CDP-alcohol phosphatidyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine phosphotransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H562_LEIDO

TriTrypDb:

LdBPK_030970.1 , LdCL_030013300 , LDHU3_03.0900

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S5H562

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H562

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	8
GO:0008654	phospholipid biosynthetic process	5	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.409
CLV_C14_Caspase3-7	267	271	PF00656	0.564
CLV_C14_Caspase3-7	518	522	PF00656	0.588
CLV_NRD_NRD_1	128	130	PF00675	0.207
CLV_NRD_NRD_1	35	37	PF00675	0.365
CLV_NRD_NRD_1	370	372	PF00675	0.606
CLV_NRD_NRD_1	383	385	PF00675	0.607
CLV_NRD_NRD_1	421	423	PF00675	0.301
CLV_NRD_NRD_1	456	458	PF00675	0.422
CLV_NRD_NRD_1	481	483	PF00675	0.437
CLV_NRD_NRD_1	614	616	PF00675	0.491
CLV_PCSK_KEX2_1	128	130	PF00082	0.207
CLV_PCSK_KEX2_1	370	372	PF00082	0.606
CLV_PCSK_KEX2_1	383	385	PF00082	0.614
CLV_PCSK_KEX2_1	421	423	PF00082	0.301
CLV_PCSK_KEX2_1	456	458	PF00082	0.422
CLV_PCSK_KEX2_1	481	483	PF00082	0.437
CLV_PCSK_SKI1_1	12	16	PF00082	0.319
CLV_PCSK_SKI1_1	189	193	PF00082	0.483
CLV_PCSK_SKI1_1	296	300	PF00082	0.378
CLV_PCSK_SKI1_1	325	329	PF00082	0.272
CLV_PCSK_SKI1_1	335	339	PF00082	0.225
CLV_PCSK_SKI1_1	599	603	PF00082	0.483
DEG_Nend_Nbox_1	1	3	PF02207	0.605
DEG_ODPH_VHL_1	459	471	PF01847	0.266
DEG_ODPH_VHL_1	46	58	PF01847	0.287
DEG_SCF_FBW7_2	369	376	PF00400	0.362
DOC_CDC14_PxL_1	272	280	PF14671	0.569
DOC_CYCLIN_yClb3_PxF_3	98	104	PF00134	0.273
DOC_MAPK_gen_1	10	17	PF00069	0.494
DOC_MAPK_gen_1	36	44	PF00069	0.508
DOC_MAPK_gen_1	383	389	PF00069	0.316
DOC_MAPK_HePTP_8	34	46	PF00069	0.442
DOC_MAPK_MEF2A_6	10	17	PF00069	0.494
DOC_MAPK_MEF2A_6	189	196	PF00069	0.286
DOC_MAPK_MEF2A_6	341	349	PF00069	0.422
DOC_MAPK_MEF2A_6	37	46	PF00069	0.510
DOC_MAPK_MEF2A_6	397	406	PF00069	0.233
DOC_MAPK_MEF2A_6	437	444	PF00069	0.268
DOC_MAPK_MEF2A_6	456	465	PF00069	0.207
DOC_MAPK_NFAT4_5	10	18	PF00069	0.494
DOC_MAPK_NFAT4_5	189	197	PF00069	0.290
DOC_MAPK_NFAT4_5	437	445	PF00069	0.233
DOC_MAPK_RevD_3	442	457	PF00069	0.335
DOC_PP2B_LxvP_1	192	195	PF13499	0.239
DOC_PP2B_LxvP_1	576	579	PF13499	0.499
DOC_PP4_FxxP_1	581	584	PF00568	0.490
DOC_SPAK_OSR1_1	384	388	PF12202	0.315
DOC_USP7_MATH_1	162	166	PF00917	0.448
DOC_USP7_MATH_1	355	359	PF00917	0.226
DOC_USP7_MATH_1	492	496	PF00917	0.609
DOC_USP7_MATH_1	517	521	PF00917	0.674
DOC_USP7_MATH_1	522	526	PF00917	0.640
DOC_USP7_MATH_1	531	535	PF00917	0.561
DOC_WW_Pin1_4	131	136	PF00397	0.435
DOC_WW_Pin1_4	369	374	PF00397	0.355
DOC_WW_Pin1_4	607	612	PF00397	0.584
DOC_WW_Pin1_4	86	91	PF00397	0.505
LIG_14-3-3_CanoR_1	129	135	PF00244	0.424
LIG_14-3-3_CanoR_1	341	346	PF00244	0.446
LIG_14-3-3_CanoR_1	456	460	PF00244	0.222
LIG_Actin_WH2_2	576	594	PF00022	0.512
LIG_BIR_III_2	521	525	PF00653	0.596
LIG_BIR_III_4	268	272	PF00653	0.524
LIG_BRCT_BRCA1_1	385	389	PF00533	0.364
LIG_BRCT_BRCA1_1	448	452	PF00533	0.330
LIG_eIF4E_1	187	193	PF01652	0.259
LIG_EVH1_2	100	104	PF00568	0.246
LIG_FHA_1	166	172	PF00498	0.419
LIG_FHA_1	176	182	PF00498	0.227
LIG_FHA_1	212	218	PF00498	0.287
LIG_FHA_1	293	299	PF00498	0.574
LIG_FHA_1	342	348	PF00498	0.407
LIG_FHA_1	428	434	PF00498	0.248
LIG_FHA_1	570	576	PF00498	0.579
LIG_FHA_1	60	66	PF00498	0.314
LIG_FHA_1	602	608	PF00498	0.609
LIG_FHA_1	86	92	PF00498	0.518
LIG_FHA_2	181	187	PF00498	0.254
LIG_FHA_2	261	267	PF00498	0.613
LIG_FHA_2	412	418	PF00498	0.411
LIG_FHA_2	516	522	PF00498	0.588
LIG_FHA_2	534	540	PF00498	0.556
LIG_FHA_2	80	86	PF00498	0.467
LIG_GBD_Chelix_1	111	119	PF00786	0.266
LIG_LIR_Gen_1	168	177	PF02991	0.233
LIG_LIR_Gen_1	24	34	PF02991	0.472
LIG_LIR_Gen_1	270	279	PF02991	0.534
LIG_LIR_Gen_1	339	350	PF02991	0.532
LIG_LIR_Gen_1	505	513	PF02991	0.691
LIG_LIR_Gen_1	558	569	PF02991	0.544
LIG_LIR_Nem_3	168	172	PF02991	0.255
LIG_LIR_Nem_3	183	187	PF02991	0.245
LIG_LIR_Nem_3	270	275	PF02991	0.599
LIG_LIR_Nem_3	339	345	PF02991	0.550
LIG_LIR_Nem_3	386	392	PF02991	0.445
LIG_LIR_Nem_3	40	44	PF02991	0.574
LIG_LIR_Nem_3	449	455	PF02991	0.288
LIG_LIR_Nem_3	505	509	PF02991	0.693
LIG_LIR_Nem_3	558	564	PF02991	0.560
LIG_NRBOX	114	120	PF00104	0.347
LIG_PCNA_PIPBox_1	324	333	PF02747	0.516
LIG_PCNA_yPIPBox_3	324	335	PF02747	0.508
LIG_Pex14_1	184	188	PF04695	0.207
LIG_Pex14_2	180	184	PF04695	0.254
LIG_Pex14_2	385	389	PF04695	0.303
LIG_SH2_CRK	188	192	PF00017	0.230
LIG_SH2_CRK	342	346	PF00017	0.422
LIG_SH2_CRK	366	370	PF00017	0.257
LIG_SH2_CRK	435	439	PF00017	0.287
LIG_SH2_SRC	4	7	PF00017	0.542
LIG_SH2_SRC	41	44	PF00017	0.486
LIG_SH2_STAP1	435	439	PF00017	0.347
LIG_SH2_STAP1	540	544	PF00017	0.643
LIG_SH2_STAP1	551	555	PF00017	0.557
LIG_SH2_STAT5	16	19	PF00017	0.475
LIG_SH2_STAT5	211	214	PF00017	0.233
LIG_SH2_STAT5	25	28	PF00017	0.489
LIG_SH2_STAT5	261	264	PF00017	0.556
LIG_SH2_STAT5	4	7	PF00017	0.461
LIG_SH2_STAT5	41	44	PF00017	0.513
LIG_SH2_STAT5	435	438	PF00017	0.254
LIG_SH2_STAT5	473	476	PF00017	0.365
LIG_SH2_STAT5	511	514	PF00017	0.622
LIG_SH2_STAT5	80	83	PF00017	0.520
LIG_SH3_1	288	294	PF00018	0.509
LIG_SH3_2	291	296	PF14604	0.570
LIG_SH3_3	214	220	PF00018	0.258
LIG_SH3_3	288	294	PF00018	0.564
LIG_SH3_3	91	97	PF00018	0.427
LIG_SUMO_SIM_anti_2	168	175	PF11976	0.266
LIG_SUMO_SIM_par_1	168	175	PF11976	0.287
LIG_SUMO_SIM_par_1	399	405	PF11976	0.289
LIG_TRAF2_1	183	186	PF00917	0.254
LIG_TYR_ITIM	340	345	PF00017	0.461
LIG_TYR_ITIM	39	44	PF00017	0.557
LIG_TYR_ITIM	433	438	PF00017	0.287
LIG_UBA3_1	1	10	PF00899	0.501
LIG_WRC_WIRS_1	176	181	PF05994	0.266
LIG_WRC_WIRS_1	403	408	PF05994	0.266
MOD_CDC14_SPxK_1	610	613	PF00782	0.585
MOD_CDK_SPxK_1	607	613	PF00069	0.585
MOD_CK1_1	155	161	PF00069	0.450
MOD_CK1_1	165	171	PF00069	0.500
MOD_CK1_1	318	324	PF00069	0.519
MOD_CK1_1	530	536	PF00069	0.692
MOD_CK1_1	557	563	PF00069	0.492
MOD_CK2_1	180	186	PF00069	0.254
MOD_CK2_1	260	266	PF00069	0.542
MOD_CK2_1	79	85	PF00069	0.413
MOD_CMANNOS	166	169	PF00535	0.222
MOD_CMANNOS	213	216	PF00535	0.347
MOD_Cter_Amidation	381	384	PF01082	0.536
MOD_GlcNHglycan	160	163	PF01048	0.252
MOD_GlcNHglycan	317	320	PF01048	0.328
MOD_GlcNHglycan	332	335	PF01048	0.439
MOD_GlcNHglycan	357	360	PF01048	0.347
MOD_GlcNHglycan	408	411	PF01048	0.266
MOD_GlcNHglycan	448	451	PF01048	0.529
MOD_GlcNHglycan	488	491	PF01048	0.484
MOD_GlcNHglycan	494	497	PF01048	0.506
MOD_GlcNHglycan	513	516	PF01048	0.415
MOD_GlcNHglycan	529	532	PF01048	0.578
MOD_GlcNHglycan	75	78	PF01048	0.623
MOD_GSK3_1	127	134	PF00069	0.449
MOD_GSK3_1	158	165	PF00069	0.463
MOD_GSK3_1	17	24	PF00069	0.491
MOD_GSK3_1	402	409	PF00069	0.347
MOD_GSK3_1	509	516	PF00069	0.625
MOD_GSK3_1	527	534	PF00069	0.587
MOD_GSK3_1	603	610	PF00069	0.581
MOD_GSK3_1	79	86	PF00069	0.488
MOD_N-GLC_1	281	286	PF02516	0.294
MOD_N-GLC_1	475	480	PF02516	0.316
MOD_NEK2_1	281	286	PF00069	0.605
MOD_NEK2_1	330	335	PF00069	0.619
MOD_NEK2_1	406	411	PF00069	0.303
MOD_NEK2_1	427	432	PF00069	0.278
MOD_NEK2_1	433	438	PF00069	0.326
MOD_NEK2_1	455	460	PF00069	0.236
MOD_NEK2_1	554	559	PF00069	0.496
MOD_NEK2_1	564	569	PF00069	0.511
MOD_NEK2_1	58	63	PF00069	0.404
MOD_NEK2_1	595	600	PF00069	0.526
MOD_NEK2_2	336	341	PF00069	0.495
MOD_PIKK_1	475	481	PF00454	0.608
MOD_PK_1	383	389	PF00069	0.316
MOD_PKA_1	383	389	PF00069	0.316
MOD_PKA_2	127	133	PF00069	0.407
MOD_PKA_2	383	389	PF00069	0.375
MOD_PKA_2	455	461	PF00069	0.222
MOD_PKA_2	569	575	PF00069	0.469
MOD_Plk_1	21	27	PF00069	0.448
MOD_Plk_1	475	481	PF00069	0.631
MOD_Plk_4	165	171	PF00069	0.456
MOD_Plk_4	172	178	PF00069	0.358
MOD_Plk_4	318	324	PF00069	0.498
MOD_Plk_4	469	475	PF00069	0.303
MOD_ProDKin_1	131	137	PF00069	0.435
MOD_ProDKin_1	369	375	PF00069	0.359
MOD_ProDKin_1	607	613	PF00069	0.585
MOD_ProDKin_1	86	92	PF00069	0.508
TRG_DiLeu_BaEn_1	571	576	PF01217	0.473
TRG_ENDOCYTIC_2	116	119	PF00928	0.233
TRG_ENDOCYTIC_2	188	191	PF00928	0.289
TRG_ENDOCYTIC_2	27	30	PF00928	0.456
TRG_ENDOCYTIC_2	342	345	PF00928	0.443
TRG_ENDOCYTIC_2	366	369	PF00928	0.248
TRG_ENDOCYTIC_2	41	44	PF00928	0.448
TRG_ENDOCYTIC_2	435	438	PF00928	0.287
TRG_ENDOCYTIC_2	551	554	PF00928	0.503
TRG_ER_diArg_1	369	371	PF00400	0.365
TRG_ER_diArg_1	383	385	PF00400	0.411
TRG_ER_diArg_1	420	422	PF00400	0.499
TRG_ER_diArg_1	455	457	PF00400	0.334
TRG_ER_diArg_1	480	482	PF00400	0.588
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y1	Leptomonas seymouri	64%	100%
A0A0S4J7L0	Bodo saltans	46%	100%
A0A1X0P8W0	Trypanosomatidae	43%	100%
E8NHC2	Leishmania infantum	100%	100%
E9AJW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%
V5BXC7	Trypanosoma cruzi	45%	100%