Tyrosine phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5B2_LEIDO

TriTrypDb:

LdBPK_040550.1 , LdCL_040011000 , LDHU3_04.0750

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5B2

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004725	protein tyrosine phosphatase activity	4	5
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	138	140	PF00082	0.329
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.329
CLV_PCSK_SKI1_1	44	48	PF00082	0.275
DEG_COP1_1	7	15	PF00400	0.376
DEG_MDM2_SWIB_1	166	173	PF02201	0.484
DEG_SCF_FBW7_1	171	178	PF00400	0.429
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.472
DOC_MAPK_DCC_7	8	17	PF00069	0.376
DOC_MAPK_gen_1	42	49	PF00069	0.529
DOC_MAPK_MEF2A_6	8	17	PF00069	0.376
DOC_PP2B_LxvP_1	162	165	PF13499	0.481
DOC_PP2B_LxvP_1	198	201	PF13499	0.514
DOC_USP7_MATH_1	2	6	PF00917	0.580
DOC_USP7_MATH_1	253	257	PF00917	0.574
DOC_USP7_MATH_1	272	276	PF00917	0.653
DOC_USP7_MATH_1	281	285	PF00917	0.601
DOC_USP7_UBL2_3	203	207	PF12436	0.621
DOC_WW_Pin1_4	160	165	PF00397	0.457
DOC_WW_Pin1_4	171	176	PF00397	0.380
LIG_14-3-3_CanoR_1	139	147	PF00244	0.529
LIG_14-3-3_CanoR_1	176	180	PF00244	0.555
LIG_APCC_ABBA_1	131	136	PF00400	0.475
LIG_FHA_1	113	119	PF00498	0.422
LIG_FHA_1	172	178	PF00498	0.415
LIG_FHA_1	296	302	PF00498	0.528
LIG_FHA_1	97	103	PF00498	0.521
LIG_LIR_Apic_2	45	51	PF02991	0.475
LIG_LIR_Gen_1	14	25	PF02991	0.472
LIG_LIR_Gen_1	149	160	PF02991	0.478
LIG_LIR_Gen_1	169	177	PF02991	0.405
LIG_LIR_Gen_1	79	89	PF02991	0.475
LIG_LIR_Nem_3	132	137	PF02991	0.501
LIG_LIR_Nem_3	14	20	PF02991	0.472
LIG_LIR_Nem_3	149	155	PF02991	0.478
LIG_LIR_Nem_3	169	173	PF02991	0.402
LIG_LIR_Nem_3	79	84	PF02991	0.475
LIG_Pex14_2	166	170	PF04695	0.473
LIG_SH2_CRK	156	160	PF00017	0.511
LIG_SH2_CRK	196	200	PF00017	0.541
LIG_SH2_CRK	35	39	PF00017	0.460
LIG_SH2_PTP2	152	155	PF00017	0.475
LIG_SH2_SRC	54	57	PF00017	0.475
LIG_SH2_STAP1	196	200	PF00017	0.493
LIG_SH2_STAT5	152	155	PF00017	0.503
LIG_SH2_STAT5	48	51	PF00017	0.475
LIG_SH3_3	231	237	PF00018	0.634
LIG_SH3_3	266	272	PF00018	0.824
LIG_SH3_3	7	13	PF00018	0.454
LIG_SUMO_SIM_par_1	129	136	PF11976	0.551
LIG_TYR_ITIM	194	199	PF00017	0.541
MOD_CDK_SPK_2	171	176	PF00069	0.512
MOD_CK1_1	129	135	PF00069	0.475
MOD_CK1_1	169	175	PF00069	0.426
MOD_CK1_1	211	217	PF00069	0.563
MOD_CK1_1	247	253	PF00069	0.681
MOD_CK1_1	256	262	PF00069	0.619
MOD_CK1_1	284	290	PF00069	0.606
MOD_CK2_1	129	135	PF00069	0.529
MOD_CK2_1	179	185	PF00069	0.455
MOD_CK2_1	301	307	PF00069	0.548
MOD_GlcNHglycan	246	249	PF01048	0.609
MOD_GlcNHglycan	255	258	PF01048	0.612
MOD_GlcNHglycan	26	29	PF01048	0.282
MOD_GlcNHglycan	274	277	PF01048	0.562
MOD_GlcNHglycan	283	286	PF01048	0.587
MOD_GlcNHglycan	4	7	PF01048	0.566
MOD_GlcNHglycan	93	96	PF01048	0.312
MOD_GSK3_1	11	18	PF00069	0.521
MOD_GSK3_1	171	178	PF00069	0.445
MOD_GSK3_1	209	216	PF00069	0.592
MOD_GSK3_1	24	31	PF00069	0.477
MOD_GSK3_1	247	254	PF00069	0.685
MOD_GSK3_1	267	274	PF00069	0.507
MOD_GSK3_1	276	283	PF00069	0.737
MOD_GSK3_1	284	291	PF00069	0.564
MOD_N-GLC_1	15	20	PF02516	0.321
MOD_N-GLC_1	208	213	PF02516	0.651
MOD_N-GLC_1	33	38	PF02516	0.342
MOD_NEK2_1	166	171	PF00069	0.461
MOD_NEK2_1	194	199	PF00069	0.467
MOD_PIKK_1	267	273	PF00454	0.701
MOD_PK_1	42	48	PF00069	0.529
MOD_PKA_2	175	181	PF00069	0.571
MOD_Plk_1	15	21	PF00069	0.598
MOD_Plk_1	33	39	PF00069	0.512
MOD_Plk_4	114	120	PF00069	0.475
MOD_Plk_4	129	135	PF00069	0.475
MOD_Plk_4	166	172	PF00069	0.444
MOD_Plk_4	175	181	PF00069	0.429
MOD_Plk_4	194	200	PF00069	0.525
MOD_Plk_4	288	294	PF00069	0.664
MOD_Plk_4	33	39	PF00069	0.478
MOD_ProDKin_1	160	166	PF00069	0.458
MOD_ProDKin_1	171	177	PF00069	0.372
MOD_SUMO_rev_2	132	140	PF00179	0.529
MOD_SUMO_rev_2	57	67	PF00179	0.434
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.529
TRG_ENDOCYTIC_2	137	140	PF00928	0.483
TRG_ENDOCYTIC_2	152	155	PF00928	0.475
TRG_ENDOCYTIC_2	156	159	PF00928	0.515
TRG_ENDOCYTIC_2	196	199	PF00928	0.537
TRG_ENDOCYTIC_2	35	38	PF00928	0.460
TRG_ER_diArg_1	41	44	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NMS4	Trypanosomatidae	65%	100%
A4H3X6	Leishmania braziliensis	77%	93%
A4HS51	Leishmania infantum	99%	100%
E9AK38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	94%
Q95Z86	Leishmania major	92%	100%