Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5D8_LEIDO

TriTrypDb:

LdBPK_040970.1 , LdCL_040015300 , LDHU3_04.1210

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5D8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.596
CLV_C14_Caspase3-7	416	420	PF00656	0.516
CLV_NRD_NRD_1	212	214	PF00675	0.637
CLV_NRD_NRD_1	474	476	PF00675	0.631
CLV_NRD_NRD_1	522	524	PF00675	0.608
CLV_NRD_NRD_1	63	65	PF00675	0.614
CLV_NRD_NRD_1	99	101	PF00675	0.660
CLV_PCSK_FUR_1	57	61	PF00082	0.684
CLV_PCSK_KEX2_1	123	125	PF00082	0.707
CLV_PCSK_KEX2_1	212	214	PF00082	0.638
CLV_PCSK_KEX2_1	474	476	PF00082	0.631
CLV_PCSK_KEX2_1	522	524	PF00082	0.608
CLV_PCSK_KEX2_1	59	61	PF00082	0.681
CLV_PCSK_KEX2_1	63	65	PF00082	0.651
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.674
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.681
CLV_PCSK_SKI1_1	212	216	PF00082	0.638
CLV_PCSK_SKI1_1	394	398	PF00082	0.590
CLV_PCSK_SKI1_1	70	74	PF00082	0.652
DEG_SCF_TRCP1_1	419	425	PF00400	0.630
DEG_SPOP_SBC_1	203	207	PF00917	0.614
DEG_SPOP_SBC_1	231	235	PF00917	0.704
DEG_SPOP_SBC_1	90	94	PF00917	0.705
DOC_CYCLIN_RxL_1	209	217	PF00134	0.637
DOC_MAPK_DCC_7	289	297	PF00069	0.579
DOC_MAPK_DCC_7	394	404	PF00069	0.548
DOC_MAPK_MEF2A_6	289	297	PF00069	0.579
DOC_MAPK_MEF2A_6	390	399	PF00069	0.564
DOC_PP2B_LxvP_1	156	159	PF13499	0.675
DOC_PP2B_PxIxI_1	292	298	PF00149	0.564
DOC_USP7_MATH_1	232	236	PF00917	0.666
DOC_USP7_MATH_1	245	249	PF00917	0.568
DOC_USP7_MATH_1	281	285	PF00917	0.502
DOC_USP7_MATH_1	32	36	PF00917	0.562
DOC_USP7_MATH_1	328	332	PF00917	0.591
DOC_USP7_MATH_1	491	495	PF00917	0.510
DOC_USP7_MATH_1	90	94	PF00917	0.704
DOC_USP7_MATH_1	99	103	PF00917	0.635
DOC_WW_Pin1_4	134	139	PF00397	0.729
DOC_WW_Pin1_4	149	154	PF00397	0.578
DOC_WW_Pin1_4	157	162	PF00397	0.614
DOC_WW_Pin1_4	188	193	PF00397	0.638
DOC_WW_Pin1_4	287	292	PF00397	0.535
DOC_WW_Pin1_4	300	305	PF00397	0.577
DOC_WW_Pin1_4	38	43	PF00397	0.642
DOC_WW_Pin1_4	422	427	PF00397	0.632
DOC_WW_Pin1_4	72	77	PF00397	0.567
DOC_WW_Pin1_4	95	100	PF00397	0.664
LIG_14-3-3_CanoR_1	10	14	PF00244	0.556
LIG_14-3-3_CanoR_1	100	107	PF00244	0.656
LIG_14-3-3_CanoR_1	174	179	PF00244	0.653
LIG_14-3-3_CanoR_1	196	200	PF00244	0.672
LIG_14-3-3_CanoR_1	202	210	PF00244	0.647
LIG_14-3-3_CanoR_1	383	392	PF00244	0.576
LIG_14-3-3_CanoR_1	428	433	PF00244	0.517
LIG_14-3-3_CanoR_1	454	461	PF00244	0.521
LIG_14-3-3_CanoR_1	57	63	PF00244	0.641
LIG_14-3-3_CanoR_1	70	78	PF00244	0.552
LIG_Actin_WH2_2	453	470	PF00022	0.583
LIG_APCC_ABBA_1	453	458	PF00400	0.563
LIG_BRCT_BRCA1_1	190	194	PF00533	0.581
LIG_FHA_1	135	141	PF00498	0.611
LIG_FHA_1	158	164	PF00498	0.712
LIG_FHA_1	205	211	PF00498	0.648
LIG_FHA_1	236	242	PF00498	0.583
LIG_FHA_1	292	298	PF00498	0.576
LIG_FHA_1	73	79	PF00498	0.577
LIG_FHA_2	493	499	PF00498	0.557
LIG_LIR_Apic_2	12	16	PF02991	0.557
LIG_LIR_Apic_2	299	304	PF02991	0.607
LIG_LIR_Apic_2	506	512	PF02991	0.622
LIG_Pex14_1	13	17	PF04695	0.567
LIG_PTAP_UEV_1	246	251	PF05743	0.589
LIG_SH2_CRK	301	305	PF00017	0.621
LIG_SH2_CRK	509	513	PF00017	0.601
LIG_SH2_STAT5	437	440	PF00017	0.599
