Nucleolin_bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5E1_LEIDO

TriTrypDb:

LdBPK_041000.1 , LdCL_040015600 , LDHU3_04.1240

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.793
CLV_NRD_NRD_1	176	178	PF00675	0.606
CLV_NRD_NRD_1	242	244	PF00675	0.715
CLV_PCSK_FUR_1	223	227	PF00082	0.491
CLV_PCSK_KEX2_1	220	222	PF00082	0.441
CLV_PCSK_KEX2_1	225	227	PF00082	0.452
CLV_PCSK_KEX2_1	242	244	PF00082	0.647
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.466
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.428
CLV_PCSK_PC7_1	221	227	PF00082	0.422
CLV_PCSK_SKI1_1	147	151	PF00082	0.576
CLV_PCSK_SKI1_1	35	39	PF00082	0.588
CLV_PCSK_SKI1_1	70	74	PF00082	0.651
CLV_Separin_Metazoa	13	17	PF03568	0.552
DOC_MAPK_gen_1	220	230	PF00069	0.573
DOC_MAPK_gen_1	245	255	PF00069	0.611
DOC_MAPK_HePTP_8	7	19	PF00069	0.547
DOC_MAPK_MEF2A_6	10	19	PF00069	0.544
DOC_MAPK_MEF2A_6	197	204	PF00069	0.446
DOC_USP7_MATH_1	111	115	PF00917	0.701
DOC_USP7_MATH_1	157	161	PF00917	0.697
DOC_USP7_MATH_1	188	192	PF00917	0.604
DOC_USP7_MATH_1	259	263	PF00917	0.676
DOC_USP7_MATH_1	268	272	PF00917	0.694
DOC_USP7_MATH_1	51	55	PF00917	0.401
DOC_USP7_UBL2_3	216	220	PF12436	0.570
DOC_WW_Pin1_4	155	160	PF00397	0.556
DOC_WW_Pin1_4	264	269	PF00397	0.779
LIG_14-3-3_CanoR_1	177	182	PF00244	0.468
LIG_14-3-3_CanoR_1	276	281	PF00244	0.714
LIG_14-3-3_CanoR_1	53	57	PF00244	0.410
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_Clathr_ClatBox_1	201	205	PF01394	0.447
LIG_eIF4E_1	195	201	PF01652	0.398
LIG_FHA_1	10	16	PF00498	0.421
LIG_FHA_2	185	191	PF00498	0.605
LIG_FHA_2	42	48	PF00498	0.548
LIG_LIR_Gen_1	198	204	PF02991	0.440
LIG_LIR_Nem_3	198	202	PF02991	0.499
LIG_NRBOX	10	16	PF00104	0.546
LIG_PTB_Apo_2	249	256	PF02174	0.429
LIG_SH2_STAT5	195	198	PF00017	0.445
LIG_SH2_STAT5	199	202	PF00017	0.437
LIG_SH2_STAT5	49	52	PF00017	0.452
LIG_SH3_3	180	186	PF00018	0.590
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.573
LIG_TRAF2_1	187	190	PF00917	0.614
LIG_TRAF2_1	81	84	PF00917	0.679
MOD_CK1_1	161	167	PF00069	0.529
MOD_CK1_1	264	270	PF00069	0.724
MOD_CK1_1	271	277	PF00069	0.652
MOD_CK1_1	52	58	PF00069	0.527
MOD_CK1_1	89	95	PF00069	0.754
MOD_CK2_1	111	117	PF00069	0.619
MOD_CK2_1	161	167	PF00069	0.557
MOD_CK2_1	184	190	PF00069	0.577
MOD_CK2_1	41	47	PF00069	0.543
MOD_GlcNHglycan	101	104	PF01048	0.606
MOD_GlcNHglycan	138	141	PF01048	0.648
MOD_GlcNHglycan	160	163	PF01048	0.724
MOD_GlcNHglycan	261	264	PF01048	0.729
MOD_GlcNHglycan	270	273	PF01048	0.776
MOD_GSK3_1	157	164	PF00069	0.650
MOD_GSK3_1	184	191	PF00069	0.603
MOD_GSK3_1	264	271	PF00069	0.704
MOD_LATS_1	182	188	PF00433	0.532
MOD_N-GLC_1	24	29	PF02516	0.605
MOD_N-GLC_1	89	94	PF02516	0.683
MOD_PIKK_1	261	267	PF00454	0.670
MOD_PKA_1	136	142	PF00069	0.745
MOD_PKA_1	177	183	PF00069	0.450
MOD_PKA_2	275	281	PF00069	0.609
MOD_PKA_2	52	58	PF00069	0.463
MOD_Plk_1	145	151	PF00069	0.574
MOD_Plk_1	188	194	PF00069	0.593
MOD_Plk_1	24	30	PF00069	0.585
MOD_Plk_2-3	109	115	PF00069	0.518
MOD_Plk_2-3	118	124	PF00069	0.766
MOD_Plk_2-3	94	100	PF00069	0.679
MOD_Plk_4	276	282	PF00069	0.739
MOD_Plk_4	52	58	PF00069	0.454
MOD_ProDKin_1	155	161	PF00069	0.549
MOD_ProDKin_1	264	270	PF00069	0.773
MOD_SUMO_for_1	224	227	PF00179	0.428
MOD_SUMO_rev_2	2	12	PF00179	0.458
TRG_ENDOCYTIC_2	199	202	PF00928	0.402
TRG_ER_diArg_1	242	245	PF00400	0.715
TRG_NES_CRM1_1	190	205	PF08389	0.451
TRG_NLS_MonoExtN_4	135	140	PF00514	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7MS09	Trypanosoma rangeli	37%	67%
A4H414	Leishmania braziliensis	67%	100%
A4HS97	Leishmania infantum	99%	100%
E9AK81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5DEF7	Trypanosoma cruzi	37%	100%