LeishMANIAdb
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Beta-fructofuranosidase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Beta-fructofuranosidase, putative
Gene product:
beta-fructofuranosidase, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H596_LEIDO
TriTrypDb:
LdBPK_040300.1 , LdCL_040008600 , LDHU3_04.0380
Length:
440

Annotations

LeishMANIAdb annotations

An expanded and variable family of glycosidases. Some Leishmaniid members even incorporate an extra N-terminal fructofuronidase domain after the signal peptide.. Seems to be evolving rapidly for unclear reasons

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. no yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 7
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S5H596
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H596

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 19
GO:0008152 metabolic process 1 19
GO:0044238 primary metabolic process 2 19
GO:0071704 organic substance metabolic process 2 19
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 19
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 19
GO:0004564 beta-fructofuranosidase activity 5 9
GO:0016787 hydrolase activity 2 19
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 319 323 PF00656 0.219
CLV_NRD_NRD_1 13 15 PF00675 0.470
CLV_NRD_NRD_1 162 164 PF00675 0.437
CLV_NRD_NRD_1 35 37 PF00675 0.599
CLV_PCSK_KEX2_1 13 15 PF00082 0.685
CLV_PCSK_KEX2_1 162 164 PF00082 0.385
CLV_PCSK_KEX2_1 35 37 PF00082 0.374
CLV_PCSK_SKI1_1 139 143 PF00082 0.414
CLV_PCSK_SKI1_1 200 204 PF00082 0.367
DEG_APCC_DBOX_1 366 374 PF00400 0.434
DEG_COP1_1 262 273 PF00400 0.351
DOC_MAPK_gen_1 211 221 PF00069 0.499
DOC_MAPK_gen_1 35 44 PF00069 0.428
DOC_PP1_RVXF_1 345 351 PF00149 0.424
DOC_PP4_FxxP_1 155 158 PF00568 0.437
DOC_PP4_FxxP_1 89 92 PF00568 0.420
DOC_USP7_MATH_1 137 141 PF00917 0.407
DOC_USP7_MATH_1 25 29 PF00917 0.648
DOC_USP7_MATH_1 300 304 PF00917 0.427
DOC_USP7_MATH_1 317 321 PF00917 0.392
DOC_USP7_MATH_1 354 358 PF00917 0.293
DOC_USP7_UBL2_3 347 351 PF12436 0.452
DOC_WW_Pin1_4 16 21 PF00397 0.491
DOC_WW_Pin1_4 226 231 PF00397 0.540
DOC_WW_Pin1_4 394 399 PF00397 0.435
LIG_14-3-3_CanoR_1 139 144 PF00244 0.344
LIG_14-3-3_CanoR_1 249 253 PF00244 0.432
LIG_14-3-3_CanoR_1 302 310 PF00244 0.331
LIG_Actin_WH2_2 286 304 PF00022 0.219
LIG_Actin_WH2_2 90 108 PF00022 0.304
LIG_APCC_ABBA_1 403 408 PF00400 0.301
LIG_APCC_ABBA_1 412 417 PF00400 0.301
LIG_APCC_ABBAyCdc20_2 129 135 PF00400 0.219
LIG_BRCT_BRCA1_1 139 143 PF00533 0.374
LIG_BRCT_BRCA1_1 151 155 PF00533 0.336
LIG_BRCT_BRCA1_1 335 339 PF00533 0.457
