Phytanoyl-CoA_dioxygenase_(PhyH)_putative/Pfam:PF 05721

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phytanoyl-CoA dioxygenase (PhyH), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5A0_LEIDO

TriTrypDb:

LdBPK_040360.1 , LdCL_040009100 , LDHU3_04.0430

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5A0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016491	oxidoreductase activity	2	4
GO:0051213	dioxygenase activity	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.494
CLV_NRD_NRD_1	2	4	PF00675	0.599
CLV_NRD_NRD_1	267	269	PF00675	0.347
CLV_PCSK_KEX2_1	19	21	PF00082	0.494
CLV_PCSK_KEX2_1	2	4	PF00082	0.605
CLV_PCSK_KEX2_1	267	269	PF00082	0.288
CLV_PCSK_SKI1_1	2	6	PF00082	0.643
CLV_PCSK_SKI1_1	277	281	PF00082	0.425
CLV_PCSK_SKI1_1	80	84	PF00082	0.321
DEG_Nend_UBRbox_1	1	4	PF02207	0.685
DEG_SCF_FBW7_1	256	263	PF00400	0.286
DOC_CDC14_PxL_1	140	148	PF14671	0.380
DOC_CKS1_1	15	20	PF01111	0.653
DOC_CYCLIN_RxL_1	274	282	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	225	228	PF00134	0.347
DOC_MAPK_DCC_7	58	66	PF00069	0.430
DOC_MAPK_DCC_7	80	90	PF00069	0.416
DOC_MAPK_gen_1	19	28	PF00069	0.468
DOC_MAPK_gen_1	267	274	PF00069	0.286
DOC_MAPK_MEF2A_6	58	66	PF00069	0.426
DOC_PP2B_LxvP_1	225	228	PF13499	0.380
DOC_PP2B_LxvP_1	83	86	PF13499	0.416
DOC_PP4_FxxP_1	60	63	PF00568	0.347
DOC_USP7_MATH_1	233	237	PF00917	0.426
DOC_USP7_MATH_1	9	13	PF00917	0.680
DOC_WW_Pin1_4	14	19	PF00397	0.653
DOC_WW_Pin1_4	187	192	PF00397	0.350
DOC_WW_Pin1_4	256	261	PF00397	0.292
LIG_14-3-3_CanoR_1	185	191	PF00244	0.347
LIG_14-3-3_CanoR_1	19	25	PF00244	0.554
LIG_BRCT_BRCA1_1	324	328	PF00533	0.461
LIG_Clathr_ClatBox_1	341	345	PF01394	0.599
LIG_EVH1_1	226	230	PF00568	0.426
LIG_FHA_1	143	149	PF00498	0.302
LIG_FHA_1	187	193	PF00498	0.286
LIG_FHA_1	261	267	PF00498	0.325
LIG_FHA_1	301	307	PF00498	0.468
LIG_FHA_1	336	342	PF00498	0.447
LIG_FHA_2	232	238	PF00498	0.314
LIG_FHA_2	241	247	PF00498	0.249
LIG_FHA_2	48	54	PF00498	0.425
LIG_HCF-1_HBM_1	109	112	PF13415	0.383
LIG_LIR_Nem_3	325	331	PF02991	0.520
LIG_LIR_Nem_3	55	60	PF02991	0.386
LIG_MYND_1	211	215	PF01753	0.302
LIG_MYND_1	81	85	PF01753	0.327
LIG_Pex14_1	179	183	PF04695	0.313
LIG_Pex14_2	329	333	PF04695	0.441
LIG_SH2_CRK	48	52	PF00017	0.384
LIG_SH2_CRK	70	74	PF00017	0.380
LIG_SH2_CRK	75	79	PF00017	0.380
LIG_SH2_NCK_1	163	167	PF00017	0.286
LIG_SH2_SRC	163	166	PF00017	0.286
LIG_SH2_STAP1	112	116	PF00017	0.286
LIG_SH2_STAP1	163	167	PF00017	0.286
LIG_SH2_STAT5	126	129	PF00017	0.345
LIG_SH2_STAT5	142	145	PF00017	0.286
LIG_SH2_STAT5	183	186	PF00017	0.426
LIG_SH2_STAT5	24	27	PF00017	0.457
LIG_SH3_1	172	178	PF00018	0.286
LIG_SH3_2	15	20	PF14604	0.533
LIG_SH3_3	12	18	PF00018	0.677
LIG_SH3_3	138	144	PF00018	0.380
LIG_SH3_3	172	178	PF00018	0.305
LIG_SH3_3	224	230	PF00018	0.317
LIG_SH3_3	307	313	PF00018	0.420
LIG_SH3_3	321	327	PF00018	0.342
LIG_SH3_3	329	335	PF00018	0.337
LIG_SH3_3	79	85	PF00018	0.365
LIG_SUMO_SIM_par_1	196	203	PF11976	0.286
LIG_SUMO_SIM_par_1	338	345	PF11976	0.589
LIG_TYR_ITIM	161	166	PF00017	0.291
LIG_TYR_ITIM	73	78	PF00017	0.321
LIG_UBA3_1	197	206	PF00899	0.306
LIG_UBA3_1	341	347	PF00899	0.533
MOD_CDK_SPK_2	14	19	PF00069	0.647
MOD_CDK_SPxK_1	14	20	PF00069	0.633
MOD_CK2_1	231	237	PF00069	0.311
MOD_GlcNHglycan	324	327	PF01048	0.486
MOD_GSK3_1	144	151	PF00069	0.286
MOD_GSK3_1	256	263	PF00069	0.286
MOD_GSK3_1	275	282	PF00069	0.286
MOD_N-GLC_1	284	289	PF02516	0.286
MOD_NEK2_1	111	116	PF00069	0.286
MOD_NEK2_1	279	284	PF00069	0.302
MOD_NEK2_1	47	52	PF00069	0.409
MOD_PIKK_1	148	154	PF00454	0.286
MOD_PIKK_1	231	237	PF00454	0.426
MOD_PKA_2	322	328	PF00069	0.510
MOD_PKB_1	317	325	PF00069	0.430
MOD_Plk_1	284	290	PF00069	0.286
MOD_Plk_4	193	199	PF00069	0.286
MOD_Plk_4	20	26	PF00069	0.511
MOD_Plk_4	240	246	PF00069	0.286
MOD_Plk_4	275	281	PF00069	0.286
MOD_ProDKin_1	14	20	PF00069	0.651
MOD_ProDKin_1	187	193	PF00069	0.350
MOD_ProDKin_1	256	262	PF00069	0.292
MOD_SUMO_for_1	106	109	PF00179	0.286
MOD_SUMO_rev_2	339	348	PF00179	0.463
TRG_DiLeu_BaEn_2	55	61	PF01217	0.382
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.423
TRG_ENDOCYTIC_2	163	166	PF00928	0.291
TRG_ENDOCYTIC_2	48	51	PF00928	0.389
TRG_ENDOCYTIC_2	57	60	PF00928	0.452
TRG_ENDOCYTIC_2	70	73	PF00928	0.242
TRG_ENDOCYTIC_2	75	78	PF00928	0.176
TRG_ER_diArg_1	1	3	PF00400	0.610
TRG_ER_diArg_1	18	20	PF00400	0.717
TRG_ER_diArg_1	266	268	PF00400	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T2	Leptomonas seymouri	87%	99%
A0A0S4IYZ7	Bodo saltans	71%	100%
A0A1X0NL63	Trypanosomatidae	76%	94%
A0A3S5IRI3	Trypanosoma rangeli	77%	95%
A4H3V6	Leishmania braziliensis	95%	100%
A4HS32	Leishmania infantum	100%	100%
C9ZY24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	96%
E9AK19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q9XZX7	Leishmania major	98%	100%
V5B953	Trypanosoma cruzi	75%	94%