Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5A7_LEIDO

TriTrypDb:

LdCL_040010000

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.737
CLV_C14_Caspase3-7	284	288	PF00656	0.659
CLV_C14_Caspase3-7	687	691	PF00656	0.513
CLV_C14_Caspase3-7	824	828	PF00656	0.526
CLV_C14_Caspase3-7	878	882	PF00656	0.550
CLV_NRD_NRD_1	231	233	PF00675	0.538
CLV_NRD_NRD_1	583	585	PF00675	0.512
CLV_NRD_NRD_1	644	646	PF00675	0.622
CLV_NRD_NRD_1	702	704	PF00675	0.552
CLV_NRD_NRD_1	753	755	PF00675	0.508
CLV_NRD_NRD_1	787	789	PF00675	0.575
CLV_PCSK_FUR_1	751	755	PF00082	0.504
CLV_PCSK_KEX2_1	231	233	PF00082	0.538
CLV_PCSK_KEX2_1	583	585	PF00082	0.517
CLV_PCSK_KEX2_1	644	646	PF00082	0.667
CLV_PCSK_KEX2_1	753	755	PF00082	0.508
CLV_PCSK_KEX2_1	778	780	PF00082	0.593
CLV_PCSK_KEX2_1	786	788	PF00082	0.554
CLV_PCSK_KEX2_1	85	87	PF00082	0.580
CLV_PCSK_PC1ET2_1	778	780	PF00082	0.593
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.580
CLV_PCSK_SKI1_1	348	352	PF00082	0.300
CLV_PCSK_SKI1_1	511	515	PF00082	0.346
CLV_PCSK_SKI1_1	64	68	PF00082	0.461
CLV_PCSK_SKI1_1	717	721	PF00082	0.648
CLV_PCSK_SKI1_1	739	743	PF00082	0.534
CLV_PCSK_SKI1_1	778	782	PF00082	0.601
CLV_PCSK_SKI1_1	832	836	PF00082	0.496
CLV_Separin_Metazoa	409	413	PF03568	0.303
DEG_APCC_DBOX_1	63	71	PF00400	0.482
DEG_SCF_FBW7_1	632	637	PF00400	0.534
DEG_SPOP_SBC_1	257	261	PF00917	0.633
DEG_SPOP_SBC_1	278	282	PF00917	0.446
DEG_SPOP_SBC_1	31	35	PF00917	0.628
DEG_SPOP_SBC_1	663	667	PF00917	0.550
DOC_CDC14_PxL_1	328	336	PF14671	0.508
DOC_CKS1_1	111	116	PF01111	0.547
DOC_CKS1_1	519	524	PF01111	0.524
DOC_CKS1_1	631	636	PF01111	0.535
DOC_CKS1_1	692	697	PF01111	0.512
DOC_CYCLIN_RxL_1	736	746	PF00134	0.541
DOC_CYCLIN_RxL_1	829	836	PF00134	0.531
DOC_MAPK_gen_1	231	238	PF00069	0.544
DOC_MAPK_gen_1	558	566	PF00069	0.381
DOC_MAPK_gen_1	778	785	PF00069	0.598
DOC_MAPK_gen_1	85	93	PF00069	0.576
DOC_MAPK_MEF2A_6	102	111	PF00069	0.547
DOC_MAPK_MEF2A_6	231	238	PF00069	0.580
DOC_MAPK_MEF2A_6	778	785	PF00069	0.598
DOC_MAPK_MEF2A_6	85	93	PF00069	0.544
DOC_MAPK_NFAT4_5	778	786	PF00069	0.602
DOC_PP1_RVXF_1	410	417	PF00149	0.289
DOC_PP4_FxxP_1	791	794	PF00568	0.563
DOC_USP7_MATH_1	105	109	PF00917	0.607
DOC_USP7_MATH_1	148	152	PF00917	0.532
DOC_USP7_MATH_1	173	177	PF00917	0.575
DOC_USP7_MATH_1	188	192	PF00917	0.617
DOC_USP7_MATH_1	203	207	PF00917	0.563
DOC_USP7_MATH_1	258	262	PF00917	0.614
DOC_USP7_MATH_1	29	33	PF00917	0.537
DOC_USP7_MATH_1	381	385	PF00917	0.408
DOC_USP7_MATH_1	547	551	PF00917	0.418
DOC_USP7_MATH_1	634	638	PF00917	0.546
DOC_USP7_MATH_1	693	697	PF00917	0.546
DOC_USP7_MATH_1	77	81	PF00917	0.690
DOC_USP7_MATH_1	771	775	PF00917	0.767
DOC_USP7_MATH_1	838	842	PF00917	0.499
DOC_WW_Pin1_4	110	115	PF00397	0.538
DOC_WW_Pin1_4	128	133	PF00397	0.587
DOC_WW_Pin1_4	157	162	PF00397	0.577
DOC_WW_Pin1_4	236	241	PF00397	0.551
DOC_WW_Pin1_4	333	338	PF00397	0.426
DOC_WW_Pin1_4	370	375	PF00397	0.552
DOC_WW_Pin1_4	477	482	PF00397	0.530
DOC_WW_Pin1_4	514	519	PF00397	0.476
DOC_WW_Pin1_4	630	635	PF00397	0.529
DOC_WW_Pin1_4	691	696	PF00397	0.533
DOC_WW_Pin1_4	710	715	PF00397	0.526
DOC_WW_Pin1_4	722	727	PF00397	0.500
DOC_WW_Pin1_4	792	797	PF00397	0.620
DOC_WW_Pin1_4	845	850	PF00397	0.534
LIG_14-3-3_CanoR_1	216	225	PF00244	0.628
LIG_14-3-3_CanoR_1	392	401	PF00244	0.331
LIG_14-3-3_CanoR_1	497	506	PF00244	0.418
LIG_14-3-3_CanoR_1	621	626	PF00244	0.554
LIG_14-3-3_CanoR_1	671	681	PF00244	0.616
LIG_14-3-3_CanoR_1	684	692	PF00244	0.475
LIG_14-3-3_CanoR_1	786	792	PF00244	0.615
LIG_14-3-3_CanoR_1	867	871	PF00244	0.496
LIG_ActinCP_TwfCPI_2	791	799	PF01115	0.567
LIG_Clathr_ClatBox_1	485	489	PF01394	0.330
LIG_eIF4E_1	104	110	PF01652	0.521
LIG_FHA_1	164	170	PF00498	0.627
LIG_FHA_1	216	222	PF00498	0.631
LIG_FHA_1	278	284	PF00498	0.527
LIG_FHA_1	323	329	PF00498	0.654
LIG_FHA_1	365	371	PF00498	0.499
LIG_FHA_1	375	381	PF00498	0.478
LIG_FHA_1	452	458	PF00498	0.379
LIG_FHA_1	46	52	PF00498	0.506
LIG_FHA_1	519	525	PF00498	0.553
LIG_FHA_1	550	556	PF00498	0.343
LIG_FHA_1	589	595	PF00498	0.452
LIG_FHA_1	714	720	PF00498	0.647
LIG_FHA_1	727	733	PF00498	0.492
LIG_FHA_1	878	884	PF00498	0.550
LIG_FHA_2	180	186	PF00498	0.577
LIG_FHA_2	36	42	PF00498	0.572
LIG_KLC1_Yacidic_2	881	886	PF13176	0.555
LIG_LIR_Apic_2	101	107	PF02991	0.529
LIG_LIR_Apic_2	790	794	PF02991	0.559
LIG_LIR_Gen_1	353	363	PF02991	0.426
LIG_LIR_Gen_1	626	635	PF02991	0.641
LIG_LIR_Gen_1	746	757	PF02991	0.496
LIG_LIR_Nem_3	353	358	PF02991	0.511
LIG_LIR_Nem_3	489	493	PF02991	0.367
LIG_LIR_Nem_3	591	595	PF02991	0.391
LIG_LIR_Nem_3	626	632	PF02991	0.700
LIG_LIR_Nem_3	746	752	PF02991	0.544
LIG_Pex14_2	106	110	PF04695	0.536
LIG_Pex14_2	510	514	PF04695	0.332
LIG_Pex14_2	569	573	PF04695	0.375
LIG_SH2_CRK	204	208	PF00017	0.624
LIG_SH2_CRK	586	590	PF00017	0.401
LIG_SH2_PTP2	117	120	PF00017	0.506
LIG_SH2_SRC	586	589	PF00017	0.422
LIG_SH2_STAP1	204	208	PF00017	0.624
LIG_SH2_STAP1	431	435	PF00017	0.385
LIG_SH2_STAT5	117	120	PF00017	0.619
LIG_SH2_STAT5	491	494	PF00017	0.396
LIG_SH2_STAT5	737	740	PF00017	0.569
LIG_SH3_3	158	164	PF00018	0.574
LIG_SH3_3	317	323	PF00018	0.552
LIG_SH3_3	468	474	PF00018	0.482
LIG_SH3_3	478	484	PF00018	0.480
LIG_SH3_3	516	522	PF00018	0.558
LIG_SH3_3	720	726	PF00018	0.539
LIG_SH3_3	764	770	PF00018	0.536
LIG_SH3_3	97	103	PF00018	0.517
LIG_SUMO_SIM_par_1	367	373	PF11976	0.480
LIG_SUMO_SIM_par_1	594	600	PF11976	0.379
LIG_SUMO_SIM_par_1	718	725	PF11976	0.637
LIG_SUMO_SIM_par_1	729	736	PF11976	0.493