LIG_deltaCOP1_diTrp_1 38 44 PF00928 0.173
LIG_FHA_1 202 208 PF00498 0.348
LIG_FHA_1 229 235 PF00498 0.483
LIG_FHA_1 260 266 PF00498 0.252
LIG_FHA_1 286 292 PF00498 0.433
LIG_FHA_1 343 349 PF00498 0.374
LIG_FHA_1 382 388 PF00498 0.422
LIG_FHA_1 422 428 PF00498 0.326
LIG_FHA_1 433 439 PF00498 0.326
LIG_FHA_2 140 146 PF00498 0.312
LIG_FHA_2 152 158 PF00498 0.280
LIG_FHA_2 167 173 PF00498 0.407
LIG_FHA_2 227 233 PF00498 0.490
LIG_FHA_2 249 255 PF00498 0.404
LIG_FHA_2 363 369 PF00498 0.427
LIG_LIR_Apic_2 152 158 PF02991 0.436
LIG_LIR_Apic_2 86 92 PF02991 0.397
LIG_LIR_Gen_1 102 111 PF02991 0.348
LIG_LIR_Gen_1 128 138 PF02991 0.436
LIG_LIR_Gen_1 140 149 PF02991 0.438
LIG_LIR_Gen_1 241 250 PF02991 0.435
LIG_LIR_Gen_1 284 294 PF02991 0.286
LIG_LIR_Nem_3 102 107 PF02991 0.317
LIG_LIR_Nem_3 115 119 PF02991 0.259
LIG_LIR_Nem_3 128 134 PF02991 0.301
LIG_LIR_Nem_3 140 146 PF02991 0.240
LIG_LIR_Nem_3 154 159 PF02991 0.279
LIG_LIR_Nem_3 241 246 PF02991 0.527
LIG_LIR_Nem_3 284 289 PF02991 0.334
LIG_LIR_Nem_3 307 313 PF02991 0.393
LIG_LIR_Nem_3 93 97 PF02991 0.306
LIG_LYPXL_yS_3 310 313 PF13949 0.432
LIG_PCNA_yPIPBox_3 187 201 PF02747 0.432
LIG_PDZ_Class_2 435 440 PF00595 0.156
LIG_Pex14_1 40 44 PF04695 0.293
LIG_REV1ctd_RIR_1 92 102 PF16727 0.322
LIG_SH2_CRK 156 160 PF00017 0.313
LIG_SH2_CRK 286 290 PF00017 0.405
LIG_SH2_NCK_1 286 290 PF00017 0.405
LIG_SH2_PTP2 131 134 PF00017 0.436
LIG_SH2_SRC 156 159 PF00017 0.329
LIG_SH2_STAT5 104 107 PF00017 0.301
LIG_SH2_STAT5 116 119 PF00017 0.284
LIG_SH2_STAT5 131 134 PF00017 0.239
LIG_SH2_STAT5 264 267 PF00017 0.283
LIG_SH2_STAT5 286 289 PF00017 0.301
LIG_SH2_STAT5 337 340 PF00017 0.394
LIG_SH2_STAT5 372 375 PF00017 0.434
LIG_SH2_STAT5 428 431 PF00017 0.301
LIG_SH2_STAT5 79 82 PF00017 0.432
LIG_SH3_1 14 20 PF00018 0.469
LIG_SH3_3 1 7 PF00018 0.484
LIG_SH3_3 131 137 PF00018 0.435
LIG_SH3_3 21 27 PF00018 0.756
LIG_SH3_3 288 294 PF00018 0.307
LIG_SH3_3 363 369 PF00018 0.310
LIG_SH3_3 9 15 PF00018 0.488
LIG_SUMO_SIM_par_1 216 223 PF11976 0.361
LIG_TYR_ITSM 152 159 PF00017 0.453
LIG_TYR_ITSM 239 246 PF00017 0.548
LIG_WW_3 10 14 PF00397 0.486
MOD_CK1_1 18 24 PF00069 0.466
MOD_CK1_1 284 290 PF00069 0.369
MOD_CK1_1 67 73 PF00069 0.440
MOD_CK2_1 166 172 PF00069 0.437
MOD_CK2_1 226 232 PF00069 0.447
MOD_CK2_1 362 368 PF00069 0.465
MOD_CK2_1 407 413 PF00069 0.405
MOD_GlcNHglycan 183 186 PF01048 0.304
MOD_GlcNHglycan 319 322 PF01048 0.419
MOD_GlcNHglycan 324 327 PF01048 0.404
MOD_GlcNHglycan 362 365 PF01048 0.338
MOD_GlcNHglycan 377 380 PF01048 0.250
MOD_GlcNHglycan 69 72 PF01048 0.379
MOD_GSK3_1 105 112 PF00069 0.304
