Adenylate_kinase_putative/GeneDB:LmjF.04.0960

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylate kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5D7_LEIDO

TriTrypDb:

LdBPK_040960.1 , LdCL_040015200 , LDHU3_04.1200

Length:

209

Annotations

Annotations by Jardim et al.

Purine metabolism, adenylate kinase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

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Expansion

Sequence features

A0A3S5H5D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5D7

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006220	pyrimidine nucleotide metabolic process	5	1
GO:0006221	pyrimidine nucleotide biosynthetic process	6	1
GO:0006225	UDP biosynthetic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004017	adenylate kinase activity	6	8
GO:0004127	cytidylate kinase activity	6	1
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0009041	uridylate kinase activity	6	1
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.353
CLV_PCSK_KEX2_1	146	148	PF00082	0.409
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.439
CLV_PCSK_SKI1_1	17	21	PF00082	0.500
CLV_PCSK_SKI1_1	196	200	PF00082	0.547
CLV_PCSK_SKI1_1	205	209	PF00082	0.594
CLV_Separin_Metazoa	49	53	PF03568	0.670
CLV_Separin_Metazoa	82	86	PF03568	0.632
DOC_MAPK_gen_1	156	163	PF00069	0.594
DOC_PP1_RVXF_1	15	21	PF00149	0.505

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6F5	Leptomonas seymouri	25%	96%
A0A0N1PB66	Leptomonas seymouri	83%	100%
A0A0S4IL79	Bodo saltans	27%	95%
A0A0S4ILX8	Bodo saltans	32%	81%
A0A0S4JF47	Bodo saltans	28%	95%
A0A0S4JIH6	Bodo saltans	27%	81%
A0A0S4JLR6	Bodo saltans	27%	81%
A0A0S4JR37	Bodo saltans	60%	100%
A0A1X0NMM2	Trypanosomatidae	62%	100%
A0A1X0P0N7	Trypanosomatidae	21%	80%

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