Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H577_LEIDO

TriTrypDb:

LdBPK_040120.1 , LdCL_040006300 , LDHU3_04.0140

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H577

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H577

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.624
CLV_C14_Caspase3-7	136	140	PF00656	0.379
CLV_C14_Caspase3-7	58	62	PF00656	0.544
CLV_NRD_NRD_1	125	127	PF00675	0.564
CLV_NRD_NRD_1	215	217	PF00675	0.594
CLV_NRD_NRD_1	337	339	PF00675	0.577
CLV_PCSK_KEX2_1	125	127	PF00082	0.564
CLV_PCSK_KEX2_1	215	217	PF00082	0.594
CLV_PCSK_KEX2_1	337	339	PF00082	0.583
CLV_PCSK_KEX2_1	87	89	PF00082	0.484
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.570
CLV_PCSK_PC7_1	211	217	PF00082	0.567
CLV_PCSK_SKI1_1	117	121	PF00082	0.522
CLV_PCSK_SKI1_1	125	129	PF00082	0.422
CLV_PCSK_SKI1_1	138	142	PF00082	0.461
CLV_PCSK_SKI1_1	145	149	PF00082	0.334
CLV_PCSK_SKI1_1	215	219	PF00082	0.608
CLV_PCSK_SKI1_1	273	277	PF00082	0.694
CLV_PCSK_SKI1_1	325	329	PF00082	0.578
CLV_PCSK_SKI1_1	80	84	PF00082	0.517
DEG_APCC_DBOX_1	124	132	PF00400	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.574
DOC_CKS1_1	219	224	PF01111	0.634
DOC_CKS1_1	265	270	PF01111	0.689
DOC_CKS1_1	281	286	PF01111	0.495
DOC_MAPK_gen_1	125	133	PF00069	0.471
DOC_MAPK_RevD_3	202	216	PF00069	0.639
DOC_USP7_MATH_1	279	283	PF00917	0.595
DOC_USP7_MATH_1	301	305	PF00917	0.651
DOC_USP7_MATH_1	47	51	PF00917	0.401
DOC_WW_Pin1_4	195	200	PF00397	0.737
DOC_WW_Pin1_4	218	223	PF00397	0.644
DOC_WW_Pin1_4	264	269	PF00397	0.653
DOC_WW_Pin1_4	280	285	PF00397	0.726
DOC_WW_Pin1_4	297	302	PF00397	0.700
DOC_WW_Pin1_4	316	321	PF00397	0.709
LIG_14-3-3_CanoR_1	11	19	PF00244	0.742
LIG_14-3-3_CanoR_1	273	278	PF00244	0.692
LIG_Clathr_ClatBox_1	18	22	PF01394	0.466
LIG_eIF4E_1	207	213	PF01652	0.632
LIG_FHA_1	1	7	PF00498	0.626
LIG_FHA_1	195	201	PF00498	0.594
LIG_FHA_1	225	231	PF00498	0.528
LIG_FHA_1	276	282	PF00498	0.611
LIG_FHA_2	10	16	PF00498	0.629
LIG_FHA_2	132	138	PF00498	0.446
LIG_FHA_2	166	172	PF00498	0.468
LIG_FHA_2	18	24	PF00498	0.527
LIG_FHA_2	308	314	PF00498	0.739
LIG_FHA_2	81	87	PF00498	0.468
LIG_Integrin_RGD_1	258	260	PF01839	0.662
LIG_LIR_Gen_1	146	157	PF02991	0.554
LIG_LIR_Nem_3	146	152	PF02991	0.585
LIG_NRBOX	127	133	PF00104	0.529
LIG_SH2_CRK	214	218	PF00017	0.595
LIG_SH2_SRC	207	210	PF00017	0.634
LIG_SH2_SRC	59	62	PF00017	0.542
LIG_SH2_STAP1	59	63	PF00017	0.423
LIG_SH3_1	216	222	PF00018	0.578
LIG_SH3_2	206	211	PF14604	0.630
LIG_SH3_3	203	209	PF00018	0.645
LIG_SH3_3	216	222	PF00018	0.514
LIG_SH3_3	262	268	PF00018	0.810
LIG_SH3_3	278	284	PF00018	0.549
LIG_SH3_3	314	320	PF00018	0.583
LIG_SH3_3	43	49	PF00018	0.442
LIG_Sin3_3	53	60	PF02671	0.550
LIG_SUMO_SIM_anti_2	61	68	PF11976	0.448
LIG_SUMO_SIM_par_1	17	23	PF11976	0.527
LIG_SUMO_SIM_par_1	42	48	PF11976	0.436
LIG_TRAF2_1	119	122	PF00917	0.454
LIG_TRAF2_1	134	137	PF00917	0.441
LIG_TRAF2_1	168	171	PF00917	0.595
LIG_TRAF2_1	20	23	PF00917	0.671
LIG_TRAF2_1	83	86	PF00917	0.432
LIG_TYR_ITIM	212	217	PF00017	0.646
LIG_UBA3_1	326	334	PF00899	0.577
MOD_CDK_SPK_2	266	271	PF00069	0.722
MOD_CDK_SPxK_1	297	303	PF00069	0.644
MOD_CDK_SPxxK_3	264	271	PF00069	0.642
MOD_CDK_SPxxK_3	316	323	PF00069	0.693
MOD_CK1_1	112	118	PF00069	0.592
MOD_CK1_1	14	20	PF00069	0.536
MOD_CK1_1	269	275	PF00069	0.730
MOD_CK2_1	131	137	PF00069	0.448
MOD_CK2_1	165	171	PF00069	0.600
MOD_CK2_1	17	23	PF00069	0.583
MOD_CK2_1	241	247	PF00069	0.605
MOD_CK2_1	26	32	PF00069	0.404
MOD_CK2_1	307	313	PF00069	0.741
MOD_CK2_1	80	86	PF00069	0.531
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.623
MOD_GlcNHglycan	181	184	PF01048	0.620
MOD_GlcNHglycan	188	191	PF01048	0.511
MOD_GlcNHglycan	307	310	PF01048	0.772
MOD_GlcNHglycan	48	52	PF01048	0.426
MOD_GSK3_1	105	112	PF00069	0.535
MOD_GSK3_1	269	276	PF00069	0.645
MOD_GSK3_1	289	296	PF00069	0.801
MOD_GSK3_1	297	304	PF00069	0.659
MOD_N-GLC_1	289	294	PF02516	0.693
MOD_N-GLC_1	305	310	PF02516	0.607
MOD_NEK2_1	194	199	PF00069	0.670
MOD_NEK2_1	2	7	PF00069	0.544
MOD_NEK2_1	293	298	PF00069	0.607
MOD_PIKK_1	131	137	PF00454	0.585
MOD_PIKK_1	307	313	PF00454	0.696
MOD_PK_1	241	247	PF00069	0.528
MOD_PKA_2	113	119	PF00069	0.553
MOD_PKA_2	302	308	PF00069	0.679
MOD_PKB_1	271	279	PF00069	0.661
MOD_Plk_1	14	20	PF00069	0.587
MOD_Plk_1	143	149	PF00069	0.562
MOD_Plk_1	289	295	PF00069	0.683
MOD_Plk_4	14	20	PF00069	0.539
MOD_Plk_4	226	232	PF00069	0.528
MOD_Plk_4	59	65	PF00069	0.474
MOD_ProDKin_1	195	201	PF00069	0.736
MOD_ProDKin_1	218	224	PF00069	0.637
MOD_ProDKin_1	264	270	PF00069	0.650
MOD_ProDKin_1	280	286	PF00069	0.720
MOD_ProDKin_1	297	303	PF00069	0.702
MOD_ProDKin_1	316	322	PF00069	0.697
MOD_SUMO_rev_2	331	336	PF00179	0.526
TRG_DiLeu_BaEn_1	123	128	PF01217	0.499
TRG_DiLeu_BaEn_4	136	142	PF01217	0.420
TRG_DiLeu_BaEn_4	331	337	PF01217	0.532
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.630
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.550
TRG_DiLeu_LyEn_5	123	128	PF01217	0.499
TRG_ENDOCYTIC_2	214	217	PF00928	0.599
TRG_ER_diArg_1	125	127	PF00400	0.578
TRG_ER_diArg_1	214	216	PF00400	0.602
TRG_ER_diArg_1	255	258	PF00400	0.646
TRG_ER_diArg_1	270	273	PF00400	0.721
TRG_ER_diArg_1	322	325	PF00400	0.588
TRG_ER_diArg_1	336	338	PF00400	0.569
TRG_ER_diArg_1	52	55	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB32	Leptomonas seymouri	47%	96%
A4H3T2	Leishmania braziliensis	74%	100%
A4HS07	Leishmania infantum	100%	100%
E9AJZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q9GRM8	Leishmania major	92%	100%