LeishMANIAdb
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GRAM domain family protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
GRAM domain family protein
Gene product:
GRAM domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H589_LEIDO
TriTrypDb:
LdBPK_040230.1 , LdCL_040007800 , LDHU3_04.0300
Length:
290

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 63, 78
Promastigote/Amastigote: 65

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S5H589
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H589

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 43 45 PF00675 0.655
CLV_NRD_NRD_1 59 61 PF00675 0.490
CLV_PCSK_KEX2_1 43 45 PF00082 0.467
CLV_PCSK_KEX2_1 59 61 PF00082 0.414
CLV_PCSK_SKI1_1 50 54 PF00082 0.648
DEG_Nend_UBRbox_3 1 3 PF02207 0.683
DEG_SPOP_SBC_1 155 159 PF00917 0.378
DOC_MAPK_JIP1_4 229 235 PF00069 0.447
DOC_PP2B_LxvP_1 223 226 PF13499 0.451
DOC_USP7_MATH_1 155 159 PF00917 0.369
DOC_USP7_MATH_1 197 201 PF00917 0.284
DOC_USP7_MATH_1 89 93 PF00917 0.525
DOC_USP7_UBL2_3 50 54 PF12436 0.590
DOC_WW_Pin1_4 34 39 PF00397 0.461
LIG_14-3-3_CanoR_1 130 138 PF00244 0.468
LIG_14-3-3_CanoR_1 59 69 PF00244 0.672
LIG_eIF4E_1 12 18 PF01652 0.558
LIG_FHA_1 163 169 PF00498 0.487
LIG_FHA_1 280 286 PF00498 0.543
LIG_FHA_2 264 270 PF00498 0.522
LIG_FHA_2 35 41 PF00498 0.459
LIG_FHA_2 91 97 PF00498 0.669
LIG_LIR_Gen_1 147 155 PF02991 0.393
LIG_LIR_Gen_1 240 251 PF02991 0.459
LIG_LIR_Gen_1 269 278 PF02991 0.365
LIG_LIR_Nem_3 147 153 PF02991 0.397
LIG_LIR_Nem_3 269 275 PF02991 0.365
LIG_Pex14_2 111 115 PF04695 0.337
LIG_SH2_CRK 22 26 PF00017 0.498
LIG_SH2_PTP2 14 17 PF00017 0.449
LIG_SH2_SRC 12 15 PF00017 0.471
LIG_SH2_SRC 274 277 PF00017 0.377
LIG_SH2_STAT5 14 17 PF00017 0.436
LIG_SH2_STAT5 150 153 PF00017 0.345
LIG_SH2_STAT5 22 25 PF00017 0.498
LIG_SH2_STAT5 236 239 PF00017 0.448
LIG_SH2_STAT5 274 277 PF00017 0.377
LIG_SH3_1 22 28 PF00018 0.456
LIG_SH3_3 175 181 PF00018 0.579
LIG_SH3_3 22 28 PF00018 0.431
LIG_SUMO_SIM_par_1 194 200 PF11976 0.396
LIG_TRFH_1 220 224 PF08558 0.541
LIG_UBA3_1 69 74 PF00899 0.700
MOD_CK1_1 200 206 PF00069 0.512
MOD_CK1_1 250 256 PF00069 0.574
MOD_CK1_1 64 70 PF00069 0.670
MOD_CK1_1 72 78 PF00069 0.665
MOD_CK1_1 92 98 PF00069 0.474
MOD_CK2_1 34 40 PF00069 0.470
MOD_CK2_1 90 96 PF00069 0.598
MOD_GlcNHglycan 120 123 PF01048 0.386
MOD_GlcNHglycan 131 134 PF01048 0.356
MOD_GlcNHglycan 255 258 PF01048 0.666
MOD_GlcNHglycan 64 67 PF01048 0.595
MOD_GlcNHglycan 74 77 PF01048 0.553
MOD_GSK3_1 157 164 PF00069 0.535
MOD_GSK3_1 200 207 PF00069 0.424
MOD_GSK3_1 224 231 PF00069 0.559
MOD_GSK3_1 60 67 PF00069 0.618
MOD_GSK3_1 90 97 PF00069 0.569
MOD_NEK2_1 154 159 PF00069 0.374
MOD_NEK2_1 20 25 PF00069 0.495
MOD_NEK2_1 62 67 PF00069 0.729
MOD_NEK2_1 69 74 PF00069 0.660
MOD_PIKK_1 234 240 PF00454 0.388
MOD_PIKK_1 75 81 PF00454 0.616
MOD_PIKK_1 94 100 PF00454 0.391
MOD_PKA_2 129 135 PF00069 0.457
MOD_PKA_2 228 234 PF00069 0.477
MOD_PKA_2 253 259 PF00069 0.691
MOD_PKA_2 279 285 PF00069 0.525
MOD_Plk_4 197 203 PF00069 0.431
MOD_Plk_4 204 210 PF00069 0.422
MOD_Plk_4 247 253 PF00069 0.449
MOD_ProDKin_1 34 40 PF00069 0.460
TRG_DiLeu_LyEn_5 16 21 PF01217 0.474
TRG_ENDOCYTIC_2 12 15 PF00928 0.462
TRG_ENDOCYTIC_2 150 153 PF00928 0.410
TRG_ENDOCYTIC_2 243 246 PF00928 0.460
TRG_ENDOCYTIC_2 272 275 PF00928 0.358
TRG_ER_diArg_1 185 188 PF00400 0.616
TRG_ER_diArg_1 42 44 PF00400 0.469
TRG_Pf-PMV_PEXEL_1 100 105 PF00026 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAZ3 Leptomonas seymouri 51% 85%
A0A0S4IUM5 Bodo saltans 33% 98%
A0A1X0NMU9 Trypanosomatidae 42% 100%
A0A3R7NSA7 Trypanosoma rangeli 44% 97%
A4H3U4 Leishmania braziliensis 58% 100%
A4HS19 Leishmania infantum 100% 100%
C9ZY11 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 98%
E9AK06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q9XZY4 Leishmania major 93% 100%
V5BA94 Trypanosoma cruzi 24% 80%
V5D9R6 Trypanosoma cruzi 41% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS