Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H555_LEIDO

TriTrypDb:

LdBPK_030700.1 , LdCL_030012200 , LDHU3_03.0790

Length:

879

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H555

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H555

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.609
CLV_C14_Caspase3-7	179	183	PF00656	0.559
CLV_C14_Caspase3-7	250	254	PF00656	0.683
CLV_C14_Caspase3-7	256	260	PF00656	0.651
CLV_C14_Caspase3-7	29	33	PF00656	0.669
CLV_C14_Caspase3-7	462	466	PF00656	0.595
CLV_C14_Caspase3-7	629	633	PF00656	0.488
CLV_NRD_NRD_1	10	12	PF00675	0.634
CLV_NRD_NRD_1	286	288	PF00675	0.676
CLV_NRD_NRD_1	395	397	PF00675	0.459
CLV_NRD_NRD_1	40	42	PF00675	0.731
CLV_NRD_NRD_1	420	422	PF00675	0.518
CLV_NRD_NRD_1	517	519	PF00675	0.797
CLV_NRD_NRD_1	610	612	PF00675	0.411
CLV_NRD_NRD_1	673	675	PF00675	0.743
CLV_NRD_NRD_1	706	708	PF00675	0.540
CLV_NRD_NRD_1	738	740	PF00675	0.485
CLV_NRD_NRD_1	801	803	PF00675	0.484
CLV_NRD_NRD_1	837	839	PF00675	0.773
CLV_PCSK_FUR_1	35	39	PF00082	0.734
CLV_PCSK_FUR_1	704	708	PF00082	0.517
CLV_PCSK_KEX2_1	10	12	PF00082	0.634
CLV_PCSK_KEX2_1	285	287	PF00082	0.680
CLV_PCSK_KEX2_1	37	39	PF00082	0.735
CLV_PCSK_KEX2_1	395	397	PF00082	0.459
CLV_PCSK_KEX2_1	40	42	PF00082	0.681
CLV_PCSK_KEX2_1	419	421	PF00082	0.471
CLV_PCSK_KEX2_1	517	519	PF00082	0.797
CLV_PCSK_KEX2_1	673	675	PF00082	0.688
CLV_PCSK_KEX2_1	706	708	PF00082	0.559
CLV_PCSK_KEX2_1	738	740	PF00082	0.485
CLV_PCSK_KEX2_1	76	78	PF00082	0.611
CLV_PCSK_KEX2_1	801	803	PF00082	0.520
CLV_PCSK_KEX2_1	836	838	PF00082	0.759
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.735
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.611
CLV_PCSK_PC7_1	35	41	PF00082	0.657
CLV_PCSK_PC7_1	797	803	PF00082	0.550
CLV_PCSK_SKI1_1	140	144	PF00082	0.587
CLV_PCSK_SKI1_1	206	210	PF00082	0.593
CLV_PCSK_SKI1_1	286	290	PF00082	0.671
CLV_PCSK_SKI1_1	421	425	PF00082	0.635
CLV_PCSK_SKI1_1	520	524	PF00082	0.747
CLV_PCSK_SKI1_1	614	618	PF00082	0.543
CLV_PCSK_SKI1_1	626	630	PF00082	0.519
CLV_PCSK_SKI1_1	645	649	PF00082	0.512
CLV_PCSK_SKI1_1	66	70	PF00082	0.629
CLV_Separin_Metazoa	7	11	PF03568	0.741
DEG_APCC_DBOX_1	139	147	PF00400	0.607
DEG_APCC_DBOX_1	613	621	PF00400	0.572
DEG_APCC_DBOX_1	644	652	PF00400	0.550
DEG_APCC_DBOX_1	76	84	PF00400	0.704
DEG_SCF_FBW7_1	14	19	PF00400	0.704
DEG_SPOP_SBC_1	841	845	PF00917	0.721
DOC_CKS1_1	130	135	PF01111	0.468
DOC_CKS1_1	510	515	PF01111	0.578
DOC_CYCLIN_RxL_1	137	147	PF00134	0.569
DOC_CYCLIN_RxL_1	642	652	PF00134	0.470
DOC_MAPK_gen_1	395	405	PF00069	0.592
DOC_MAPK_gen_1	611	621	PF00069	0.572
DOC_MAPK_gen_1	76	82	PF00069	0.618
DOC_MAPK_HePTP_8	609	621	PF00069	0.477
DOC_MAPK_MEF2A_6	612	621	PF00069	0.561
DOC_MAPK_NFAT4_5	614	622	PF00069	0.578
DOC_MAPK_RevD_3	404	420	PF00069	0.518
DOC_MAPK_RevD_3	789	802	PF00069	0.528
DOC_PP1_RVXF_1	357	363	PF00149	0.438
DOC_PP2B_LxvP_1	127	130	PF13499	0.575
DOC_PP2B_LxvP_1	371	374	PF13499	0.581
DOC_USP7_MATH_1	155	159	PF00917	0.483
DOC_USP7_MATH_1	16	20	PF00917	0.714
DOC_USP7_MATH_1	329	333	PF00917	0.721
DOC_USP7_MATH_1	336	340	PF00917	0.594
DOC_USP7_MATH_1	525	529	PF00917	0.664
DOC_USP7_MATH_1	554	558	PF00917	0.785
DOC_USP7_MATH_1	598	602	PF00917	0.730
DOC_USP7_MATH_1	667	671	PF00917	0.665
DOC_USP7_MATH_1	761	765	PF00917	0.648
DOC_USP7_MATH_1	820	824	PF00917	0.646
DOC_USP7_MATH_1	841	845	PF00917	0.795
DOC_USP7_MATH_1	97	101	PF00917	0.706
DOC_WW_Pin1_4	10	15	PF00397	0.756
DOC_WW_Pin1_4	129	134	PF00397	0.647
DOC_WW_Pin1_4	195	200	PF00397	0.704
DOC_WW_Pin1_4	509	514	PF00397	0.748
DOC_WW_Pin1_4	530	535	PF00397	0.733
DOC_WW_Pin1_4	537	542	PF00397	0.797
DOC_WW_Pin1_4	682	687	PF00397	0.590
DOC_WW_Pin1_4	845	850	PF00397	0.757
DOC_WW_Pin1_4	87	92	PF00397	0.723
LIG_14-3-3_CanoR_1	126	130	PF00244	0.651
LIG_14-3-3_CanoR_1	206	211	PF00244	0.520
LIG_14-3-3_CanoR_1	229	233	PF00244	0.609
LIG_14-3-3_CanoR_1	234	244	PF00244	0.651
LIG_14-3-3_CanoR_1	344	353	PF00244	0.560
LIG_14-3-3_CanoR_1	502	510	PF00244	0.756
LIG_14-3-3_CanoR_1	626	632	PF00244	0.550
LIG_14-3-3_CanoR_1	645	651	PF00244	0.505
LIG_14-3-3_CanoR_1	66	75	PF00244	0.623
LIG_14-3-3_CanoR_1	824	829	PF00244	0.658
LIG_14-3-3_CanoR_1	863	871	PF00244	0.435
LIG_Actin_WH2_2	213	231	PF00022	0.602
LIG_APCC_ABBA_1	184	189	PF00400	0.639
LIG_BIR_III_4	259	263	PF00653	0.661
LIG_BRCT_BRCA1_1	213	217	PF00533	0.590
LIG_BRCT_BRCA1_1	348	352	PF00533	0.518
LIG_BRCT_BRCA1_1	518	522	PF00533	0.609
LIG_BRCT_BRCA1_1	559	563	PF00533	0.650
LIG_CaM_NSCaTE_8	363	370	PF13499	0.547
LIG_Clathr_ClatBox_1	170	174	PF01394	0.673
LIG_FHA_1	104	110	PF00498	0.608
LIG_FHA_1	154	160	PF00498	0.642
LIG_FHA_1	16	22	PF00498	0.763
LIG_FHA_1	253	259	PF00498	0.662
LIG_FHA_1	328	334	PF00498	0.678
LIG_FHA_1	346	352	PF00498	0.402
LIG_FHA_1	374	380	PF00498	0.533
LIG_FHA_1	413	419	PF00498	0.500
LIG_FHA_1	450	456	PF00498	0.674
LIG_FHA_1	531	537	PF00498	0.754
LIG_FHA_1	652	658	PF00498	0.597
LIG_FHA_1	67	73	PF00498	0.592
LIG_FHA_1	862	868	PF00498	0.484
LIG_FHA_1	870	876	PF00498	0.466
LIG_FHA_2	177	183	PF00498	0.498
LIG_FHA_2	207	213	PF00498	0.600
LIG_FHA_2	560	566	PF00498	0.656
LIG_FHA_2	598	604	PF00498	0.731
LIG_FHA_2	627	633	PF00498	0.573
LIG_FHA_2	647	653	PF00498	0.218
LIG_FHA_2	794	800	PF00498	0.489
LIG_GBD_Chelix_1	180	188	PF00786	0.593
LIG_GBD_Chelix_1	305	313	PF00786	0.552
LIG_Integrin_isoDGR_2	298	300	PF01839	0.661
LIG_LIR_Apic_2	507	513	PF02991	0.579
LIG_LIR_Gen_1	132	143	PF02991	0.461
LIG_LIR_Gen_1	211	221	PF02991	0.468
LIG_LIR_Gen_1	348	357	PF02991	0.466
LIG_LIR_Gen_1	560	570	PF02991	0.476
LIG_LIR_Gen_1	693	703	PF02991	0.484
LIG_LIR_Gen_1	823	830	PF02991	0.478
LIG_LIR_LC3C_4	384	389	PF02991	0.581
LIG_LIR_Nem_3	132	138	PF02991	0.472
LIG_LIR_Nem_3	211	216	PF02991	0.480
LIG_LIR_Nem_3	348	353	PF02991	0.475
LIG_LIR_Nem_3	560	566	PF02991	0.503
LIG_LIR_Nem_3	693	699	PF02991	0.394
LIG_LIR_Nem_3	823	828	PF02991	0.476
LIG_LIR_Nem_3	865	871	PF02991	0.442
LIG_NRBOX	137	143	PF00104	0.512
LIG_NRBOX	412	418	PF00104	0.443
LIG_NRBOX	646	652	PF00104	0.468
LIG_PCNA_yPIPBox_3	410	421	PF02747	0.565
LIG_PCNA_yPIPBox_3	59	72	PF02747	0.590
LIG_Pex14_2	638	642	PF04695	0.359
LIG_RPA_C_Fungi	415	427	PF08784	0.599
LIG_RPA_C_Fungi	819	831	PF08784	0.648
LIG_SH2_CRK	135	139	PF00017	0.401
LIG_SH2_CRK	213	217	PF00017	0.484
LIG_SH2_CRK	510	514	PF00017	0.579
LIG_SH2_CRK	728	732	PF00017	0.594
LIG_SH2_CRK	825	829	PF00017	0.623
LIG_SH2_NCK_1	510	514	PF00017	0.579
LIG_SH2_NCK_1	825	829	PF00017	0.664
LIG_SH2_STAP1	213	217	PF00017	0.484
LIG_SH2_STAP1	677	681	PF00017	0.703
LIG_SH2_STAP1	696	700	PF00017	0.274
LIG_SH2_STAP1	825	829	PF00017	0.691
LIG_SH2_STAP1	871	875	PF00017	0.522
LIG_SH2_STAT3	232	235	PF00017	0.682
LIG_SH2_STAT5	232	235	PF00017	0.682
LIG_SH2_STAT5	378	381	PF00017	0.496
LIG_SH2_STAT5	510	513	PF00017	0.686
LIG_SH2_STAT5	677	680	PF00017	0.775
LIG_SH2_STAT5	871	874	PF00017	0.568
LIG_SH3_1	706	712	PF00018	0.633
LIG_SH3_3	127	133	PF00018	0.650
LIG_SH3_3	543	549	PF00018	0.705
LIG_SH3_3	584	590	PF00018	0.624
LIG_SH3_3	683	689	PF00018	0.613
LIG_SH3_3	705	711	PF00018	0.606
LIG_SH3_4	114	121	PF00018	0.715
LIG_SUMO_SIM_anti_2	310	315	PF11976	0.529
LIG_SUMO_SIM_anti_2	384	391	PF11976	0.584
LIG_SUMO_SIM_anti_2	402	407	PF11976	0.403
LIG_SUMO_SIM_anti_2	411	418	PF11976	0.476
LIG_SUMO_SIM_par_1	646	652	PF11976	0.468
LIG_TRAF2_1	209	212	PF00917	0.622
LIG_TRAF2_1	237	240	PF00917	0.662
LIG_TYR_ITIM	694	699	PF00017	0.393
LIG_TYR_ITIM	726	731	PF00017	0.530
LIG_UBA3_1	170	178	PF00899	0.543
LIG_Vh1_VBS_1	67	85	PF01044	0.607
LIG_WW_3	588	592	PF00397	0.647
LIG_WW_3	707	711	PF00397	0.635
MOD_CK1_1	412	418	PF00069	0.537
MOD_CK1_1	506	512	PF00069	0.678
MOD_CK1_1	526	532	PF00069	0.477
MOD_CK1_1	557	563	PF00069	0.725
MOD_CK1_1	679	685	PF00069	0.589
MOD_CK1_1	840	846	PF00069	0.795
MOD_CK2_1	125	131	PF00069	0.734
MOD_CK2_1	206	212	PF00069	0.618
MOD_CK2_1	244	250	PF00069	0.794
MOD_CK2_1	45	51	PF00069	0.690
MOD_CK2_1	597	603	PF00069	0.744
MOD_CK2_1	646	652	PF00069	0.486
MOD_CK2_1	793	799	PF00069	0.497
MOD_Cter_Amidation	393	396	PF01082	0.443
MOD_GlcNHglycan	18	21	PF01048	0.744
MOD_GlcNHglycan	192	195	PF01048	0.632
MOD_GlcNHglycan	246	249	PF01048	0.775
MOD_GlcNHglycan	278	281	PF01048	0.665
MOD_GlcNHglycan	337	341	PF01048	0.612
MOD_GlcNHglycan	384	387	PF01048	0.530
MOD_GlcNHglycan	399	402	PF01048	0.587
MOD_GlcNHglycan	506	509	PF01048	0.662
MOD_GlcNHglycan	55	58	PF01048	0.735
MOD_GlcNHglycan	556	559	PF01048	0.745
MOD_GlcNHglycan	600	603	PF01048	0.718
MOD_GlcNHglycan	733	736	PF01048	0.581
MOD_GlcNHglycan	832	835	PF01048	0.681
MOD_GlcNHglycan	839	842	PF01048	0.763
MOD_GlcNHglycan	94	97	PF01048	0.783
MOD_GlcNHglycan	99	102	PF01048	0.746
MOD_GSK3_1	10	17	PF00069	0.675
MOD_GSK3_1	125	132	PF00069	0.769
MOD_GSK3_1	144	151	PF00069	0.430
MOD_GSK3_1	176	183	PF00069	0.586
MOD_GSK3_1	351	358	PF00069	0.527
MOD_GSK3_1	465	472	PF00069	0.825
MOD_GSK3_1	473	480	PF00069	0.817
MOD_GSK3_1	502	509	PF00069	0.715
MOD_GSK3_1	512	519	PF00069	0.659
MOD_GSK3_1	525	532	PF00069	0.617
MOD_GSK3_1	53	60	PF00069	0.703
MOD_GSK3_1	622	629	PF00069	0.541
MOD_GSK3_1	66	73	PF00069	0.564
MOD_GSK3_1	675	682	PF00069	0.776
MOD_GSK3_1	820	827	PF00069	0.642
MOD_GSK3_1	837	844	PF00069	0.746
MOD_GSK3_1	869	876	PF00069	0.476
MOD_GSK3_1	87	94	PF00069	0.738
MOD_N-GLC_1	345	350	PF02516	0.607
MOD_N-GLC_1	397	402	PF02516	0.597
MOD_N-GLC_1	92	97	PF02516	0.711
MOD_NEK2_1	153	158	PF00069	0.657
MOD_NEK2_1	180	185	PF00069	0.631
MOD_NEK2_1	216	221	PF00069	0.519
MOD_NEK2_1	228	233	PF00069	0.455
MOD_NEK2_1	289	294	PF00069	0.645
MOD_NEK2_1	345	350	PF00069	0.513
MOD_NEK2_1	351	356	PF00069	0.441
MOD_NEK2_1	409	414	PF00069	0.390
MOD_NEK2_1	503	508	PF00069	0.682
MOD_NEK2_1	523	528	PF00069	0.588
MOD_NEK2_1	621	626	PF00069	0.454
MOD_NEK2_1	651	656	PF00069	0.545
MOD_NEK2_1	753	758	PF00069	0.592
MOD_NEK2_1	793	798	PF00069	0.609
MOD_PIKK_1	235	241	PF00454	0.660
MOD_PIKK_1	454	460	PF00454	0.750
MOD_PIKK_1	712	718	PF00454	0.695
MOD_PK_1	824	830	PF00069	0.480
MOD_PKA_1	837	843	PF00069	0.711
MOD_PKA_2	125	131	PF00069	0.691
MOD_PKA_2	136	142	PF00069	0.481
MOD_PKA_2	228	234	PF00069	0.648
MOD_PKA_2	516	522	PF00069	0.797
MOD_PKA_2	830	836	PF00069	0.702
MOD_PKA_2	837	843	PF00069	0.791
MOD_PKA_2	862	868	PF00069	0.472
MOD_Plk_1	148	154	PF00069	0.588
MOD_Plk_1	211	217	PF00069	0.548
MOD_Plk_1	263	269	PF00069	0.709
MOD_Plk_1	345	351	PF00069	0.606
MOD_Plk_1	469	475	PF00069	0.691
MOD_Plk_1	667	673	PF00069	0.548
MOD_Plk_2-3	125	131	PF00069	0.701
MOD_Plk_2-3	253	259	PF00069	0.701
MOD_Plk_4	176	182	PF00069	0.587
MOD_Plk_4	211	217	PF00069	0.503
MOD_Plk_4	228	234	PF00069	0.639
MOD_Plk_4	253	259	PF00069	0.662
MOD_Plk_4	263	269	PF00069	0.504
MOD_Plk_4	346	352	PF00069	0.468
MOD_Plk_4	409	415	PF00069	0.394
MOD_Plk_4	559	565	PF00069	0.540
MOD_Plk_4	646	652	PF00069	0.555
MOD_Plk_4	667	673	PF00069	0.622
MOD_Plk_4	70	76	PF00069	0.561
MOD_ProDKin_1	10	16	PF00069	0.759
MOD_ProDKin_1	129	135	PF00069	0.637
MOD_ProDKin_1	195	201	PF00069	0.707
MOD_ProDKin_1	509	515	PF00069	0.748
MOD_ProDKin_1	530	536	PF00069	0.734
MOD_ProDKin_1	537	543	PF00069	0.798
MOD_ProDKin_1	682	688	PF00069	0.574
MOD_ProDKin_1	845	851	PF00069	0.756
MOD_ProDKin_1	87	93	PF00069	0.725
MOD_SUMO_rev_2	84	90	PF00179	0.707
TRG_DiLeu_BaEn_1	211	216	PF01217	0.555
TRG_DiLeu_BaEn_1	615	620	PF01217	0.571
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.501
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.565
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.571
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.573
TRG_DiLeu_BaLyEn_6	874	879	PF01217	0.535
TRG_ENDOCYTIC_2	135	138	PF00928	0.532
TRG_ENDOCYTIC_2	213	216	PF00928	0.490
TRG_ENDOCYTIC_2	696	699	PF00928	0.470
TRG_ENDOCYTIC_2	728	731	PF00928	0.599
TRG_ENDOCYTIC_2	825	828	PF00928	0.476
TRG_ER_diArg_1	284	287	PF00400	0.708
TRG_ER_diArg_1	38	41	PF00400	0.737
TRG_ER_diArg_1	418	421	PF00400	0.513
TRG_ER_diArg_1	517	520	PF00400	0.702
TRG_ER_diArg_1	605	608	PF00400	0.620
TRG_ER_diArg_1	672	674	PF00400	0.675
TRG_ER_diArg_1	703	706	PF00400	0.542
TRG_ER_diArg_1	737	739	PF00400	0.530
TRG_ER_diArg_1	770	773	PF00400	0.650
TRG_ER_diArg_1	836	838	PF00400	0.754
TRG_ER_diArg_1	9	11	PF00400	0.640
TRG_ER_FFAT_2	505	515	PF00635	0.579
TRG_NLS_MonoCore_2	36	41	PF00514	0.657
TRG_NLS_MonoExtC_3	36	41	PF00514	0.734
TRG_NLS_MonoExtN_4	35	41	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	169	174	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG87	Leptomonas seymouri	33%	81%
A0A422MU26	Trypanosoma rangeli	24%	100%
A4H3N3	Leishmania braziliensis	66%	100%
A4HRW0	Leishmania infantum	100%	100%
C9ZKG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9ACL7	Leishmania major	90%	99%
E9AJV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BXD7	Trypanosoma cruzi	24%	100%