LeishMANIAdb
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Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania donovani
UniProt:
A0A3S5H586_LEIDO
TriTrypDb:
LdBPK_040200.1 , LdCL_040007500 , LDHU3_04.0270
Length:
285

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 1
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A0A3S5H586
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H586

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 255 257 PF00675 0.717
CLV_NRD_NRD_1 55 57 PF00675 0.515
CLV_PCSK_KEX2_1 12 14 PF00082 0.655
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.655
DEG_SPOP_SBC_1 136 140 PF00917 0.428
DEG_SPOP_SBC_1 141 145 PF00917 0.408
DEG_SPOP_SBC_1 159 163 PF00917 0.479
DEG_SPOP_SBC_1 175 179 PF00917 0.417
DOC_CKS1_1 77 82 PF01111 0.391
DOC_MAPK_gen_1 12 20 PF00069 0.614
DOC_MAPK_gen_1 56 63 PF00069 0.361
DOC_MAPK_MEF2A_6 13 22 PF00069 0.532
DOC_USP7_MATH_1 137 141 PF00917 0.476
DOC_USP7_MATH_1 176 180 PF00917 0.535
DOC_USP7_MATH_1 218 222 PF00917 0.385
DOC_USP7_MATH_1 232 236 PF00917 0.373
DOC_USP7_MATH_1 255 259 PF00917 0.438
DOC_USP7_MATH_1 44 48 PF00917 0.334
DOC_WW_Pin1_4 146 151 PF00397 0.585
DOC_WW_Pin1_4 263 268 PF00397 0.452
DOC_WW_Pin1_4 6 11 PF00397 0.495
DOC_WW_Pin1_4 73 78 PF00397 0.413
LIG_14-3-3_CanoR_1 237 245 PF00244 0.357
LIG_BIR_II_1 1 5 PF00653 0.507
LIG_FHA_1 106 112 PF00498 0.280
LIG_FHA_1 165 171 PF00498 0.464
LIG_FHA_1 198 204 PF00498 0.351
LIG_FHA_1 264 270 PF00498 0.276
LIG_FHA_1 91 97 PF00498 0.382
LIG_FHA_2 77 83 PF00498 0.391
LIG_LIR_Gen_1 248 255 PF02991 0.369
LIG_LIR_Nem_3 248 254 PF02991 0.436
LIG_LIR_Nem_3 38 43 PF02991 0.354
LIG_LYPXL_yS_3 117 120 PF13949 0.377
LIG_LYPXL_yS_3 40 43 PF13949 0.378
LIG_SH2_CRK 251 255 PF00017 0.363
LIG_SH2_NCK_1 251 255 PF00017 0.363
LIG_SH2_SRC 89 92 PF00017 0.327
LIG_SH2_STAP1 199 203 PF00017 0.352
LIG_SH2_STAP1 245 249 PF00017 0.363
LIG_SH2_STAP1 71 75 PF00017 0.354
LIG_SH2_STAT5 123 126 PF00017 0.488
LIG_SH2_STAT5 199 202 PF00017 0.348
LIG_SH2_STAT5 251 254 PF00017 0.359
LIG_SH3_1 85 91 PF00018 0.338
LIG_SH3_3 108 114 PF00018 0.336
LIG_SH3_3 74 80 PF00018 0.445
LIG_SH3_3 85 91 PF00018 0.363
LIG_SUMO_SIM_par_1 28 33 PF11976 0.545
LIG_SUMO_SIM_par_1 59 65 PF11976 0.358
LIG_SxIP_EBH_1 247 257 PF03271 0.377
LIG_TYR_ITIM 115 120 PF00017 0.379
LIG_TYR_ITIM 249 254 PF00017 0.371
LIG_UBA3_1 60 68 PF00899 0.357
MOD_CDC14_SPxK_1 9 12 PF00782 0.487
MOD_CDK_SPxK_1 6 12 PF00069 0.495
MOD_CDK_SPxxK_3 6 13 PF00069 0.496
MOD_CK1_1 140 146 PF00069 0.549
MOD_CK1_1 149 155 PF00069 0.468
MOD_CK1_1 179 185 PF00069 0.416
MOD_CK1_1 258 264 PF00069 0.405
MOD_CK1_1 62 68 PF00069 0.347
MOD_CK1_1 76 82 PF00069 0.389
MOD_CK2_1 236 242 PF00069 0.364
MOD_CK2_1 76 82 PF00069 0.394
MOD_GlcNHglycan 1 4 PF01048 0.616
MOD_GlcNHglycan 139 142 PF01048 0.706
MOD_GlcNHglycan 178 181 PF01048 0.642
MOD_GlcNHglycan 205 208 PF01048 0.609
MOD_GlcNHglycan 212 215 PF01048 0.539
MOD_GlcNHglycan 257 260 PF01048 0.688
MOD_GlcNHglycan 32 35 PF01048 0.612
MOD_GSK3_1 126 133 PF00069 0.476
MOD_GSK3_1 136 143 PF00069 0.435
MOD_GSK3_1 144 151 PF00069 0.492
MOD_GSK3_1 154 161 PF00069 0.436
MOD_GSK3_1 165 172 PF00069 0.532
MOD_GSK3_1 175 182 PF00069 0.440
MOD_GSK3_1 218 225 PF00069 0.448
MOD_GSK3_1 232 239 PF00069 0.312
MOD_GSK3_1 245 252 PF00069 0.352
MOD_GSK3_1 69 76 PF00069 0.404
MOD_N-GLC_1 232 237 PF02516 0.519
MOD_N-GLC_2 236 238 PF02516 0.555
MOD_NEK2_1 210 215 PF00069 0.336
MOD_NEK2_1 247 252 PF00069 0.385
MOD_NEK2_1 30 35 PF00069 0.539
MOD_OFUCOSY 185 190 PF10250 0.571
MOD_OFUCOSY 216 222 PF10250 0.697
MOD_PKA_2 236 242 PF00069 0.323
MOD_PKA_2 255 261 PF00069 0.515
MOD_Plk_1 45 51 PF00069 0.354
MOD_Plk_4 119 125 PF00069 0.392
MOD_ProDKin_1 146 152 PF00069 0.584
MOD_ProDKin_1 263 269 PF00069 0.293
MOD_ProDKin_1 6 12 PF00069 0.495
MOD_ProDKin_1 73 79 PF00069 0.414
TRG_ENDOCYTIC_2 117 120 PF00928 0.377
TRG_ENDOCYTIC_2 251 254 PF00928 0.359
TRG_ENDOCYTIC_2 40 43 PF00928 0.378

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZJ5 Leptomonas seymouri 33% 100%
A4H439 Leishmania braziliensis 24% 90%
A4H446 Leishmania braziliensis 30% 100%
A4HS16 Leishmania infantum 92% 100%
E9AK03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
Q9XZY1 Leishmania major 79% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS