Tyrosine phospatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phospatase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5D1_LEIDO

TriTrypDb:

LdBPK_040840.1 , LdCL_040014000 , LDHU3_04.1060

Length:

879

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5D1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004721	phosphoprotein phosphatase activity	3	5
GO:0004725	protein tyrosine phosphatase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	796	802	PF00089	0.681
CLV_NRD_NRD_1	14	16	PF00675	0.718
CLV_NRD_NRD_1	282	284	PF00675	0.830
CLV_NRD_NRD_1	414	416	PF00675	0.423
CLV_NRD_NRD_1	496	498	PF00675	0.420
CLV_NRD_NRD_1	773	775	PF00675	0.727
CLV_PCSK_KEX2_1	14	16	PF00082	0.718
CLV_PCSK_KEX2_1	282	284	PF00082	0.830
CLV_PCSK_KEX2_1	414	416	PF00082	0.423
CLV_PCSK_KEX2_1	556	558	PF00082	0.547
CLV_PCSK_KEX2_1	773	775	PF00082	0.727
CLV_PCSK_KEX2_1	874	876	PF00082	0.851
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.547
CLV_PCSK_PC1ET2_1	874	876	PF00082	0.755
CLV_PCSK_SKI1_1	486	490	PF00082	0.351
CLV_PCSK_SKI1_1	497	501	PF00082	0.268
DEG_APCC_DBOX_1	414	422	PF00400	0.551
DEG_COP1_1	806	814	PF00400	0.541
DEG_SCF_FBW7_1	107	113	PF00400	0.556
DEG_SPOP_SBC_1	157	161	PF00917	0.540
DEG_SPOP_SBC_1	746	750	PF00917	0.697
DOC_CKS1_1	107	112	PF01111	0.585
DOC_CKS1_1	228	233	PF01111	0.692
DOC_CKS1_1	299	304	PF01111	0.736
DOC_CYCLIN_RxL_1	408	420	PF00134	0.551
DOC_CYCLIN_RxL_1	494	503	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	268	274	PF00134	0.695
DOC_CYCLIN_yCln2_LP_2	386	389	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	533	536	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	679	685	PF00134	0.591
DOC_MAPK_gen_1	414	424	PF00069	0.551
DOC_MAPK_gen_1	451	458	PF00069	0.551
DOC_MAPK_gen_1	556	564	PF00069	0.554
DOC_MAPK_MEF2A_6	557	566	PF00069	0.555
DOC_MAPK_MEF2A_6	668	675	PF00069	0.587
DOC_PP1_RVXF_1	496	503	PF00149	0.551
DOC_PP2B_LxvP_1	105	108	PF13499	0.702
DOC_PP2B_LxvP_1	386	389	PF13499	0.537
DOC_PP2B_LxvP_1	532	535	PF13499	0.551
DOC_PP2B_LxvP_1	809	812	PF13499	0.627
DOC_USP7_MATH_1	112	116	PF00917	0.636
DOC_USP7_MATH_1	305	309	PF00917	0.744
DOC_USP7_MATH_1	331	335	PF00917	0.660
DOC_USP7_MATH_1	374	378	PF00917	0.588
DOC_USP7_MATH_1	597	601	PF00917	0.659
DOC_USP7_MATH_1	621	625	PF00917	0.652
DOC_USP7_MATH_1	695	699	PF00917	0.686
DOC_USP7_MATH_1	70	74	PF00917	0.680
DOC_USP7_MATH_1	723	727	PF00917	0.675
DOC_USP7_MATH_1	740	744	PF00917	0.544
DOC_USP7_MATH_1	745	749	PF00917	0.648
DOC_USP7_MATH_1	77	81	PF00917	0.616
DOC_USP7_MATH_1	784	788	PF00917	0.634
DOC_USP7_MATH_1	790	794	PF00917	0.777
DOC_USP7_MATH_1	833	837	PF00917	0.717
DOC_USP7_MATH_1	861	865	PF00917	0.719
DOC_USP7_MATH_1	873	877	PF00917	0.763
DOC_WW_Pin1_4	106	111	PF00397	0.616
DOC_WW_Pin1_4	158	163	PF00397	0.656
