Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5D9_LEIDO

TriTrypDb:

LdBPK_040980.1 , LdCL_040015400 , LDHU3_04.1220

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5D9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.633
CLV_NRD_NRD_1	34	36	PF00675	0.607
CLV_NRD_NRD_1	62	64	PF00675	0.721
CLV_NRD_NRD_1	72	74	PF00675	0.643
CLV_PCSK_FUR_1	32	36	PF00082	0.611
CLV_PCSK_KEX2_1	34	36	PF00082	0.607
CLV_PCSK_KEX2_1	61	63	PF00082	0.713
CLV_PCSK_PC7_1	30	36	PF00082	0.612
CLV_PCSK_SKI1_1	412	416	PF00082	0.569
DEG_SPOP_SBC_1	137	141	PF00917	0.718
DOC_CKS1_1	266	271	PF01111	0.620
DOC_CYCLIN_yCln2_LP_2	119	122	PF00134	0.716
DOC_MAPK_DCC_7	115	125	PF00069	0.730
DOC_PP2B_LxvP_1	119	122	PF13499	0.731
DOC_PP2B_LxvP_1	46	49	PF13499	0.670
DOC_USP7_MATH_1	100	104	PF00917	0.674
DOC_USP7_MATH_1	105	109	PF00917	0.648
DOC_USP7_MATH_1	124	128	PF00917	0.616
DOC_USP7_MATH_1	217	221	PF00917	0.610
DOC_USP7_MATH_1	227	231	PF00917	0.615
DOC_USP7_MATH_1	235	239	PF00917	0.726
DOC_USP7_MATH_1	267	271	PF00917	0.677
DOC_USP7_MATH_1	322	326	PF00917	0.708
DOC_USP7_MATH_1	371	375	PF00917	0.695
DOC_WW_Pin1_4	191	196	PF00397	0.753
DOC_WW_Pin1_4	225	230	PF00397	0.643
DOC_WW_Pin1_4	236	241	PF00397	0.740
DOC_WW_Pin1_4	265	270	PF00397	0.558
DOC_WW_Pin1_4	329	334	PF00397	0.821
DOC_WW_Pin1_4	36	41	PF00397	0.550
DOC_WW_Pin1_4	374	379	PF00397	0.790
DOC_WW_Pin1_4	388	393	PF00397	0.573
DOC_WW_Pin1_4	443	448	PF00397	0.709
DOC_WW_Pin1_4	466	471	PF00397	0.630
LIG_14-3-3_CanoR_1	299	305	PF00244	0.676
LIG_14-3-3_CanoR_1	357	361	PF00244	0.593
LIG_14-3-3_CanoR_1	412	421	PF00244	0.580
LIG_Actin_WH2_2	396	414	PF00022	0.519
LIG_APCC_ABBAyCdc20_2	10	16	PF00400	0.561
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_EVH1_2	121	125	PF00568	0.660
LIG_FHA_1	175	181	PF00498	0.738
LIG_FHA_2	138	144	PF00498	0.717
LIG_FHA_2	165	171	PF00498	0.677
LIG_FHA_2	348	354	PF00498	0.708
LIG_FHA_2	400	406	PF00498	0.590
LIG_FHA_2	81	87	PF00498	0.550
LIG_LIR_Apic_2	448	453	PF02991	0.654
LIG_LIR_Nem_3	131	136	PF02991	0.733
LIG_LIR_Nem_3	147	153	PF02991	0.502
LIG_MYND_1	41	45	PF01753	0.527
LIG_PCNA_PIPBox_1	248	257	PF02747	0.454
LIG_Pex14_1	92	96	PF04695	0.644
LIG_SH2_CRK	96	100	PF00017	0.580
LIG_SH2_STAT5	136	139	PF00017	0.791
LIG_SH2_STAT5	8	11	PF00017	0.566
LIG_SH3_1	54	60	PF00018	0.642
LIG_SH3_2	57	62	PF14604	0.762
LIG_SH3_3	115	121	PF00018	0.594
LIG_SH3_3	146	152	PF00018	0.650
LIG_SH3_3	193	199	PF00018	0.812
LIG_SH3_3	231	237	PF00018	0.747
LIG_SH3_3	263	269	PF00018	0.688
LIG_SH3_3	280	286	PF00018	0.590
