Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H573_LEIDO

TriTrypDb:

LdBPK_040060.1 , LdCL_040005700 , LDHU3_04.0080

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H573

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H573

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.791
CLV_NRD_NRD_1	208	210	PF00675	0.555
CLV_NRD_NRD_1	232	234	PF00675	0.478
CLV_NRD_NRD_1	311	313	PF00675	0.679
CLV_NRD_NRD_1	325	327	PF00675	0.738
CLV_NRD_NRD_1	462	464	PF00675	0.562
CLV_NRD_NRD_1	505	507	PF00675	0.675
CLV_PCSK_KEX2_1	231	233	PF00082	0.534
CLV_PCSK_KEX2_1	311	313	PF00082	0.679
CLV_PCSK_KEX2_1	324	326	PF00082	0.737
CLV_PCSK_KEX2_1	450	452	PF00082	0.606
CLV_PCSK_KEX2_1	462	464	PF00082	0.480
CLV_PCSK_KEX2_1	505	507	PF00082	0.675
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.534
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.606
CLV_PCSK_SKI1_1	147	151	PF00082	0.685
CLV_PCSK_SKI1_1	210	214	PF00082	0.437
CLV_PCSK_SKI1_1	381	385	PF00082	0.531
DEG_APCC_DBOX_1	425	433	PF00400	0.559
DEG_Nend_UBRbox_1	1	4	PF02207	0.698
DOC_CKS1_1	185	190	PF01111	0.596
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.583
DOC_MAPK_gen_1	162	172	PF00069	0.671
DOC_MAPK_gen_1	426	434	PF00069	0.639
DOC_USP7_MATH_1	215	219	PF00917	0.541
DOC_USP7_MATH_1	490	494	PF00917	0.660
DOC_USP7_MATH_1	516	520	PF00917	0.787
DOC_USP7_MATH_1	95	99	PF00917	0.746
DOC_USP7_MATH_2	29	35	PF00917	0.710
DOC_USP7_UBL2_3	137	141	PF12436	0.744
DOC_USP7_UBL2_3	165	169	PF12436	0.668
DOC_USP7_UBL2_3	241	245	PF12436	0.572
DOC_USP7_UBL2_3	443	447	PF12436	0.572
DOC_WW_Pin1_4	184	189	PF00397	0.617
DOC_WW_Pin1_4	21	26	PF00397	0.791
DOC_WW_Pin1_4	324	329	PF00397	0.718
DOC_WW_Pin1_4	344	349	PF00397	0.699
DOC_WW_Pin1_4	65	70	PF00397	0.614
LIG_14-3-3_CanoR_1	2	8	PF00244	0.732
LIG_14-3-3_CanoR_1	225	230	PF00244	0.517
LIG_14-3-3_CanoR_1	311	316	PF00244	0.634
LIG_14-3-3_CanoR_1	350	354	PF00244	0.691
LIG_14-3-3_CanoR_1	381	390	PF00244	0.534
LIG_14-3-3_CanoR_1	505	512	PF00244	0.663
LIG_APCC_ABBAyCdc20_2	10	16	PF00400	0.649
LIG_APCC_ABBAyCdc20_2	415	421	PF00400	0.514
LIG_BRCT_BRCA1_1	507	511	PF00533	0.675
LIG_Clathr_ClatBox_1	417	421	PF01394	0.530
LIG_FHA_1	2	8	PF00498	0.685
LIG_FHA_2	382	388	PF00498	0.533
LIG_FHA_2	66	72	PF00498	0.619
LIG_IBAR_NPY_1	489	491	PF08397	0.712
LIG_LIR_Gen_1	488	499	PF02991	0.610
LIG_LIR_Nem_3	223	229	PF02991	0.525
LIG_LIR_Nem_3	488	494	PF02991	0.599
LIG_SH2_CRK	491	495	PF00017	0.635
LIG_SH2_STAP1	373	377	PF00017	0.529
LIG_SH2_STAP1	491	495	PF00017	0.635
LIG_SH3_2	69	74	PF14604	0.607
LIG_SH3_3	176	182	PF00018	0.695
LIG_SH3_3	360	366	PF00018	0.669
LIG_SH3_3	39	45	PF00018	0.679
LIG_SH3_3	66	72	PF00018	0.611
LIG_SH3_4	165	172	PF00018	0.690
LIG_SH3_4	241	248	PF00018	0.571
LIG_SUMO_SIM_par_1	386	393	PF11976	0.558
LIG_TRAF2_1	267	270	PF00917	0.730
LIG_TRAF2_1	520	523	PF00917	0.615
LIG_TRAF2_1	89	92	PF00917	0.790
LIG_TRAF2_2	512	517	PF00917	0.682
LIG_TRFH_1	33	37	PF08558	0.702
LIG_WW_3	327	331	PF00397	0.709
MOD_CDC14_SPxK_1	327	330	PF00782	0.710
MOD_CDC14_SPxK_1	347	350	PF00782	0.585
MOD_CDK_SPK_2	184	189	PF00069	0.617
MOD_CDK_SPK_2	65	70	PF00069	0.614
MOD_CDK_SPxK_1	324	330	PF00069	0.719
MOD_CDK_SPxK_1	344	350	PF00069	0.703
MOD_CK1_1	338	344	PF00069	0.763
MOD_CK1_1	352	358	PF00069	0.610
MOD_CK1_1	46	52	PF00069	0.738
MOD_CK1_1	500	506	PF00069	0.774
MOD_CK1_1	510	516	PF00069	0.766
MOD_CK2_1	373	379	PF00069	0.572
MOD_CK2_1	381	387	PF00069	0.482
MOD_CK2_1	47	53	PF00069	0.775
MOD_CK2_1	474	480	PF00069	0.569
MOD_CK2_1	523	529	PF00069	0.726
MOD_CK2_1	86	92	PF00069	0.724
MOD_Cter_Amidation	322	325	PF01082	0.683
MOD_GlcNHglycan	156	160	PF01048	0.657
MOD_GlcNHglycan	258	261	PF01048	0.609
MOD_GlcNHglycan	316	319	PF01048	0.678
MOD_GlcNHglycan	367	370	PF01048	0.603
MOD_GlcNHglycan	373	376	PF01048	0.627
MOD_GlcNHglycan	499	502	PF01048	0.639
MOD_GlcNHglycan	517	521	PF01048	0.710
MOD_GSK3_1	151	158	PF00069	0.531
MOD_GSK3_1	314	321	PF00069	0.743
MOD_GSK3_1	338	345	PF00069	0.746
MOD_GSK3_1	349	356	PF00069	0.682
MOD_GSK3_1	373	380	PF00069	0.541
MOD_GSK3_1	43	50	PF00069	0.730
MOD_GSK3_1	497	504	PF00069	0.665
MOD_GSK3_1	506	513	PF00069	0.717
MOD_GSK3_1	518	525	PF00069	0.704
MOD_GSK3_1	73	80	PF00069	0.734
MOD_N-GLC_1	21	26	PF02516	0.752
MOD_N-GLC_1	353	358	PF02516	0.737
MOD_N-GLC_1	65	70	PF02516	0.614
MOD_NEK2_1	353	358	PF00069	0.709
MOD_NEK2_2	244	249	PF00069	0.539
MOD_NEK2_2	335	340	PF00069	0.711
MOD_PIKK_1	381	387	PF00454	0.503
MOD_PIKK_1	401	407	PF00454	0.438
MOD_PIKK_1	510	516	PF00454	0.763
MOD_PIKK_1	518	524	PF00454	0.695
MOD_PKA_1	140	146	PF00069	0.735
MOD_PKA_1	311	317	PF00069	0.629
MOD_PKA_1	505	511	PF00069	0.668
MOD_PKA_2	1	7	PF00069	0.720
MOD_PKA_2	311	317	PF00069	0.714
MOD_PKA_2	349	355	PF00069	0.743
MOD_PKA_2	359	365	PF00069	0.743
MOD_PKA_2	504	510	PF00069	0.691
MOD_Plk_1	353	359	PF00069	0.697
MOD_Plk_2-3	31	37	PF00069	0.758
MOD_Plk_2-3	48	54	PF00069	0.524
MOD_Plk_2-3	523	529	PF00069	0.681
MOD_Plk_2-3	86	92	PF00069	0.669
MOD_Plk_4	373	379	PF00069	0.559
MOD_Plk_4	490	496	PF00069	0.592
MOD_ProDKin_1	184	190	PF00069	0.606
MOD_ProDKin_1	21	27	PF00069	0.791
MOD_ProDKin_1	324	330	PF00069	0.719
MOD_ProDKin_1	344	350	PF00069	0.703
MOD_ProDKin_1	65	71	PF00069	0.615
MOD_SUMO_for_1	37	40	PF00179	0.598
MOD_SUMO_rev_2	143	152	PF00179	0.700
MOD_SUMO_rev_2	202	212	PF00179	0.541
MOD_SUMO_rev_2	31	39	PF00179	0.606
TRG_DiLeu_BaEn_1	413	418	PF01217	0.538
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.562
TRG_ENDOCYTIC_2	491	494	PF00928	0.712
TRG_ER_diArg_1	324	326	PF00400	0.670
TRG_NES_CRM1_1	423	435	PF08389	0.559
TRG_NLS_MonoCore_2	161	166	PF00514	0.683
TRG_NLS_MonoExtC_3	161	166	PF00514	0.661
TRG_NLS_MonoExtN_4	137	143	PF00514	0.706
TRG_NLS_MonoExtN_4	161	167	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.746
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	422	427	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAY3	Leptomonas seymouri	45%	100%
A4H3S6	Leishmania braziliensis	58%	100%
A4HS01	Leishmania infantum	99%	100%
E9AJY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q95Z90	Leishmania major	88%	97%