DOC_WW_Pin1_4	194	199	PF00397	0.734
DOC_WW_Pin1_4	227	232	PF00397	0.766
DOC_WW_Pin1_4	234	239	PF00397	0.714
DOC_WW_Pin1_4	241	246	PF00397	0.585
DOC_WW_Pin1_4	298	303	PF00397	0.738
DOC_WW_Pin1_4	312	317	PF00397	0.644
DOC_WW_Pin1_4	81	86	PF00397	0.672
DOC_WW_Pin1_4	862	867	PF00397	0.687
DOC_WW_Pin1_4	869	874	PF00397	0.678
DOC_WW_Pin1_4	92	97	PF00397	0.558
DOC_WW_Pin1_4	99	104	PF00397	0.605
LIG_14-3-3_CanoR_1	270	279	PF00244	0.648
LIG_14-3-3_CanoR_1	333	339	PF00244	0.687
LIG_14-3-3_CanoR_1	353	358	PF00244	0.728
LIG_14-3-3_CanoR_1	417	422	PF00244	0.550
LIG_14-3-3_CanoR_1	7	12	PF00244	0.570
LIG_14-3-3_CanoR_1	727	735	PF00244	0.646
LIG_14-3-3_CanoR_1	758	768	PF00244	0.667
LIG_14-3-3_CanoR_1	779	786	PF00244	0.613
LIG_14-3-3_CanoR_1	799	805	PF00244	0.692
LIG_14-3-3_CterR_2	875	879	PF00244	0.750
LIG_Actin_WH2_2	662	678	PF00022	0.646
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BIR_III_2	783	787	PF00653	0.614
LIG_BRCT_BRCA1_1	170	174	PF00533	0.609
LIG_BRCT_BRCA1_1	319	323	PF00533	0.694
LIG_eIF4E_1	528	534	PF01652	0.551
LIG_EVH1_2	388	392	PF00568	0.551
LIG_FHA_1	294	300	PF00498	0.675
LIG_FHA_1	334	340	PF00498	0.650
LIG_FHA_1	428	434	PF00498	0.551
LIG_FHA_1	487	493	PF00498	0.580
LIG_FHA_1	513	519	PF00498	0.551
LIG_FHA_1	527	533	PF00498	0.445
LIG_FHA_1	607	613	PF00498	0.665
LIG_FHA_1	697	703	PF00498	0.657
LIG_FHA_1	709	715	PF00498	0.581
LIG_FHA_1	748	754	PF00498	0.693
LIG_FHA_1	804	810	PF00498	0.671
LIG_FHA_2	324	330	PF00498	0.606
LIG_FHA_2	66	72	PF00498	0.639
LIG_FHA_2	761	767	PF00498	0.621
LIG_LIR_Apic_2	152	158	PF02991	0.587
LIG_LIR_Apic_2	161	167	PF02991	0.597
LIG_LIR_Apic_2	527	531	PF02991	0.551
LIG_LIR_Gen_1	510	518	PF02991	0.551
LIG_LIR_Nem_3	118	123	PF02991	0.603
LIG_LIR_Nem_3	171	177	PF02991	0.607
LIG_LIR_Nem_3	510	514	PF02991	0.628
LIG_LIR_Nem_3	762	768	PF02991	0.667
LIG_LYPXL_yS_3	404	407	PF13949	0.551
LIG_MYND_1	531	535	PF01753	0.551
LIG_NRBOX	495	501	PF00104	0.551
LIG_PTB_Apo_2	406	413	PF02174	0.551
LIG_PTB_Apo_2	505	512	PF02174	0.516
LIG_PTB_Phospho_1	406	412	PF10480	0.551
LIG_SH2_CRK	528	532	PF00017	0.551
LIG_SH2_NCK_1	548	552	PF00017	0.541
LIG_SH2_PTP2	663	666	PF00017	0.673
LIG_SH2_SRC	663	666	PF00017	0.673
LIG_SH2_STAT5	120	123	PF00017	0.654
LIG_SH2_STAT5	164	167	PF00017	0.554
LIG_SH2_STAT5	251	254	PF00017	0.698
LIG_SH2_STAT5	412	415	PF00017	0.551
LIG_SH2_STAT5	479	482	PF00017	0.551
LIG_SH2_STAT5	528	531	PF00017	0.573
LIG_SH2_STAT5	663	666	PF00017	0.673
LIG_SH3_3	2	8	PF00018	0.622
LIG_SH3_3	243	249	PF00018	0.737
LIG_SH3_3	296	302	PF00018	0.741
LIG_SH3_3	423	429	PF00018	0.624
LIG_SH3_3	533	539	PF00018	0.551
LIG_SH3_3	609	615	PF00018	0.736
LIG_SH3_3	668	674	PF00018	0.642
LIG_SH3_3	679	685	PF00018	0.585
LIG_SH3_3	90	96	PF00018	0.675
LIG_SH3_CIN85_PxpxPR_1	48	53	PF14604	0.542
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.551
LIG_SUMO_SIM_anti_2	489	495	PF11976	0.551
LIG_SUMO_SIM_par_1	101	109	PF11976	0.579
LIG_SxIP_EBH_1	815	827	PF03271	0.671
LIG_TYR_ITSM	116	123	PF00017	0.577
LIG_UBA3_1	493	498	PF00899	0.407
LIG_WW_1	428	431	PF00397	0.412
LIG_WW_3	4	8	PF00397	0.554
MOD_CDK_SPK_2	869	874	PF00069	0.674
MOD_CDK_SPxK_1	869	875	PF00069	0.676
MOD_CK1_1	115	121	PF00069	0.613
MOD_CK1_1	128	134	PF00069	0.535
MOD_CK1_1	160	166	PF00069	0.695
MOD_CK1_1	168	174	PF00069	0.578
MOD_CK1_1	179	185	PF00069	0.642
MOD_CK1_1	197	203	PF00069	0.837
MOD_CK1_1	204	210	PF00069	0.722
MOD_CK1_1	226	232	PF00069	0.679
MOD_CK1_1	255	261	PF00069	0.730
MOD_CK1_1	335	341	PF00069	0.629
MOD_CK1_1	372	378	PF00069	0.633
MOD_CK1_1	461	467	PF00069	0.412
MOD_CK1_1	600	606	PF00069	0.659
MOD_CK1_1	617	623	PF00069	0.569
MOD_CK1_1	698	704	PF00069	0.739
MOD_CK1_1	722	728	PF00069	0.725
MOD_CK1_1	730	736	PF00069	0.687
MOD_CK1_1	761	767	PF00069	0.758
MOD_CK1_1	829	835	PF00069	0.759
MOD_CK1_1	869	875	PF00069	0.812
MOD_CK2_1	65	71	PF00069	0.584
MOD_CK2_1	725	731	PF00069	0.674
MOD_Cter_Amidation	280	283	PF01082	0.719
MOD_GlcNHglycan	1	4	PF01048	0.693
MOD_GlcNHglycan	114	117	PF01048	0.728
MOD_GlcNHglycan	130	133	PF01048	0.665
MOD_GlcNHglycan	178	181	PF01048	0.674
MOD_GlcNHglycan	219	222	PF01048	0.714
MOD_GlcNHglycan	272	275	PF01048	0.650
MOD_GlcNHglycan	284	287	PF01048	0.748
MOD_GlcNHglycan	307	310	PF01048	0.824
MOD_GlcNHglycan	339	342	PF01048	0.683
MOD_GlcNHglycan	371	374	PF01048	0.704
MOD_GlcNHglycan	378	381	PF01048	0.607
MOD_GlcNHglycan	396	399	PF01048	0.376
MOD_GlcNHglycan	570	573	PF01048	0.732
MOD_GlcNHglycan	575	578	PF01048	0.709
MOD_GlcNHglycan	595	598	PF01048	0.730
MOD_GlcNHglycan	599	602	PF01048	0.692
MOD_GlcNHglycan	604	607	PF01048	0.648
MOD_GlcNHglycan	616	619	PF01048	0.579
MOD_GlcNHglycan	635	638	PF01048	0.534
MOD_GlcNHglycan	692	696	PF01048	0.695
MOD_GlcNHglycan	702	705	PF01048	0.625
MOD_GlcNHglycan	721	724	PF01048	0.733
MOD_GlcNHglycan	742	745	PF01048	0.677
MOD_GlcNHglycan	79	82	PF01048	0.587
MOD_GlcNHglycan	792	795	PF01048	0.773
MOD_GlcNHglycan	800	803	PF01048	0.653
MOD_GlcNHglycan	806	809	PF01048	0.555
MOD_GlcNHglycan	812	815	PF01048	0.586
MOD_GlcNHglycan	819	822	PF01048	0.578
MOD_GlcNHglycan	824	827	PF01048	0.610
MOD_GlcNHglycan	828	831	PF01048	0.649
MOD_GlcNHglycan	835	838	PF01048	0.601
MOD_GlcNHglycan	868	871	PF01048	0.705
MOD_GlcNHglycan	96	99	PF01048	0.684
MOD_GSK3_1	106	113	PF00069	0.631
MOD_GSK3_1	139	146	PF00069	0.779
MOD_GSK3_1	156	163	PF00069	0.551
MOD_GSK3_1	176	183	PF00069	0.572
MOD_GSK3_1	196	203	PF00069	0.767
MOD_GSK3_1	204	211	PF00069	0.682
MOD_GSK3_1	223	230	PF00069	0.806
MOD_GSK3_1	289	296	PF00069	0.789
MOD_GSK3_1	331	338	PF00069	0.702
MOD_GSK3_1	372	379	PF00069	0.670
MOD_GSK3_1	564	571	PF00069	0.618
MOD_GSK3_1	573	580	PF00069	0.650
MOD_GSK3_1	593	600	PF00069	0.687
MOD_GSK3_1	602	609	PF00069	0.632
MOD_GSK3_1	617	624	PF00069	0.619
MOD_GSK3_1	687	694	PF00069	0.784
MOD_GSK3_1	696	703	PF00069	0.659
MOD_GSK3_1	718	725	PF00069	0.707
MOD_GSK3_1	726	733	PF00069	0.692
MOD_GSK3_1	754	761	PF00069	0.730
MOD_GSK3_1	77	84	PF00069	0.740
MOD_GSK3_1	775	782	PF00069	0.667
MOD_GSK3_1	822	829	PF00069	0.746
MOD_GSK3_1	85	92	PF00069	0.709
MOD_GSK3_1	862	869	PF00069	0.736
MOD_GSK3_1	94	101	PF00069	0.629
MOD_LATS_1	141	147	PF00433	0.652
MOD_NEK2_1	201	206	PF00069	0.819
MOD_NEK2_1	208	213	PF00069	0.744
MOD_NEK2_1	564	569	PF00069	0.527
MOD_NEK2_1	675	680	PF00069	0.647
MOD_NEK2_1	716	721	PF00069	0.665
MOD_NEK2_1	775	780	PF00069	0.685
MOD_NEK2_1	803	808	PF00069	0.621
MOD_NEK2_2	543	548	PF00069	0.499
MOD_PIKK_1	202	208	PF00454	0.794
MOD_PIKK_1	353	359	PF00454	0.679
MOD_PIKK_1	72	78	PF00454	0.702
MOD_PKA_1	282	288	PF00069	0.717
MOD_PKA_2	282	288	PF00069	0.776
MOD_PKA_2	332	338	PF00069	0.698
MOD_PKA_2	341	347	PF00069	0.649
MOD_PKA_2	512	518	PF00069	0.412
MOD_PKA_2	564	570	PF00069	0.586
MOD_PKA_2	593	599	PF00069	0.648
MOD_PKA_2	675	681	PF00069	0.644
MOD_PKA_2	719	725	PF00069	0.670
MOD_PKA_2	726	732	PF00069	0.617
MOD_PKA_2	798	804	PF00069	0.693
MOD_PKA_2	826	832	PF00069	0.726
MOD_PKB_1	415	423	PF00069	0.412
MOD_PKB_1	563	571	PF00069	0.574
MOD_Plk_1	730	736	PF00069	0.649
MOD_Plk_2-3	427	433	PF00069	0.412
MOD_Plk_4	160	166	PF00069	0.553
MOD_Plk_4	318	324	PF00069	0.664
MOD_Plk_4	382	388	PF00069	0.554
MOD_Plk_4	420	426	PF00069	0.412
MOD_Plk_4	543	549	PF00069	0.613
MOD_Plk_4	7	13	PF00069	0.681
MOD_ProDKin_1	106	112	PF00069	0.599
MOD_ProDKin_1	158	164	PF00069	0.659
MOD_ProDKin_1	194	200	PF00069	0.734
MOD_ProDKin_1	227	233	PF00069	0.769
MOD_ProDKin_1	234	240	PF00069	0.712
MOD_ProDKin_1	241	247	PF00069	0.583
MOD_ProDKin_1	298	304	PF00069	0.738
MOD_ProDKin_1	312	318	PF00069	0.647
MOD_ProDKin_1	81	87	PF00069	0.671
MOD_ProDKin_1	862	868	PF00069	0.685
MOD_ProDKin_1	869	875	PF00069	0.680
MOD_ProDKin_1	92	98	PF00069	0.558
MOD_ProDKin_1	99	105	PF00069	0.619
MOD_SUMO_for_1	452	455	PF00179	0.412
MOD_SUMO_rev_2	427	436	PF00179	0.412
TRG_DiLeu_BaEn_1	465	470	PF01217	0.412
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.412
TRG_ENDOCYTIC_2	120	123	PF00928	0.654
TRG_ENDOCYTIC_2	404	407	PF00928	0.412
TRG_ENDOCYTIC_2	663	666	PF00928	0.673
TRG_ER_diArg_1	413	415	PF00400	0.496
TRG_ER_diArg_1	416	419	PF00400	0.481
TRG_ER_diArg_1	562	565	PF00400	0.536
TRG_ER_diArg_1	773	775	PF00400	0.727
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3Z4	Leishmania braziliensis	68%	100%
A4HS81	Leishmania infantum	98%	100%
E9AK67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q9U0Z9	Leishmania major	88%	100%