RNB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H568_LEIDO

TriTrypDb:

LdBPK_030920.1 , LdCL_030014500 , LDHU3_03.1030

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H568

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H568

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.764
CLV_NRD_NRD_1	111	113	PF00675	0.723
CLV_NRD_NRD_1	12	14	PF00675	0.536
CLV_NRD_NRD_1	16	18	PF00675	0.514
CLV_NRD_NRD_1	187	189	PF00675	0.655
CLV_NRD_NRD_1	227	229	PF00675	0.448
CLV_NRD_NRD_1	269	271	PF00675	0.497
CLV_NRD_NRD_1	314	316	PF00675	0.705
CLV_NRD_NRD_1	99	101	PF00675	0.729
CLV_PCSK_KEX2_1	110	112	PF00082	0.737
CLV_PCSK_KEX2_1	12	14	PF00082	0.536
CLV_PCSK_KEX2_1	16	18	PF00082	0.514
CLV_PCSK_KEX2_1	187	189	PF00082	0.655
CLV_PCSK_KEX2_1	269	271	PF00082	0.474
CLV_PCSK_KEX2_1	49	51	PF00082	0.643
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.676
CLV_PCSK_PC7_1	12	18	PF00082	0.620
CLV_PCSK_SKI1_1	157	161	PF00082	0.533
CLV_PCSK_SKI1_1	17	21	PF00082	0.528
CLV_PCSK_SKI1_1	3	7	PF00082	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.606
DEG_SPOP_SBC_1	129	133	PF00917	0.692
DOC_MAPK_DCC_7	161	170	PF00069	0.536
DOC_MAPK_MEF2A_6	161	170	PF00069	0.522
DOC_USP7_MATH_1	129	133	PF00917	0.655
DOC_USP7_MATH_1	190	194	PF00917	0.711
DOC_USP7_MATH_1	205	209	PF00917	0.653
DOC_USP7_MATH_1	296	300	PF00917	0.541
DOC_USP7_MATH_1	63	67	PF00917	0.781
DOC_USP7_MATH_1	71	75	PF00917	0.570
LIG_14-3-3_CanoR_1	16	22	PF00244	0.511
LIG_14-3-3_CanoR_1	322	326	PF00244	0.701
LIG_14-3-3_CanoR_1	55	64	PF00244	0.680
LIG_Actin_WH2_2	147	163	PF00022	0.426
LIG_Actin_WH2_2	301	317	PF00022	0.691
LIG_FHA_1	39	45	PF00498	0.532
LIG_FHA_1	67	73	PF00498	0.727
LIG_FHA_2	34	40	PF00498	0.605
LIG_GBD_Chelix_1	216	224	PF00786	0.556
LIG_LIR_Gen_1	132	140	PF02991	0.621
LIG_LIR_Gen_1	149	159	PF02991	0.445
LIG_LIR_Nem_3	132	138	PF02991	0.607
LIG_LIR_Nem_3	149	154	PF02991	0.320
LIG_LIR_Nem_3	324	328	PF02991	0.713
LIG_Pex14_1	321	325	PF04695	0.580
LIG_PTB_Apo_2	248	255	PF02174	0.399
LIG_PTB_Phospho_1	248	254	PF10480	0.403
LIG_SH2_CRK	135	139	PF00017	0.681
LIG_SH2_CRK	162	166	PF00017	0.453
LIG_SH2_NCK_1	135	139	PF00017	0.513
LIG_SH2_NCK_1	194	198	PF00017	0.569
LIG_SH2_NCK_1	213	217	PF00017	0.434
LIG_SH2_SRC	213	216	PF00017	0.435
LIG_SH2_STAP1	213	217	PF00017	0.578
LIG_SH2_STAP1	323	327	PF00017	0.706
LIG_SH2_STAT5	254	257	PF00017	0.402
LIG_SH2_STAT5	323	326	PF00017	0.717
LIG_SH3_1	161	167	PF00018	0.434
LIG_SH3_3	161	167	PF00018	0.434
LIG_Sin3_3	151	158	PF02671	0.487
LIG_TRAF2_1	146	149	PF00917	0.595
LIG_TRAF2_1	87	90	PF00917	0.697
LIG_TYR_ITIM	211	216	PF00017	0.518
LIG_UBA3_1	223	229	PF00899	0.463
LIG_UBA3_1	43	49	PF00899	0.692
LIG_WW_2	164	167	PF00397	0.441
MOD_CK1_1	178	184	PF00069	0.612
MOD_CK1_1	33	39	PF00069	0.651
MOD_CK1_1	66	72	PF00069	0.733
MOD_CK1_1	74	80	PF00069	0.672
MOD_CK2_1	33	39	PF00069	0.669
MOD_CK2_1	70	76	PF00069	0.725
MOD_GlcNHglycan	125	128	PF01048	0.712
MOD_GlcNHglycan	144	147	PF01048	0.276
MOD_GlcNHglycan	177	180	PF01048	0.565
MOD_GlcNHglycan	183	186	PF01048	0.630
MOD_GlcNHglycan	206	211	PF01048	0.652
MOD_GlcNHglycan	23	26	PF01048	0.659
MOD_GlcNHglycan	277	280	PF01048	0.720
MOD_GlcNHglycan	65	68	PF01048	0.707
MOD_GlcNHglycan	73	76	PF01048	0.532
MOD_GlcNHglycan	77	80	PF01048	0.681
MOD_GSK3_1	119	126	PF00069	0.688
MOD_GSK3_1	17	24	PF00069	0.572
MOD_GSK3_1	33	40	PF00069	0.443
MOD_GSK3_1	66	73	PF00069	0.639
MOD_N-GLC_2	251	253	PF02516	0.554
MOD_NEK2_1	38	43	PF00069	0.589
MOD_NEK2_2	232	237	PF00069	0.473
MOD_PIKK_1	307	313	PF00454	0.676
MOD_PKA_2	321	327	PF00069	0.698
MOD_PKA_2	33	39	PF00069	0.575
MOD_Plk_1	206	212	PF00069	0.619
MOD_Plk_1	38	44	PF00069	0.640
MOD_Plk_4	222	228	PF00069	0.477
MOD_Plk_4	243	249	PF00069	0.499
MOD_Plk_4	33	39	PF00069	0.651
TRG_DiLeu_BaEn_1	39	44	PF01217	0.592
TRG_DiLeu_LyEn_5	39	44	PF01217	0.592
TRG_ENDOCYTIC_2	135	138	PF00928	0.536
TRG_ENDOCYTIC_2	213	216	PF00928	0.435
TRG_ENDOCYTIC_2	264	267	PF00928	0.464
TRG_ENDOCYTIC_2	325	328	PF00928	0.621
TRG_ER_diArg_1	109	112	PF00400	0.736
TRG_ER_diArg_1	16	18	PF00400	0.530
TRG_ER_diArg_1	268	270	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	306	311	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I474	Leptomonas seymouri	50%	100%
A0A1X0P9T2	Trypanosomatidae	39%	98%
A0A3R7JZ70	Trypanosoma rangeli	37%	100%
A4H3Q6	Leishmania braziliensis	79%	100%
A4HRY0	Leishmania infantum	100%	100%
C9ZKI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ACN9	Leishmania major	93%	100%
E9AJX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BC75	Trypanosoma cruzi	36%	100%