LIG_SH2_STAT5	65	68	PF00017	0.600
LIG_SH3_3	104	110	PF00018	0.687
LIG_SH3_3	156	162	PF00018	0.708
LIG_SH3_3	197	203	PF00018	0.663
LIG_SH3_3	237	243	PF00018	0.622
LIG_SH3_3	244	250	PF00018	0.572
LIG_SH3_3	420	426	PF00018	0.637
LIG_SH3_3	449	455	PF00018	0.528
LIG_SH3_3	75	81	PF00018	0.687
LIG_TRAF2_1	376	379	PF00917	0.611
LIG_TRAF2_1	495	498	PF00917	0.555
LIG_TRFH_1	274	278	PF08558	0.668
LIG_TRFH_1	65	69	PF08558	0.578
MOD_CDC14_SPxK_1	425	428	PF00782	0.498
MOD_CDC14_SPxK_1	98	101	PF00782	0.664
MOD_CDK_SPK_2	95	100	PF00069	0.664
MOD_CDK_SPxK_1	422	428	PF00069	0.512
MOD_CDK_SPxK_1	95	101	PF00069	0.667
MOD_CK1_1	134	140	PF00069	0.649
MOD_CK1_1	177	183	PF00069	0.698
MOD_CK1_1	188	194	PF00069	0.620
MOD_CK1_1	217	223	PF00069	0.670
MOD_CK1_1	233	239	PF00069	0.562
MOD_CK1_1	41	47	PF00069	0.670
MOD_CK2_1	373	379	PF00069	0.627
MOD_CK2_1	428	434	PF00069	0.573
MOD_CK2_1	492	498	PF00069	0.568
MOD_GlcNHglycan	101	104	PF01048	0.706
MOD_GlcNHglycan	140	143	PF01048	0.772
MOD_GlcNHglycan	170	173	PF01048	0.702
MOD_GlcNHglycan	176	179	PF01048	0.649
MOD_GlcNHglycan	226	229	PF01048	0.659
MOD_GlcNHglycan	247	250	PF01048	0.595
MOD_GlcNHglycan	252	255	PF01048	0.612
MOD_GlcNHglycan	283	286	PF01048	0.520
MOD_GlcNHglycan	30	33	PF01048	0.644
MOD_GlcNHglycan	334	337	PF01048	0.610
MOD_GlcNHglycan	419	422	PF01048	0.622
MOD_GlcNHglycan	43	46	PF01048	0.612
MOD_GlcNHglycan	430	433	PF01048	0.505
MOD_GlcNHglycan	93	96	PF01048	0.640
MOD_GSK3_1	130	137	PF00069	0.668
MOD_GSK3_1	188	195	PF00069	0.629
MOD_GSK3_1	231	238	PF00069	0.655
MOD_GSK3_1	272	279	PF00069	0.666
MOD_GSK3_1	28	35	PF00069	0.572
MOD_GSK3_1	287	294	PF00069	0.466
MOD_GSK3_1	328	335	PF00069	0.599
MOD_GSK3_1	354	361	PF00069	0.621
MOD_GSK3_1	369	376	PF00069	0.451
MOD_GSK3_1	40	47	PF00069	0.638
MOD_GSK3_1	413	420	PF00069	0.556
MOD_GSK3_1	91	98	PF00069	0.701
MOD_NEK2_1	214	219	PF00069	0.636
MOD_NEK2_2	272	277	PF00069	0.655
MOD_PKA_1	123	129	PF00069	0.674
MOD_PKA_2	123	129	PF00069	0.674
MOD_PKA_2	195	201	PF00069	0.641
MOD_PKA_2	217	223	PF00069	0.650
MOD_PKA_2	224	230	PF00069	0.620
MOD_PKA_2	276	282	PF00069	0.618
MOD_PKA_2	427	433	PF00069	0.601
MOD_PKA_2	9	15	PF00069	0.562
MOD_PKA_2	99	105	PF00069	0.654
MOD_Plk_2-3	354	360	PF00069	0.623
MOD_ProDKin_1	134	140	PF00069	0.733
MOD_ProDKin_1	149	155	PF00069	0.580
MOD_ProDKin_1	157	163	PF00069	0.614
MOD_ProDKin_1	188	194	PF00069	0.640
MOD_ProDKin_1	287	293	PF00069	0.531
MOD_ProDKin_1	300	306	PF00069	0.568
MOD_ProDKin_1	38	44	PF00069	0.642
MOD_ProDKin_1	422	428	PF00069	0.632
MOD_ProDKin_1	72	78	PF00069	0.571
MOD_ProDKin_1	95	101	PF00069	0.667
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.586
TRG_ENDOCYTIC_2	365	368	PF00928	0.611
TRG_ER_diArg_1	19	22	PF00400	0.516
TRG_ER_diArg_1	212	214	PF00400	0.657
TRG_ER_diArg_1	310	313	PF00400	0.545
TRG_ER_diArg_1	474	476	PF00400	0.631
TRG_ER_diArg_1	62	64	PF00400	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H411	Leishmania braziliensis	66%	95%
A4HS94	Leishmania infantum	100%	100%
E9AK78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q9U1D2	Leishmania major	84%	97%