Ribosomal protein L10.e

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L10, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5C4_LEIDO

TriTrypDb:

LdBPK_040750.1 , LdCL_040013100 , LdCL_040015100 , LDHU3_04.0970 , LDHU3_04.1190

Length:

213

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L10

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 8
Forrest at al. (procyclic)	yes	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 20

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A0A3S5H5C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5C4

PDB structure(s): 6az3_N

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0000027	ribosomal large subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.349
CLV_NRD_NRD_1	3	5	PF00675	0.505
CLV_NRD_NRD_1	39	41	PF00675	0.351
CLV_PCSK_KEX2_1	153	155	PF00082	0.349
CLV_PCSK_KEX2_1	3	5	PF00082	0.505
CLV_PCSK_KEX2_1	38	40	PF00082	0.351
CLV_PCSK_KEX2_1	78	80	PF00082	0.354
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.364
CLV_PCSK_SKI1_1	116	120	PF00082	0.431
CLV_PCSK_SKI1_1	153	157	PF00082	0.348
CLV_PCSK_SKI1_1	39	43	PF00082	0.388
CLV_PCSK_SKI1_1	82	86	PF00082	0.356
DOC_MAPK_gen_1	128	136	PF00069	0.551
DOC_MAPK_gen_1	153	159	PF00069	0.551
DOC_MAPK_MEF2A_6	130	138	PF00069	0.551
DOC_PP2B_LxvP_1	199	202	PF13499	0.657
DOC_PP4_FxxP_1	119	122	PF00568	0.631
DOC_USP7_UBL2_3	15	19	PF12436	0.551
DOC_USP7_UBL2_3	74	78	PF12436	0.551
LIG_14-3-3_CanoR_1	38	44	PF00244	0.576
LIG_Actin_WH2_2	169	187	PF00022	0.481
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_FHA_1	172	178	PF00498	0.455
LIG_FHA_2	177	183	PF00498	0.601
LIG_FHA_2	40	46	PF00498	0.603
LIG_LIR_Gen_1	179	187	PF02991	0.527
LIG_LIR_Nem_3	168	173	PF02991	0.450
LIG_LIR_Nem_3	179	184	PF02991	0.496
LIG_PDZ_Class_2	208	213	PF00595	0.565
LIG_SH2_STAT3	144	147	PF00017	0.564
LIG_SH2_STAT5	144	147	PF00017	0.551
LIG_SH3_3	23	29	PF00018	0.564
LIG_SH3_4	15	22	PF00018	0.551
LIG_UBA3_1	134	141	PF00899	0.551
LIG_UBA3_1	164	169	PF00899	0.667
MOD_CK1_1	137	143	PF00069	0.551
MOD_CK2_1	176	182	PF00069	0.497
MOD_CK2_1	39	45	PF00069	0.603
MOD_Cter_Amidation	36	39	PF01082	0.351
MOD_NEK2_2	204	209	PF00069	0.665
MOD_PKA_1	3	9	PF00069	0.521
MOD_PKA_1	39	45	PF00069	0.603
MOD_PKA_2	192	198	PF00069	0.563
MOD_PKA_2	3	9	PF00069	0.521
MOD_PKA_2	39	45	PF00069	0.603
TRG_ENDOCYTIC_2	170	173	PF00928	0.440
TRG_ENDOCYTIC_2	181	184	PF00928	0.489
TRG_ER_diArg_1	128	131	PF00400	0.551
TRG_ER_diArg_1	152	154	PF00400	0.548
TRG_ER_diArg_1	3	5	PF00400	0.505
TRG_ER_diArg_1	38	40	PF00400	0.590
TRG_ER_diArg_1	87	90	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGD2	Leptomonas seymouri	96%	100%
A0A0S4IP85	Bodo saltans	83%	100%
A0A1X0NMN9	Trypanosomatidae	88%	100%
A0A422N6C7	Trypanosoma rangeli	90%	100%
A1RT11	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	43%	100%
A1RXM2	Thermofilum pendens (strain DSM 2475 / Hrk 5)	41%	100%
A2BNA6	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	43%	100%
A2SQE9	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	42%	100%
A2Y0T4	Oryza sativa subsp. indica	64%	97%
A2ZCQ7	Oryza sativa subsp. indica	65%	95%
A3CTT1	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	42%	100%
A3DM76	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	45%	100%
A3MXP3	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	42%	100%
A4FWP5	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	38%	100%
A4H3Y8	Leishmania braziliensis	97%	100%
A4HS71	Leishmania infantum	100%	100%
A4WN05	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	44%	100%
A4YHV3	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	38%	100%
A6USY4	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	43%	100%
A6VGM6	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	38%	100%
A8D8X1	Ovis aries	66%	100%
A8MDE4	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	41%	100%
A9AA25	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	38%	100%
A9CB60	Papio anubis	66%	100%
B0R2M5	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	35%	100%
B1YDH6	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	45%	100%
B6YSL0	Thermococcus onnurineus (strain NA1)	40%	100%
