Ubiquitin-like domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquitin-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H558_LEIDO

TriTrypDb:

LdBPK_030750.1 , LdCL_030012700 , LDHU3_03.0840

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S5H558

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H558

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0007023	post-chaperonin tubulin folding pathway	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0043014	alpha-tubulin binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.403
CLV_C14_Caspase3-7	320	324	PF00656	0.384
CLV_C14_Caspase3-7	374	378	PF00656	0.376
CLV_C14_Caspase3-7	395	399	PF00656	0.621
CLV_PCSK_SKI1_1	128	132	PF00082	0.423
CLV_PCSK_SKI1_1	158	162	PF00082	0.356
CLV_PCSK_SKI1_1	303	307	PF00082	0.456
CLV_PCSK_SKI1_1	331	335	PF00082	0.455
CLV_PCSK_SKI1_1	385	389	PF00082	0.521
DEG_APCC_DBOX_1	63	71	PF00400	0.501
DEG_SCF_FBW7_1	9	15	PF00400	0.417
DEG_SPOP_SBC_1	150	154	PF00917	0.569
DEG_SPOP_SBC_1	467	471	PF00917	0.662
DOC_CDC14_PxL_1	123	131	PF14671	0.485
DOC_CDC14_PxL_1	134	142	PF14671	0.514
DOC_CDC14_PxL_1	175	183	PF14671	0.437
DOC_CKS1_1	521	526	PF01111	0.531
DOC_CKS1_1	6	11	PF01111	0.462
DOC_CYCLIN_RxL_1	179	188	PF00134	0.528
DOC_MAPK_gen_1	300	310	PF00069	0.411
DOC_MAPK_gen_1	424	432	PF00069	0.424
DOC_MAPK_gen_1	45	52	PF00069	0.621
DOC_MAPK_gen_1	58	67	PF00069	0.402
DOC_MAPK_MEF2A_6	414	422	PF00069	0.440
DOC_MAPK_MEF2A_6	426	434	PF00069	0.491
DOC_MAPK_MEF2A_6	61	69	PF00069	0.516
DOC_MAPK_MEF2A_6	71	79	PF00069	0.371
DOC_PP2B_LxvP_1	270	273	PF13499	0.500
DOC_PP4_MxPP_1	143	146	PF00568	0.548
DOC_USP7_MATH_1	14	18	PF00917	0.485
DOC_USP7_MATH_1	150	154	PF00917	0.543
DOC_USP7_MATH_1	213	217	PF00917	0.732
DOC_USP7_MATH_1	4	8	PF00917	0.741
DOC_USP7_MATH_1	467	471	PF00917	0.663
DOC_USP7_UBL2_3	424	428	PF12436	0.471
DOC_WW_Pin1_4	197	202	PF00397	0.645
DOC_WW_Pin1_4	2	7	PF00397	0.707
DOC_WW_Pin1_4	471	476	PF00397	0.531
DOC_WW_Pin1_4	520	525	PF00397	0.514
DOC_WW_Pin1_4	8	13	PF00397	0.735
LIG_14-3-3_CanoR_1	128	133	PF00244	0.477
LIG_14-3-3_CanoR_1	303	308	PF00244	0.451
LIG_14-3-3_CanoR_1	336	346	PF00244	0.372
LIG_14-3-3_CanoR_1	508	512	PF00244	0.487
LIG_14-3-3_CanoR_1	64	68	PF00244	0.506
LIG_deltaCOP1_diTrp_1	44	49	PF00928	0.662
LIG_eIF4E_1	382	388	PF01652	0.506
LIG_FHA_1	129	135	PF00498	0.425
LIG_FHA_1	146	152	PF00498	0.535
LIG_FHA_1	230	236	PF00498	0.359
LIG_FHA_1	285	291	PF00498	0.550
LIG_FHA_1	317	323	PF00498	0.442
LIG_FHA_1	332	338	PF00498	0.236
LIG_FHA_1	359	365	PF00498	0.472
LIG_FHA_1	450	456	PF00498	0.392
LIG_FHA_1	478	484	PF00498	0.514
LIG_FHA_1	64	70	PF00498	0.427
LIG_FHA_2	190	196	PF00498	0.522
LIG_FHA_2	343	349	PF00498	0.517
LIG_FHA_2	521	527	PF00498	0.465
LIG_Integrin_isoDGR_2	350	352	PF01839	0.289
LIG_LIR_Gen_1	338	344	PF02991	0.389
LIG_LIR_Gen_1	44	52	PF02991	0.591
LIG_LIR_Gen_1	447	456	PF02991	0.486
LIG_LIR_LC3C_4	66	69	PF02991	0.498
LIG_LIR_Nem_3	164	169	PF02991	0.470
LIG_LIR_Nem_3	224	230	PF02991	0.430
LIG_LIR_Nem_3	241	246	PF02991	0.343
LIG_LIR_Nem_3	338	342	PF02991	0.391
LIG_LIR_Nem_3	44	50	PF02991	0.605
LIG_LIR_Nem_3	447	451	PF02991	0.521
LIG_LIR_Nem_3	531	537	PF02991	0.465
LIG_LYPXL_yS_3	417	420	PF13949	0.403
LIG_MYND_1	138	142	PF01753	0.510
LIG_PTB_Apo_2	160	167	PF02174	0.451
LIG_SH2_CRK	299	303	PF00017	0.409
LIG_SH2_CRK	339	343	PF00017	0.425
LIG_SH2_NCK_1	461	465	PF00017	0.597
LIG_SH2_PTP2	448	451	PF00017	0.530
LIG_SH2_STAP1	339	343	PF00017	0.384
LIG_SH2_STAP1	461	465	PF00017	0.626
LIG_SH2_STAT5	125	128	PF00017	0.489
LIG_SH2_STAT5	261	264	PF00017	0.471
LIG_SH2_STAT5	301	304	PF00017	0.364
LIG_SH2_STAT5	354	357	PF00017	0.350
LIG_SH2_STAT5	382	385	PF00017	0.373
LIG_SH2_STAT5	448	451	PF00017	0.530
LIG_SH2_STAT5	456	459	PF00017	0.508
LIG_SH2_STAT5	544	547	PF00017	0.526
LIG_SH3_1	121	127	PF00018	0.500
LIG_SH3_3	121	127	PF00018	0.500
LIG_SH3_3	139	145	PF00018	0.375
LIG_SH3_3	173	179	PF00018	0.427
LIG_SH3_3	195	201	PF00018	0.626
LIG_SH3_3	222	228	PF00018	0.584
LIG_SH3_3	292	298	PF00018	0.529
LIG_SH3_3	3	9	PF00018	0.479
LIG_SH3_3	412	418	PF00018	0.499
LIG_SH3_4	503	510	PF00018	0.536
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.564
LIG_SUMO_SIM_anti_2	361	366	PF11976	0.473
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.518
LIG_SUMO_SIM_par_1	449	454	PF11976	0.493
LIG_SUMO_SIM_par_1	515	523	PF11976	0.503
LIG_TYR_ITIM	337	342	PF00017	0.418
LIG_TYR_ITIM	415	420	PF00017	0.439
LIG_TYR_ITIM	532	537	PF00017	0.391
LIG_UBA3_1	307	311	PF00899	0.480
LIG_WRC_WIRS_1	332	337	PF05994	0.330
MOD_CK1_1	109	115	PF00069	0.538
MOD_CK1_1	154	160	PF00069	0.449
MOD_CK1_1	204	210	PF00069	0.710
MOD_CK1_1	470	476	PF00069	0.406
MOD_CK1_1	485	491	PF00069	0.238
MOD_CK1_1	5	11	PF00069	0.746
MOD_CK1_1	510	516	PF00069	0.306
MOD_CK1_1	538	544	PF00069	0.375
MOD_CK1_1	83	89	PF00069	0.649
MOD_CK2_1	112	118	PF00069	0.444
MOD_CK2_1	342	348	PF00069	0.511
MOD_GlcNHglycan	215	218	PF01048	0.720
MOD_GlcNHglycan	27	30	PF01048	0.607
MOD_GlcNHglycan	405	408	PF01048	0.649
MOD_GlcNHglycan	512	515	PF01048	0.308
MOD_GlcNHglycan	81	85	PF01048	0.684
MOD_GSK3_1	145	152	PF00069	0.555
MOD_GSK3_1	161	168	PF00069	0.392
MOD_GSK3_1	185	192	PF00069	0.489
MOD_GSK3_1	197	204	PF00069	0.646
MOD_GSK3_1	312	319	PF00069	0.459
MOD_GSK3_1	331	338	PF00069	0.182
MOD_GSK3_1	342	349	PF00069	0.391
MOD_GSK3_1	4	11	PF00069	0.768
MOD_GSK3_1	437	444	PF00069	0.623
MOD_GSK3_1	466	473	PF00069	0.614
MOD_GSK3_1	474	481	PF00069	0.299
MOD_N-GLC_1	161	166	PF02516	0.445
MOD_N-GLC_1	189	194	PF02516	0.552
MOD_N-GLC_1	213	218	PF02516	0.632
MOD_N-GLC_1	312	317	PF02516	0.419
MOD_N-GLC_1	346	351	PF02516	0.368
MOD_NEK2_1	151	156	PF00069	0.440
MOD_NEK2_1	161	166	PF00069	0.399
MOD_NEK2_1	316	321	PF00069	0.514
MOD_NEK2_1	335	340	PF00069	0.184
MOD_PIKK_1	255	261	PF00454	0.472
MOD_PIKK_1	475	481	PF00454	0.425
MOD_PKA_2	335	341	PF00069	0.353
MOD_PKA_2	366	372	PF00069	0.532
MOD_PKA_2	507	513	PF00069	0.355
MOD_PKA_2	63	69	PF00069	0.506
MOD_Plk_1	109	115	PF00069	0.432
MOD_Plk_1	189	195	PF00069	0.336
MOD_Plk_1	312	318	PF00069	0.432
MOD_Plk_2-3	30	36	PF00069	0.627
MOD_Plk_4	14	20	PF00069	0.455
MOD_Plk_4	272	278	PF00069	0.477
MOD_Plk_4	303	309	PF00069	0.411
MOD_Plk_4	338	344	PF00069	0.456
MOD_Plk_4	444	450	PF00069	0.603
MOD_Plk_4	451	457	PF00069	0.471
MOD_Plk_4	538	544	PF00069	0.388
MOD_Plk_4	63	69	PF00069	0.506
MOD_ProDKin_1	197	203	PF00069	0.646
MOD_ProDKin_1	2	8	PF00069	0.704
MOD_ProDKin_1	471	477	PF00069	0.415
MOD_ProDKin_1	520	526	PF00069	0.391
TRG_DiLeu_BaEn_1	118	123	PF01217	0.491
TRG_ENDOCYTIC_2	299	302	PF00928	0.366
TRG_ENDOCYTIC_2	339	342	PF00928	0.373
TRG_ENDOCYTIC_2	417	420	PF00928	0.403
TRG_ENDOCYTIC_2	448	451	PF00928	0.530
TRG_ENDOCYTIC_2	534	537	PF00928	0.391
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTC4	Leptomonas seymouri	63%	100%
A0A0S4JLX2	Bodo saltans	38%	100%
A0A1X0P967	Trypanosomatidae	42%	100%
A0A422NHN6	Trypanosoma rangeli	44%	100%
A4H3N8	Leishmania braziliensis	81%	100%
A4HRW5	Leishmania infantum	100%	100%
C9ZKH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACM2	Leishmania major	93%	100%
E9AJW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q15813	Homo sapiens	23%	100%
Q32KS0	Bos taurus	23%	100%
Q5RBD9	Pongo abelii	23%	100%
Q5U508	Xenopus laevis	22%	100%
Q8CIV8	Mus musculus	22%	100%
Q8GRL7	Arabidopsis thaliana	25%	100%
V5C274	Trypanosoma cruzi	42%	100%