Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H588_LEIDO

TriTrypDb:

LdBPK_040220.1 , LdCL_040007700 , LDHU3_04.0290

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S5H588

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H588

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.552
CLV_NRD_NRD_1	248	250	PF00675	0.597
CLV_NRD_NRD_1	78	80	PF00675	0.489
CLV_PCSK_KEX2_1	108	110	PF00082	0.552
CLV_PCSK_KEX2_1	247	249	PF00082	0.603
CLV_PCSK_KEX2_1	78	80	PF00082	0.443
CLV_PCSK_SKI1_1	80	84	PF00082	0.485
DEG_SIAH_1	162	170	PF03145	0.773
DEG_SPOP_SBC_1	122	126	PF00917	0.745
DEG_SPOP_SBC_1	186	190	PF00917	0.715
DOC_CYCLIN_yClb3_PxF_3	162	168	PF00134	0.715
DOC_MAPK_gen_1	247	255	PF00069	0.793
DOC_PP1_RVXF_1	250	256	PF00149	0.787
DOC_PP1_RVXF_1	45	52	PF00149	0.375
DOC_PP2B_PxIxI_1	37	43	PF00149	0.549
DOC_USP7_MATH_1	215	219	PF00917	0.693
DOC_USP7_MATH_1	25	29	PF00917	0.521
DOC_WW_Pin1_4	109	114	PF00397	0.727
DOC_WW_Pin1_4	118	123	PF00397	0.648
DOC_WW_Pin1_4	131	136	PF00397	0.692
DOC_WW_Pin1_4	190	195	PF00397	0.781
DOC_WW_Pin1_4	216	221	PF00397	0.819
DOC_WW_Pin1_4	234	239	PF00397	0.642
DOC_WW_Pin1_4	34	39	PF00397	0.560
LIG_14-3-3_CanoR_1	108	113	PF00244	0.698
LIG_14-3-3_CanoR_1	147	152	PF00244	0.768
LIG_14-3-3_CanoR_1	227	231	PF00244	0.780
LIG_BIR_II_1	1	5	PF00653	0.428
LIG_FHA_1	123	129	PF00498	0.735
LIG_FHA_1	35	41	PF00498	0.511
LIG_FHA_2	15	21	PF00498	0.488
LIG_FHA_2	238	244	PF00498	0.771
LIG_LIR_Nem_3	85	91	PF02991	0.678
LIG_PDZ_Class_2	253	258	PF00595	0.784
LIG_Pex14_1	89	93	PF04695	0.572
LIG_Pex14_2	52	56	PF04695	0.393
LIG_PTB_Apo_2	177	184	PF02174	0.776
LIG_PTB_Apo_2	3	10	PF02174	0.518
LIG_PTB_Phospho_1	177	183	PF10480	0.774
LIG_SH2_STAT5	183	186	PF00017	0.774
LIG_SH2_STAT5	195	198	PF00017	0.670
LIG_SH3_2	242	247	PF14604	0.806
LIG_SH3_3	157	163	PF00018	0.779
LIG_SH3_3	166	172	PF00018	0.680
LIG_SH3_3	211	217	PF00018	0.752
LIG_SH3_3	229	235	PF00018	0.703
LIG_SH3_3	239	245	PF00018	0.740
LIG_SUMO_SIM_anti_2	37	43	PF11976	0.549
LIG_WRC_WIRS_1	72	77	PF05994	0.508
MOD_CK1_1	107	113	PF00069	0.788
MOD_CK1_1	190	196	PF00069	0.804
MOD_CK1_1	237	243	PF00069	0.738
MOD_CK1_1	251	257	PF00069	0.681
MOD_CK1_1	34	40	PF00069	0.515
MOD_CK2_1	14	20	PF00069	0.477
MOD_CK2_1	237	243	PF00069	0.775
MOD_CK2_1	24	30	PF00069	0.424
MOD_GlcNHglycan	189	192	PF01048	0.540
MOD_GSK3_1	104	111	PF00069	0.689
MOD_GSK3_1	118	125	PF00069	0.680
MOD_GSK3_1	147	154	PF00069	0.751
MOD_GSK3_1	186	193	PF00069	0.715
MOD_GSK3_1	234	241	PF00069	0.716
MOD_GSK3_1	67	74	PF00069	0.295
MOD_N-GLC_1	42	47	PF02516	0.672
MOD_N-GLC_1	98	103	PF02516	0.428
MOD_NEK2_1	67	72	PF00069	0.305
MOD_NEK2_2	204	209	PF00069	0.746
MOD_PIKK_1	129	135	PF00454	0.737
MOD_PIKK_1	151	157	PF00454	0.744
MOD_PK_1	141	147	PF00069	0.750
MOD_PKA_1	108	114	PF00069	0.691
MOD_PKA_1	248	254	PF00069	0.792
MOD_PKA_2	107	113	PF00069	0.736
MOD_PKA_2	151	157	PF00069	0.767
MOD_PKA_2	223	229	PF00069	0.781
MOD_PKA_2	248	254	PF00069	0.792
MOD_Plk_1	98	104	PF00069	0.591
MOD_Plk_4	204	210	PF00069	0.748
MOD_Plk_4	251	257	PF00069	0.784
MOD_Plk_4	67	73	PF00069	0.333
MOD_Plk_4	98	104	PF00069	0.607
MOD_ProDKin_1	109	115	PF00069	0.730
MOD_ProDKin_1	118	124	PF00069	0.650
MOD_ProDKin_1	131	137	PF00069	0.693
MOD_ProDKin_1	190	196	PF00069	0.781
MOD_ProDKin_1	216	222	PF00069	0.818
MOD_ProDKin_1	234	240	PF00069	0.644
MOD_ProDKin_1	34	40	PF00069	0.557
MOD_SUMO_for_1	82	85	PF00179	0.685
TRG_ENDOCYTIC_2	88	91	PF00928	0.676
TRG_ER_diArg_1	246	249	PF00400	0.802

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H444	Leishmania braziliensis	57%	99%
A4HS18	Leishmania infantum	100%	100%
E9AK05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q9U191	Leishmania major	91%	100%