RNB domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial exoribonuclease DSS-1, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H597_LEIDO

TriTrypDb:

LdBPK_040320.1 , LdCL_040008700 , LDHU3_04.0390

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1

Expansion

Sequence features

A0A3S5H597

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H597

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	6
GO:0004532	RNA exonuclease activity	5	6
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	6
GO:0008859	exoribonuclease II activity	7	6
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	6
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	6
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000175	3'-5'-RNA exonuclease activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.554
CLV_C14_Caspase3-7	420	424	PF00656	0.518
CLV_C14_Caspase3-7	495	499	PF00656	0.537
CLV_C14_Caspase3-7	553	557	PF00656	0.511
CLV_C14_Caspase3-7	705	709	PF00656	0.589
CLV_C14_Caspase3-7	850	854	PF00656	0.696
CLV_NRD_NRD_1	241	243	PF00675	0.614
CLV_NRD_NRD_1	297	299	PF00675	0.362
CLV_NRD_NRD_1	30	32	PF00675	0.762
CLV_NRD_NRD_1	359	361	PF00675	0.280
CLV_NRD_NRD_1	571	573	PF00675	0.362
CLV_NRD_NRD_1	604	606	PF00675	0.276
CLV_NRD_NRD_1	623	625	PF00675	0.659
CLV_NRD_NRD_1	723	725	PF00675	0.591
CLV_NRD_NRD_1	760	762	PF00675	0.752
CLV_PCSK_FUR_1	239	243	PF00082	0.583
CLV_PCSK_KEX2_1	241	243	PF00082	0.600
CLV_PCSK_KEX2_1	297	299	PF00082	0.362
CLV_PCSK_KEX2_1	30	32	PF00082	0.762
CLV_PCSK_KEX2_1	359	361	PF00082	0.272
CLV_PCSK_KEX2_1	571	573	PF00082	0.362
CLV_PCSK_KEX2_1	604	606	PF00082	0.276
CLV_PCSK_KEX2_1	623	625	PF00082	0.659
CLV_PCSK_KEX2_1	723	725	PF00082	0.585
CLV_PCSK_KEX2_1	760	762	PF00082	0.694
CLV_PCSK_SKI1_1	185	189	PF00082	0.456
CLV_PCSK_SKI1_1	297	301	PF00082	0.276
CLV_PCSK_SKI1_1	359	363	PF00082	0.271
CLV_PCSK_SKI1_1	550	554	PF00082	0.256
DEG_APCC_DBOX_1	184	192	PF00400	0.506
DEG_Kelch_Keap1_1	339	344	PF01344	0.525
DEG_Nend_UBRbox_1	1	4	PF02207	0.661
DEG_SPOP_SBC_1	37	41	PF00917	0.671
DEG_SPOP_SBC_1	634	638	PF00917	0.735
DEG_SPOP_SBC_1	751	755	PF00917	0.729
DOC_ANK_TNKS_1	240	247	PF00023	0.546
DOC_CKS1_1	17	22	PF01111	0.747
DOC_CKS1_1	465	470	PF01111	0.525
DOC_CKS1_1	775	780	PF01111	0.660
DOC_CYCLIN_RxL_1	182	189	PF00134	0.507
DOC_CYCLIN_yClb5_NLxxxL_5	422	429	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	745	751	PF00134	0.622
DOC_MAPK_gen_1	327	336	PF00069	0.487
DOC_MAPK_gen_1	604	611	PF00069	0.476
DOC_MAPK_gen_1	712	718	PF00069	0.497
DOC_MAPK_JIP1_4	761	767	PF00069	0.726
DOC_PP2B_LxvP_1	745	748	PF13499	0.683
DOC_PP2B_LxvP_1	749	752	PF13499	0.660
DOC_PP2B_PxIxI_1	476	482	PF00149	0.476
DOC_PP4_FxxP_1	311	314	PF00568	0.476
DOC_PP4_FxxP_1	472	475	PF00568	0.537
DOC_SPAK_OSR1_1	680	684	PF12202	0.521
DOC_USP7_MATH_1	248	252	PF00917	0.498
DOC_USP7_MATH_1	286	290	PF00917	0.537
DOC_USP7_MATH_1	45	49	PF00917	0.801
DOC_USP7_MATH_1	532	536	PF00917	0.540
DOC_USP7_MATH_1	565	569	PF00917	0.526
DOC_USP7_MATH_1	635	639	PF00917	0.689
DOC_USP7_MATH_1	656	660	PF00917	0.544
DOC_USP7_MATH_1	735	739	PF00917	0.658
DOC_WW_Pin1_4	16	21	PF00397	0.732
DOC_WW_Pin1_4	396	401	PF00397	0.537
DOC_WW_Pin1_4	41	46	PF00397	0.757
DOC_WW_Pin1_4	464	469	PF00397	0.525
DOC_WW_Pin1_4	598	603	PF00397	0.476
DOC_WW_Pin1_4	774	779	PF00397	0.683
DOC_WW_Pin1_4	97	102	PF00397	0.577
LIG_14-3-3_CanoR_1	121	131	PF00244	0.511
LIG_14-3-3_CanoR_1	297	306	PF00244	0.480
LIG_14-3-3_CanoR_1	327	333	PF00244	0.501
LIG_14-3-3_CanoR_1	359	364	PF00244	0.476
LIG_14-3-3_CanoR_1	531	539	PF00244	0.524
LIG_14-3-3_CanoR_1	550	556	PF00244	0.493
LIG_14-3-3_CanoR_1	571	577	PF00244	0.482
LIG_14-3-3_CanoR_1	670	674	PF00244	0.538
LIG_14-3-3_CanoR_1	733	741	PF00244	0.641
LIG_14-3-3_CanoR_1	760	766	PF00244	0.709
LIG_Actin_WH2_1	80	97	PF00022	0.574
LIG_Actin_WH2_2	81	97	PF00022	0.546
LIG_BIR_III_4	259	263	PF00653	0.476
LIG_BRCT_BRCA1_1	557	561	PF00533	0.562
LIG_BRCT_BRCA1_1	677	681	PF00533	0.512
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.500
LIG_deltaCOP1_diTrp_1	841	848	PF00928	0.609
LIG_EVH1_2	468	472	PF00568	0.581
LIG_FHA_1	106	112	PF00498	0.638
LIG_FHA_1	12	18	PF00498	0.742
LIG_FHA_1	124	130	PF00498	0.396
LIG_FHA_1	19	25	PF00498	0.636
LIG_FHA_1	218	224	PF00498	0.487
LIG_FHA_1	252	258	PF00498	0.476
LIG_FHA_1	300	306	PF00498	0.496
LIG_FHA_1	329	335	PF00498	0.476
LIG_FHA_1	340	346	PF00498	0.476
LIG_FHA_1	383	389	PF00498	0.544
LIG_FHA_1	465	471	PF00498	0.553
LIG_FHA_1	482	488	PF00498	0.436
LIG_FHA_1	528	534	PF00498	0.476
LIG_FHA_1	575	581	PF00498	0.476
LIG_FHA_1	598	604	PF00498	0.476
LIG_FHA_1	720	726	PF00498	0.447
LIG_FHA_1	818	824	PF00498	0.461
LIG_FHA_2	157	163	PF00498	0.540
LIG_FHA_2	184	190	PF00498	0.455
LIG_FHA_2	251	257	PF00498	0.498
LIG_FHA_2	320	326	PF00498	0.486
LIG_FHA_2	416	422	PF00498	0.487
LIG_FHA_2	542	548	PF00498	0.571
LIG_FHA_2	551	557	PF00498	0.579
LIG_FHA_2	70	76	PF00498	0.619
LIG_LIR_Apic_2	124	130	PF02991	0.495
LIG_LIR_Apic_2	471	475	PF02991	0.539
LIG_LIR_Gen_1	233	243	PF02991	0.469
LIG_LIR_Gen_1	331	338	PF02991	0.562
LIG_LIR_Gen_1	362	370	PF02991	0.476
LIG_LIR_Gen_1	70	77	PF02991	0.579
LIG_LIR_Gen_1	714	719	PF02991	0.500
LIG_LIR_Gen_1	777	788	PF02991	0.496
LIG_LIR_Gen_1	837	848	PF02991	0.538
LIG_LIR_Nem_3	233	238	PF02991	0.433
LIG_LIR_Nem_3	282	287	PF02991	0.521
LIG_LIR_Nem_3	307	313	PF02991	0.469
LIG_LIR_Nem_3	331	335	PF02991	0.562
LIG_LIR_Nem_3	362	366	PF02991	0.476
LIG_LIR_Nem_3	423	429	PF02991	0.550
LIG_LIR_Nem_3	678	684	PF02991	0.376
LIG_LIR_Nem_3	70	76	PF02991	0.581
LIG_LIR_Nem_3	714	718	PF02991	0.487
LIG_LIR_Nem_3	777	783	PF02991	0.490
LIG_LIR_Nem_3	837	843	PF02991	0.521
LIG_NRBOX	83	89	PF00104	0.433
LIG_PCNA_yPIPBox_3	80	88	PF02747	0.529
LIG_PDZ_Class_2	849	854	PF00595	0.692
LIG_Pex14_1	682	686	PF04695	0.432
LIG_Pex14_1	78	82	PF04695	0.434
LIG_Pex14_1	844	848	PF04695	0.615
LIG_Pex14_2	332	336	PF04695	0.476
LIG_SH2_CRK	363	367	PF00017	0.537
LIG_SH2_CRK	91	95	PF00017	0.549
LIG_SH2_NCK_1	363	367	PF00017	0.459
LIG_SH2_NCK_1	543	547	PF00017	0.517
LIG_SH2_PTP2	193	196	PF00017	0.465
LIG_SH2_SRC	193	196	PF00017	0.465
LIG_SH2_SRC	73	76	PF00017	0.479
LIG_SH2_SRC	96	99	PF00017	0.671
LIG_SH2_STAP1	348	352	PF00017	0.517
LIG_SH2_STAP1	606	610	PF00017	0.459
LIG_SH2_STAP1	731	735	PF00017	0.585
LIG_SH2_STAP1	840	844	PF00017	0.603
LIG_SH2_STAT3	211	214	PF00017	0.544
LIG_SH2_STAT5	193	196	PF00017	0.443
LIG_SH2_STAT5	273	276	PF00017	0.473
LIG_SH2_STAT5	277	280	PF00017	0.465
LIG_SH2_STAT5	284	287	PF00017	0.464
LIG_SH2_STAT5	304	307	PF00017	0.471
LIG_SH2_STAT5	427	430	PF00017	0.554
LIG_SH2_STAT5	543	546	PF00017	0.507
LIG_SH2_STAT5	596	599	PF00017	0.501
LIG_SH2_STAT5	686	689	PF00017	0.434
LIG_SH2_STAT5	715	718	PF00017	0.502
LIG_SH2_STAT5	73	76	PF00017	0.420
LIG_SH2_STAT5	782	785	PF00017	0.423
LIG_SH2_STAT5	787	790	PF00017	0.432
LIG_SH3_1	95	101	PF00018	0.596
LIG_SH3_3	127	133	PF00018	0.513
LIG_SH3_3	14	20	PF00018	0.723
LIG_SH3_3	169	175	PF00018	0.502
LIG_SH3_3	280	286	PF00018	0.476
LIG_SH3_3	462	468	PF00018	0.575
LIG_SH3_3	642	648	PF00018	0.623
LIG_SH3_3	723	729	PF00018	0.594
LIG_SH3_3	756	762	PF00018	0.750
LIG_SH3_3	783	789	PF00018	0.545
LIG_SH3_3	95	101	PF00018	0.614
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.494
LIG_SUMO_SIM_par_1	484	491	PF11976	0.477
LIG_TRAF2_1	666	669	PF00917	0.464
LIG_TYR_ITIM	361	366	PF00017	0.328
MOD_CDC14_SPxK_1	44	47	PF00782	0.740
MOD_CDC14_SPxK_1	601	604	PF00782	0.328
MOD_CDK_SPxK_1	41	47	PF00069	0.749
MOD_CDK_SPxK_1	598	604	PF00069	0.328
MOD_CDK_SPxxK_3	598	605	PF00069	0.328
MOD_CK1_1	251	257	PF00069	0.328
