NLI interacting factor-like phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H565_LEIDO

TriTrypDb:

LdBPK_030870.1 , LdCL_030014000 , LDHU3_03.0970

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H565

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H565

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	428	432	PF00656	0.566
CLV_C14_Caspase3-7	661	665	PF00656	0.679
CLV_C14_Caspase3-7	667	671	PF00656	0.589
CLV_C14_Caspase3-7	96	100	PF00656	0.632
CLV_MEL_PAP_1	273	279	PF00089	0.636
CLV_NRD_NRD_1	138	140	PF00675	0.719
CLV_NRD_NRD_1	151	153	PF00675	0.533
CLV_NRD_NRD_1	412	414	PF00675	0.602
CLV_NRD_NRD_1	622	624	PF00675	0.837
CLV_PCSK_KEX2_1	138	140	PF00082	0.720
CLV_PCSK_KEX2_1	151	153	PF00082	0.531
CLV_PCSK_KEX2_1	275	277	PF00082	0.581
CLV_PCSK_KEX2_1	621	623	PF00082	0.797
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.641
CLV_PCSK_PC7_1	617	623	PF00082	0.718
CLV_PCSK_SKI1_1	151	155	PF00082	0.561
CLV_PCSK_SKI1_1	359	363	PF00082	0.366
CLV_PCSK_SKI1_1	409	413	PF00082	0.441
CLV_PCSK_SKI1_1	573	577	PF00082	0.346
CLV_PCSK_SKI1_1	660	664	PF00082	0.665
CLV_PCSK_SKI1_1	730	734	PF00082	0.522
DEG_APCC_DBOX_1	408	416	PF00400	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SPOP_SBC_1	118	122	PF00917	0.493
DEG_SPOP_SBC_1	324	328	PF00917	0.366
DOC_ANK_TNKS_1	387	394	PF00023	0.249
DOC_CYCLIN_yCln2_LP_2	173	176	PF00134	0.560
DOC_MAPK_DCC_7	573	583	PF00069	0.306
DOC_MAPK_gen_1	107	116	PF00069	0.607
DOC_MAPK_gen_1	309	317	PF00069	0.306
DOC_MAPK_gen_1	573	583	PF00069	0.306
DOC_MAPK_MEF2A_6	107	116	PF00069	0.607
DOC_MAPK_MEF2A_6	309	317	PF00069	0.339
DOC_MAPK_MEF2A_6	40	48	PF00069	0.616
DOC_MAPK_MEF2A_6	576	585	PF00069	0.306
DOC_PP1_RVXF_1	149	156	PF00149	0.613
DOC_PP1_RVXF_1	278	285	PF00149	0.563
DOC_PP1_SILK_1	730	735	PF00149	0.589
DOC_PP2B_LxvP_1	172	175	PF13499	0.608
DOC_PP2B_LxvP_1	575	578	PF13499	0.306
DOC_PP2B_LxvP_1	600	603	PF13499	0.342
DOC_PP2B_LxvP_1	724	727	PF13499	0.482
DOC_PP4_MxPP_1	612	615	PF00568	0.635
DOC_USP7_MATH_1	117	121	PF00917	0.710
DOC_USP7_MATH_1	125	129	PF00917	0.718
DOC_USP7_MATH_1	167	171	PF00917	0.623
DOC_USP7_MATH_1	200	204	PF00917	0.632
DOC_USP7_MATH_1	342	346	PF00917	0.306
DOC_USP7_MATH_1	425	429	PF00917	0.672
DOC_USP7_MATH_1	438	442	PF00917	0.597
DOC_USP7_MATH_1	470	474	PF00917	0.615
DOC_USP7_MATH_1	517	521	PF00917	0.771
DOC_USP7_MATH_1	642	646	PF00917	0.687
DOC_USP7_MATH_1	67	71	PF00917	0.654
DOC_USP7_MATH_1	74	78	PF00917	0.567
DOC_USP7_MATH_1	85	89	PF00917	0.535
DOC_USP7_UBL2_3	566	570	PF12436	0.366
LIG_14-3-3_CanoR_1	110	115	PF00244	0.663
LIG_14-3-3_CanoR_1	267	273	PF00244	0.589
LIG_14-3-3_CanoR_1	276	284	PF00244	0.627
LIG_14-3-3_CanoR_1	359	369	PF00244	0.366
LIG_14-3-3_CanoR_1	434	438	PF00244	0.722
LIG_14-3-3_CanoR_1	660	669	PF00244	0.632
LIG_Actin_WH2_2	719	736	PF00022	0.490
LIG_BIR_III_4	652	656	PF00653	0.760
LIG_Clathr_ClatBox_1	582	586	PF01394	0.366
LIG_deltaCOP1_diTrp_1	211	218	PF00928	0.685
LIG_deltaCOP1_diTrp_1	31	36	PF00928	0.546
