Secreted protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H570_LEIDO

TriTrypDb:

LdBPK_030940.1 , LdCL_030014700 , LDHU3_03.1050

Length:

104

Annotations

LeishMANIAdb annotations

A very short protein with a possible mitochondrial transit signal. Ancient and conserved without known function.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H570

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H570

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.582
CLV_NRD_NRD_1	67	69	PF00675	0.537
CLV_PCSK_KEX2_1	67	69	PF00082	0.552
CLV_PCSK_SKI1_1	17	21	PF00082	0.362
DOC_MAPK_DCC_7	7	16	PF00069	0.646
DOC_MAPK_gen_1	5	13	PF00069	0.575
DOC_MAPK_MEF2A_6	7	16	PF00069	0.646
LIG_BRCT_BRCA1_1	32	36	PF00533	0.385
LIG_LIR_Gen_1	20	31	PF02991	0.562
LIG_LIR_Nem_3	70	76	PF02991	0.379
LIG_LRP6_Inhibitor_1	66	72	PF00058	0.634
LIG_OCRL_FandH_1	35	47	PF00620	0.463
LIG_Pex14_1	54	58	PF04695	0.395
LIG_SH2_CRK	73	77	PF00017	0.375
LIG_SH2_STAT5	3	6	PF00017	0.579
LIG_SH2_STAT5	43	46	PF00017	0.424
LIG_TYR_ITIM	71	76	PF00017	0.441
LIG_UBA3_1	31	39	PF00899	0.344
MOD_CAAXbox	101	104	PF01239	0.269
MOD_CK1_1	42	48	PF00069	0.368
MOD_NEK2_1	1	6	PF00069	0.588
MOD_PIKK_1	17	23	PF00454	0.562
MOD_Plk_4	30	36	PF00069	0.365
MOD_SUMO_rev_2	81	90	PF00179	0.378
TRG_ENDOCYTIC_2	23	26	PF00928	0.449
TRG_ENDOCYTIC_2	73	76	PF00928	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJT6	Leptomonas seymouri	91%	100%
A0A0S4ISH0	Bodo saltans	61%	100%
A0A1X0P8Z5	Trypanosomatidae	79%	100%
A0A422MTR4	Trypanosoma rangeli	76%	100%
A4H3Q8	Leishmania braziliensis	95%	100%
A4HRY2	Leishmania infantum	99%	100%
C9ZKJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9AJY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q1X7K5	Leishmania major	99%	100%
V5C2D3	Trypanosoma cruzi	76%	100%