Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5B1_LEIDO

TriTrypDb:

LdBPK_040530.1 , LdCL_040010800 , LDHU3_04.0710

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5B1

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.450
CLV_C14_Caspase3-7	347	351	PF00656	0.387
CLV_NRD_NRD_1	170	172	PF00675	0.597
CLV_NRD_NRD_1	259	261	PF00675	0.449
CLV_NRD_NRD_1	460	462	PF00675	0.568
CLV_PCSK_KEX2_1	170	172	PF00082	0.571
CLV_PCSK_KEX2_1	259	261	PF00082	0.449
CLV_PCSK_KEX2_1	46	48	PF00082	0.252
CLV_PCSK_KEX2_1	460	462	PF00082	0.561
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.252
CLV_PCSK_PC7_1	166	172	PF00082	0.545
CLV_PCSK_SKI1_1	405	409	PF00082	0.372
CLV_PCSK_SKI1_1	412	416	PF00082	0.373
CLV_PCSK_SKI1_1	8	12	PF00082	0.377
CLV_PCSK_SKI1_1	83	87	PF00082	0.458
DEG_APCC_DBOX_1	259	267	PF00400	0.388
DEG_APCC_DBOX_1	404	412	PF00400	0.329
DEG_APCC_DBOX_1	82	90	PF00400	0.394
DEG_Nend_UBRbox_2	1	3	PF02207	0.477
DEG_SPOP_SBC_1	433	437	PF00917	0.535
DEG_SPOP_SBC_1	450	454	PF00917	0.505
DOC_CKS1_1	228	233	PF01111	0.553
DOC_CKS1_1	422	427	PF01111	0.457
DOC_CYCLIN_RxL_1	79	88	PF00134	0.405
DOC_MAPK_gen_1	79	86	PF00069	0.362
DOC_MAPK_MEF2A_6	302	310	PF00069	0.345
DOC_PP1_RVXF_1	289	296	PF00149	0.399
DOC_PP2B_LxvP_1	525	528	PF13499	0.567
DOC_PP2B_PxIxI_1	426	432	PF00149	0.512
DOC_PP4_FxxP_1	22	25	PF00568	0.337
DOC_PP4_FxxP_1	66	69	PF00568	0.295
DOC_USP7_MATH_1	120	124	PF00917	0.507
DOC_USP7_MATH_1	249	253	PF00917	0.610
DOC_USP7_MATH_1	335	339	PF00917	0.411
DOC_USP7_MATH_1	450	454	PF00917	0.549
DOC_USP7_MATH_1	462	466	PF00917	0.525
DOC_USP7_MATH_1	494	498	PF00917	0.527
DOC_USP7_MATH_2	212	218	PF00917	0.538
DOC_WW_Pin1_4	137	142	PF00397	0.591
DOC_WW_Pin1_4	152	157	PF00397	0.608
DOC_WW_Pin1_4	159	164	PF00397	0.561
DOC_WW_Pin1_4	195	200	PF00397	0.574
DOC_WW_Pin1_4	223	228	PF00397	0.582
DOC_WW_Pin1_4	247	252	PF00397	0.571
DOC_WW_Pin1_4	380	385	PF00397	0.337
DOC_WW_Pin1_4	421	426	PF00397	0.460
DOC_WW_Pin1_4	451	456	PF00397	0.606
DOC_WW_Pin1_4	520	525	PF00397	0.639
DOC_WW_Pin1_4	550	555	PF00397	0.522
DOC_WW_Pin1_4	561	566	PF00397	0.532
LIG_14-3-3_CanoR_1	193	200	PF00244	0.576
LIG_14-3-3_CanoR_1	260	268	PF00244	0.475
LIG_14-3-3_CanoR_1	284	290	PF00244	0.306
LIG_14-3-3_CanoR_1	328	334	PF00244	0.409
LIG_14-3-3_CanoR_1	8	13	PF00244	0.369
LIG_BIR_III_4	367	371	PF00653	0.273
LIG_BRCT_BRCA1_1	337	341	PF00533	0.409
LIG_BRCT_BRCA1_1	485	489	PF00533	0.545
LIG_CtBP_PxDLS_1	34	38	PF00389	0.272
LIG_FHA_1	223	229	PF00498	0.580
LIG_FHA_1	347	353	PF00498	0.373
LIG_FHA_1	397	403	PF00498	0.377
LIG_FHA_2	113	119	PF00498	0.490
LIG_FHA_2	138	144	PF00498	0.538
LIG_FHA_2	414	420	PF00498	0.406