LIG_FHA_1	533	539	PF00498	0.607
LIG_FHA_1	55	61	PF00498	0.627
LIG_FHA_2	334	340	PF00498	0.306
LIG_FHA_2	487	493	PF00498	0.697
LIG_FHA_2	540	546	PF00498	0.659
LIG_FHA_2	646	652	PF00498	0.753
LIG_FHA_2	659	665	PF00498	0.624
LIG_FHA_2	687	693	PF00498	0.667
LIG_FHA_2	703	709	PF00498	0.754
LIG_FHA_2	71	77	PF00498	0.525
LIG_GBD_Chelix_1	313	321	PF00786	0.366
LIG_Integrin_isoDGR_2	136	138	PF01839	0.556
LIG_LIR_Gen_1	30	39	PF02991	0.566
LIG_LIR_Gen_1	336	344	PF02991	0.306
LIG_LIR_Gen_1	354	365	PF02991	0.306
LIG_LIR_LC3C_4	721	726	PF02991	0.460
LIG_LIR_Nem_3	271	277	PF02991	0.628
LIG_LIR_Nem_3	30	36	PF02991	0.584
LIG_LIR_Nem_3	336	340	PF02991	0.306
LIG_LIR_Nem_3	354	360	PF02991	0.306
LIG_LIR_Nem_3	88	92	PF02991	0.619
LIG_NRBOX	712	718	PF00104	0.529
LIG_NRBOX	719	725	PF00104	0.419
LIG_PAM2_1	360	372	PF00658	0.366
LIG_Pex14_1	214	218	PF04695	0.686
LIG_Pex14_1	353	357	PF04695	0.366
LIG_SH2_CRK	274	278	PF00017	0.637
LIG_SH2_CRK	357	361	PF00017	0.366
LIG_SH2_CRK	89	93	PF00017	0.682
LIG_SH2_NCK_1	683	687	PF00017	0.562
LIG_SH2_SRC	605	608	PF00017	0.534
LIG_SH2_STAP1	357	361	PF00017	0.366
LIG_SH2_STAP1	381	385	PF00017	0.306
LIG_SH2_STAP1	8	12	PF00017	0.461
LIG_SH2_STAT3	399	402	PF00017	0.366
LIG_SH2_STAT5	20	23	PF00017	0.461
LIG_SH2_STAT5	605	608	PF00017	0.534
LIG_SH3_3	13	19	PF00018	0.460
LIG_SH3_3	173	179	PF00018	0.636
LIG_SH3_3	190	196	PF00018	0.573
LIG_SH3_3	209	215	PF00018	0.622
LIG_SH3_3	598	604	PF00018	0.306
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.588
LIG_SUMO_SIM_anti_2	580	586	PF11976	0.306
LIG_SUMO_SIM_anti_2	721	728	PF11976	0.474
LIG_SUMO_SIM_par_1	311	316	PF11976	0.339
LIG_SUMO_SIM_par_1	580	586	PF11976	0.350
LIG_SUMO_SIM_par_1	707	718	PF11976	0.627
LIG_SUMO_SIM_par_1	721	728	PF11976	0.394
LIG_TYR_ITIM	272	277	PF00017	0.639
LIG_UBA3_1	1	7	PF00899	0.484
MOD_CK1_1	24	30	PF00069	0.482
MOD_CK1_1	244	250	PF00069	0.676
MOD_CK1_1	325	331	PF00069	0.366
MOD_CK1_1	462	468	PF00069	0.770
MOD_CK1_1	473	479	PF00069	0.597
MOD_CK1_1	485	491	PF00069	0.616
MOD_CK1_1	524	530	PF00069	0.682
MOD_CK1_1	54	60	PF00069	0.567
MOD_CK1_1	645	651	PF00069	0.598
MOD_CK1_1	690	696	PF00069	0.773
MOD_CK1_1	70	76	PF00069	0.551
MOD_CK2_1	117	123	PF00069	0.640
MOD_CK2_1	333	339	PF00069	0.306
MOD_CK2_1	342	348	PF00069	0.310
MOD_CK2_1	60	66	PF00069	0.556
MOD_CK2_1	70	76	PF00069	0.551
MOD_CK2_1	715	721	PF00069	0.543
MOD_CK2_1	90	96	PF00069	0.593
MOD_Cter_Amidation	136	139	PF01082	0.797
MOD_Cter_Amidation	155	158	PF01082	0.579
MOD_GlcNHglycan	127	130	PF01048	0.751
MOD_GlcNHglycan	165	168	PF01048	0.643
MOD_GlcNHglycan	223	226	PF01048	0.618
MOD_GlcNHglycan	247	250	PF01048	0.655
MOD_GlcNHglycan	344	347	PF01048	0.333
MOD_GlcNHglycan	375	378	PF01048	0.306
MOD_GlcNHglycan	427	430	PF01048	0.689
MOD_GlcNHglycan	445	449	PF01048	0.744
MOD_GlcNHglycan	466	469	PF01048	0.714
MOD_GlcNHglycan	475	478	PF01048	0.599
MOD_GlcNHglycan	484	487	PF01048	0.514
MOD_GlcNHglycan	497	500	PF01048	0.606
MOD_GlcNHglycan	523	526	PF01048	0.688
MOD_GlcNHglycan	62	65	PF01048	0.592
MOD_GlcNHglycan	632	635	PF01048	0.697
MOD_GlcNHglycan	69	72	PF01048	0.581
MOD_GlcNHglycan	80	83	PF01048	0.589
MOD_GSK3_1	119	126	PF00069	0.732
MOD_GSK3_1	163	170	PF00069	0.630
MOD_GSK3_1	20	27	PF00069	0.475
MOD_GSK3_1	200	207	PF00069	0.651
MOD_GSK3_1	221	228	PF00069	0.616
MOD_GSK3_1	236	243	PF00069	0.590
MOD_GSK3_1	301	308	PF00069	0.537
MOD_GSK3_1	459	466	PF00069	0.629
MOD_GSK3_1	472	479	PF00069	0.758
MOD_GSK3_1	482	489	PF00069	0.673
MOD_GSK3_1	517	524	PF00069	0.733
MOD_GSK3_1	54	61	PF00069	0.565
MOD_GSK3_1	585	592	PF00069	0.391
MOD_GSK3_1	642	649	PF00069	0.788
MOD_GSK3_1	660	667	PF00069	0.731
MOD_GSK3_1	686	693	PF00069	0.696
MOD_GSK3_1	698	705	PF00069	0.570
MOD_GSK3_1	70	77	PF00069	0.424
MOD_N-GLC_1	241	246	PF02516	0.760
MOD_N-GLC_1	495	500	PF02516	0.716
MOD_NEK2_1	180	185	PF00069	0.586
MOD_NEK2_1	218	223	PF00069	0.678
MOD_NEK2_1	282	287	PF00069	0.602
MOD_NEK2_1	293	298	PF00069	0.560
MOD_NEK2_1	317	322	PF00069	0.328
MOD_NEK2_1	360	365	PF00069	0.308
MOD_NEK2_1	373	378	PF00069	0.418
MOD_NEK2_1	39	44	PF00069	0.497
MOD_NEK2_1	521	526	PF00069	0.695
MOD_NEK2_1	534	539	PF00069	0.634
MOD_NEK2_1	60	65	PF00069	0.592
MOD_NEK2_2	642	647	PF00069	0.662
MOD_PK_1	110	116	PF00069	0.605
MOD_PKA_1	275	281	PF00069	0.570
MOD_PKA_1	622	628	PF00069	0.728
MOD_PKA_2	219	225	PF00069	0.618
MOD_PKA_2	275	281	PF00069	0.570
MOD_PKA_2	433	439	PF00069	0.684
MOD_PKA_2	482	488	PF00069	0.665
MOD_PKA_2	502	508	PF00069	0.699
MOD_PKA_2	616	622	PF00069	0.755
MOD_PKA_2	78	84	PF00069	0.579
MOD_PKA_2	90	96	PF00069	0.614
MOD_PKB_1	265	273	PF00069	0.640
MOD_Plk_1	317	323	PF00069	0.308
MOD_Plk_1	589	595	PF00069	0.308
MOD_Plk_1	690	696	PF00069	0.646
MOD_Plk_2-3	236	242	PF00069	0.681
MOD_Plk_2-3	691	697	PF00069	0.596
MOD_Plk_2-3	99	105	PF00069	0.658
MOD_Plk_4	188	194	PF00069	0.552
MOD_Plk_4	229	235	PF00069	0.655
MOD_Plk_4	268	274	PF00069	0.608
MOD_Plk_4	32	38	PF00069	0.526
MOD_Plk_4	381	387	PF00069	0.327
MOD_Plk_4	39	45	PF00069	0.430
MOD_Plk_4	517	523	PF00069	0.606
MOD_Plk_4	534	540	PF00069	0.629
MOD_Plk_4	589	595	PF00069	0.308
MOD_Plk_4	715	721	PF00069	0.532
MOD_SUMO_rev_2	514	520	PF00179	0.675
MOD_SUMO_rev_2	99	109	PF00179	0.633
TRG_DiLeu_BaEn_1	589	594	PF01217	0.366
TRG_DiLeu_BaEn_1	709	714	PF01217	0.605
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.623
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.754
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.391
TRG_ENDOCYTIC_2	274	277	PF00928	0.642
TRG_ENDOCYTIC_2	357	360	PF00928	0.366
TRG_ENDOCYTIC_2	89	92	PF00928	0.711
TRG_ER_diArg_1	151	153	PF00400	0.529
TRG_ER_diArg_1	168	171	PF00400	0.532
TRG_ER_diArg_1	254	257	PF00400	0.672
TRG_ER_diArg_1	621	623	PF00400	0.735
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT8	Leptomonas seymouri	55%	100%
A4H3Q1	Leishmania braziliensis	78%	98%
A4HRX5	Leishmania infantum	100%	100%
E9ACN4	Leishmania major	94%	100%
E9AJX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
V5BXB7	Trypanosoma cruzi	38%	100%