Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H587_LEIDO

TriTrypDb:

LdBPK_040210.1 , LdCL_040007600 , LDHU3_04.0280

Length:

354

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Highly expanded in the Trypanosoma genus, while relatively limited in Leishmaniids.. Localization: ER (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 5
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S5H587

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H587

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.420
CLV_C14_Caspase3-7	221	225	PF00656	0.501
CLV_C14_Caspase3-7	336	340	PF00656	0.717
CLV_NRD_NRD_1	317	319	PF00675	0.471
CLV_PCSK_KEX2_1	317	319	PF00082	0.446
CLV_PCSK_PC7_1	313	319	PF00082	0.459
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.437
DOC_PP4_FxxP_1	182	185	PF00568	0.449
DOC_PP4_FxxP_1	37	40	PF00568	0.394
DOC_USP7_MATH_1	144	148	PF00917	0.457
DOC_USP7_MATH_1	257	261	PF00917	0.415
DOC_USP7_MATH_1	75	79	PF00917	0.351
LIG_14-3-3_CanoR_1	134	138	PF00244	0.461
LIG_14-3-3_CanoR_1	162	168	PF00244	0.448
LIG_14-3-3_CanoR_1	217	223	PF00244	0.391
LIG_14-3-3_CanoR_1	317	325	PF00244	0.667
LIG_14-3-3_CanoR_1	334	338	PF00244	0.679
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	272	276	PF00533	0.299
LIG_BRCT_BRCA1_1	77	81	PF00533	0.360
LIG_deltaCOP1_diTrp_1	114	121	PF00928	0.435
LIG_FHA_1	144	150	PF00498	0.468
LIG_FHA_1	154	160	PF00498	0.488
LIG_FHA_1	20	26	PF00498	0.497
LIG_FHA_1	205	211	PF00498	0.424
LIG_FHA_1	63	69	PF00498	0.394
LIG_FHA_2	122	128	PF00498	0.569
LIG_FHA_2	219	225	PF00498	0.499
LIG_FHA_2	234	240	PF00498	0.378
LIG_FHA_2	43	49	PF00498	0.358
LIG_LIR_Apic_2	34	40	PF02991	0.400
LIG_LIR_Gen_1	282	288	PF02991	0.251
LIG_LIR_Gen_1	82	93	PF02991	0.371
LIG_LIR_Nem_3	102	108	PF02991	0.422
LIG_LIR_Nem_3	239	243	PF02991	0.334
LIG_LIR_Nem_3	282	286	PF02991	0.257
LIG_LIR_Nem_3	78	84	PF02991	0.381
LIG_Pex14_1	117	121	PF04695	0.439
LIG_Pex14_1	211	215	PF04695	0.458
LIG_Pex14_1	267	271	PF04695	0.345
LIG_Pex14_2	176	180	PF04695	0.433
LIG_Pex14_2	272	276	PF04695	0.333
LIG_SH2_CRK	28	32	PF00017	0.392
LIG_SH2_CRK	85	89	PF00017	0.385
LIG_SH2_NCK_1	254	258	PF00017	0.396
LIG_SH2_SRC	151	154	PF00017	0.384
LIG_SH2_SRC	38	41	PF00017	0.370
LIG_SH2_STAP1	169	173	PF00017	0.444
LIG_SH2_STAT3	161	164	PF00017	0.439
LIG_SH2_STAT3	169	172	PF00017	0.468
LIG_SH2_STAT3	319	322	PF00017	0.683
LIG_SH2_STAT5	319	322	PF00017	0.691
LIG_SH2_STAT5	38	41	PF00017	0.362
LIG_SH2_STAT5	59	62	PF00017	0.393
LIG_SH3_3	178	184	PF00018	0.443
LIG_Sin3_3	64	71	PF02671	0.399
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.430
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.399
LIG_SUMO_SIM_par_1	6	12	PF11976	0.435
LIG_WRC_WIRS_1	280	285	PF05994	0.299
LIG_WW_1	184	187	PF00397	0.451
MOD_CK1_1	258	264	PF00069	0.410
MOD_CK1_1	321	327	PF00069	0.689
MOD_CK1_1	330	336	PF00069	0.705
MOD_CK1_1	338	344	PF00069	0.814
MOD_CK2_1	341	347	PF00069	0.696
MOD_CK2_1	42	48	PF00069	0.358
MOD_GlcNHglycan	146	149	PF01048	0.665
MOD_GlcNHglycan	257	260	PF01048	0.638
MOD_GSK3_1	117	124	PF00069	0.500
MOD_GSK3_1	253	260	PF00069	0.448
MOD_GSK3_1	329	336	PF00069	0.769
MOD_GSK3_1	40	47	PF00069	0.325
MOD_GSK3_1	75	82	PF00069	0.423
MOD_N-GLC_1	327	332	PF02516	0.443
MOD_N-GLC_1	341	346	PF02516	0.539
MOD_N-GLC_2	129	131	PF02516	0.608
MOD_NEK2_1	121	126	PF00069	0.422
MOD_PIKK_1	119	125	PF00454	0.460
MOD_PIKK_1	258	264	PF00454	0.427
MOD_PIKK_1	318	324	PF00454	0.691
MOD_PKA_2	133	139	PF00069	0.457
MOD_PKA_2	333	339	PF00069	0.703
MOD_Plk_1	117	123	PF00069	0.467
MOD_Plk_1	233	239	PF00069	0.381
MOD_Plk_1	62	68	PF00069	0.461
MOD_Plk_4	32	38	PF00069	0.369
MOD_Plk_4	80	86	PF00069	0.426
MOD_Plk_4	9	15	PF00069	0.335
MOD_SUMO_rev_2	147	156	PF00179	0.426
TRG_ENDOCYTIC_2	28	31	PF00928	0.405
TRG_ENDOCYTIC_2	84	87	PF00928	0.380
TRG_ER_diArg_1	317	319	PF00400	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY91	Leptomonas seymouri	47%	100%
A0A0N1PG18	Leptomonas seymouri	36%	79%
A0A3S5H6P8	Leishmania donovani	35%	84%
A4H3U3	Leishmania braziliensis	81%	100%
A4H7B4	Leishmania braziliensis	34%	100%
A4HS17	Leishmania infantum	100%	100%
A4HVQ9	Leishmania infantum	33%	100%
E9AK04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9APF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QG23	Leishmania major	33%	100%
Q9XZY2	Leishmania major	92%	100%