Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5C8_LEIDO

TriTrypDb:

LdBPK_040800.1 , LdCL_040013600 , LDHU3_04.1020

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5C8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.527
CLV_NRD_NRD_1	29	31	PF00675	0.405
CLV_NRD_NRD_1	66	68	PF00675	0.621
CLV_NRD_NRD_1	69	71	PF00675	0.596
CLV_NRD_NRD_1	9	11	PF00675	0.593
CLV_PCSK_FUR_1	67	71	PF00082	0.578
CLV_PCSK_KEX2_1	182	184	PF00082	0.533
CLV_PCSK_KEX2_1	29	31	PF00082	0.619
CLV_PCSK_KEX2_1	66	68	PF00082	0.672
CLV_PCSK_KEX2_1	69	71	PF00082	0.667
CLV_PCSK_SKI1_1	69	73	PF00082	0.561
CLV_PCSK_SKI1_1	84	88	PF00082	0.567
DEG_SPOP_SBC_1	287	291	PF00917	0.651
DOC_MAPK_gen_1	182	188	PF00069	0.508
DOC_MAPK_gen_1	8	16	PF00069	0.549
DOC_MAPK_MEF2A_6	8	16	PF00069	0.544
DOC_PP1_RVXF_1	166	172	PF00149	0.584
DOC_USP7_MATH_1	159	163	PF00917	0.490
DOC_USP7_MATH_1	232	236	PF00917	0.665
DOC_USP7_MATH_1	287	291	PF00917	0.597
DOC_USP7_MATH_1	48	52	PF00917	0.745
DOC_WW_Pin1_4	145	150	PF00397	0.532
DOC_WW_Pin1_4	17	22	PF00397	0.554
DOC_WW_Pin1_4	280	285	PF00397	0.586
DOC_WW_Pin1_4	52	57	PF00397	0.648
LIG_14-3-3_CanoR_1	238	242	PF00244	0.546
LIG_BRCT_BRCA1_1	289	293	PF00533	0.627
LIG_BRCT_BRCA1_2	289	295	PF00533	0.624
LIG_FHA_1	127	133	PF00498	0.574
LIG_FHA_1	146	152	PF00498	0.379
LIG_FHA_1	164	170	PF00498	0.502
LIG_FHA_1	274	280	PF00498	0.533
LIG_FHA_2	22	28	PF00498	0.502
LIG_FHA_2	238	244	PF00498	0.632
LIG_FHA_2	281	287	PF00498	0.543
LIG_FHA_2	60	66	PF00498	0.606
LIG_LIR_Gen_1	28	38	PF02991	0.623
LIG_LIR_Gen_1	297	306	PF02991	0.531
LIG_LIR_Nem_3	28	34	PF02991	0.646
LIG_LIR_Nem_3	297	302	PF02991	0.527
LIG_SH2_CRK	31	35	PF00017	0.613
LIG_SH2_PTP2	13	16	PF00017	0.572
LIG_SH2_SRC	13	16	PF00017	0.572
LIG_SH2_STAT5	13	16	PF00017	0.572
LIG_SH2_STAT5	141	144	PF00017	0.538
LIG_SH2_STAT5	150	153	PF00017	0.484
LIG_SH2_STAT5	258	261	PF00017	0.482
LIG_SH2_STAT5	267	270	PF00017	0.444
LIG_SH3_3	281	287	PF00018	0.543
LIG_SH3_3	9	15	PF00018	0.548
LIG_SUMO_SIM_par_1	260	268	PF11976	0.475
LIG_SUMO_SIM_par_1	85	91	PF11976	0.538
LIG_TRAF2_1	211	214	PF00917	0.574
LIG_TRAF2_1	88	91	PF00917	0.544
MOD_CK1_1	162	168	PF00069	0.572
MOD_CK1_1	172	178	PF00069	0.458
MOD_CK1_1	51	57	PF00069	0.717
MOD_CK2_1	21	27	PF00069	0.514
MOD_GlcNHglycan	109	112	PF01048	0.683
MOD_GlcNHglycan	121	124	PF01048	0.508
MOD_GlcNHglycan	50	53	PF01048	0.669
MOD_GSK3_1	139	146	PF00069	0.561
MOD_GSK3_1	159	166	PF00069	0.640
MOD_GSK3_1	169	176	PF00069	0.628
MOD_GSK3_1	17	24	PF00069	0.542
MOD_GSK3_1	48	55	PF00069	0.708
MOD_N-GLC_1	232	237	PF02516	0.682
MOD_NEK2_1	105	110	PF00069	0.682
MOD_NEK2_1	119	124	PF00069	0.457
MOD_NEK2_1	163	168	PF00069	0.535
MOD_NEK2_1	171	176	PF00069	0.513
MOD_NEK2_1	226	231	PF00069	0.673
MOD_PIKK_1	187	193	PF00454	0.598
MOD_PIKK_1	252	258	PF00454	0.552
MOD_PKA_2	237	243	PF00069	0.589
MOD_PKA_2	34	40	PF00069	0.704
MOD_Plk_1	163	169	PF00069	0.640
MOD_Plk_1	219	225	PF00069	0.545
MOD_Plk_2-3	257	263	PF00069	0.507
MOD_Plk_4	21	27	PF00069	0.521
MOD_ProDKin_1	145	151	PF00069	0.534
MOD_ProDKin_1	17	23	PF00069	0.547
MOD_ProDKin_1	280	286	PF00069	0.586
MOD_ProDKin_1	52	58	PF00069	0.646
MOD_SUMO_rev_2	300	305	PF00179	0.485
TRG_ENDOCYTIC_2	13	16	PF00928	0.572
TRG_ENDOCYTIC_2	31	34	PF00928	0.684
TRG_ER_diArg_1	181	183	PF00400	0.538
TRG_ER_diArg_1	209	212	PF00400	0.499
TRG_ER_diArg_1	29	31	PF00400	0.608
TRG_ER_diArg_1	33	36	PF00400	0.581
TRG_ER_diArg_1	66	69	PF00400	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTL4	Leptomonas seymouri	46%	100%
A0A0S4JP65	Bodo saltans	32%	100%
A0A1X0NLR1	Trypanosomatidae	45%	100%
A0A3R7K5C5	Trypanosoma rangeli	45%	100%
A4HS77	Leishmania infantum	99%	100%
C9ZY71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AK63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O97210	Leishmania major	96%	100%
V5DEH0	Trypanosoma cruzi	44%	100%