LIG_Integrin_isoDGR_2	579	581	PF01839	0.569
LIG_Integrin_RGD_1	584	586	PF01839	0.524
LIG_LIR_Apic_2	19	25	PF02991	0.363
LIG_LIR_Apic_2	29	34	PF02991	0.302
LIG_LIR_Gen_1	267	276	PF02991	0.413
LIG_LIR_Gen_1	399	408	PF02991	0.411
LIG_LIR_Gen_1	512	522	PF02991	0.542
LIG_LIR_Nem_3	177	183	PF02991	0.604
LIG_LIR_Nem_3	256	261	PF02991	0.427
LIG_LIR_Nem_3	267	271	PF02991	0.458
LIG_LIR_Nem_3	359	365	PF02991	0.423
LIG_LIR_Nem_3	369	374	PF02991	0.362
LIG_LIR_Nem_3	399	404	PF02991	0.413
LIG_LIR_Nem_3	512	517	PF02991	0.544
LIG_Pex14_2	295	299	PF04695	0.371
LIG_Rb_pABgroove_1	272	280	PF01858	0.369
LIG_SH2_CRK	268	272	PF00017	0.388
LIG_SH2_CRK	362	366	PF00017	0.512
LIG_SH2_CRK	501	505	PF00017	0.663
LIG_SH2_CRK	514	518	PF00017	0.563
LIG_SH2_PTP2	180	183	PF00017	0.574
LIG_SH2_PTP2	401	404	PF00017	0.353
LIG_SH2_SRC	180	183	PF00017	0.574
LIG_SH2_STAP1	268	272	PF00017	0.388
LIG_SH2_STAP1	348	352	PF00017	0.401
LIG_SH2_STAP1	514	518	PF00017	0.549
LIG_SH2_STAT3	320	323	PF00017	0.339
LIG_SH2_STAT5	180	183	PF00017	0.581
LIG_SH2_STAT5	320	323	PF00017	0.347
LIG_SH2_STAT5	348	351	PF00017	0.395
LIG_SH2_STAT5	373	376	PF00017	0.352
LIG_SH2_STAT5	401	404	PF00017	0.353
LIG_SH2_STAT5	501	504	PF00017	0.528
LIG_SH2_STAT5	98	101	PF00017	0.383
LIG_SH3_2	521	526	PF14604	0.562
LIG_SH3_3	153	159	PF00018	0.618
LIG_SH3_3	331	337	PF00018	0.352
LIG_SH3_3	444	450	PF00018	0.502
LIG_SH3_3	518	524	PF00018	0.678
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.282
LIG_SUMO_SIM_par_1	88	93	PF11976	0.331
LIG_TRAF2_2	14	19	PF00917	0.389
LIG_TYR_ITIM	266	271	PF00017	0.363
LIG_UBA3_1	309	318	PF00899	0.365
MOD_CAAXbox	589	592	PF01239	0.588
MOD_CDC14_SPxK_1	198	201	PF00782	0.557
MOD_CDC14_SPxK_1	523	526	PF00782	0.553
MOD_CDK_SPxK_1	195	201	PF00069	0.570
MOD_CDK_SPxK_1	520	526	PF00069	0.546
MOD_CDK_SPxxK_3	159	166	PF00069	0.547
MOD_CDK_SPxxK_3	561	568	PF00069	0.570
MOD_CK1_1	136	142	PF00069	0.594
MOD_CK1_1	188	194	PF00069	0.622
MOD_CK1_1	195	201	PF00069	0.616
MOD_CK1_1	217	223	PF00069	0.736
MOD_CK1_1	413	419	PF00069	0.468
MOD_CK1_1	434	440	PF00069	0.753
MOD_CK1_1	472	478	PF00069	0.522
MOD_CK1_1	512	518	PF00069	0.515
MOD_CK2_1	137	143	PF00069	0.533
MOD_CK2_1	261	267	PF00069	0.368
MOD_CK2_1	341	347	PF00069	0.387
MOD_CK2_1	413	419	PF00069	0.394
MOD_GlcNHglycan	188	191	PF01048	0.624
MOD_GlcNHglycan	238	241	PF01048	0.591
MOD_GlcNHglycan	247	250	PF01048	0.491
MOD_GlcNHglycan	285	288	PF01048	0.345
MOD_GlcNHglycan	336	340	PF01048	0.411
MOD_GlcNHglycan	367	371	PF01048	0.273
MOD_GlcNHglycan	438	441	PF01048	0.631
MOD_GlcNHglycan	474	477	PF01048	0.575
MOD_GlcNHglycan	479	482	PF01048	0.530
