Surface_antigen-like_protein/GeneDB:LmjF.04.0180

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S5H584_LEIDO

TriTrypDb:

LdBPK_040170.1 , LdCL_040007200 , LDHU3_04.0240

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H584

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H584

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	121	123	PF00082	0.481
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.481
CLV_PCSK_SKI1_1	154	158	PF00082	0.456
CLV_PCSK_SKI1_1	4	8	PF00082	0.585
DEG_APCC_DBOX_1	121	129	PF00400	0.261
DEG_APCC_DBOX_1	3	11	PF00400	0.454
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DEG_SCF_FBW7_1	317	322	PF00400	0.340
DEG_SPOP_SBC_1	23	27	PF00917	0.340
DOC_ANK_TNKS_1	33	40	PF00023	0.329
DOC_CKS1_1	316	321	PF01111	0.344
DOC_CKS1_1	338	343	PF01111	0.342
DOC_MAPK_gen_1	2	10	PF00069	0.455
DOC_MAPK_MEF2A_6	2	10	PF00069	0.455
DOC_PP1_RVXF_1	152	158	PF00149	0.261
DOC_USP7_MATH_1	146	150	PF00917	0.366
DOC_USP7_MATH_1	156	160	PF00917	0.253
DOC_USP7_MATH_1	164	168	PF00917	0.257
DOC_USP7_MATH_1	177	181	PF00917	0.283
DOC_USP7_MATH_1	220	224	PF00917	0.356
DOC_USP7_MATH_1	376	380	PF00917	0.264
DOC_WW_Pin1_4	16	21	PF00397	0.540
DOC_WW_Pin1_4	160	165	PF00397	0.251
DOC_WW_Pin1_4	315	320	PF00397	0.347
DOC_WW_Pin1_4	321	326	PF00397	0.306
DOC_WW_Pin1_4	337	342	PF00397	0.249
DOC_WW_Pin1_4	397	402	PF00397	0.344
LIG_14-3-3_CanoR_1	361	369	PF00244	0.312
LIG_BRCT_BRCA1_1	179	183	PF00533	0.289
LIG_eIF4E_1	315	321	PF01652	0.326
LIG_FHA_1	229	235	PF00498	0.265
LIG_FHA_1	316	322	PF00498	0.317
LIG_FHA_1	376	382	PF00498	0.315
LIG_FHA_1	55	61	PF00498	0.364
LIG_FHA_1	91	97	PF00498	0.378
LIG_GBD_Chelix_1	326	334	PF00786	0.534
LIG_LIR_Apic_2	251	257	PF02991	0.287
LIG_LIR_Nem_3	127	133	PF02991	0.314
LIG_LIR_Nem_3	354	359	PF02991	0.318
LIG_LIR_Nem_3	468	474	PF02991	0.329
LIG_PTB_Apo_2	423	430	PF02174	0.337
LIG_PTB_Phospho_1	423	429	PF10480	0.338
LIG_SH2_CRK	254	258	PF00017	0.281
LIG_SH2_CRK	356	360	PF00017	0.316
LIG_SH2_CRK	471	475	PF00017	0.319
LIG_SH2_STAP1	248	252	PF00017	0.307
LIG_SH2_STAP1	389	393	PF00017	0.340
LIG_SH2_STAP1	486	490	PF00017	0.294
LIG_SH2_STAT5	197	200	PF00017	0.308
LIG_SH2_STAT5	24	27	PF00017	0.365
LIG_SH2_STAT5	248	251	PF00017	0.359
LIG_SH2_STAT5	254	257	PF00017	0.339
LIG_SH2_STAT5	316	319	PF00017	0.352
LIG_SH2_STAT5	351	354	PF00017	0.307
LIG_SH2_STAT5	389	392	PF00017	0.268
LIG_SH2_STAT5	424	427	PF00017	0.349
LIG_SH2_STAT5	430	433	PF00017	0.315
LIG_SH2_STAT5	443	446	PF00017	0.252
LIG_SH2_STAT5	465	468	PF00017	0.328
LIG_SH2_STAT5	95	98	PF00017	0.346
LIG_SH3_2	338	343	PF14604	0.342
LIG_SH3_3	335	341	PF00018	0.335
LIG_SH3_3	47	53	PF00018	0.296
LIG_SH3_3	70	76	PF00018	0.318
LIG_SH3_3	93	99	PF00018	0.373
LIG_SUMO_SIM_par_1	9	14	PF11976	0.427
