LeishMANIAdb
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TNFR-Cys domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TNFR-Cys domain-containing protein
Gene product:
hypothetical protein, conserved in leishmania
Species:
Leishmania donovani
UniProt:
A0A3S5H583_LEIDO
TriTrypDb:
LdBPK_040160.1 , LdCL_040006900 , LdCL_040007000 , LDHU3_04.0200
Length:
525

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 8
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A0A3S5H583
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H583

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 359 363 PF00656 0.398
CLV_C14_Caspase3-7 37 41 PF00656 0.325
CLV_PCSK_SKI1_1 34 38 PF00082 0.583
DEG_SPOP_SBC_1 457 461 PF00917 0.371
DOC_MAPK_FxFP_2 282 285 PF00069 0.366
DOC_PP4_FxxP_1 282 285 PF00568 0.366
DOC_USP7_MATH_1 110 114 PF00917 0.442
DOC_USP7_MATH_1 126 130 PF00917 0.291
DOC_USP7_MATH_1 137 141 PF00917 0.327
DOC_USP7_MATH_1 154 158 PF00917 0.471
DOC_USP7_MATH_1 224 228 PF00917 0.390
DOC_USP7_MATH_1 275 279 PF00917 0.414
DOC_USP7_MATH_1 319 323 PF00917 0.418
DOC_USP7_MATH_1 385 389 PF00917 0.435
DOC_USP7_MATH_1 470 474 PF00917 0.379
DOC_USP7_MATH_1 476 480 PF00917 0.366
DOC_USP7_MATH_1 79 83 PF00917 0.479
DOC_WW_Pin1_4 80 85 PF00397 0.527
LIG_14-3-3_CanoR_1 116 126 PF00244 0.431
LIG_14-3-3_CanoR_1 220 228 PF00244 0.326
LIG_14-3-3_CanoR_1 439 447 PF00244 0.478
LIG_14-3-3_CanoR_1 487 493 PF00244 0.416
LIG_14-3-3_CanoR_1 88 92 PF00244 0.471
LIG_BRCT_BRCA1_1 236 240 PF00533 0.402
LIG_FHA_1 119 125 PF00498 0.344
LIG_FHA_1 141 147 PF00498 0.418
LIG_FHA_1 158 164 PF00498 0.277
LIG_FHA_1 176 182 PF00498 0.336
LIG_FHA_1 31 37 PF00498 0.452
LIG_FHA_1 406 412 PF00498 0.357
LIG_FHA_1 45 51 PF00498 0.470
LIG_FHA_1 507 513 PF00498 0.452
LIG_FHA_1 59 65 PF00498 0.311
LIG_FHA_2 260 266 PF00498 0.346
LIG_FHA_2 284 290 PF00498 0.409
LIG_FHA_2 35 41 PF00498 0.501
LIG_FHA_2 357 363 PF00498 0.432
LIG_FHA_2 439 445 PF00498 0.344
LIG_LIR_Gen_1 44 52 PF02991 0.366
LIG_LIR_Gen_1 468 477 PF02991 0.320
LIG_LIR_Nem_3 132 136 PF02991 0.418
LIG_LIR_Nem_3 304 310 PF02991 0.435
LIG_LIR_Nem_3 40 46 PF02991 0.406
LIG_LIR_Nem_3 468 474 PF02991 0.317
LIG_PDZ_Class_2 520 525 PF00595 0.657
LIG_SH2_CRK 471 475 PF00017 0.312
LIG_SH2_SRC 269 272 PF00017 0.264
LIG_SH2_STAP1 46 50 PF00017 0.414
LIG_SH2_STAT5 269 272 PF00017 0.406
LIG_SH2_STAT5 46 49 PF00017 0.452
LIG_SH2_STAT5 471 474 PF00017 0.386
LIG_SH2_STAT5 490 493 PF00017 0.328
LIG_SH3_3 148 154 PF00018 0.457
LIG_SH3_3 407 413 PF00018 0.359
LIG_SUMO_SIM_anti_2 162 167 PF11976 0.411
LIG_SUMO_SIM_par_1 101 106 PF11976 0.271
LIG_SUMO_SIM_par_1 142 147 PF11976 0.405
LIG_SUMO_SIM_par_1 162 167 PF11976 0.220
LIG_SUMO_SIM_par_1 193 199 PF11976 0.299
LIG_SUMO_SIM_par_1 230 235 PF11976 0.391
LIG_SUMO_SIM_par_1 47 56 PF11976 0.429
LIG_TRAF2_2 413 418 PF00917 0.378
MOD_CK1_1 101 107 PF00069 0.331
MOD_CK1_1 140 146 PF00069 0.373
MOD_CK1_1 157 163 PF00069 0.449
MOD_CK1_1 167 173 PF00069 0.376
MOD_CK1_1 193 199 PF00069 0.385
MOD_CK1_1 257 263 PF00069 0.346
MOD_CK1_1 264 270 PF00069 0.337
MOD_CK1_1 283 289 PF00069 0.332
MOD_CK1_1 300 306 PF00069 0.304
MOD_CK1_1 356 362 PF00069 0.410
MOD_CK1_1 367 373 PF00069 0.429
MOD_CK1_1 39 45 PF00069 0.465
MOD_CK1_1 481 487 PF00069 0.468
MOD_CK1_1 53 59 PF00069 0.432
MOD_CK1_1 67 73 PF00069 0.372
MOD_CK1_1 82 88 PF00069 0.380
MOD_CK2_1 271 277 PF00069 0.400
MOD_CK2_1 283 289 PF00069 0.395
MOD_CK2_1 385 391 PF00069 0.440
MOD_GlcNHglycan 105 108 PF01048 0.625
MOD_GlcNHglycan 132 136 PF01048 0.587
MOD_GlcNHglycan 166 169 PF01048 0.622
MOD_GlcNHglycan 222 225 PF01048 0.531
MOD_GlcNHglycan 256 259 PF01048 0.570
MOD_GlcNHglycan 265 269 PF01048 0.648
MOD_GlcNHglycan 273 276 PF01048 0.537
MOD_GlcNHglycan 277 280 PF01048 0.569
MOD_GlcNHglycan 299 302 PF01048 0.603
MOD_GlcNHglycan 367 370 PF01048 0.700
MOD_GlcNHglycan 387 390 PF01048 0.596
MOD_GlcNHglycan 478 481 PF01048 0.667
MOD_GlcNHglycan 55 58 PF01048 0.648
MOD_GlcNHglycan 69 72 PF01048 0.574
MOD_GlcNHglycan 85 88 PF01048 0.536
MOD_GSK3_1 199 206 PF00069 0.403
MOD_GSK3_1 220 227 PF00069 0.328
MOD_GSK3_1 253 260 PF00069 0.366
MOD_GSK3_1 26 33 PF00069 0.564
MOD_GSK3_1 271 278 PF00069 0.435
MOD_GSK3_1 297 304 PF00069 0.375
MOD_GSK3_1 319 326 PF00069 0.425
MOD_GSK3_1 345 352 PF00069 0.380
MOD_GSK3_1 356 363 PF00069 0.327
MOD_GSK3_1 383 390 PF00069 0.495
MOD_GSK3_1 391 398 PF00069 0.378
MOD_GSK3_1 434 441 PF00069 0.465
MOD_GSK3_1 455 462 PF00069 0.429
MOD_GSK3_1 478 485 PF00069 0.406
MOD_GSK3_1 79 86 PF00069 0.452
MOD_GSK3_1 94 101 PF00069 0.281
MOD_N-GLC_1 140 145 PF02516 0.626
MOD_N-GLC_1 184 189 PF02516 0.524
MOD_N-GLC_2 438 440 PF02516 0.646
MOD_NEK2_1 131 136 PF00069 0.382
MOD_NEK2_1 184 189 PF00069 0.431
MOD_NEK2_1 254 259 PF00069 0.392
MOD_NEK2_1 297 302 PF00069 0.398
MOD_NEK2_1 310 315 PF00069 0.330
MOD_NEK2_1 327 332 PF00069 0.285
MOD_NEK2_1 406 411 PF00069 0.369
MOD_NEK2_1 50 55 PF00069 0.367
MOD_NEK2_1 64 69 PF00069 0.309
MOD_NEK2_1 93 98 PF00069 0.336
MOD_NEK2_2 126 131 PF00069 0.340
MOD_PIKK_1 196 202 PF00454 0.386
MOD_PIKK_1 360 366 PF00454 0.400
MOD_PIKK_1 64 70 PF00454 0.436
MOD_PKA_2 219 225 PF00069 0.334
MOD_PKA_2 438 444 PF00069 0.469
MOD_PKA_2 79 85 PF00069 0.505
MOD_PKA_2 87 93 PF00069 0.410
MOD_Plk_1 140 146 PF00069 0.447
MOD_Plk_1 184 190 PF00069 0.331
MOD_Plk_1 234 240 PF00069 0.360
MOD_Plk_1 264 270 PF00069 0.400
MOD_Plk_1 34 40 PF00069 0.464
MOD_Plk_1 44 50 PF00069 0.279
MOD_Plk_4 126 132 PF00069 0.432
MOD_Plk_4 140 146 PF00069 0.322
MOD_Plk_4 159 165 PF00069 0.350
MOD_Plk_4 190 196 PF00069 0.448
MOD_Plk_4 235 241 PF00069 0.320
MOD_Plk_4 303 309 PF00069 0.345
MOD_Plk_4 356 362 PF00069 0.453
MOD_Plk_4 406 412 PF00069 0.355
MOD_Plk_4 44 50 PF00069 0.350
MOD_Plk_4 98 104 PF00069 0.327
MOD_ProDKin_1 80 86 PF00069 0.525
TRG_ENDOCYTIC_2 46 49 PF00928 0.337
TRG_ENDOCYTIC_2 471 474 PF00928 0.317
TRG_NES_CRM1_1 128 139 PF08389 0.414

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P251 Leptomonas seymouri 22% 100%
A0A381M9M8 Leishmania infantum 98% 100%
A0A3S5H581 Leishmania donovani 100% 100%
A0A451EJW1 Leishmania donovani 99% 100%
A0A451EJW4 Leishmania donovani 100% 100%
A0A451EJW6 Leishmania donovani 22% 74%
A4H3T7 Leishmania braziliensis 75% 100%
A4H3T8 Leishmania braziliensis 69% 100%
A4H3T9 Leishmania braziliensis 69% 100%
A4H3U0 Leishmania braziliensis 67% 100%
A4H3U1 Leishmania braziliensis 67% 100%
A4HS14 Leishmania infantum 22% 74%
E9AJZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9AK01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 74%
Q9N852 Leishmania major 92% 100%
Q9N853 Leishmania major 91% 100%
Q9N856 Leishmania major 91% 100%
Q9XZX9 Leishmania major 24% 74%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS