Alcohol dehydrogenase GroES-like domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alcohol dehydrogenase GroES-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H593_LEIDO

TriTrypDb:

LdBPK_040280.1 , LdCL_040008300 , LDHU3_04.0350

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H593

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H593

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	5	1
GO:0003960	NADPH:quinone reductase activity	5	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	2
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.484
CLV_NRD_NRD_1	231	233	PF00675	0.368
CLV_NRD_NRD_1	352	354	PF00675	0.386
CLV_NRD_NRD_1	367	369	PF00675	0.547
CLV_NRD_NRD_1	433	435	PF00675	0.608
CLV_PCSK_KEX2_1	231	233	PF00082	0.368
CLV_PCSK_KEX2_1	367	369	PF00082	0.530
CLV_PCSK_KEX2_1	433	435	PF00082	0.588
CLV_PCSK_SKI1_1	100	104	PF00082	0.397
CLV_PCSK_SKI1_1	189	193	PF00082	0.312
CLV_PCSK_SKI1_1	214	218	PF00082	0.340
CLV_PCSK_SKI1_1	231	235	PF00082	0.348
CLV_PCSK_SKI1_1	241	245	PF00082	0.331
CLV_PCSK_SKI1_1	291	295	PF00082	0.320
CLV_PCSK_SKI1_1	354	358	PF00082	0.306
CLV_PCSK_SKI1_1	428	432	PF00082	0.556
DEG_APCC_DBOX_1	230	238	PF00400	0.386
DEG_Nend_UBRbox_1	1	4	PF02207	0.573
DOC_CKS1_1	405	410	PF01111	0.517
DOC_CYCLIN_RxL_1	226	236	PF00134	0.396
DOC_CYCLIN_RxL_1	238	247	PF00134	0.339
DOC_MAPK_gen_1	189	199	PF00069	0.328
DOC_MAPK_gen_1	301	310	PF00069	0.391
DOC_MAPK_gen_1	353	359	PF00069	0.321
DOC_MAPK_MEF2A_6	44	53	PF00069	0.286
DOC_PP1_RVXF_1	426	433	PF00149	0.553
DOC_PP2B_LxvP_1	54	57	PF13499	0.267
DOC_PP4_FxxP_1	293	296	PF00568	0.310
DOC_PP4_FxxP_1	432	435	PF00568	0.605
DOC_USP7_MATH_1	174	178	PF00917	0.342
DOC_USP7_MATH_1	349	353	PF00917	0.391
DOC_USP7_MATH_1	419	423	PF00917	0.585
DOC_USP7_UBL2_3	100	104	PF12436	0.303
DOC_WW_Pin1_4	404	409	PF00397	0.534
LIG_14-3-3_CanoR_1	231	240	PF00244	0.346
LIG_14-3-3_CanoR_1	367	376	PF00244	0.543
LIG_Actin_WH2_2	88	106	PF00022	0.345
LIG_ActinCP_TwfCPI_2	432	439	PF01115	0.589
LIG_CaM_IQ_9	179	194	PF13499	0.294
LIG_FHA_1	119	125	PF00498	0.300
LIG_FHA_1	194	200	PF00498	0.346
LIG_FHA_2	123	129	PF00498	0.328
LIG_FHA_2	405	411	PF00498	0.642
LIG_LIR_Apic_2	343	349	PF02991	0.388
LIG_LIR_Apic_2	36	41	PF02991	0.370
LIG_LIR_Apic_2	365	369	PF02991	0.518
LIG_LIR_Apic_2	402	408	PF02991	0.524
LIG_LIR_Apic_2	429	435	PF02991	0.599
LIG_LIR_Gen_1	157	168	PF02991	0.317
LIG_LIR_Gen_1	407	417	PF02991	0.511
LIG_LIR_Nem_3	157	163	PF02991	0.310
LIG_LIR_Nem_3	407	412	PF02991	0.550
LIG_NRBOX	254	260	PF00104	0.327
LIG_OCRL_FandH_1	408	420	PF00620	0.578
LIG_Pex14_2	294	298	PF04695	0.322
LIG_Pex14_2	342	346	PF04695	0.354
LIG_REV1ctd_RIR_1	208	218	PF16727	0.391
LIG_REV1ctd_RIR_1	429	434	PF16727	0.579
LIG_SH2_CRK	38	42	PF00017	0.431
LIG_SH2_STAP1	251	255	PF00017	0.309
LIG_SH2_STAT5	143	146	PF00017	0.284
LIG_SH2_STAT5	185	188	PF00017	0.306