LIG_TRFH_1	315	319	PF08558	0.344
LIG_TRFH_1	95	99	PF08558	0.308
LIG_TYR_ITIM	128	133	PF00017	0.271
MOD_CDK_SPxK_1	337	343	PF00069	0.339
MOD_CK1_1	144	150	PF00069	0.363
MOD_CK1_1	246	252	PF00069	0.358
MOD_CK1_1	268	274	PF00069	0.362
MOD_CK1_1	300	306	PF00069	0.316
MOD_CK1_1	397	403	PF00069	0.348
MOD_CK1_1	498	504	PF00069	0.470
MOD_CK1_1	74	80	PF00069	0.333
MOD_CK2_1	113	119	PF00069	0.313
MOD_CK2_1	131	137	PF00069	0.258
MOD_Cter_Amidation	119	122	PF01082	0.511
MOD_GlcNHglycan	133	136	PF01048	0.509
MOD_GlcNHglycan	200	203	PF01048	0.479
MOD_GlcNHglycan	207	210	PF01048	0.465
MOD_GlcNHglycan	213	216	PF01048	0.461
MOD_GlcNHglycan	218	221	PF01048	0.443
MOD_GlcNHglycan	222	225	PF01048	0.484
MOD_GlcNHglycan	245	248	PF01048	0.519
MOD_GlcNHglycan	45	48	PF01048	0.513
MOD_GSK3_1	156	163	PF00069	0.335
MOD_GSK3_1	205	212	PF00069	0.256
MOD_GSK3_1	216	223	PF00069	0.312
MOD_GSK3_1	236	243	PF00069	0.281
MOD_GSK3_1	268	275	PF00069	0.366
MOD_GSK3_1	315	322	PF00069	0.342
MOD_GSK3_1	360	367	PF00069	0.302
MOD_GSK3_1	389	396	PF00069	0.328
MOD_GSK3_1	452	459	PF00069	0.342
MOD_N-GLC_2	101	103	PF02516	0.479
MOD_N-GLC_2	104	106	PF02516	0.486
MOD_N-GLC_2	306	308	PF02516	0.496
MOD_N-GLC_2	412	414	PF02516	0.538
MOD_NEK2_1	11	16	PF00069	0.437
MOD_NEK2_1	157	162	PF00069	0.297
MOD_NEK2_1	195	200	PF00069	0.290
MOD_NEK2_1	452	457	PF00069	0.355
MOD_NEK2_1	466	471	PF00069	0.271
MOD_NEK2_1	495	500	PF00069	0.294
MOD_OFUCOSY	269	276	PF10250	0.556
MOD_OFUCOSY	72	78	PF10250	0.498
MOD_PIKK_1	141	147	PF00454	0.360
MOD_PIKK_1	24	30	PF00454	0.284
MOD_PIKK_1	274	280	PF00454	0.329
MOD_PIKK_1	306	312	PF00454	0.302
MOD_PIKK_1	400	406	PF00454	0.363
MOD_PIKK_1	472	478	PF00454	0.328
MOD_PK_1	124	130	PF00069	0.244
MOD_PKA_2	360	366	PF00069	0.310
MOD_Plk_1	376	382	PF00069	0.282
MOD_Plk_4	37	43	PF00069	0.363
MOD_Plk_4	484	490	PF00069	0.306
MOD_Plk_4	495	501	PF00069	0.231
MOD_ProDKin_1	16	22	PF00069	0.535
MOD_ProDKin_1	160	166	PF00069	0.246
MOD_ProDKin_1	315	321	PF00069	0.346
MOD_ProDKin_1	337	343	PF00069	0.339
MOD_ProDKin_1	397	403	PF00069	0.352
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.318
TRG_ENDOCYTIC_2	130	133	PF00928	0.322
TRG_ENDOCYTIC_2	283	286	PF00928	0.309
TRG_ENDOCYTIC_2	356	359	PF00928	0.321
TRG_ENDOCYTIC_2	471	474	PF00928	0.318
TRG_ER_diArg_1	1	4	PF00400	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJW6	Leishmania donovani	75%	71%
A4H3U2	Leishmania braziliensis	68%	93%
A4H3Y2	Leishmania braziliensis	34%	100%
A4HS13	Leishmania infantum	99%	100%
A4HS14	Leishmania infantum	74%	71%
E9AK00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AK01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	71%
Q03185	Giardia intestinalis	29%	76%
Q9XZX8	Leishmania major	93%	100%
Q9XZX9	Leishmania major	70%	71%