Hypothetical_protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF974), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5C3_LEIDO

TriTrypDb:

LdBPK_040730.1 , LdCL_040012900 , LDHU3_04.0950

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030008	TRAPP complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1990072	TRAPPIII protein complex	4	1

Expansion

Sequence features

A0A3S5H5C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5C3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.356
CLV_C14_Caspase3-7	261	265	PF00656	0.294
CLV_C14_Caspase3-7	557	561	PF00656	0.495
CLV_C14_Caspase3-7	597	601	PF00656	0.689
CLV_NRD_NRD_1	132	134	PF00675	0.426
CLV_NRD_NRD_1	175	177	PF00675	0.424
CLV_NRD_NRD_1	387	389	PF00675	0.467
CLV_NRD_NRD_1	85	87	PF00675	0.617
CLV_PCSK_FUR_1	83	87	PF00082	0.600
CLV_PCSK_KEX2_1	175	177	PF00082	0.424
CLV_PCSK_KEX2_1	387	389	PF00082	0.467
CLV_PCSK_KEX2_1	446	448	PF00082	0.558
CLV_PCSK_KEX2_1	85	87	PF00082	0.617
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.558
CLV_PCSK_SKI1_1	145	149	PF00082	0.317
CLV_PCSK_SKI1_1	175	179	PF00082	0.360
CLV_PCSK_SKI1_1	222	226	PF00082	0.324
CLV_PCSK_SKI1_1	301	305	PF00082	0.494
CLV_PCSK_SKI1_1	373	377	PF00082	0.380
CLV_PCSK_SKI1_1	421	425	PF00082	0.545
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DEG_ODPH_VHL_1	512	525	PF01847	0.456
DEG_SPOP_SBC_1	448	452	PF00917	0.556
DOC_CYCLIN_RxL_1	173	182	PF00134	0.411
DOC_CYCLIN_RxL_1	418	428	PF00134	0.456
DOC_CYCLIN_RxL_1	521	531	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.447
DOC_MAPK_gen_1	106	115	PF00069	0.502
DOC_MAPK_HePTP_8	285	297	PF00069	0.427
DOC_MAPK_MEF2A_6	108	117	PF00069	0.662
DOC_MAPK_MEF2A_6	288	297	PF00069	0.372
DOC_MAPK_MEF2A_6	346	354	PF00069	0.356
DOC_MAPK_MEF2A_6	500	509	PF00069	0.403
DOC_PP1_RVXF_1	220	227	PF00149	0.302
DOC_PP2B_LxvP_1	129	132	PF13499	0.302
DOC_PP2B_LxvP_1	302	305	PF13499	0.354
DOC_PP2B_LxvP_1	352	355	PF13499	0.427
DOC_PP2B_LxvP_1	39	42	PF13499	0.572
DOC_PP2B_LxvP_1	568	571	PF13499	0.482
DOC_USP7_MATH_1	14	18	PF00917	0.683
DOC_USP7_MATH_1	168	172	PF00917	0.397
DOC_USP7_MATH_1	258	262	PF00917	0.403
DOC_USP7_MATH_1	342	346	PF00917	0.450
DOC_USP7_MATH_1	442	446	PF00917	0.680
DOC_USP7_MATH_1	449	453	PF00917	0.619
DOC_USP7_MATH_1	561	565	PF00917	0.598
DOC_USP7_MATH_1	592	596	PF00917	0.667
DOC_WW_Pin1_4	387	392	PF00397	0.391
DOC_WW_Pin1_4	472	477	PF00397	0.716
DOC_WW_Pin1_4	481	486	PF00397	0.596
DOC_WW_Pin1_4	98	103	PF00397	0.785
LIG_14-3-3_CanoR_1	180	184	PF00244	0.392
LIG_14-3-3_CanoR_1	248	258	PF00244	0.418
LIG_14-3-3_CanoR_1	373	378	PF00244	0.429
LIG_14-3-3_CanoR_1	392	397	PF00244	0.422
LIG_14-3-3_CanoR_1	447	456	PF00244	0.580
LIG_14-3-3_CanoR_1	562	570	PF00244	0.498
LIG_14-3-3_CanoR_1	9	16	PF00244	0.721
LIG_14-3-3_CanoR_1	93	102	PF00244	0.766
LIG_Actin_WH2_2	160	177	PF00022	0.356
LIG_Actin_WH2_2	232	247	PF00022	0.420
LIG_Actin_WH2_2	358	375	PF00022	0.411
LIG_Actin_WH2_2	416	434	PF00022	0.402
LIG_AP2alpha_2	79	81	PF02296	0.640
LIG_BRCT_BRCA1_1	140	144	PF00533	0.488
LIG_BRCT_BRCA1_1	226	230	PF00533	0.405
LIG_BRCT_BRCA1_1	533	537	PF00533	0.501
LIG_CSL_BTD_1	568	571	PF09270	0.482
LIG_EH1_1	362	370	PF00400	0.420
LIG_FHA_1	110	116	PF00498	0.678
LIG_FHA_1	203	209	PF00498	0.365
LIG_FHA_1	34	40	PF00498	0.612
LIG_FHA_1	356	362	PF00498	0.425
LIG_FHA_1	384	390	PF00498	0.430
LIG_FHA_1	432	438	PF00498	0.559
LIG_FHA_1	451	457	PF00498	0.561
LIG_FHA_1	520	526	PF00498	0.454
LIG_FHA_1	534	540	PF00498	0.377
LIG_FHA_1	572	578	PF00498	0.522
LIG_FHA_2	250	256	PF00498	0.418
LIG_FHA_2	338	344	PF00498	0.436
LIG_FHA_2	452	458	PF00498	0.697
LIG_FHA_2	627	633	PF00498	0.475
LIG_LIR_Apic_2	213	217	PF02991	0.433
LIG_LIR_Gen_1	190	200	PF02991	0.420
LIG_LIR_Gen_1	465	476	PF02991	0.529
LIG_LIR_Gen_1	79	89	PF02991	0.589
LIG_LIR_Nem_3	141	147	PF02991	0.411
LIG_LIR_Nem_3	190	195	PF02991	0.458
LIG_LIR_Nem_3	275	281	PF02991	0.433
LIG_LIR_Nem_3	465	471	PF02991	0.532
LIG_LIR_Nem_3	487	493	PF02991	0.405
LIG_LIR_Nem_3	54	59	PF02991	0.547
LIG_LIR_Nem_3	71	77	PF02991	0.533
LIG_LIR_Nem_3	79	84	PF02991	0.522
LIG_NRBOX	524	530	PF00104	0.444
LIG_PCNA_yPIPBox_3	414	424	PF02747	0.378
LIG_PDZ_Class_2	631	636	PF00595	0.447
LIG_Pex14_1	226	230	PF04695	0.427
LIG_PTAP_UEV_1	169	174	PF05743	0.245
LIG_SH2_CRK	192	196	PF00017	0.420
LIG_SH2_CRK	468	472	PF00017	0.534
LIG_SH2_CRK	518	522	PF00017	0.404
LIG_SH2_NCK_1	192	196	PF00017	0.420
LIG_SH2_PTP2	246	249	PF00017	0.420
LIG_SH2_SRC	215	218	PF00017	0.362
LIG_SH2_STAP1	192	196	PF00017	0.420
LIG_SH2_STAP1	206	210	PF00017	0.346
LIG_SH2_STAP1	501	505	PF00017	0.495
LIG_SH2_STAT5	192	195	PF00017	0.427
LIG_SH2_STAT5	246	249	PF00017	0.427
LIG_SH2_STAT5	398	401	PF00017	0.323
LIG_SH3_1	473	479	PF00018	0.525
LIG_SH3_2	170	175	PF14604	0.411
LIG_SH3_3	108	114	PF00018	0.706
LIG_SH3_3	164	170	PF00018	0.445
LIG_SH3_3	344	350	PF00018	0.410
LIG_SH3_3	473	479	PF00018	0.729
LIG_SH3_3	564	570	PF00018	0.429
LIG_SUMO_SIM_anti_2	538	543	PF11976	0.403
LIG_SUMO_SIM_anti_2	554	560	PF11976	0.484
LIG_SUMO_SIM_par_1	572	579	PF11976	0.558
LIG_TRAF2_1	341	344	PF00917	0.245
MOD_CDK_SPK_2	387	392	PF00069	0.423
MOD_CK1_1	17	23	PF00069	0.803
MOD_CK1_1	190	196	PF00069	0.427
MOD_CK1_1	201	207	PF00069	0.447
MOD_CK1_1	271	277	PF00069	0.359
MOD_CK1_1	336	342	PF00069	0.391
MOD_CK1_1	450	456	PF00069	0.790
MOD_CK1_1	484	490	PF00069	0.529
MOD_CK1_1	51	57	PF00069	0.624
MOD_CK1_1	531	537	PF00069	0.445
MOD_CK1_1	581	587	PF00069	0.669
MOD_CK1_1	92	98	PF00069	0.766
MOD_CK2_1	249	255	PF00069	0.398
MOD_CK2_1	337	343	PF00069	0.457
MOD_CK2_1	451	457	PF00069	0.696
MOD_CK2_1	55	61	PF00069	0.607
MOD_GlcNHglycan	16	19	PF01048	0.752
MOD_GlcNHglycan	170	173	PF01048	0.318
MOD_GlcNHglycan	252	255	PF01048	0.438
MOD_GlcNHglycan	321	324	PF01048	0.382