LIG_SH2_STAT5	406	409	PF00017	0.557
LIG_SH3_3	234	240	PF00018	0.341
LIG_SH3_3	432	438	PF00018	0.568
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.345
MOD_CK1_1	115	121	PF00069	0.509
MOD_CK1_1	393	399	PF00069	0.521
MOD_CK2_1	122	128	PF00069	0.371
MOD_GlcNHglycan	337	340	PF01048	0.543
MOD_GlcNHglycan	392	395	PF01048	0.510
MOD_GlcNHglycan	45	48	PF01048	0.351
MOD_GSK3_1	118	125	PF00069	0.298
MOD_GSK3_1	12	19	PF00069	0.444
MOD_GSK3_1	145	152	PF00069	0.269
MOD_GSK3_1	169	176	PF00069	0.293
MOD_GSK3_1	264	271	PF00069	0.323
MOD_GSK3_1	314	321	PF00069	0.362
MOD_GSK3_1	390	397	PF00069	0.512
MOD_N-GLC_1	244	249	PF02516	0.302
MOD_N-GLC_1	269	274	PF02516	0.478
MOD_NEK2_1	1	6	PF00069	0.546
MOD_NEK2_1	149	154	PF00069	0.275
MOD_NEK2_1	193	198	PF00069	0.334
MOD_NEK2_1	244	249	PF00069	0.304
MOD_NEK2_1	276	281	PF00069	0.512
MOD_NEK2_1	318	323	PF00069	0.393
MOD_NEK2_1	340	345	PF00069	0.375
MOD_NEK2_1	390	395	PF00069	0.504
MOD_NEK2_1	42	47	PF00069	0.416
MOD_NEK2_2	145	150	PF00069	0.284
MOD_PIKK_1	318	324	PF00454	0.378
MOD_PKA_2	1	7	PF00069	0.547
MOD_PKA_2	300	306	PF00069	0.391
MOD_PKA_2	43	49	PF00069	0.424
MOD_Plk_4	145	151	PF00069	0.268
MOD_Plk_4	294	300	PF00069	0.408
MOD_Plk_4	412	418	PF00069	0.596
MOD_ProDKin_1	404	410	PF00069	0.531
MOD_SUMO_rev_2	414	422	PF00179	0.507
TRG_DiLeu_BaEn_1	203	208	PF01217	0.389
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.349
TRG_ENDOCYTIC_2	406	409	PF00928	0.549
TRG_ER_diArg_1	230	232	PF00400	0.353
TRG_ER_diArg_1	307	310	PF00400	0.361
TRG_ER_diArg_1	366	368	PF00400	0.517
TRG_ER_diArg_1	432	434	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X4	Leptomonas seymouri	92%	100%
A0A0S4ILA6	Bodo saltans	27%	100%
A0A0S4J2L6	Bodo saltans	72%	100%
A0A1X0NL46	Trypanosomatidae	81%	97%
A0A3R7KI38	Trypanosoma rangeli	81%	100%
A0A3S5H5I3	Leishmania donovani	30%	100%
A4H3U9	Leishmania braziliensis	96%	100%
A4H498	Leishmania braziliensis	28%	100%
A4HS24	Leishmania infantum	100%	100%
A4HSH5	Leishmania infantum	30%	100%
C9ZY17	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9AK11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AKF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q10488	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q28GQ2	Xenopus tropicalis	29%	100%
Q4QJF0	Leishmania major	30%	100%
Q54YT4	Dictyostelium discoideum	33%	100%
Q6BLV6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	100%
Q6BV30	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	100%
Q6CBE4	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	100%
Q6CIR6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	100%
Q8LCU7	Arabidopsis thaliana	32%	100%
Q8NJJ9	Kluyveromyces marxianus	25%	100%
Q8WZM3	Candida tropicalis	24%	100%
Q8WZM4	Candida tropicalis	24%	100%
Q9V6U9	Drosophila melanogaster	29%	100%
Q9XZY9	Leishmania major	100%	100%
V5D9R3	Trypanosoma cruzi	83%	99%