Cytochrome_c_oxidase_copper_chaperone_putative/Ge neDB:LmjF.03.0740

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase copper chaperone, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H556_LEIDO

TriTrypDb:

LdBPK_030720.1 , LdCL_030012400 , LDHU3_03.0810

Length:

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c oxidase copper chaperone

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005758	mitochondrial intermembrane space	6	9
GO:0031970	organelle envelope lumen	5	9
GO:0031974	membrane-enclosed lumen	2	9
GO:0043233	organelle lumen	3	9
GO:0070013	intracellular organelle lumen	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S5H556

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H556

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005507	copper ion binding	6	9
GO:0016530	metallochaperone activity	2	9
GO:0016531	copper chaperone activity	3	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0140104	molecular carrier activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	38	40	PF00675	0.490
CLV_NRD_NRD_1	65	67	PF00675	0.503
CLV_PCSK_KEX2_1	38	40	PF00082	0.490
CLV_PCSK_KEX2_1	65	67	PF00082	0.503
CLV_PCSK_KEX2_1	78	80	PF00082	0.577
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.577
DOC_USP7_UBL2_3	78	82	PF12436	0.576
DOC_WW_Pin1_4	22	27	PF00397	0.605
LIG_14-3-3_CanoR_1	20	26	PF00244	0.612
LIG_14-3-3_CterR_2	79	84	PF00244	0.573
LIG_FHA_1	3	9	PF00498	0.642
LIG_FHA_2	53	59	PF00498	0.313
LIG_LIR_Gen_1	58	69	PF02991	0.319
LIG_LIR_Nem_3	58	64	PF02991	0.319
LIG_SH2_CRK	61	65	PF00017	0.266
LIG_TRAF2_1	70	73	PF00917	0.498
LIG_TRAF2_2	13	18	PF00917	0.660
MOD_CDK_SPxxK_3	22	29	PF00069	0.583
MOD_CK1_1	22	28	PF00069	0.401
MOD_CK1_1	4	10	PF00069	0.656
MOD_CK2_1	52	58	PF00069	0.248
MOD_CK2_1	67	73	PF00069	0.244
MOD_GlcNHglycan	69	72	PF01048	0.629
MOD_GSK3_1	20	27	PF00069	0.630
MOD_N-GLC_1	2	7	PF02516	0.599
MOD_NEK2_1	1	6	PF00069	0.631
MOD_NMyristoyl	1	7	PF02799	0.674
MOD_PKA_1	78	84	PF00069	0.597
MOD_PKA_2	19	25	PF00069	0.623
MOD_PKA_2	78	84	PF00069	0.597
MOD_Plk_1	42	48	PF00069	0.259
MOD_Plk_2-3	52	58	PF00069	0.333
MOD_Plk_4	42	48	PF00069	0.272
MOD_ProDKin_1	22	28	PF00069	0.598
TRG_DiLeu_BaEn_4	72	78	PF01217	0.495
TRG_ENDOCYTIC_2	61	64	PF00928	0.266
TRG_ER_diArg_1	38	41	PF00400	0.290
TRG_ER_diArg_1	64	66	PF00400	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM2	Leptomonas seymouri	65%	100%
A0A422MU41	Trypanosoma rangeli	53%	82%
A4H3N5	Leishmania braziliensis	71%	94%
A4HRW2	Leishmania infantum	100%	100%
C9ZKG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ACL9	Leishmania major	95%	100%
E9AJV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q9LJQ9	Arabidopsis thaliana	35%	100%