Anaphase_promoting_complex_subunit_10-like_protei n/GeneDB:LmjF.04.0400

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anaphase promoting complex, subunit 10-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5A1_LEIDO

TriTrypDb:

LdBPK_040380.1 , LdCL_040009300 , LDHU3_04.0500

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	12
GO:0000152	nuclear ubiquitin ligase complex	3	12
GO:0005680	anaphase-promoting complex	4	12
GO:0031461	cullin-RING ubiquitin ligase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

A0A3S5H5A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5A1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007049	cell cycle	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0030163	protein catabolic process	4	12
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	12
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051301	cell division	2	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12
GO:0000209	protein polyubiquitination	8	1
GO:0016567	protein ubiquitination	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0070979	protein K11-linked ubiquitination	9	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.588
CLV_C14_Caspase3-7	37	41	PF00656	0.481
DEG_APCC_DBOX_1	109	117	PF00400	0.535
DEG_Nend_UBRbox_2	1	3	PF02207	0.606
DEG_SPOP_SBC_1	34	38	PF00917	0.691
DOC_CKS1_1	115	120	PF01111	0.535
DOC_CKS1_1	50	55	PF01111	0.472
DOC_USP7_MATH_1	221	225	PF00917	0.557
DOC_USP7_MATH_1	244	248	PF00917	0.576
DOC_USP7_MATH_1	251	255	PF00917	0.742
DOC_USP7_MATH_1	34	38	PF00917	0.702
DOC_USP7_MATH_1	43	47	PF00917	0.472
DOC_WW_Pin1_4	114	119	PF00397	0.488
DOC_WW_Pin1_4	132	137	PF00397	0.392
DOC_WW_Pin1_4	223	228	PF00397	0.478
DOC_WW_Pin1_4	242	247	PF00397	0.457
DOC_WW_Pin1_4	49	54	PF00397	0.432
LIG_14-3-3_CanoR_1	48	53	PF00244	0.482
LIG_deltaCOP1_diTrp_1	269	273	PF00928	0.495
LIG_FHA_1	313	319	PF00498	0.588
LIG_FHA_1	50	56	PF00498	0.491
LIG_FHA_2	115	121	PF00498	0.535
LIG_FHA_2	168	174	PF00498	0.481
LIG_FHA_2	201	207	PF00498	0.508
LIG_FHA_2	273	279	PF00498	0.435
LIG_FHA_2	331	337	PF00498	0.596
LIG_Integrin_isoDGR_2	287	289	PF01839	0.392
LIG_LIR_Apic_2	223	228	PF02991	0.446
LIG_LIR_Gen_1	163	174	PF02991	0.535
LIG_LIR_Nem_3	163	169	PF02991	0.478
LIG_LIR_Nem_3	46	50	PF02991	0.561
LIG_LYPXL_SIV_4	230	238	PF13949	0.478
LIG_SH2_CRK	225	229	PF00017	0.468
LIG_SH2_GRB2like	125	128	PF00017	0.535
LIG_SH2_NCK_1	231	235	PF00017	0.478
LIG_SH2_SRC	125	128	PF00017	0.478
LIG_SH2_STAP1	231	235	PF00017	0.478
LIG_SH2_STAT5	125	128	PF00017	0.458
LIG_SH3_3	224	230	PF00018	0.532
LIG_SH3_3	255	261	PF00018	0.749
LIG_SUMO_SIM_par_1	167	173	PF11976	0.563
LIG_TRAF2_1	13	16	PF00917	0.547
LIG_TRAF2_1	160	163	PF00917	0.535
LIG_TRAF2_1	203	206	PF00917	0.503
LIG_TYR_ITIM	229	234	PF00017	0.478
MOD_CDK_SPK_2	132	137	PF00069	0.442
MOD_CK1_1	20	26	PF00069	0.691
MOD_CK1_1	223	229	PF00069	0.531
MOD_CK1_1	28	34	PF00069	0.606
MOD_CK1_1	36	42	PF00069	0.468
MOD_CK1_1	70	76	PF00069	0.518
MOD_CK2_1	114	120	PF00069	0.535
MOD_CK2_1	167	173	PF00069	0.576
MOD_CK2_1	200	206	PF00069	0.565
MOD_CK2_1	330	336	PF00069	0.598
MOD_CK2_1	9	15	PF00069	0.710
MOD_GlcNHglycan	127	130	PF01048	0.322
MOD_GlcNHglycan	146	149	PF01048	0.165
MOD_GlcNHglycan	247	250	PF01048	0.278
MOD_GlcNHglycan	253	256	PF01048	0.585
MOD_GlcNHglycan	27	30	PF01048	0.620
MOD_GlcNHglycan	40	44	PF01048	0.513
MOD_GlcNHglycan	69	72	PF01048	0.281
MOD_GlcNHglycan	78	81	PF01048	0.196
MOD_GSK3_1	144	151	PF00069	0.520
MOD_GSK3_1	312	319	PF00069	0.549
MOD_GSK3_1	35	42	PF00069	0.571
MOD_N-GLC_1	262	267	PF02516	0.604
MOD_NEK2_1	272	277	PF00069	0.458
MOD_PIKK_1	17	23	PF00454	0.618
MOD_PIKK_1	200	206	PF00454	0.392
MOD_PK_1	10	16	PF00069	0.600
MOD_PKA_2	307	313	PF00069	0.568
MOD_PKA_2	9	15	PF00069	0.597
MOD_Plk_1	10	16	PF00069	0.600
MOD_Plk_1	130	136	PF00069	0.431
MOD_Plk_4	272	278	PF00069	0.401
MOD_Plk_4	70	76	PF00069	0.500
MOD_ProDKin_1	114	120	PF00069	0.488
MOD_ProDKin_1	132	138	PF00069	0.392
MOD_ProDKin_1	223	229	PF00069	0.478
MOD_ProDKin_1	242	248	PF00069	0.457
MOD_ProDKin_1	49	55	PF00069	0.432
TRG_ENDOCYTIC_2	231	234	PF00928	0.535
TRG_ENDOCYTIC_2	303	306	PF00928	0.548
TRG_ER_diArg_1	207	210	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G0	Leptomonas seymouri	62%	99%
A0A0S4JNN0	Bodo saltans	34%	100%
A0A1X0P6H6	Trypanosomatidae	35%	100%
A0A3R7LQ45	Trypanosoma rangeli	38%	100%
A4H3W0	Leishmania braziliensis	76%	98%
A4HS34	Leishmania infantum	100%	100%
D0A0Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AK21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q9U198	Leishmania major	91%	100%
V5BNI3	Trypanosoma cruzi	40%	100%