Exosome_complex_exonuclease_RRP40_putative/GeneDB:LmjF.04.0120

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome complex exonuclease RRP40, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H578_LEIDO

TriTrypDb:

LdBPK_040130.1 , LdCL_040006400 , LDHU3_04.0150

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1905354	exoribonuclease complex	3	12
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S5H578

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H578

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071034	CUT catabolic process	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071043	CUT metabolic process	7	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:0106354	tRNA surveillance	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	8
GO:0004527	exonuclease activity	5	8
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.305
CLV_NRD_NRD_1	212	214	PF00675	0.312
CLV_NRD_NRD_1	239	241	PF00675	0.326
CLV_NRD_NRD_1	269	271	PF00675	0.380
CLV_NRD_NRD_1	67	69	PF00675	0.484
CLV_NRD_NRD_1	82	84	PF00675	0.388
CLV_PCSK_KEX2_1	195	197	PF00082	0.332
CLV_PCSK_KEX2_1	239	241	PF00082	0.326
CLV_PCSK_KEX2_1	269	271	PF00082	0.380
CLV_PCSK_KEX2_1	67	69	PF00082	0.484
CLV_PCSK_SKI1_1	196	200	PF00082	0.265
DEG_SCF_FBW7_1	197	203	PF00400	0.466
DOC_CKS1_1	197	202	PF01111	0.507
DOC_CKS1_1	61	66	PF01111	0.577
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.520
DOC_MAPK_gen_1	239	247	PF00069	0.520
DOC_MAPK_HePTP_8	237	249	PF00069	0.453
DOC_MAPK_MEF2A_6	240	249	PF00069	0.453
DOC_MAPK_MEF2A_6	72	80	PF00069	0.360
DOC_PP2B_LxvP_1	187	190	PF13499	0.520
DOC_USP7_MATH_1	132	136	PF00917	0.490
DOC_USP7_MATH_1	200	204	PF00917	0.526
DOC_USP7_MATH_1	273	277	PF00917	0.437
DOC_WW_Pin1_4	196	201	PF00397	0.541
DOC_WW_Pin1_4	20	25	PF00397	0.546
DOC_WW_Pin1_4	60	65	PF00397	0.545
LIG_14-3-3_CanoR_1	131	137	PF00244	0.637
LIG_14-3-3_CanoR_1	269	273	PF00244	0.376
LIG_14-3-3_CanoR_1	58	62	PF00244	0.422
LIG_14-3-3_CanoR_1	83	91	PF00244	0.433
LIG_BRCT_BRCA1_1	145	149	PF00533	0.576
LIG_deltaCOP1_diTrp_1	170	178	PF00928	0.396
LIG_FHA_1	150	156	PF00498	0.490
LIG_FHA_1	269	275	PF00498	0.363
LIG_FHA_2	149	155	PF00498	0.564
LIG_FHA_2	158	164	PF00498	0.372
LIG_FHA_2	170	176	PF00498	0.371
LIG_FHA_2	216	222	PF00498	0.512
LIG_FHA_2	284	290	PF00498	0.363
LIG_LIR_Gen_1	122	132	PF02991	0.363
LIG_LIR_Nem_3	122	128	PF02991	0.332
LIG_LIR_Nem_3	175	181	PF02991	0.360
LIG_NRBOX	232	238	PF00104	0.439
LIG_SH2_CRK	125	129	PF00017	0.331
LIG_SH2_CRK	59	63	PF00017	0.557
LIG_SH2_CRK	91	95	PF00017	0.426
LIG_SH2_NCK_1	59	63	PF00017	0.531
LIG_SH2_PTP2	127	130	PF00017	0.467
LIG_SH2_STAT3	232	235	PF00017	0.524
LIG_SH2_STAT5	125	128	PF00017	0.399
LIG_SH2_STAT5	136	139	PF00017	0.610
LIG_SH2_STAT5	193	196	PF00017	0.524
LIG_SH2_STAT5	232	235	PF00017	0.524
LIG_SH2_STAT5	297	300	PF00017	0.401
LIG_SH2_STAT5	41	44	PF00017	0.518
LIG_SH2_STAT5	59	62	PF00017	0.314
LIG_SH2_STAT5	69	72	PF00017	0.397
LIG_SH2_STAT5	91	94	PF00017	0.324
LIG_SH3_3	110	116	PF00018	0.502
LIG_SH3_3	161	167	PF00018	0.473
LIG_SH3_3	293	299	PF00018	0.412
LIG_SH3_3	58	64	PF00018	0.499
LIG_SUMO_SIM_par_1	270	276	PF11976	0.474
LIG_TYR_ITIM	123	128	PF00017	0.324
MOD_CDC14_SPxK_1	204	207	PF00782	0.512
MOD_CDK_SPxK_1	201	207	PF00069	0.512
MOD_CDK_SPxxK_3	60	67	PF00069	0.579
MOD_CK1_1	143	149	PF00069	0.632
MOD_CK1_1	276	282	PF00069	0.457
MOD_CK2_1	148	154	PF00069	0.600
MOD_CK2_1	157	163	PF00069	0.372
MOD_CK2_1	169	175	PF00069	0.389
MOD_CK2_1	215	221	PF00069	0.469
MOD_CK2_1	283	289	PF00069	0.394
MOD_Cter_Amidation	237	240	PF01082	0.320
MOD_GlcNHglycan	172	175	PF01048	0.476
MOD_GlcNHglycan	208	211	PF01048	0.336
MOD_GlcNHglycan	96	99	PF01048	0.467
MOD_GSK3_1	196	203	PF00069	0.489
MOD_GSK3_1	257	264	PF00069	0.508
MOD_GSK3_1	268	275	PF00069	0.496
MOD_GSK3_1	27	34	PF00069	0.567
MOD_GSK3_1	41	48	PF00069	0.388
MOD_NEK2_1	45	50	PF00069	0.504
MOD_PIKK_1	27	33	PF00454	0.672
MOD_PIKK_1	83	89	PF00454	0.498
MOD_PKA_1	83	89	PF00069	0.417
MOD_PKA_2	268	274	PF00069	0.376
MOD_PKA_2	46	52	PF00069	0.482
MOD_PKA_2	57	63	PF00069	0.353
MOD_Plk_4	132	138	PF00069	0.622
MOD_Plk_4	228	234	PF00069	0.463
MOD_ProDKin_1	196	202	PF00069	0.541
MOD_ProDKin_1	20	26	PF00069	0.549
MOD_ProDKin_1	60	66	PF00069	0.545
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.545
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.547
TRG_ENDOCYTIC_2	125	128	PF00928	0.307
TRG_ENDOCYTIC_2	91	94	PF00928	0.441
TRG_ER_diArg_1	115	118	PF00400	0.360
TRG_ER_diArg_1	194	196	PF00400	0.532
TRG_ER_diArg_1	239	241	PF00400	0.521
TRG_ER_diArg_1	67	69	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B7	Leptomonas seymouri	72%	91%
A0A0S4IMH2	Bodo saltans	39%	100%
A0A1X0NL22	Trypanosomatidae	47%	99%
A0A422NN72	Trypanosoma rangeli	47%	100%
A4H3T3	Leishmania braziliensis	86%	100%
A4HS08	Leishmania infantum	99%	100%
C9ZY06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9AJZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q08285	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q9N857	Leishmania major	95%	100%
V5BI90	Trypanosoma cruzi	46%	100%