LIG_SH3_3	323	329	PF00018	0.783
LIG_SH3_3	375	381	PF00018	0.786
LIG_SH3_3	418	424	PF00018	0.557
LIG_SH3_3	52	58	PF00018	0.721
LIG_SH3_CIN85_PxpxPR_1	49	54	PF14604	0.599
LIG_SUMO_SIM_par_1	44	50	PF11976	0.550
LIG_TRAF2_1	200	203	PF00917	0.602
LIG_TRAF2_1	350	353	PF00917	0.608
LIG_WW_2	328	331	PF00397	0.620
LIG_WW_3	39	43	PF00397	0.550
LIG_WW_3	58	62	PF00397	0.507
LIG_WW_3	70	74	PF00397	0.504
MOD_CDK_SPxK_1	36	42	PF00069	0.573
MOD_CDK_SPxK_1	443	449	PF00069	0.545
MOD_CK1_1	138	144	PF00069	0.717
MOD_CK1_1	174	180	PF00069	0.639
MOD_CK1_1	239	245	PF00069	0.558
MOD_CK1_1	374	380	PF00069	0.763
MOD_CK2_1	267	273	PF00069	0.664
MOD_CK2_1	347	353	PF00069	0.685
MOD_CK2_1	399	405	PF00069	0.565
MOD_CK2_1	80	86	PF00069	0.547
MOD_GlcNHglycan	107	110	PF01048	0.807
MOD_GlcNHglycan	126	129	PF01048	0.568
MOD_GlcNHglycan	173	176	PF01048	0.658
MOD_GlcNHglycan	213	216	PF01048	0.663
MOD_GlcNHglycan	219	222	PF01048	0.618
MOD_GlcNHglycan	229	232	PF01048	0.602
MOD_GlcNHglycan	269	272	PF01048	0.646
MOD_GlcNHglycan	373	376	PF01048	0.768
MOD_GlcNHglycan	434	438	PF01048	0.611
MOD_GlcNHglycan	64	67	PF01048	0.585
MOD_GSK3_1	181	188	PF00069	0.693
MOD_GSK3_1	235	242	PF00069	0.697
MOD_GSK3_1	338	345	PF00069	0.813
MOD_GSK3_1	379	386	PF00069	0.672
MOD_GSK3_1	62	69	PF00069	0.611
MOD_N-GLC_1	412	417	PF02516	0.599
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	111	116	PF00069	0.668
MOD_NEK2_1	201	206	PF00069	0.590
MOD_PIKK_1	201	207	PF00454	0.627
MOD_PIKK_1	293	299	PF00454	0.728
MOD_PKA_1	62	68	PF00069	0.591
MOD_PKA_2	356	362	PF00069	0.620
MOD_PKA_2	62	68	PF00069	0.631
MOD_Plk_1	100	106	PF00069	0.659
MOD_Plk_1	111	117	PF00069	0.577
MOD_Plk_1	322	328	PF00069	0.759
MOD_Plk_2-3	399	405	PF00069	0.565
MOD_Plk_4	23	29	PF00069	0.694
MOD_ProDKin_1	191	197	PF00069	0.755
MOD_ProDKin_1	225	231	PF00069	0.645
MOD_ProDKin_1	236	242	PF00069	0.545
MOD_ProDKin_1	265	271	PF00069	0.562
MOD_ProDKin_1	329	335	PF00069	0.823
MOD_ProDKin_1	36	42	PF00069	0.558
MOD_ProDKin_1	374	380	PF00069	0.790
MOD_ProDKin_1	388	394	PF00069	0.573
MOD_ProDKin_1	443	449	PF00069	0.709
MOD_ProDKin_1	466	472	PF00069	0.629
TRG_ENDOCYTIC_2	96	99	PF00928	0.581
TRG_ER_diArg_1	29	32	PF00400	0.563
TRG_ER_diArg_1	420	423	PF00400	0.598
TRG_ER_diArg_1	60	63	PF00400	0.664
TRG_ER_diArg_1	77	80	PF00400	0.756

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B3	Leptomonas seymouri	30%	100%
A4H412	Leishmania braziliensis	63%	93%
A4HS95	Leishmania infantum	100%	100%
E9ACP9	Leishmania major	85%	100%
E9AK79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	93%