Ribosomal L5P C-terminus family protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L11 (L5, L16)

Species:

Leishmania donovani

UniProt:

A0A3S5H5A8_LEIDO

TriTrypDb:

LdBPK_220004.1 , LdCL_040010100 , LdCL_220005300 , LDHU3_04.0620 , LDHU3_22.0070

Length:

188

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L11 (L5, L16) RPL11

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005840	ribosome	5	10
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H5A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5A8

PDB structure(s): 6az3_D

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11
GO:0005488	binding	1	1
GO:0019843	rRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.248
CLV_NRD_NRD_1	142	144	PF00675	0.248
CLV_NRD_NRD_1	62	64	PF00675	0.407
CLV_PCSK_FUR_1	184	188	PF00082	0.583
CLV_PCSK_KEX2_1	135	137	PF00082	0.248
CLV_PCSK_KEX2_1	144	146	PF00082	0.248
CLV_PCSK_KEX2_1	184	186	PF00082	0.561
CLV_PCSK_KEX2_1	62	64	PF00082	0.407
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.280
CLV_PCSK_SKI1_1	84	88	PF00082	0.248

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9G4	Leptomonas seymouri	96%	100%
A0A0S4JHP0	Bodo saltans	85%	99%
A0A1D8PHW1	Candida albicans (strain SC5314 / ATCC MYA-2876)	70%	100%
A0A1X0NDJ0	Trypanosomatidae	95%	97%
A0A422MSR7	Trypanosoma rangeli	91%	97%
A0LIK2	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	28%	100%
A0PXV8	Clostridium novyi (strain NT)	31%	100%
A0R8J2	Bacillus thuringiensis (strain Al Hakam)	27%	100%
A0RVY6	Cenarchaeum symbiosum (strain A)	39%	100%
A1AVL2	Ruthia magnifica subsp. Calyptogena magnifica	27%	100%

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