MOD_GlcNHglycan	327	330	PF01048	0.390
MOD_GlcNHglycan	33	36	PF01048	0.557
MOD_GlcNHglycan	414	417	PF01048	0.339
MOD_GlcNHglycan	439	442	PF01048	0.652
MOD_GlcNHglycan	530	533	PF01048	0.473
MOD_GlcNHglycan	571	574	PF01048	0.645
MOD_GlcNHglycan	580	583	PF01048	0.574
MOD_GlcNHglycan	594	597	PF01048	0.625
MOD_GSK3_1	198	205	PF00069	0.453
MOD_GSK3_1	225	232	PF00069	0.336
MOD_GSK3_1	264	271	PF00069	0.385
MOD_GSK3_1	33	40	PF00069	0.576
MOD_GSK3_1	333	340	PF00069	0.495
MOD_GSK3_1	383	390	PF00069	0.401
MOD_GSK3_1	447	454	PF00069	0.802
MOD_GSK3_1	51	58	PF00069	0.494
MOD_GSK3_1	531	538	PF00069	0.448
MOD_GSK3_1	603	610	PF00069	0.699
MOD_GSK3_1	89	96	PF00069	0.696
MOD_N-GLC_1	154	159	PF02516	0.410
MOD_N-GLC_1	264	269	PF02516	0.429
MOD_N-GLC_1	288	293	PF02516	0.345
MOD_N-GLC_1	493	498	PF02516	0.539
MOD_N-GLC_2	116	118	PF02516	0.573
MOD_N-GLC_2	333	335	PF02516	0.245
MOD_NEK2_1	117	122	PF00069	0.687
MOD_NEK2_1	224	229	PF00069	0.335
MOD_NEK2_1	269	274	PF00069	0.431
MOD_NEK2_1	297	302	PF00069	0.345
MOD_NEK2_1	361	366	PF00069	0.376
MOD_NEK2_1	431	436	PF00069	0.466
MOD_NEK2_1	45	50	PF00069	0.506
MOD_NEK2_1	528	533	PF00069	0.476
MOD_NEK2_1	535	540	PF00069	0.418
MOD_NEK2_1	576	581	PF00069	0.655
MOD_NEK2_1	607	612	PF00069	0.739
MOD_NEK2_1	94	99	PF00069	0.767
MOD_NEK2_2	226	231	PF00069	0.427
MOD_PIKK_1	156	162	PF00454	0.467
MOD_PIKK_1	48	54	PF00454	0.591
MOD_PIKK_1	561	567	PF00454	0.512
MOD_PK_1	590	596	PF00069	0.605
MOD_PKA_2	179	185	PF00069	0.427
MOD_PKA_2	247	253	PF00069	0.402
MOD_PKA_2	431	437	PF00069	0.601
MOD_PKA_2	561	567	PF00069	0.482
MOD_PKA_2	8	14	PF00069	0.649
MOD_PKA_2	92	98	PF00069	0.741
MOD_Plk_1	154	160	PF00069	0.420
MOD_Plk_1	201	207	PF00069	0.473
MOD_Plk_1	288	294	PF00069	0.345
MOD_Plk_1	342	348	PF00069	0.324
MOD_Plk_1	603	609	PF00069	0.633
MOD_Plk_2-3	626	632	PF00069	0.468
MOD_Plk_4	190	196	PF00069	0.420
MOD_Plk_4	373	379	PF00069	0.479
MOD_Plk_4	45	51	PF00069	0.476
MOD_Plk_4	537	543	PF00069	0.399
MOD_Plk_4	571	577	PF00069	0.493
MOD_ProDKin_1	387	393	PF00069	0.391
MOD_ProDKin_1	472	478	PF00069	0.705
MOD_ProDKin_1	481	487	PF00069	0.592
MOD_ProDKin_1	98	104	PF00069	0.784
MOD_SUMO_for_1	230	233	PF00179	0.427
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.634
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.471
TRG_ENDOCYTIC_2	192	195	PF00928	0.420
TRG_ENDOCYTIC_2	468	471	PF00928	0.537
TRG_ER_diArg_1	174	176	PF00400	0.388
TRG_ER_diArg_1	387	389	PF00400	0.457
TRG_ER_diArg_1	83	86	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB8	Leptomonas seymouri	49%	98%
A0A1X0NLJ7	Trypanosomatidae	30%	100%
A0A3R7LPQ4	Trypanosoma rangeli	29%	100%
A4H407	Leishmania braziliensis	72%	100%
A4HS69	Leishmania infantum	99%	100%
C9ZY64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AK56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O97215	Leishmania major	90%	100%
V5BIB6	Trypanosoma cruzi	29%	100%