LIG_TRAF2_1	262	265	PF00917	0.571
LIG_TRAF2_1	7	10	PF00917	0.403
LIG_TRAF2_1	707	710	PF00917	0.597
LIG_TRAF2_1	743	746	PF00917	0.481
LIG_TYR_ITIM	202	207	PF00017	0.619
LIG_WRC_WIRS_1	566	571	PF05994	0.361
MOD_CDK_SPK_2	110	115	PF00069	0.538
MOD_CDK_SPxxK_3	710	717	PF00069	0.550
MOD_CDK_SPxxK_3	792	799	PF00069	0.632
MOD_CK1_1	133	139	PF00069	0.594
MOD_CK1_1	174	180	PF00069	0.632
MOD_CK1_1	24	30	PF00069	0.463
MOD_CK1_1	252	258	PF00069	0.623
MOD_CK1_1	259	265	PF00069	0.641
MOD_CK1_1	32	38	PF00069	0.722
MOD_CK1_1	4	10	PF00069	0.462
MOD_CK1_1	40	46	PF00069	0.409
MOD_CK1_1	447	453	PF00069	0.603
MOD_CK1_1	543	549	PF00069	0.555
MOD_CK1_1	568	574	PF00069	0.401
MOD_CK1_1	597	603	PF00069	0.388
MOD_CK1_1	675	681	PF00069	0.700
MOD_CK2_1	179	185	PF00069	0.581
MOD_CK2_1	259	265	PF00069	0.678
MOD_CK2_1	300	306	PF00069	0.557
MOD_CK2_1	35	41	PF00069	0.716
MOD_CK2_1	4	10	PF00069	0.396
MOD_CK2_1	694	700	PF00069	0.619
MOD_CK2_1	704	710	PF00069	0.590
MOD_CK2_1	740	746	PF00069	0.473
MOD_Cter_Amidation	581	584	PF01082	0.516
MOD_Cter_Amidation	83	86	PF01082	0.575
MOD_GlcNHglycan	190	193	PF01048	0.667
MOD_GlcNHglycan	218	221	PF01048	0.601
MOD_GlcNHglycan	253	257	PF01048	0.536
MOD_GlcNHglycan	29	32	PF01048	0.534
MOD_GlcNHglycan	361	364	PF01048	0.479
MOD_GlcNHglycan	387	390	PF01048	0.425
MOD_GlcNHglycan	394	397	PF01048	0.345
MOD_GlcNHglycan	41	45	PF01048	0.462
MOD_GlcNHglycan	417	420	PF01048	0.373
MOD_GlcNHglycan	500	503	PF01048	0.438
MOD_GlcNHglycan	6	9	PF01048	0.464
MOD_GlcNHglycan	674	677	PF01048	0.608
MOD_GlcNHglycan	686	689	PF01048	0.472
MOD_GlcNHglycan	696	699	PF01048	0.546
MOD_GlcNHglycan	774	777	PF01048	0.698
MOD_GlcNHglycan	823	826	PF01048	0.543
MOD_GlcNHglycan	93	96	PF01048	0.636
MOD_GSK3_1	148	155	PF00069	0.530
MOD_GSK3_1	176	183	PF00069	0.618
MOD_GSK3_1	21	28	PF00069	0.523
MOD_GSK3_1	252	259	PF00069	0.626
MOD_GSK3_1	277	284	PF00069	0.524
MOD_GSK3_1	290	297	PF00069	0.520
MOD_GSK3_1	300	307	PF00069	0.542
MOD_GSK3_1	31	38	PF00069	0.666
MOD_GSK3_1	322	329	PF00069	0.608
MOD_GSK3_1	333	340	PF00069	0.372
MOD_GSK3_1	370	377	PF00069	0.518
MOD_GSK3_1	381	388	PF00069	0.354
MOD_GSK3_1	436	443	PF00069	0.509
MOD_GSK3_1	447	454	PF00069	0.540
MOD_GSK3_1	514	521	PF00069	0.457
MOD_GSK3_1	539	546	PF00069	0.547
MOD_GSK3_1	565	572	PF00069	0.407
MOD_GSK3_1	600	607	PF00069	0.472
MOD_GSK3_1	630	637	PF00069	0.496
MOD_GSK3_1	640	647	PF00069	0.570
MOD_GSK3_1	672	679	PF00069	0.530
MOD_GSK3_1	704	711	PF00069	0.629
MOD_GSK3_1	713	720	PF00069	0.573
MOD_GSK3_1	722	729	PF00069	0.564
MOD_GSK3_1	73	80	PF00069	0.558
MOD_GSK3_1	733	740	PF00069	0.514
MOD_GSK3_1	826	833	PF00069	0.480
MOD_N-GLC_1	171	176	PF02516	0.570
MOD_N-GLC_1	216	221	PF02516	0.771
MOD_N-GLC_1	234	239	PF02516	0.492
