Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H580_LEIDO

TriTrypDb:

LdBPK_040150.1 , LdCL_040006600 , LDHU3_04.0170

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H580

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H580

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.798
CLV_NRD_NRD_1	241	243	PF00675	0.703
CLV_NRD_NRD_1	267	269	PF00675	0.588
CLV_NRD_NRD_1	28	30	PF00675	0.722
CLV_NRD_NRD_1	420	422	PF00675	0.553
CLV_NRD_NRD_1	429	431	PF00675	0.625
CLV_PCSK_FUR_1	149	153	PF00082	0.760
CLV_PCSK_KEX2_1	151	153	PF00082	0.798
CLV_PCSK_KEX2_1	182	184	PF00082	0.737
CLV_PCSK_KEX2_1	267	269	PF00082	0.588
CLV_PCSK_KEX2_1	28	30	PF00082	0.722
CLV_PCSK_KEX2_1	420	422	PF00082	0.553
CLV_PCSK_KEX2_1	429	431	PF00082	0.625
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.702
CLV_PCSK_PC7_1	178	184	PF00082	0.697
CLV_PCSK_SKI1_1	226	230	PF00082	0.736
CLV_PCSK_SKI1_1	267	271	PF00082	0.686
CLV_PCSK_SKI1_1	28	32	PF00082	0.814
DEG_APCC_DBOX_1	266	274	PF00400	0.682
DEG_APCC_KENBOX_2	66	70	PF00400	0.641
DEG_Nend_Nbox_1	1	3	PF02207	0.717
DEG_SCF_FBW7_1	188	193	PF00400	0.749
DOC_MAPK_gen_1	314	323	PF00069	0.620
DOC_MAPK_gen_1	404	414	PF00069	0.629
DOC_MAPK_gen_1	420	426	PF00069	0.375
DOC_MAPK_MEF2A_6	197	205	PF00069	0.721
DOC_PP2B_PxIxI_1	200	206	PF00149	0.717
DOC_USP7_MATH_1	159	163	PF00917	0.708
DOC_USP7_MATH_1	176	180	PF00917	0.747
DOC_USP7_MATH_1	277	281	PF00917	0.679
DOC_USP7_MATH_1	344	348	PF00917	0.537
DOC_USP7_MATH_1	384	388	PF00917	0.619
DOC_USP7_MATH_2	190	196	PF00917	0.578
DOC_USP7_UBL2_3	67	71	PF12436	0.639
DOC_WW_Pin1_4	16	21	PF00397	0.696
DOC_WW_Pin1_4	186	191	PF00397	0.798
DOC_WW_Pin1_4	257	262	PF00397	0.648
LIG_14-3-3_CanoR_1	353	357	PF00244	0.735
LIG_14-3-3_CanoR_1	93	101	PF00244	0.691
LIG_Actin_WH2_2	213	228	PF00022	0.727
LIG_Actin_WH2_2	389	406	PF00022	0.618
LIG_BIR_III_2	21	25	PF00653	0.695
LIG_BRCT_BRCA1_1	168	172	PF00533	0.579
LIG_eIF4E_1	115	121	PF01652	0.670
LIG_FHA_1	13	19	PF00498	0.675
LIG_FHA_1	276	282	PF00498	0.598
LIG_FHA_1	388	394	PF00498	0.545
LIG_FHA_1	398	404	PF00498	0.529
LIG_FHA_2	100	106	PF00498	0.658
LIG_FHA_2	187	193	PF00498	0.830
LIG_FHA_2	52	58	PF00498	0.643
LIG_GBD_Chelix_1	281	289	PF00786	0.563
LIG_HCF-1_HBM_1	212	215	PF13415	0.598
LIG_LIR_Gen_1	110	121	PF02991	0.664
LIG_LIR_Nem_3	110	116	PF02991	0.548
LIG_LIR_Nem_3	367	372	PF02991	0.774
LIG_LIR_Nem_3	413	417	PF02991	0.453
LIG_SH2_CRK	328	332	PF00017	0.471
LIG_SH2_CRK	83	87	PF00017	0.608
LIG_SH2_STAT5	115	118	PF00017	0.491
LIG_SH2_STAT5	215	218	PF00017	0.734
LIG_SH2_STAT5	417	420	PF00017	0.492
LIG_SH2_STAT5	427	430	PF00017	0.654
LIG_SH3_3	329	335	PF00018	0.592
LIG_SH3_3	354	360	PF00018	0.725
LIG_SUMO_SIM_par_1	13	19	PF11976	0.679
LIG_TRAF2_1	209	212	PF00917	0.754
LIG_TYR_ITIM	81	86	PF00017	0.581
MOD_CK1_1	193	199	PF00069	0.760
MOD_CK1_1	204	210	PF00069	0.679
MOD_CK1_1	302	308	PF00069	0.656
MOD_CK1_1	348	354	PF00069	0.663
MOD_CK1_1	387	393	PF00069	0.553
MOD_CK2_1	126	132	PF00069	0.689
MOD_CK2_1	186	192	PF00069	0.765
MOD_CK2_1	252	258	PF00069	0.726
MOD_CK2_1	51	57	PF00069	0.639
MOD_GlcNHglycan	161	164	PF01048	0.747
MOD_GlcNHglycan	226	229	PF01048	0.747
MOD_GlcNHglycan	34	37	PF01048	0.777
MOD_GlcNHglycan	350	353	PF01048	0.782
MOD_GlcNHglycan	360	363	PF01048	0.623
MOD_GlcNHglycan	49	52	PF01048	0.403
MOD_GSK3_1	12	19	PF00069	0.700
MOD_GSK3_1	134	141	PF00069	0.687
MOD_GSK3_1	174	181	PF00069	0.747
MOD_GSK3_1	186	193	PF00069	0.780
MOD_GSK3_1	20	27	PF00069	0.699
MOD_GSK3_1	234	241	PF00069	0.768
MOD_GSK3_1	28	35	PF00069	0.719
MOD_GSK3_1	344	351	PF00069	0.620
MOD_GSK3_1	383	390	PF00069	0.707
MOD_GSK3_1	47	54	PF00069	0.376
MOD_N-GLC_1	24	29	PF02516	0.707
MOD_N-GLC_1	348	353	PF02516	0.654
MOD_NEK2_1	232	237	PF00069	0.781
MOD_NEK2_1	370	375	PF00069	0.683
MOD_NEK2_1	47	52	PF00069	0.447
MOD_NEK2_1	85	90	PF00069	0.588
MOD_NEK2_2	51	56	PF00069	0.528
MOD_PIKK_1	85	91	PF00454	0.600
MOD_PIKK_1	92	98	PF00454	0.610
MOD_PKA_1	28	34	PF00069	0.639
MOD_PKA_2	137	143	PF00069	0.711
MOD_PKA_2	150	156	PF00069	0.744
MOD_PKA_2	275	281	PF00069	0.679
MOD_PKA_2	28	34	PF00069	0.639
MOD_PKA_2	302	308	PF00069	0.686
MOD_PKA_2	345	351	PF00069	0.621
MOD_PKA_2	352	358	PF00069	0.718
MOD_PKA_2	428	434	PF00069	0.737
MOD_PKA_2	92	98	PF00069	0.683
MOD_PKA_2	99	105	PF00069	0.705
MOD_PKB_1	59	67	PF00069	0.676
MOD_Plk_2-3	252	258	PF00069	0.690
MOD_Plk_4	12	18	PF00069	0.674
MOD_Plk_4	277	283	PF00069	0.582
MOD_Plk_4	285	291	PF00069	0.499
MOD_Plk_4	389	395	PF00069	0.630
MOD_ProDKin_1	16	22	PF00069	0.697
MOD_ProDKin_1	186	192	PF00069	0.802
MOD_ProDKin_1	257	263	PF00069	0.640
TRG_DiLeu_BaEn_4	211	217	PF01217	0.636
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.598
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.679
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.573
TRG_ENDOCYTIC_2	328	331	PF00928	0.469
TRG_ENDOCYTIC_2	83	86	PF00928	0.560
TRG_ER_diArg_1	143	146	PF00400	0.819
TRG_ER_diArg_1	149	152	PF00400	0.806
TRG_ER_diArg_1	267	269	PF00400	0.580
TRG_ER_diArg_1	420	422	PF00400	0.544
TRG_ER_diArg_1	429	432	PF00400	0.616
TRG_ER_FFAT_2	169	177	PF00635	0.587
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVL6	Leptomonas seymouri	35%	100%
A4H3T5	Leishmania braziliensis	61%	100%
A4HS10	Leishmania infantum	99%	100%
E9ACP7	Leishmania major	89%	100%
E9AJZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%