Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H557_LEIDO

TriTrypDb:

LdBPK_030740.1 , LdCL_030012600 , LDHU3_03.0830

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H557

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H557

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.584
CLV_NRD_NRD_1	278	280	PF00675	0.757
CLV_NRD_NRD_1	54	56	PF00675	0.640
CLV_NRD_NRD_1	88	90	PF00675	0.404
CLV_PCSK_KEX2_1	278	280	PF00082	0.757
CLV_PCSK_KEX2_1	54	56	PF00082	0.638
CLV_PCSK_KEX2_1	87	89	PF00082	0.436
CLV_PCSK_PC7_1	274	280	PF00082	0.515
CLV_PCSK_SKI1_1	10	14	PF00082	0.621
CLV_Separin_Metazoa	268	272	PF03568	0.502
DEG_APCC_DBOX_1	86	94	PF00400	0.396
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DEG_SPOP_SBC_1	151	155	PF00917	0.564
DEG_SPOP_SBC_1	191	195	PF00917	0.568
DEG_SPOP_SBC_1	43	47	PF00917	0.745
DOC_CKS1_1	167	172	PF01111	0.440
DOC_MAPK_gen_1	87	94	PF00069	0.385
DOC_MAPK_MEF2A_6	210	219	PF00069	0.358
DOC_MAPK_MEF2A_6	87	94	PF00069	0.385
DOC_USP7_MATH_1	12	16	PF00917	0.619
DOC_USP7_MATH_1	151	155	PF00917	0.582
DOC_USP7_MATH_1	187	191	PF00917	0.529
DOC_USP7_MATH_1	42	46	PF00917	0.671
DOC_WW_Pin1_4	163	168	PF00397	0.624
DOC_WW_Pin1_4	45	50	PF00397	0.688
LIG_14-3-3_CanoR_1	114	122	PF00244	0.490
LIG_14-3-3_CanoR_1	2	7	PF00244	0.579
LIG_14-3-3_CanoR_1	260	265	PF00244	0.423
LIG_14-3-3_CanoR_1	54	59	PF00244	0.725
LIG_BRCT_BRCA1_1	115	119	PF00533	0.475
LIG_CtBP_PxDLS_1	177	181	PF00389	0.406
LIG_eIF4E_1	113	119	PF01652	0.419
LIG_EVH1_1	76	80	PF00568	0.611
LIG_FHA_1	11	17	PF00498	0.633
LIG_FHA_1	113	119	PF00498	0.530
LIG_FHA_1	232	238	PF00498	0.466
LIG_FHA_1	259	265	PF00498	0.521
LIG_FHA_2	105	111	PF00498	0.531
LIG_FHA_2	167	173	PF00498	0.682
LIG_Integrin_RGD_1	36	38	PF01839	0.596
LIG_LIR_Gen_1	116	127	PF02991	0.476
LIG_LIR_Nem_3	116	122	PF02991	0.477
LIG_LIR_Nem_3	207	211	PF02991	0.337
LIG_LIR_Nem_3	212	217	PF02991	0.365
LIG_LIR_Nem_3	74	79	PF02991	0.586
LIG_MYND_1	99	103	PF01753	0.453
LIG_NRBOX	265	271	PF00104	0.600
LIG_SH2_PTP2	252	255	PF00017	0.509
LIG_SH2_STAT5	208	211	PF00017	0.470
LIG_SH2_STAT5	242	245	PF00017	0.511
LIG_SH2_STAT5	252	255	PF00017	0.546
LIG_SH2_STAT5	296	299	PF00017	0.455
LIG_SH3_2	49	54	PF14604	0.600
LIG_SH3_3	126	132	PF00018	0.361
LIG_SH3_3	142	148	PF00018	0.364
LIG_SH3_3	164	170	PF00018	0.729
LIG_SH3_3	178	184	PF00018	0.569
LIG_SH3_3	196	202	PF00018	0.488
LIG_SH3_3	46	52	PF00018	0.676
LIG_SH3_3	74	80	PF00018	0.676
LIG_SUMO_SIM_par_1	260	265	PF11976	0.423
LIG_SxIP_EBH_1	16	26	PF03271	0.539
LIG_TRAF2_1	282	285	PF00917	0.636
LIG_WW_3	58	62	PF00397	0.629
MOD_CK1_1	153	159	PF00069	0.628
MOD_CK1_1	166	172	PF00069	0.526
MOD_CK1_1	189	195	PF00069	0.679
MOD_CK1_1	45	51	PF00069	0.692
MOD_CK1_1	5	11	PF00069	0.538
MOD_CK2_1	251	257	PF00069	0.567
MOD_Cter_Amidation	276	279	PF01082	0.597
MOD_GlcNHglycan	115	118	PF01048	0.479
MOD_GlcNHglycan	155	158	PF01048	0.614
MOD_GlcNHglycan	161	164	PF01048	0.653
MOD_GlcNHglycan	189	192	PF01048	0.610
MOD_GlcNHglycan	56	59	PF01048	0.697
MOD_GSK3_1	113	120	PF00069	0.489
MOD_GSK3_1	159	166	PF00069	0.585
MOD_GSK3_1	185	192	PF00069	0.622
MOD_GSK3_1	43	50	PF00069	0.637
MOD_GSK3_1	8	15	PF00069	0.623
MOD_N-GLC_1	18	23	PF02516	0.609
MOD_NEK2_1	118	123	PF00069	0.319
MOD_NEK2_1	150	155	PF00069	0.678
MOD_NEK2_1	231	236	PF00069	0.479
MOD_NEK2_1	251	256	PF00069	0.295
MOD_NEK2_1	308	313	PF00069	0.581
MOD_PK_1	260	266	PF00069	0.527
MOD_PKA_1	54	60	PF00069	0.720
MOD_PKA_2	113	119	PF00069	0.412
MOD_PKA_2	231	237	PF00069	0.483
MOD_PKA_2	277	283	PF00069	0.715
MOD_PKA_2	53	59	PF00069	0.646
MOD_Plk_1	18	24	PF00069	0.724
MOD_Plk_1	29	35	PF00069	0.605
MOD_Plk_4	118	124	PF00069	0.336
MOD_Plk_4	18	24	PF00069	0.749
MOD_ProDKin_1	163	169	PF00069	0.619
MOD_ProDKin_1	45	51	PF00069	0.688
MOD_SUMO_for_1	282	285	PF00179	0.554
MOD_SUMO_rev_2	281	288	PF00179	0.550
TRG_DiLeu_BaEn_1	265	270	PF01217	0.535
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.437
TRG_ENDOCYTIC_2	208	211	PF00928	0.470
TRG_ENDOCYTIC_2	252	255	PF00928	0.514
TRG_ER_diArg_1	53	55	PF00400	0.641
TRG_ER_diArg_1	86	89	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN8	Leptomonas seymouri	58%	95%
A0A1X0PA92	Trypanosomatidae	39%	100%
A0A3R7KEM6	Trypanosoma rangeli	41%	100%
A4HRW4	Leishmania infantum	99%	100%
C9ZKG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ACM1	Leishmania major	91%	100%
E9AJV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
V5BC94	Trypanosoma cruzi	40%	100%