MOD_GlcNHglycan	541	544	PF01048	0.596
MOD_GSK3_1	101	108	PF00069	0.391
MOD_GSK3_1	120	127	PF00069	0.582
MOD_GSK3_1	133	140	PF00069	0.556
MOD_GSK3_1	154	161	PF00069	0.671
MOD_GSK3_1	188	195	PF00069	0.616
MOD_GSK3_1	200	207	PF00069	0.658
MOD_GSK3_1	214	221	PF00069	0.573
MOD_GSK3_1	223	230	PF00069	0.676
MOD_GSK3_1	236	243	PF00069	0.654
MOD_GSK3_1	245	252	PF00069	0.553
MOD_GSK3_1	396	403	PF00069	0.426
MOD_GSK3_1	427	434	PF00069	0.581
MOD_GSK3_1	470	477	PF00069	0.550
MOD_GSK3_1	479	486	PF00069	0.505
MOD_GSK3_1	490	497	PF00069	0.488
MOD_GSK3_1	509	516	PF00069	0.636
MOD_GSK3_1	539	546	PF00069	0.531
MOD_GSK3_1	70	77	PF00069	0.442
MOD_N-GLC_1	218	223	PF02516	0.585
MOD_N-GLC_1	236	241	PF02516	0.605
MOD_NEK2_1	245	250	PF00069	0.549
MOD_NEK2_1	341	346	PF00069	0.462
MOD_NEK2_1	407	412	PF00069	0.390
MOD_NEK2_1	490	495	PF00069	0.537
MOD_NEK2_1	539	544	PF00069	0.618
MOD_NEK2_1	70	75	PF00069	0.419
MOD_NEK2_1	85	90	PF00069	0.416
MOD_NEK2_2	400	405	PF00069	0.441
MOD_NEK2_2	494	499	PF00069	0.498
MOD_PIKK_1	261	267	PF00454	0.435
MOD_PIKK_1	319	325	PF00454	0.338
MOD_PIKK_1	499	505	PF00454	0.770
MOD_PIKK_1	526	532	PF00454	0.535
MOD_PKA_2	101	107	PF00069	0.406
MOD_PKA_2	192	198	PF00069	0.581
MOD_PKA_2	200	206	PF00069	0.556
MOD_PKA_2	283	289	PF00069	0.333
MOD_PKA_2	580	586	PF00069	0.619
MOD_Plk_1	218	224	PF00069	0.682
MOD_Plk_4	70	76	PF00069	0.391
MOD_Plk_4	85	91	PF00069	0.378
MOD_ProDKin_1	137	143	PF00069	0.595
MOD_ProDKin_1	152	158	PF00069	0.606
MOD_ProDKin_1	159	165	PF00069	0.562
MOD_ProDKin_1	195	201	PF00069	0.573
MOD_ProDKin_1	223	229	PF00069	0.585
MOD_ProDKin_1	247	253	PF00069	0.563
MOD_ProDKin_1	380	386	PF00069	0.335
MOD_ProDKin_1	421	427	PF00069	0.462
MOD_ProDKin_1	451	457	PF00069	0.605
MOD_ProDKin_1	520	526	PF00069	0.641
MOD_ProDKin_1	550	556	PF00069	0.525
MOD_ProDKin_1	561	567	PF00069	0.534
MOD_SUMO_rev_2	77	81	PF00179	0.390
TRG_DiLeu_BaEn_1	267	272	PF01217	0.409
TRG_ENDOCYTIC_2	180	183	PF00928	0.594
TRG_ENDOCYTIC_2	268	271	PF00928	0.409
TRG_ENDOCYTIC_2	362	365	PF00928	0.540
TRG_ENDOCYTIC_2	373	376	PF00928	0.268
TRG_ENDOCYTIC_2	401	404	PF00928	0.353
TRG_ENDOCYTIC_2	501	504	PF00928	0.553
TRG_ENDOCYTIC_2	514	517	PF00928	0.550
TRG_ER_diArg_1	169	171	PF00400	0.603
TRG_ER_diArg_1	258	260	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV78	Leptomonas seymouri	51%	94%
A0A3R7KFH5	Trypanosoma rangeli	27%	100%
A4HDK3	Leishmania braziliensis	27%	93%
A4HDK4	Leishmania braziliensis	27%	93%
A4HS49	Leishmania infantum	99%	100%
E9AK36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O97201	Leishmania major	90%	99%
Q4QAJ3	Leishmania major	29%	97%
Q4QBX6	Leishmania major	22%	100%