MOD_N-GLC_1	4	9	PF02516	0.400
MOD_N-GLC_1	534	539	PF02516	0.429
MOD_N-GLC_1	569	574	PF02516	0.402
MOD_N-GLC_1	672	677	PF02516	0.576
MOD_N-GLC_2	309	311	PF02516	0.538
MOD_NEK2_1	152	157	PF00069	0.663
MOD_NEK2_1	304	309	PF00069	0.641
MOD_NEK2_1	460	465	PF00069	0.386
MOD_NEK2_1	498	503	PF00069	0.438
MOD_NEK2_1	534	539	PF00069	0.470
MOD_NEK2_1	569	574	PF00069	0.402
MOD_NEK2_1	594	599	PF00069	0.374
MOD_NEK2_1	640	645	PF00069	0.615
MOD_NEK2_1	843	848	PF00069	0.512
MOD_NEK2_2	45	50	PF00069	0.319
MOD_NEK2_2	866	871	PF00069	0.539
MOD_PK_1	171	177	PF00069	0.635
MOD_PK_1	621	627	PF00069	0.493
MOD_PKA_1	644	650	PF00069	0.603
MOD_PKA_1	787	793	PF00069	0.553
MOD_PKA_2	215	221	PF00069	0.630
MOD_PKA_2	440	446	PF00069	0.527
MOD_PKA_2	644	650	PF00069	0.619
MOD_PKA_2	78	84	PF00069	0.629
MOD_PKA_2	787	793	PF00069	0.553
MOD_PKA_2	838	844	PF00069	0.482
MOD_PKA_2	866	872	PF00069	0.499
MOD_Plk_1	148	154	PF00069	0.525
MOD_Plk_1	171	177	PF00069	0.571
MOD_Plk_1	216	222	PF00069	0.769
MOD_Plk_1	234	240	PF00069	0.492
MOD_Plk_1	314	320	PF00069	0.545
MOD_Plk_1	569	575	PF00069	0.456
MOD_Plk_1	826	832	PF00069	0.437
MOD_Plk_4	105	111	PF00069	0.540
MOD_Plk_4	164	170	PF00069	0.645
MOD_Plk_4	290	296	PF00069	0.722
MOD_Plk_4	354	360	PF00069	0.521
MOD_Plk_4	45	51	PF00069	0.360
MOD_Plk_4	733	739	PF00069	0.568
MOD_Plk_4	744	750	PF00069	0.586
MOD_Plk_4	826	832	PF00069	0.526
MOD_Plk_4	838	844	PF00069	0.488
MOD_ProDKin_1	110	116	PF00069	0.540
MOD_ProDKin_1	128	134	PF00069	0.584
MOD_ProDKin_1	157	163	PF00069	0.577
MOD_ProDKin_1	236	242	PF00069	0.550
MOD_ProDKin_1	333	339	PF00069	0.421
MOD_ProDKin_1	370	376	PF00069	0.546
MOD_ProDKin_1	477	483	PF00069	0.515
MOD_ProDKin_1	514	520	PF00069	0.484
MOD_ProDKin_1	630	636	PF00069	0.533
MOD_ProDKin_1	691	697	PF00069	0.536
MOD_ProDKin_1	710	716	PF00069	0.527
MOD_ProDKin_1	722	728	PF00069	0.499
MOD_ProDKin_1	792	798	PF00069	0.622
MOD_ProDKin_1	845	851	PF00069	0.527
MOD_SUMO_rev_2	696	706	PF00179	0.543
TRG_DiLeu_BaEn_4	9	15	PF01217	0.437
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.516
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.437
TRG_DiLeu_BaLyEn_6	779	784	PF01217	0.557
TRG_ENDOCYTIC_2	117	120	PF00928	0.611
TRG_ENDOCYTIC_2	204	207	PF00928	0.628
TRG_ENDOCYTIC_2	629	632	PF00928	0.519
TRG_ER_diArg_1	231	233	PF00400	0.538
TRG_ER_diArg_1	583	585	PF00400	0.517
TRG_ER_diArg_1	751	754	PF00400	0.500
TRG_ER_diArg_1	785	788	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	621	626	PF00026	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZH0	Leptomonas seymouri	39%	100%
A4H3W6	Leishmania braziliensis	70%	98%
E9AG61	Leishmania infantum	99%	100%
E9AK28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%