LeishMANIAdb
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Beta-fructofuranosidase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Beta-fructofuranosidase, putative
Gene product:
beta-fructofuranosidase, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H595_LEIDO
TriTrypDb:
LdBPK_040300.1 * , LdCL_040008500 , LDHU3_04.0370
Length:
643

Annotations

LeishMANIAdb annotations

An expanded and variable family of glycosidases. Some Leishmaniid members even incorporate an extra N-terminal fructofuronidase domain after the signal peptide.. Seems to be evolving rapidly for unclear reasons

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. no yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 6
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S5H595
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H595

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 18
GO:0008152 metabolic process 1 18
GO:0044238 primary metabolic process 2 18
GO:0071704 organic substance metabolic process 2 18
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 18
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 18
GO:0004564 beta-fructofuranosidase activity 5 10
GO:0016787 hydrolase activity 2 18
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 476 480 PF00656 0.229
CLV_NRD_NRD_1 319 321 PF00675 0.444
CLV_NRD_NRD_1 7 9 PF00675 0.587
CLV_PCSK_KEX2_1 152 154 PF00082 0.338
CLV_PCSK_KEX2_1 319 321 PF00082 0.391
CLV_PCSK_KEX2_1 7 9 PF00082 0.608
CLV_PCSK_PC1ET2_1 152 154 PF00082 0.320
CLV_PCSK_SKI1_1 160 164 PF00082 0.251
CLV_PCSK_SKI1_1 296 300 PF00082 0.420
CLV_PCSK_SKI1_1 357 361 PF00082 0.373
CLV_PCSK_SKI1_1 627 631 PF00082 0.624
DEG_APCC_DBOX_1 523 531 PF00400 0.440
DEG_COP1_1 419 430 PF00400 0.357
DEG_Nend_Nbox_1 1 3 PF02207 0.574
DOC_CYCLIN_yClb3_PxF_3 33 41 PF00134 0.246
DOC_MAPK_gen_1 368 378 PF00069 0.474
DOC_MAPK_gen_1 7 15 PF00069 0.602
DOC_MAPK_gen_1 90 100 PF00069 0.406
DOC_MAPK_HePTP_8 597 609 PF00069 0.393
DOC_MAPK_MEF2A_6 160 167 PF00069 0.273
DOC_MAPK_MEF2A_6 600 609 PF00069 0.393
DOC_MAPK_MEF2A_6 7 15 PF00069 0.622
DOC_MAPK_NFAT4_5 8 16 PF00069 0.600
DOC_PP1_RVXF_1 502 508 PF00149 0.415
DOC_PP4_FxxP_1 181 184 PF00568 0.291
DOC_PP4_FxxP_1 246 249 PF00568 0.442
DOC_PP4_FxxP_1 312 315 PF00568 0.444
DOC_USP7_MATH_1 294 298 PF00917 0.413
DOC_USP7_MATH_1 457 461 PF00917 0.478
DOC_USP7_MATH_1 474 478 PF00917 0.398
DOC_USP7_MATH_1 511 515 PF00917 0.305
DOC_USP7_UBL2_3 104 108 PF12436 0.363
DOC_USP7_UBL2_3 504 508 PF12436 0.430
DOC_WW_Pin1_4 383 388 PF00397 0.544
DOC_WW_Pin1_4 551 556 PF00397 0.442
DOC_WW_Pin1_4 619 624 PF00397 0.623
DOC_WW_Pin1_4 93 98 PF00397 0.430
LIG_14-3-3_CanoR_1 296 301 PF00244 0.350
LIG_14-3-3_CanoR_1 406 410 PF00244 0.437
LIG_14-3-3_CanoR_1 459 467 PF00244 0.310
LIG_Actin_WH2_2 247 265 PF00022 0.310
LIG_Actin_WH2_2 443 461 PF00022 0.229
LIG_APCC_ABBA_1 560 565 PF00400 0.319
LIG_APCC_ABBA_1 569 574 PF00400 0.319
LIG_APCC_ABBAyCdc20_2 286 292 PF00400 0.229
LIG_BRCT_BRCA1_1 296 300 PF00533 0.389
LIG_BRCT_BRCA1_1 308 312 PF00533 0.389
LIG_BRCT_BRCA1_1 492 496 PF00533 0.437
LIG_deltaCOP1_diTrp_1 103 109 PF00928 0.430
LIG_FHA_1 359 365 PF00498 0.373
LIG_FHA_1 386 392 PF00498 0.489
LIG_FHA_1 417 423 PF00498 0.267
LIG_FHA_1 443 449 PF00498 0.441
LIG_FHA_1 500 506 PF00498 0.380
LIG_FHA_1 539 545 PF00498 0.427
LIG_FHA_1 57 63 PF00498 0.398
LIG_FHA_1 579 585 PF00498 0.332
LIG_FHA_1 590 596 PF00498 0.332
LIG_FHA_1 604 610 PF00498 0.404
LIG_FHA_1 628 634 PF00498 0.606
LIG_FHA_2 127 133 PF00498 0.395
LIG_FHA_2 297 303 PF00498 0.323
LIG_FHA_2 309 315 PF00498 0.310
LIG_FHA_2 324 330 PF00498 0.444
LIG_FHA_2 384 390 PF00498 0.483
LIG_FHA_2 406 412 PF00498 0.410
LIG_FHA_2 520 526 PF00498 0.423
LIG_FHA_2 82 88 PF00498 0.279
LIG_FHA_2 90 96 PF00498 0.279
LIG_LIR_Apic_2 179 184 PF02991 0.308
LIG_LIR_Apic_2 185 191 PF02991 0.253
LIG_LIR_Apic_2 243 249 PF02991 0.438
LIG_LIR_Apic_2 309 315 PF02991 0.443
LIG_LIR_Apic_2 615 621 PF02991 0.542
LIG_LIR_Gen_1 259 268 PF02991 0.351
LIG_LIR_Gen_1 285 295 PF02991 0.443
LIG_LIR_Gen_1 297 306 PF02991 0.445
LIG_LIR_Gen_1 398 407 PF02991 0.496
LIG_LIR_Gen_1 441 451 PF02991 0.303
LIG_LIR_Gen_1 631 642 PF02991 0.468
LIG_LIR_Nem_3 107 112 PF02991 0.364
LIG_LIR_Nem_3 250 254 PF02991 0.325
LIG_LIR_Nem_3 259 264 PF02991 0.324
LIG_LIR_Nem_3 272 276 PF02991 0.331
LIG_LIR_Nem_3 285 291 PF02991 0.307
LIG_LIR_Nem_3 297 303 PF02991 0.247
LIG_LIR_Nem_3 311 316 PF02991 0.286
LIG_LIR_Nem_3 398 403 PF02991 0.498
LIG_LIR_Nem_3 441 446 PF02991 0.360
LIG_LIR_Nem_3 464 470 PF02991 0.425
LIG_LIR_Nem_3 631 637 PF02991 0.485
LIG_LIR_Nem_3 77 83 PF02991 0.305
LIG_LYPXL_yS_3 467 470 PF13949 0.437
LIG_NRBOX 632 638 PF00104 0.587
LIG_PCNA_yPIPBox_3 344 358 PF02747 0.437
LIG_PDZ_Class_2 638 643 PF00595 0.554
LIG_Pex14_1 197 201 PF04695 0.302
LIG_PTB_Apo_2 115 122 PF02174 0.360
LIG_PTB_Phospho_1 115 121 PF10480 0.360
LIG_REV1ctd_RIR_1 249 259 PF16727 0.328
LIG_SH2_CRK 313 317 PF00017 0.319
LIG_SH2_CRK 443 447 PF00017 0.442
LIG_SH2_NCK_1 34 38 PF00017 0.482
LIG_SH2_NCK_1 443 447 PF00017 0.442
LIG_SH2_PTP2 288 291 PF00017 0.442
LIG_SH2_SRC 313 316 PF00017 0.335
LIG_SH2_SRC 34 37 PF00017 0.486
LIG_SH2_STAP1 598 602 PF00017 0.437
LIG_SH2_STAT5 128 131 PF00017 0.279
LIG_SH2_STAT5 236 239 PF00017 0.423
LIG_SH2_STAT5 261 264 PF00017 0.309
LIG_SH2_STAT5 273 276 PF00017 0.305
LIG_SH2_STAT5 288 291 PF00017 0.251
LIG_SH2_STAT5 421 424 PF00017 0.284
LIG_SH2_STAT5 443 446 PF00017 0.319
LIG_SH2_STAT5 494 497 PF00017 0.424
LIG_SH2_STAT5 529 532 PF00017 0.440
LIG_SH2_STAT5 585 588 PF00017 0.319
LIG_SH2_STAT5 612 615 PF00017 0.499
LIG_SH2_STAT5 88 91 PF00017 0.291
LIG_SH3_2 191 196 PF14604 0.426
LIG_SH3_2 50 55 PF14604 0.304
LIG_SH3_3 188 194 PF00018 0.432
LIG_SH3_3 288 294 PF00018 0.441
LIG_SH3_3 30 36 PF00018 0.441
LIG_SH3_3 445 451 PF00018 0.312
LIG_SH3_3 47 53 PF00018 0.237
LIG_SH3_3 520 526 PF00018 0.326
LIG_SH3_3 67 73 PF00018 0.131
LIG_SH3_3 91 97 PF00018 0.430
LIG_SUMO_SIM_par_1 122 129 PF11976 0.414
LIG_SUMO_SIM_par_1 373 380 PF11976 0.345
LIG_SUMO_SIM_par_1 605 610 PF11976 0.460
LIG_TYR_ITIM 32 37 PF00017 0.514
LIG_TYR_ITSM 309 316 PF00017 0.459
LIG_TYR_ITSM 396 403 PF00017 0.528
LIG_UBA3_1 37 44 PF00899 0.185
MOD_CK1_1 224 230 PF00069 0.424
MOD_CK1_1 441 447 PF00069 0.403
MOD_CK2_1 126 132 PF00069 0.395
MOD_CK2_1 323 329 PF00069 0.444
MOD_CK2_1 383 389 PF00069 0.471
MOD_CK2_1 519 525 PF00069 0.470
MOD_CK2_1 564 570 PF00069 0.442
MOD_CK2_1 89 95 PF00069 0.428
MOD_Cter_Amidation 150 153 PF01082 0.320
MOD_DYRK1A_RPxSP_1 93 97 PF00069 0.428
MOD_GlcNHglycan 112 115 PF01048 0.304
MOD_GlcNHglycan 160 163 PF01048 0.374
MOD_GlcNHglycan 226 229 PF01048 0.408
MOD_GlcNHglycan 340 343 PF01048 0.310
MOD_GlcNHglycan 476 479 PF01048 0.445
MOD_GlcNHglycan 481 484 PF01048 0.456
MOD_GlcNHglycan 519 522 PF01048 0.351
MOD_GlcNHglycan 534 537 PF01048 0.263
MOD_GSK3_1 217 224 PF00069 0.384
MOD_GSK3_1 227 234 PF00069 0.360
MOD_GSK3_1 262 269 PF00069 0.322
MOD_GSK3_1 381 388 PF00069 0.515
MOD_GSK3_1 416 423 PF00069 0.436
MOD_GSK3_1 438 445 PF00069 0.298
MOD_GSK3_1 457 464 PF00069 0.472
MOD_GSK3_1 530 537 PF00069 0.358
MOD_GSK3_1 89 96 PF00069 0.422
MOD_N-GLC_1 119 124 PF02516 0.420
MOD_N-GLC_1 281 286 PF02516 0.343
MOD_N-GLC_1 395 400 PF02516 0.517
MOD_N-GLC_1 438 443 PF02516 0.431
MOD_N-GLC_1 479 484 PF02516 0.395
MOD_N-GLC_1 627 632 PF02516 0.621
MOD_N-GLC_2 501 503 PF02516 0.360
MOD_NEK2_1 126 131 PF00069 0.274
MOD_NEK2_1 158 163 PF00069 0.273
MOD_NEK2_1 231 236 PF00069 0.321
MOD_NEK2_1 262 267 PF00069 0.310
MOD_NEK2_1 281 286 PF00069 0.310
MOD_NEK2_1 306 311 PF00069 0.398
MOD_NEK2_1 346 351 PF00069 0.451
MOD_NEK2_1 473 478 PF00069 0.447
MOD_NEK2_1 490 495 PF00069 0.325
MOD_NEK2_1 530 535 PF00069 0.326
MOD_NEK2_1 629 634 PF00069 0.593
MOD_NEK2_1 636 641 PF00069 0.510
MOD_NEK2_2 308 313 PF00069 0.444
MOD_PIKK_1 358 364 PF00454 0.450
MOD_PIKK_1 438 444 PF00454 0.435
MOD_PIKK_1 530 536 PF00454 0.400
MOD_PKA_2 318 324 PF00069 0.423
MOD_PKA_2 405 411 PF00069 0.437
MOD_PKA_2 458 464 PF00069 0.433
MOD_Plk_1 395 401 PF00069 0.532
MOD_Plk_1 438 444 PF00069 0.442
MOD_Plk_1 564 570 PF00069 0.319
MOD_Plk_2-3 610 616 PF00069 0.408
MOD_Plk_4 112 118 PF00069 0.392
MOD_Plk_4 231 237 PF00069 0.375
MOD_Plk_4 308 314 PF00069 0.445
MOD_Plk_4 395 401 PF00069 0.554
MOD_Plk_4 417 423 PF00069 0.420
MOD_Plk_4 492 498 PF00069 0.381
MOD_Plk_4 564 570 PF00069 0.332
MOD_Plk_4 613 619 PF00069 0.408
MOD_Plk_4 629 635 PF00069 0.627
MOD_Plk_4 636 642 PF00069 0.529
MOD_ProDKin_1 383 389 PF00069 0.548
MOD_ProDKin_1 551 557 PF00069 0.442
MOD_ProDKin_1 619 625 PF00069 0.629
MOD_ProDKin_1 93 99 PF00069 0.430
MOD_SUMO_for_1 572 575 PF00179 0.426
MOD_SUMO_rev_2 353 359 PF00179 0.419
TRG_DiLeu_BaEn_2 558 564 PF01217 0.426
TRG_DiLeu_BaLyEn_6 523 528 PF01217 0.441
TRG_ENDOCYTIC_2 261 264 PF00928 0.349
TRG_ENDOCYTIC_2 288 291 PF00928 0.435
TRG_ENDOCYTIC_2 303 306 PF00928 0.254
TRG_ENDOCYTIC_2 313 316 PF00928 0.262
TRG_ENDOCYTIC_2 34 37 PF00928 0.486
TRG_ENDOCYTIC_2 400 403 PF00928 0.361
TRG_ENDOCYTIC_2 443 446 PF00928 0.319
TRG_ENDOCYTIC_2 467 470 PF00928 0.452
TRG_ENDOCYTIC_2 634 637 PF00928 0.603
TRG_ER_diArg_1 6 8 PF00400 0.609
TRG_NES_CRM1_1 575 587 PF08389 0.426
TRG_Pf-PMV_PEXEL_1 368 373 PF00026 0.373

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBT6 Leptomonas seymouri 77% 100%
A0A0S4J9J2 Bodo saltans 31% 100%
A0A1X0NFY9 Trypanosomatidae 41% 100%
A0A1X0NTL0 Trypanosomatidae 40% 100%
A0A1X0NTM3 Trypanosomatidae 41% 100%
A0A1X0NY19 Trypanosomatidae 42% 100%
A0A1X0NYR4 Trypanosomatidae 37% 100%
A0A1X0P322 Trypanosomatidae 37% 100%
A0A1X0P5Y7 Trypanosomatidae 41% 100%
A0A3Q8IB13 Leishmania donovani 26% 100%
A0A3Q8IFU7 Leishmania donovani 27% 100%
A0A3S5H596 Leishmania donovani 100% 100%
