cAMP-specific phosphodiesterase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP-specific phosphodiesterase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H571_LEIDO

TriTrypDb:

LdBPK_040030.1 , LdCL_040005300 , LDHU3_04.0040

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H571

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H571

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	12
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.435
CLV_C14_Caspase3-7	436	440	PF00656	0.612
CLV_C14_Caspase3-7	649	653	PF00656	0.477
CLV_NRD_NRD_1	187	189	PF00675	0.503
CLV_NRD_NRD_1	482	484	PF00675	0.582
CLV_NRD_NRD_1	598	600	PF00675	0.541
CLV_PCSK_KEX2_1	525	527	PF00082	0.748
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.709
CLV_PCSK_SKI1_1	114	118	PF00082	0.510
CLV_PCSK_SKI1_1	157	161	PF00082	0.359
CLV_PCSK_SKI1_1	188	192	PF00082	0.497
CLV_PCSK_SKI1_1	306	310	PF00082	0.344
CLV_PCSK_SKI1_1	413	417	PF00082	0.482
CLV_PCSK_SKI1_1	473	477	PF00082	0.548
CLV_PCSK_SKI1_1	526	530	PF00082	0.560
DEG_APCC_DBOX_1	388	396	PF00400	0.475
DEG_SPOP_SBC_1	95	99	PF00917	0.696
DOC_AGCK_PIF_1	167	172	PF00069	0.380
DOC_CKS1_1	290	295	PF01111	0.398
DOC_CYCLIN_RxL_1	182	192	PF00134	0.441
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.628
DOC_MAPK_gen_1	155	162	PF00069	0.419
DOC_MAPK_MEF2A_6	155	162	PF00069	0.446
DOC_MAPK_MEF2A_6	385	392	PF00069	0.398
DOC_MAPK_MEF2A_6	714	722	PF00069	0.789
DOC_MAPK_NFAT4_5	155	163	PF00069	0.475
DOC_PP1_RVXF_1	180	187	PF00149	0.374
DOC_PP1_RVXF_1	428	434	PF00149	0.556
DOC_PP4_FxxP_1	217	220	PF00568	0.449
DOC_PP4_FxxP_1	290	293	PF00568	0.398
DOC_USP7_MATH_1	246	250	PF00917	0.377
DOC_USP7_MATH_1	259	263	PF00917	0.330
DOC_USP7_MATH_1	317	321	PF00917	0.421
DOC_USP7_MATH_1	353	357	PF00917	0.459
DOC_USP7_MATH_1	358	362	PF00917	0.436
DOC_USP7_MATH_1	440	444	PF00917	0.527
DOC_USP7_MATH_1	493	497	PF00917	0.675
DOC_USP7_MATH_1	552	556	PF00917	0.635
DOC_USP7_MATH_1	571	575	PF00917	0.260
DOC_USP7_MATH_1	636	640	PF00917	0.681
DOC_USP7_MATH_2	293	299	PF00917	0.300
DOC_WW_Pin1_4	104	109	PF00397	0.558
DOC_WW_Pin1_4	14	19	PF00397	0.608
DOC_WW_Pin1_4	289	294	PF00397	0.445
DOC_WW_Pin1_4	491	496	PF00397	0.593
DOC_WW_Pin1_4	544	549	PF00397	0.749
DOC_WW_Pin1_4	681	686	PF00397	0.765
DOC_WW_Pin1_4	700	705	PF00397	0.462
LIG_14-3-3_CanoR_1	157	163	PF00244	0.358
LIG_14-3-3_CanoR_1	188	196	PF00244	0.522
LIG_14-3-3_CanoR_1	336	343	PF00244	0.428
LIG_14-3-3_CanoR_1	389	393	PF00244	0.463
LIG_14-3-3_CanoR_1	551	561	PF00244	0.577
LIG_Actin_WH2_2	113	131	PF00022	0.413
LIG_Actin_WH2_2	17	34	PF00022	0.597
LIG_Actin_WH2_2	458	474	PF00022	0.605
LIG_Actin_WH2_2	52	69	PF00022	0.552
LIG_BRCT_BRCA1_1	213	217	PF00533	0.413
LIG_BRCT_BRCA1_1	355	359	PF00533	0.448
LIG_Clathr_ClatBox_1	253	257	PF01394	0.449
LIG_Clathr_ClatBox_1	656	660	PF01394	0.512
LIG_FHA_1	105	111	PF00498	0.540
LIG_FHA_1	277	283	PF00498	0.355
LIG_FHA_1	417	423	PF00498	0.358
LIG_FHA_1	460	466	PF00498	0.565
LIG_FHA_1	625	631	PF00498	0.547
LIG_FHA_2	290	296	PF00498	0.378
LIG_FHA_2	336	342	PF00498	0.435
LIG_LIR_Apic_2	214	220	PF02991	0.449
LIG_LIR_Gen_1	115	125	PF02991	0.404
LIG_LIR_Gen_1	156	167	PF02991	0.386
LIG_LIR_Gen_1	171	180	PF02991	0.333
LIG_LIR_Gen_1	181	191	PF02991	0.452
LIG_LIR_Gen_1	307	318	PF02991	0.410
LIG_LIR_Gen_1	405	415	PF02991	0.365
LIG_LIR_Gen_1	54	64	PF02991	0.616
LIG_LIR_Gen_1	556	565	PF02991	0.435
LIG_LIR_Gen_1	651	662	PF02991	0.508
LIG_LIR_Nem_3	115	120	PF02991	0.467
LIG_LIR_Nem_3	156	162	PF02991	0.403
LIG_LIR_Nem_3	165	170	PF02991	0.345
LIG_LIR_Nem_3	171	176	PF02991	0.358
LIG_LIR_Nem_3	181	186	PF02991	0.325
LIG_LIR_Nem_3	262	267	PF02991	0.402
LIG_LIR_Nem_3	307	313	PF02991	0.389
LIG_LIR_Nem_3	405	410	PF02991	0.365
LIG_LIR_Nem_3	555	561	PF02991	0.456
LIG_LIR_Nem_3	651	657	PF02991	0.506
LIG_MLH1_MIPbox_1	213	217	PF16413	0.449
LIG_MYND_1	14	18	PF01753	0.528
LIG_PTB_Apo_2	166	173	PF02174	0.360
LIG_REV1ctd_RIR_1	214	219	PF16727	0.449
LIG_SH2_CRK	310	314	PF00017	0.432
LIG_SH2_GRB2like	200	203	PF00017	0.344
LIG_SH2_GRB2like	407	410	PF00017	0.430
LIG_SH2_PTP2	407	410	PF00017	0.449
LIG_SH2_SRC	407	410	PF00017	0.403
LIG_SH2_STAP1	310	314	PF00017	0.425
LIG_SH2_STAT5	130	133	PF00017	0.405
LIG_SH2_STAT5	407	410	PF00017	0.347
LIG_SH2_STAT5	55	58	PF00017	0.605
LIG_SH2_STAT5	558	561	PF00017	0.414
LIG_SH2_STAT5	593	596	PF00017	0.388
LIG_SH2_STAT5	662	665	PF00017	0.492
LIG_SH3_3	240	246	PF00018	0.449
LIG_SH3_3	387	393	PF00018	0.341
LIG_SH3_3	408	414	PF00018	0.413
LIG_SH3_3	684	690	PF00018	0.798
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.449
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.475
LIG_SUMO_SIM_anti_2	462	469	PF11976	0.517
LIG_SUMO_SIM_par_1	237	242	PF11976	0.401
LIG_SUMO_SIM_par_1	252	257	PF11976	0.442
LIG_SUMO_SIM_par_1	274	280	PF11976	0.455
LIG_TRAF2_1	227	230	PF00917	0.413
LIG_WRC_WIRS_1	558	563	PF05994	0.454
LIG_WW_3	46	50	PF00397	0.576
MOD_CDC14_SPxK_1	494	497	PF00782	0.688
MOD_CDC14_SPxK_1	703	706	PF00782	0.715
MOD_CDK_SPK_2	109	114	PF00069	0.578
MOD_CDK_SPxK_1	491	497	PF00069	0.632
MOD_CDK_SPxK_1	700	706	PF00069	0.730
MOD_CDK_SPxxK_3	14	21	PF00069	0.605
MOD_CDK_SPxxK_3	544	551	PF00069	0.738
MOD_CK1_1	171	177	PF00069	0.384
MOD_CK1_1	298	304	PF00069	0.455
MOD_CK1_1	320	326	PF00069	0.438
MOD_CK1_1	463	469	PF00069	0.521
MOD_CK1_1	510	516	PF00069	0.667
MOD_CK1_1	536	542	PF00069	0.755
MOD_CK1_1	69	75	PF00069	0.697
MOD_CK1_1	713	719	PF00069	0.760
MOD_CK1_1	98	104	PF00069	0.627
MOD_CK2_1	109	115	PF00069	0.551
MOD_CK2_1	147	153	PF00069	0.502
MOD_CK2_1	224	230	PF00069	0.328
MOD_CK2_1	289	295	PF00069	0.378
MOD_CK2_1	463	469	PF00069	0.461
MOD_CK2_1	51	57	PF00069	0.601
MOD_CK2_1	616	622	PF00069	0.490
MOD_CK2_1	623	629	PF00069	0.516
MOD_GlcNHglycan	300	303	PF01048	0.376
MOD_GlcNHglycan	325	328	PF01048	0.427
MOD_GlcNHglycan	332	336	PF01048	0.390
MOD_GlcNHglycan	517	520	PF01048	0.778
MOD_GlcNHglycan	521	524	PF01048	0.760
MOD_GlcNHglycan	542	545	PF01048	0.710
MOD_GlcNHglycan	573	576	PF01048	0.529
MOD_GlcNHglycan	60	63	PF01048	0.606
MOD_GlcNHglycan	673	676	PF01048	0.668
MOD_GSK3_1	158	165	PF00069	0.336
MOD_GSK3_1	168	175	PF00069	0.367
MOD_GSK3_1	331	338	PF00069	0.445
MOD_GSK3_1	459	466	PF00069	0.530
MOD_GSK3_1	47	54	PF00069	0.619
MOD_GSK3_1	473	480	PF00069	0.529
MOD_GSK3_1	491	498	PF00069	0.568
MOD_GSK3_1	509	516	PF00069	0.644
MOD_GSK3_1	536	543	PF00069	0.680
MOD_GSK3_1	66	73	PF00069	0.728
MOD_GSK3_1	94	101	PF00069	0.652
MOD_N-GLC_1	168	173	PF02516	0.340
MOD_N-GLC_1	201	206	PF02516	0.417
MOD_N-GLC_1	491	496	PF02516	0.554
MOD_N-GLC_1	513	518	PF02516	0.753
MOD_N-GLC_2	143	145	PF02516	0.337
MOD_NEK2_1	103	108	PF00069	0.660
MOD_NEK2_1	139	144	PF00069	0.460
MOD_NEK2_1	158	163	PF00069	0.205
MOD_NEK2_1	172	177	PF00069	0.369
MOD_NEK2_1	196	201	PF00069	0.516
MOD_NEK2_1	276	281	PF00069	0.423
MOD_NEK2_1	288	293	PF00069	0.308
MOD_NEK2_1	461	466	PF00069	0.554
MOD_NEK2_1	616	621	PF00069	0.578
MOD_NEK2_1	66	71	PF00069	0.721
MOD_NEK2_1	96	101	PF00069	0.690
MOD_NEK2_2	124	129	PF00069	0.517
MOD_NEK2_2	168	173	PF00069	0.456
MOD_NEK2_2	259	264	PF00069	0.449
MOD_PIKK_1	358	364	PF00454	0.428
MOD_PIKK_1	495	501	PF00454	0.675
MOD_PKA_1	483	489	PF00069	0.552
MOD_PKA_2	320	326	PF00069	0.385
MOD_PKA_2	335	341	PF00069	0.376
MOD_PKA_2	388	394	PF00069	0.463
MOD_PKA_2	66	72	PF00069	0.762
MOD_Plk_1	168	174	PF00069	0.352
MOD_Plk_1	196	202	PF00069	0.533
MOD_Plk_1	453	459	PF00069	0.641
MOD_Plk_2-3	295	301	PF00069	0.300
MOD_Plk_4	147	153	PF00069	0.518
MOD_Plk_4	162	168	PF00069	0.248
MOD_Plk_4	211	217	PF00069	0.362
MOD_Plk_4	259	265	PF00069	0.405
MOD_Plk_4	271	277	PF00069	0.395
MOD_Plk_4	320	326	PF00069	0.420
MOD_Plk_4	463	469	PF00069	0.508
MOD_Plk_4	51	57	PF00069	0.560
MOD_Plk_4	650	656	PF00069	0.465
MOD_Plk_4	98	104	PF00069	0.684
MOD_ProDKin_1	104	110	PF00069	0.546
MOD_ProDKin_1	14	20	PF00069	0.608
MOD_ProDKin_1	289	295	PF00069	0.445
MOD_ProDKin_1	491	497	PF00069	0.601
MOD_ProDKin_1	544	550	PF00069	0.745
MOD_ProDKin_1	681	687	PF00069	0.765
MOD_ProDKin_1	700	706	PF00069	0.468
MOD_SUMO_for_1	524	527	PF00179	0.611
MOD_SUMO_rev_2	479	486	PF00179	0.538
TRG_DiLeu_BaEn_1	271	276	PF01217	0.449
TRG_DiLeu_BaEn_1	613	618	PF01217	0.467
TRG_ENDOCYTIC_2	310	313	PF00928	0.432
TRG_ENDOCYTIC_2	407	410	PF00928	0.359
TRG_ENDOCYTIC_2	558	561	PF00928	0.432
TRG_ER_diArg_1	29	32	PF00400	0.531
TRG_ER_diArg_1	318	321	PF00400	0.344
TRG_ER_diArg_1	718	721	PF00400	0.768
TRG_NES_CRM1_1	229	242	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J8	Leptomonas seymouri	65%	97%
A0A0S4J2W3	Bodo saltans	27%	100%
A0A1X0NMW5	Trypanosomatidae	37%	100%
A0A3R7NEI4	Trypanosoma rangeli	36%	100%
A4HRZ8	Leishmania infantum	100%	100%
C9ZXZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AI20	Leishmania braziliensis	84%	100%
E9AJY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q95Z92	Leishmania major	96%	100%
V5BDS9	Trypanosoma cruzi	37%	100%