKI1_1	57	61	PF00082	0.338
CLV_Separin_Metazoa	166	170	PF03568	0.290
DEG_Nend_UBRbox_3	1	3	PF02207	0.529
DEG_SPOP_SBC_1	25	29	PF00917	0.265
DOC_CYCLIN_RxL_1	159	171	PF00134	0.405
DOC_MAPK_gen_1	169	175	PF00069	0.382
DOC_PP2B_LxvP_1	127	130	PF13499	0.363
DOC_SPAK_OSR1_1	79	83	PF12202	0.414
DOC_USP7_MATH_1	25	29	PF00917	0.314
DOC_USP7_MATH_1	31	35	PF00917	0.263
DOC_USP7_UBL2_3	176	180	PF12436	0.363
DOC_WW_Pin1_4	125	130	PF00397	0.352
LIG_14-3-3_CanoR_1	142	148	PF00244	0.378
LIG_14-3-3_CanoR_1	159	164	PF00244	0.202
LIG_14-3-3_CanoR_1	193	200	PF00244	0.367
LIG_FHA_1	34	40	PF00498	0.273
LIG_LIR_Gen_1	198	205	PF02991	0.270
LIG_LIR_Nem_3	198	203	PF02991	0.270
LIG_LIR_Nem_3	61	67	PF02991	0.386
LIG_PCNA_APIM_2	212	218	PF02747	0.414
LIG_Pex14_2	48	52	PF04695	0.314
LIG_SH2_CRK	64	68	PF00017	0.284
LIG_SH2_STAP1	109	113	PF00017	0.414
LIG_SH2_STAT5	147	150	PF00017	0.356
LIG_SH2_STAT5	184	187	PF00017	0.363
LIG_SH2_STAT5	215	218	PF00017	0.269
LIG_SH3_1	180	186	PF00018	0.328
LIG_SH3_2	183	188	PF14604	0.328
LIG_SH3_3	180	186	PF00018	0.328
MOD_CDK_SPxxK_3	125	132	PF00069	0.314
MOD_CK1_1	33	39	PF00069	0.455
MOD_CK2_1	104	110	PF00069	0.295
MOD_Cter_Amidation	177	180	PF01082	0.303
MOD_GlcNHglycan	36	39	PF01048	0.462
MOD_GSK3_1	148	155	PF00069	0.360
MOD_GSK3_1	26	33	PF00069	0.394
MOD_NEK2_1	146	151	PF00069	0.303
MOD_PIKK_1	141	147	PF00454	0.288
MOD_PK_1	152	158	PF00069	0.338
MOD_PK_1	159	165	PF00069	0.270
MOD_PKA_1	159	165	PF00069	0.441
MOD_PKA_1	17	23	PF00069	0.329
MOD_PKA_2	141	147	PF00069	0.303
MOD_PKA_2	158	164	PF00069	0.410
MOD_PKA_2	16	22	PF00069	0.329
MOD_PKB_1	15	23	PF00069	0.381
MOD_Plk_1	152	158	PF00069	0.338
MOD_ProDKin_1	125	131	PF00069	0.352
MOD_SUMO_for_1	163	166	PF00179	0.264
MOD_SUMO_rev_2	121	128	PF00179	0.386
TRG_ENDOCYTIC_2	134	137	PF00928	0.414
TRG_ENDOCYTIC_2	64	67	PF00928	0.324
TRG_ER_diArg_1	15	18	PF00400	0.578
TRG_ER_diArg_1	217	220	PF00400	0.440
TRG_ER_diArg_1	42	44	PF00400	0.315
TRG_ER_diArg_1	78	80	PF00400	0.288
TRG_ER_diArg_1	89	91	PF00400	0.246
TRG_NLS_Bipartite_1	164	183	PF00514	0.325
TRG_NLS_MonoCore_2	13	18	PF00514	0.654
TRG_NLS_MonoCore_2	217	222	PF00514	0.405
TRG_NLS_MonoExtC_3	13	18	PF00514	0.654
TRG_NLS_MonoExtC_3	178	183	PF00514	0.325
TRG_NLS_MonoExtC_3	217	222	PF00514	0.414
TRG_NLS_MonoExtN_4	176	183	PF00514	0.303
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P373	Leptomonas seymouri	74%	100%
A0A0S4IME8	Bodo saltans	42%	96%
A0A1X0NLQ0	Trypanosomatidae	50%	100%
A0A422NNW0	Trypanosoma rangeli	48%	100%
A4H416	Leishmania braziliensis	87%	100%
A4HS99	Leishmania infantum	99%	100%
C9ZY93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AK83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q9NF94	Leishmania major	94%	100%
V5BDM1	Trypanosoma cruzi	49%	100%