B8GH15	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	41%	100%
B9LQR1	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	34%	100%
C3MRC8	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	40%	100%
C3MXL7	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	40%	100%
C3MZG3	Sulfolobus islandicus (strain M.16.27)	40%	100%
C3N7I5	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	40%	100%
C3NFZ1	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	40%	100%
C4KIP3	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	40%	100%
C5A293	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	40%	100%
C6A4T2	Thermococcus sibiricus (strain DSM 12597 / MM 739)	41%	100%
C9ZY66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9AK58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O22431	Pinus taeda	62%	93%
O27191	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	42%	100%
O28930	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	44%	100%
O58367	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	42%	100%
O61231	Drosophila melanogaster	67%	98%
O96647	Bombyx mandarina	69%	97%
O97213	Leishmania major	100%	100%
P27635	Homo sapiens	66%	100%
P41805	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	63%	96%
P45633	Zea mays	64%	97%
P58299	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	37%	100%
P60617	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	35%	100%
P86048	Mus musculus	66%	100%
P93847	Solanum melongena	65%	97%
Q08200	Gallus gallus	64%	100%
Q08770	Arabidopsis thaliana	64%	96%
Q09127	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	66%	96%
Q09533	Caenorhabditis elegans	66%	100%
Q0DKF0	Oryza sativa subsp. japonica	64%	97%
Q0ITS8	Oryza sativa subsp. japonica	65%	95%
Q0W389	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	40%	100%
Q12W43	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	39%	100%
Q18KD2	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	35%	100%
Q235M8	Tetrahymena thermophila (strain SB210)	61%	99%
Q29195	Sus scrofa	66%	100%
Q2FLD3	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	37%	100%
Q2NHZ0	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	37%	100%
Q2TBW8	Bos taurus	65%	100%
Q39724	Euglena gracilis	58%	99%
Q3IU82	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	33%	100%
Q46CR0	Methanosarcina barkeri (strain Fusaro / DSM 804)	36%	100%
Q4JC84	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	40%	100%
Q4R4D3	Macaca fascicularis	64%	100%
Q4R7Y2	Macaca fascicularis	65%	100%
Q54J69	Dictyostelium discoideum	62%	98%
Q57963	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	45%	100%
Q5AIB8	Candida albicans (strain SC5314 / ATCC MYA-2876)	64%	97%
Q5JDI6	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	40%	100%
Q5R931	Pongo abelii	65%	100%
Q6L152	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	36%	100%
Q6LXR0	Methanococcus maripaludis (strain S2 / LL)	39%	100%
Q6PDV7	Rattus norvegicus	66%	100%
Q6ZWV3	Mus musculus	66%	100%
Q74M84	Nanoarchaeum equitans (strain Kin4-M)	31%	100%
Q7ZV96	Danio rerio	64%	99%
Q8PWV0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	41%	100%
Q8SR96	Encephalitozoon cuniculi (strain GB-M1)	61%	97%
Q8TU90	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	38%	100%
Q8TYP2	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	46%	100%
Q8ZSV4	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	44%	100%
Q93VT9	Arabidopsis thaliana	63%	97%
Q93W22	Arabidopsis thaliana	64%	96%
Q96L21	Homo sapiens	63%	100%
Q96YA4	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	40%	100%
Q980J7	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	38%	100%
Q9HJB3	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	39%	100%
Q9HSS4	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	35%	100%
Q9M5M7	Euphorbia esula	65%	97%
Q9P769	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	66%	96%
Q9SPB3	Vitis riparia	63%	97%
Q9UWP5	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	42%	100%
Q9UYU9	Pyrococcus abyssi (strain GE5 / Orsay)	42%	100%
Q9XSI3	Bos taurus	66%	100%
Q9YEY5	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	44%	100%