MOD_CK1_1	279	285	PF00069	0.328
MOD_CK1_1	35	41	PF00069	0.748
MOD_CK1_1	49	55	PF00069	0.796
MOD_CK1_1	574	580	PF00069	0.344
MOD_CK1_1	629	635	PF00069	0.633
MOD_CK1_1	753	759	PF00069	0.705
MOD_CK1_1	99	105	PF00069	0.667
MOD_CK2_1	156	162	PF00069	0.541
MOD_CK2_1	183	189	PF00069	0.489
MOD_CK2_1	250	256	PF00069	0.328
MOD_CK2_1	286	292	PF00069	0.363
MOD_CK2_1	319	325	PF00069	0.344
MOD_CK2_1	338	344	PF00069	0.344
MOD_CK2_1	541	547	PF00069	0.376
MOD_CK2_1	734	740	PF00069	0.637
MOD_GlcNHglycan	113	116	PF01048	0.525
MOD_GlcNHglycan	250	253	PF01048	0.325
MOD_GlcNHglycan	408	411	PF01048	0.404
MOD_GlcNHglycan	632	635	PF01048	0.673
MOD_GlcNHglycan	637	640	PF01048	0.690
MOD_GlcNHglycan	664	667	PF01048	0.428
MOD_GlcNHglycan	69	72	PF01048	0.542
MOD_GlcNHglycan	693	696	PF01048	0.586
MOD_GlcNHglycan	737	740	PF01048	0.629
MOD_GSK3_1	248	255	PF00069	0.325
MOD_GSK3_1	32	39	PF00069	0.782
MOD_GSK3_1	41	48	PF00069	0.781
MOD_GSK3_1	481	488	PF00069	0.374
MOD_GSK3_1	49	56	PF00069	0.674
MOD_GSK3_1	527	534	PF00069	0.315
MOD_GSK3_1	551	558	PF00069	0.393
MOD_GSK3_1	590	597	PF00069	0.330
MOD_GSK3_1	625	632	PF00069	0.648
MOD_GSK3_1	735	742	PF00069	0.668
MOD_GSK3_1	743	750	PF00069	0.646
MOD_GSK3_1	751	758	PF00069	0.546
MOD_GSK3_1	774	781	PF00069	0.650
MOD_GSK3_1	96	103	PF00069	0.540
MOD_LATS_1	392	398	PF00433	0.262
MOD_N-GLC_1	346	351	PF02516	0.357
MOD_N-GLC_1	676	681	PF02516	0.430
MOD_NEK2_1	111	116	PF00069	0.555
MOD_NEK2_1	122	127	PF00069	0.495
MOD_NEK2_1	156	161	PF00069	0.532
MOD_NEK2_1	299	304	PF00069	0.331
MOD_NEK2_1	527	532	PF00069	0.449
MOD_NEK2_1	555	560	PF00069	0.417
MOD_NEK2_1	566	571	PF00069	0.337
MOD_NEK2_1	591	596	PF00069	0.425
MOD_NEK2_1	69	74	PF00069	0.491
MOD_NEK2_1	734	739	PF00069	0.598
MOD_NEK2_1	793	798	PF00069	0.522
MOD_PIKK_1	116	122	PF00454	0.572
MOD_PIKK_1	493	499	PF00454	0.449
MOD_PIKK_1	739	745	PF00454	0.615
MOD_PIKK_1	817	823	PF00454	0.407
MOD_PIKK_1	847	853	PF00454	0.673
MOD_PK_1	346	352	PF00069	0.344
MOD_PKA_1	297	303	PF00069	0.449
MOD_PKA_1	359	365	PF00069	0.328
MOD_PKA_1	571	577	PF00069	0.449
MOD_PKA_2	11	17	PF00069	0.664
MOD_PKA_2	297	303	PF00069	0.428
MOD_PKA_2	359	365	PF00069	0.328
MOD_PKA_2	527	533	PF00069	0.317
MOD_PKA_2	571	577	PF00069	0.425
MOD_PKA_2	669	675	PF00069	0.543
MOD_PKA_2	691	697	PF00069	0.602
MOD_Plk_1	279	285	PF00069	0.324
MOD_Plk_1	287	293	PF00069	0.313
MOD_Plk_1	346	352	PF00069	0.339
MOD_Plk_1	382	388	PF00069	0.419
MOD_Plk_1	470	476	PF00069	0.427
MOD_Plk_1	555	561	PF00069	0.435
MOD_Plk_1	591	597	PF00069	0.449
MOD_Plk_1	676	682	PF00069	0.447
MOD_Plk_1	739	745	PF00069	0.615
MOD_Plk_1	778	784	PF00069	0.570
MOD_Plk_2-3	319	325	PF00069	0.363
MOD_Plk_2-3	485	491	PF00069	0.339
MOD_Plk_4	279	285	PF00069	0.335
MOD_Plk_4	300	306	PF00069	0.322
MOD_Plk_4	591	597	PF00069	0.449
MOD_Plk_4	614	620	PF00069	0.444
MOD_Plk_4	669	675	PF00069	0.459
MOD_Plk_4	69	75	PF00069	0.476
MOD_Plk_4	711	717	PF00069	0.523
MOD_Plk_4	83	89	PF00069	0.450
MOD_ProDKin_1	16	22	PF00069	0.733
MOD_ProDKin_1	396	402	PF00069	0.414
MOD_ProDKin_1	41	47	PF00069	0.761
MOD_ProDKin_1	464	470	PF00069	0.398
MOD_ProDKin_1	598	604	PF00069	0.328
MOD_ProDKin_1	774	780	PF00069	0.673
MOD_ProDKin_1	97	103	PF00069	0.579
MOD_SUMO_for_1	666	669	PF00179	0.526
MOD_SUMO_rev_2	476	484	PF00179	0.398
TRG_AP2beta_CARGO_1	423	433	PF09066	0.398
TRG_DiLeu_BaEn_1	118	123	PF01217	0.586
TRG_DiLeu_BaEn_1	669	674	PF01217	0.481
TRG_DiLeu_BaEn_1	740	745	PF01217	0.661
TRG_DiLeu_BaEn_2	306	312	PF01217	0.328
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.393
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.475
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.353
TRG_DiLeu_LyEn_5	118	123	PF01217	0.586
TRG_ENDOCYTIC_2	273	276	PF00928	0.354
TRG_ENDOCYTIC_2	284	287	PF00928	0.325
TRG_ENDOCYTIC_2	363	366	PF00928	0.328
TRG_ENDOCYTIC_2	581	584	PF00928	0.475
TRG_ENDOCYTIC_2	606	609	PF00928	0.328
TRG_ENDOCYTIC_2	715	718	PF00928	0.455
TRG_ENDOCYTIC_2	73	76	PF00928	0.549
TRG_ENDOCYTIC_2	731	734	PF00928	0.490
TRG_ENDOCYTIC_2	840	843	PF00928	0.599
TRG_ENDOCYTIC_2	91	94	PF00928	0.465
TRG_ER_diArg_1	226	229	PF00400	0.526
TRG_ER_diArg_1	297	299	PF00400	0.449
TRG_ER_diArg_1	358	360	PF00400	0.327
TRG_ER_diArg_1	433	436	PF00400	0.335
TRG_ER_diArg_1	437	440	PF00400	0.335
TRG_ER_diArg_1	570	572	PF00400	0.449
TRG_ER_diArg_1	603	605	PF00400	0.328
TRG_ER_diArg_1	723	725	PF00400	0.564
TRG_ER_diArg_1	759	761	PF00400	0.761
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	531	536	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	685	689	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA76	Leptomonas seymouri	68%	100%
A0A0S4J212	Bodo saltans	42%	100%
A0A1X0NLV5	Trypanosomatidae	53%	100%
A0A422NN62	Trypanosoma rangeli	52%	100%
A4H3V2	Leishmania braziliensis	82%	98%
A4HS28	Leishmania infantum	100%	100%
C9ZY19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AK15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q86MA2	Trypanosoma brucei brucei	52%	100%
Q9XZX1	Leishmania major	95%	100%
V5B958	Trypanosoma cruzi	53%	100%