A0A3S7WXQ4 Leishmania donovani 27% 100%
A0A3S7WXS2 Leishmania donovani 27% 100%
A2YZ01 Oryza sativa subsp. indica 28% 100%
A4H3V1 Leishmania braziliensis 84% 100%
A4HCV9 Leishmania braziliensis 24% 100%
A4HCW0 Leishmania braziliensis 27% 100%
A4HG14 Leishmania braziliensis 24% 100%
A4HS26 Leishmania infantum 100% 100%
A4HS27 Leishmania infantum 99% 100%
A4I0D9 Leishmania infantum 27% 100%
A4I0E0 Leishmania infantum 26% 100%
A4IAW1 Leishmania infantum 65% 100%
B6DXP5 Leymus chinensis 29% 100%
B6DZC8 Triticum aestivum 30% 100%
B6DZD0 Triticum urartu 30% 100%
B6DZD1 Aegilops speltoides 31% 100%
B6DZD2 Aegilops tauschii 30% 100%
D2IGW7 Bromus pictus 29% 100%
E8NHF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E8NHF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ACV4 Leishmania major 23% 100%
E9AK13 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AZE3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
H2DF88 Rosa hybrid cultivar 30% 100%
O07003 Bacillus subtilis (strain 168) 22% 100%
O24509 Phaseolus vulgaris 30% 99%
O33833 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 25% 100%
P05656 Bacillus subtilis (strain 168) 23% 95%
P10596 Saccharomyces cerevisiae 24% 100%
P26792 Daucus carota 30% 100%
P29000 Solanum lycopersicum 29% 100%
P29001 Vigna radiata var. radiata 31% 99%
P80065 Daucus carota 28% 97%
P92916 Allium cepa 26% 100%
P93761 Capsicum annuum 28% 100%
Q01IS7 Oryza sativa subsp. indica 29% 100%
Q01IS8 Oryza sativa subsp. indica 29% 100%
Q0J360 Oryza sativa subsp. japonica 28% 100%
Q0JDC5 Oryza sativa subsp. japonica 29% 100%
Q0JDC6 Oryza sativa subsp. japonica 29% 100%
Q1PEF8 Arabidopsis thaliana 29% 100%
Q2UXF7 Triticum aestivum 30% 100%
Q39693 Daucus carota 30% 100%
Q43089 Pisum sativum 29% 100%
Q43857 Vicia faba 31% 100%
Q43866 Arabidopsis thaliana 32% 100%
Q4QB75 Leishmania major 27% 100%
Q4QB76 Leishmania major 25% 100%
Q56UD0 Oryza sativa subsp. japonica 29% 100%
Q56UD1 Oryza sativa subsp. japonica 25% 100%
Q5FC15 Asparagus officinalis 30% 100%
Q5JJV0 Oryza sativa subsp. japonica 30% 100%
Q67XZ3 Arabidopsis thaliana 30% 100%
Q70AT7 Hordeum vulgare 29% 100%
Q70XE6 Beta vulgaris 28% 100%
Q84LA1 Triticum aestivum 29% 100%
Q84PN8 Triticum aestivum 29% 100%
Q8W4S6 Arabidopsis thaliana 28% 100%
Q9FSV7 Festuca arundinacea 29% 98%
Q9LIB9 Arabidopsis thaliana 28% 100%
Q9XTP3 Leishmania major 94% 100%
Q9XZX0 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS