Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H575_LEIDO

TriTrypDb:

LdBPK_040090.1 , LdCL_040006000 , LDHU3_04.0110

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H575

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H575

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.611
CLV_NRD_NRD_1	16	18	PF00675	0.491
CLV_NRD_NRD_1	2	4	PF00675	0.664
CLV_NRD_NRD_1	71	73	PF00675	0.498
CLV_PCSK_KEX2_1	16	18	PF00082	0.491
CLV_PCSK_KEX2_1	2	4	PF00082	0.664
CLV_PCSK_KEX2_1	71	73	PF00082	0.498
CLV_PCSK_SKI1_1	16	20	PF00082	0.474
CLV_PCSK_SKI1_1	3	7	PF00082	0.562
CLV_PCSK_SKI1_1	42	46	PF00082	0.496
CLV_PCSK_SKI1_1	61	65	PF00082	0.488
DEG_APCC_DBOX_1	106	114	PF00400	0.494
DEG_APCC_DBOX_1	60	68	PF00400	0.497
DEG_APCC_DBOX_1	71	79	PF00400	0.383
DEG_Nend_UBRbox_1	1	4	PF02207	0.640
DEG_SCF_FBW7_2	75	80	PF00400	0.432
DEG_SPOP_SBC_1	46	50	PF00917	0.555
DOC_MAPK_MEF2A_6	61	69	PF00069	0.494
DOC_USP7_MATH_1	10	14	PF00917	0.563
DOC_USP7_MATH_1	137	141	PF00917	0.699
DOC_USP7_MATH_1	147	151	PF00917	0.571
DOC_WW_Pin1_4	3	8	PF00397	0.562
DOC_WW_Pin1_4	73	78	PF00397	0.425
LIG_14-3-3_CanoR_1	16	22	PF00244	0.711
LIG_FHA_1	74	80	PF00498	0.378
LIG_FHA_2	34	40	PF00498	0.608
LIG_FHA_2	54	60	PF00498	0.393
LIG_LIR_Nem_3	13	18	PF02991	0.588
LIG_LIR_Nem_3	57	63	PF02991	0.582
LIG_NRBOX	63	69	PF00104	0.492
LIG_PDZ_Class_2	153	158	PF00595	0.643
LIG_SH2_CRK	60	64	PF00017	0.574
LIG_SH3_3	126	132	PF00018	0.518
LIG_SH3_3	49	55	PF00018	0.596
MOD_LATS_1	99	105	PF00433	0.496
MOD_N-GLC_1	27	32	PF02516	0.622
MOD_NEK2_1	45	50	PF00069	0.469
MOD_PKA_1	16	22	PF00069	0.623
MOD_PKA_1	71	77	PF00069	0.488
MOD_PKA_2	16	22	PF00069	0.686
MOD_PKA_2	71	77	PF00069	0.488
MOD_Plk_1	101	107	PF00069	0.607
MOD_Plk_1	120	126	PF00069	0.348
MOD_Plk_1	138	144	PF00069	0.574
MOD_Plk_2-3	102	108	PF00069	0.416
MOD_ProDKin_1	3	9	PF00069	0.560
MOD_ProDKin_1	73	79	PF00069	0.427
MOD_SUMO_rev_2	85	93	PF00179	0.504
TRG_DiLeu_BaEn_3	151	157	PF01217	0.560
TRG_ENDOCYTIC_2	60	63	PF00928	0.575
TRG_ER_diArg_1	1	3	PF00400	0.678
TRG_ER_diArg_1	122	125	PF00400	0.516
TRG_ER_diArg_1	15	17	PF00400	0.494
TRG_ER_diArg_1	70	72	PF00400	0.493
TRG_NES_CRM1_1	73	88	PF08389	0.445
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3S9	Leishmania braziliensis	72%	97%
A4HE83	Leishmania braziliensis	61%	100%
A4HS04	Leishmania infantum	98%	100%
E9AJZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q9BLQ6	Leishmania major	90%	100%