MOD_GSK3_1 224 231 PF00069 0.526
MOD_GSK3_1 259 266 PF00069 0.431
MOD_GSK3_1 281 288 PF00069 0.286
MOD_GSK3_1 300 307 PF00069 0.389
MOD_GSK3_1 373 380 PF00069 0.337
MOD_GSK3_1 60 67 PF00069 0.368
MOD_GSK3_1 70 77 PF00069 0.373
MOD_N-GLC_1 124 129 PF02516 0.321
MOD_N-GLC_1 238 243 PF02516 0.525
MOD_N-GLC_1 281 286 PF02516 0.423
MOD_N-GLC_1 322 327 PF02516 0.362
MOD_N-GLC_2 344 346 PF02516 0.357
MOD_NEK2_1 105 110 PF00069 0.304
MOD_NEK2_1 124 129 PF00069 0.304
MOD_NEK2_1 149 154 PF00069 0.372
MOD_NEK2_1 189 194 PF00069 0.445
MOD_NEK2_1 316 321 PF00069 0.418
MOD_NEK2_1 333 338 PF00069 0.291
MOD_NEK2_1 373 378 PF00069 0.317
MOD_NEK2_1 74 79 PF00069 0.300
MOD_NEK2_2 151 156 PF00069 0.437
MOD_PIKK_1 201 207 PF00454 0.444
MOD_PIKK_1 281 287 PF00454 0.429
MOD_PIKK_1 373 379 PF00454 0.385
MOD_PKA_2 161 167 PF00069 0.418
MOD_PKA_2 248 254 PF00069 0.432
MOD_PKA_2 301 307 PF00069 0.436
MOD_Plk_1 238 244 PF00069 0.538
MOD_Plk_1 281 287 PF00069 0.435
MOD_Plk_1 407 413 PF00069 0.301
MOD_Plk_4 151 157 PF00069 0.408
MOD_Plk_4 238 244 PF00069 0.570
MOD_Plk_4 260 266 PF00069 0.411
MOD_Plk_4 335 341 PF00069 0.431
MOD_Plk_4 407 413 PF00069 0.313
MOD_Plk_4 74 80 PF00069 0.368
MOD_ProDKin_1 16 22 PF00069 0.492
MOD_ProDKin_1 226 232 PF00069 0.540
MOD_ProDKin_1 394 400 PF00069 0.435
MOD_SUMO_for_1 415 418 PF00179 0.421
MOD_SUMO_rev_2 196 202 PF00179 0.412
TRG_DiLeu_BaEn_2 401 407 PF01217 0.421
TRG_DiLeu_BaLyEn_6 366 371 PF01217 0.435
TRG_ENDOCYTIC_2 104 107 PF00928 0.338
TRG_ENDOCYTIC_2 131 134 PF00928 0.420
TRG_ENDOCYTIC_2 146 149 PF00928 0.247
TRG_ENDOCYTIC_2 156 159 PF00928 0.256
TRG_ENDOCYTIC_2 243 246 PF00928 0.393
TRG_ENDOCYTIC_2 286 289 PF00928 0.301
TRG_ENDOCYTIC_2 310 313 PF00928 0.412
TRG_ER_diArg_1 12 14 PF00400 0.471
TRG_NES_CRM1_1 418 430 PF08389 0.421
TRG_Pf-PMV_PEXEL_1 211 216 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBT6 Leptomonas seymouri 72% 68%
A0A0S4J9J2 Bodo saltans 32% 97%
A0A1X0NFY9 Trypanosomatidae 36% 92%
A0A1X0NTL0 Trypanosomatidae 36% 70%
A0A1X0NTM3 Trypanosomatidae 38% 70%
A0A1X0NY19 Trypanosomatidae 39% 70%
A0A1X0NYR4 Trypanosomatidae 36% 80%
A0A1X0P322 Trypanosomatidae 36% 70%
A0A1X0P5Y7 Trypanosomatidae 38% 68%
A0A3S5H595 Leishmania donovani 100% 68%
A4H3V1 Leishmania braziliensis 80% 69%
A4HS26 Leishmania infantum 99% 68%
A4HS27 Leishmania infantum 100% 100%
E9AK13 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 69%
E9AK14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q8W4S6 Arabidopsis thaliana 25% 80%
Q9XTP3 Leishmania major 93% 69%
Q9XZX0 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS