Aminoacyl-tRNA editing domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H554_LEIDO

TriTrypDb:

LdBPK_030690.1 , LdCL_030012100 , LDHU3_03.0780

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H554

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H554

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	9
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0052689	carboxylic ester hydrolase activity	4	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	133	135	PF00082	0.288
CLV_PCSK_KEX2_1	166	168	PF00082	0.246
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.297
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.305
CLV_PCSK_SKI1_1	130	134	PF00082	0.317
DEG_Nend_UBRbox_2	1	3	PF02207	0.498
DOC_CDC14_PxL_1	9	17	PF14671	0.353
DOC_MAPK_MEF2A_6	158	165	PF00069	0.472
DOC_MAPK_RevD_3	105	120	PF00069	0.560
DOC_PP1_RVXF_1	43	50	PF00149	0.381
DOC_USP7_MATH_1	114	118	PF00917	0.560
DOC_USP7_MATH_1	221	225	PF00917	0.561
DOC_USP7_MATH_1	23	27	PF00917	0.423
DOC_USP7_MATH_1	81	85	PF00917	0.637
DOC_USP7_UBL2_3	115	119	PF12436	0.481
DOC_USP7_UBL2_3	120	124	PF12436	0.446
DOC_USP7_UBL2_3	53	57	PF12436	0.601
DOC_USP7_UBL2_3	61	65	PF12436	0.616
DOC_WW_Pin1_4	87	92	PF00397	0.734
LIG_14-3-3_CanoR_1	86	94	PF00244	0.555
LIG_APCC_ABBA_1	157	162	PF00400	0.458
LIG_BRCT_BRCA1_1	45	49	PF00533	0.386
LIG_deltaCOP1_diTrp_1	198	206	PF00928	0.401
LIG_FHA_1	26	32	PF00498	0.366
LIG_FHA_2	183	189	PF00498	0.560
LIG_GBD_Chelix_1	43	51	PF00786	0.394
LIG_LIR_Gen_1	198	204	PF02991	0.394
LIG_LIR_Nem_3	138	143	PF02991	0.560
LIG_LIR_Nem_3	198	202	PF02991	0.419
LIG_NRBOX	46	52	PF00104	0.462
LIG_SH2_PTP2	170	173	PF00017	0.560
LIG_SH2_SRC	160	163	PF00017	0.522
LIG_SH2_SRC	170	173	PF00017	0.522
LIG_SH2_STAP1	192	196	PF00017	0.467
LIG_SH2_STAT5	140	143	PF00017	0.548
LIG_SH2_STAT5	160	163	PF00017	0.324
LIG_SH2_STAT5	170	173	PF00017	0.518
LIG_SH3_3	88	94	PF00018	0.552
LIG_SH3_4	53	60	PF00018	0.577
MOD_CK1_1	219	225	PF00069	0.568
MOD_CK1_1	25	31	PF00069	0.401
MOD_CK2_1	182	188	PF00069	0.495
MOD_CK2_1	53	59	PF00069	0.542
MOD_GlcNHglycan	116	119	PF01048	0.320
MOD_GlcNHglycan	223	226	PF01048	0.569
MOD_GlcNHglycan	24	28	PF01048	0.391
MOD_GlcNHglycan	78	81	PF01048	0.725
MOD_GlcNHglycan	87	90	PF01048	0.669
MOD_GSK3_1	221	228	PF00069	0.629
MOD_GSK3_1	81	88	PF00069	0.784
MOD_N-GLC_1	76	81	PF02516	0.453
MOD_NEK2_1	161	166	PF00069	0.464
MOD_NEK2_1	22	27	PF00069	0.450
MOD_PKA_1	52	58	PF00069	0.438
MOD_PKA_2	85	91	PF00069	0.696
MOD_Plk_1	161	167	PF00069	0.464
MOD_Plk_4	45	51	PF00069	0.449
MOD_ProDKin_1	87	93	PF00069	0.731
MOD_SUMO_for_1	132	135	PF00179	0.481
MOD_SUMO_rev_2	56	62	PF00179	0.593
TRG_ENDOCYTIC_2	140	143	PF00928	0.548
TRG_ENDOCYTIC_2	160	163	PF00928	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U1	Leptomonas seymouri	58%	100%
A0A1X0P8W1	Trypanosomatidae	44%	100%
A0A3R7N573	Trypanosoma rangeli	39%	100%
A4H3N2	Leishmania braziliensis	68%	100%
A4HRV9	Leishmania infantum	99%	100%
E9ACL6	Leishmania major	82%	100%
E9AJV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
P71000	Bacillus subtilis (strain 168)	38%	100%