Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H552_LEIDO

TriTrypDb:

LdBPK_030650.1 , LdCL_030011600 , LDHU3_03.0690

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H552

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H552

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	533	537	PF00656	0.721
CLV_NRD_NRD_1	200	202	PF00675	0.619
CLV_NRD_NRD_1	303	305	PF00675	0.500
CLV_NRD_NRD_1	349	351	PF00675	0.586
CLV_NRD_NRD_1	43	45	PF00675	0.630
CLV_NRD_NRD_1	476	478	PF00675	0.629
CLV_PCSK_KEX2_1	200	202	PF00082	0.621
CLV_PCSK_KEX2_1	303	305	PF00082	0.545
CLV_PCSK_KEX2_1	349	351	PF00082	0.586
CLV_PCSK_KEX2_1	43	45	PF00082	0.644
CLV_PCSK_KEX2_1	491	493	PF00082	0.525
CLV_PCSK_KEX2_1	7	9	PF00082	0.572
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.525
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.625
CLV_PCSK_PC7_1	39	45	PF00082	0.536
CLV_PCSK_SKI1_1	295	299	PF00082	0.520
CLV_PCSK_SKI1_1	349	353	PF00082	0.589
CLV_PCSK_SKI1_1	407	411	PF00082	0.534
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
DEG_SCF_FBW7_1	95	100	PF00400	0.668
DEG_SPOP_SBC_1	437	441	PF00917	0.484
DOC_CKS1_1	30	35	PF01111	0.459
DOC_MAPK_gen_1	200	206	PF00069	0.675
DOC_MAPK_gen_1	303	312	PF00069	0.436
DOC_MAPK_MEF2A_6	208	215	PF00069	0.654
DOC_PP2B_LxvP_1	38	41	PF13499	0.554
DOC_USP7_MATH_1	10	14	PF00917	0.567
DOC_USP7_MATH_1	242	246	PF00917	0.685
DOC_USP7_MATH_1	302	306	PF00917	0.508
DOC_USP7_MATH_1	322	326	PF00917	0.330
DOC_USP7_MATH_1	437	441	PF00917	0.627
DOC_USP7_MATH_1	64	68	PF00917	0.549
DOC_WW_Pin1_4	164	169	PF00397	0.680
DOC_WW_Pin1_4	213	218	PF00397	0.458
DOC_WW_Pin1_4	29	34	PF00397	0.425
DOC_WW_Pin1_4	358	363	PF00397	0.592
DOC_WW_Pin1_4	433	438	PF00397	0.661
DOC_WW_Pin1_4	465	470	PF00397	0.684
DOC_WW_Pin1_4	93	98	PF00397	0.778
LIG_14-3-3_CanoR_1	110	118	PF00244	0.538
LIG_14-3-3_CanoR_1	133	140	PF00244	0.480
LIG_14-3-3_CanoR_1	184	191	PF00244	0.571
LIG_14-3-3_CanoR_1	200	206	PF00244	0.626
LIG_14-3-3_CanoR_1	304	312	PF00244	0.469
LIG_14-3-3_CanoR_1	333	341	PF00244	0.546
LIG_14-3-3_CanoR_1	411	418	PF00244	0.590
LIG_14-3-3_CanoR_1	433	437	PF00244	0.697
LIG_AP2alpha_2	79	81	PF02296	0.498
LIG_APCC_ABBAyCdc20_2	227	233	PF00400	0.476
LIG_BRCT_BRCA1_1	547	551	PF00533	0.432
LIG_CtBP_PxDLS_1	212	216	PF00389	0.561
LIG_deltaCOP1_diTrp_1	226	231	PF00928	0.487
LIG_eIF4E_1	219	225	PF01652	0.399
LIG_FHA_1	101	107	PF00498	0.628
LIG_FHA_1	134	140	PF00498	0.496
LIG_FHA_1	191	197	PF00498	0.597
LIG_FHA_1	307	313	PF00498	0.393
LIG_FHA_1	35	41	PF00498	0.483
LIG_FHA_1	372	378	PF00498	0.542
LIG_FHA_1	411	417	PF00498	0.590
LIG_FHA_1	421	427	PF00498	0.523
LIG_FHA_1	553	559	PF00498	0.498
LIG_FHA_2	333	339	PF00498	0.500
LIG_FHA_2	439	445	PF00498	0.516
LIG_FHA_2	504	510	PF00498	0.586
LIG_GBD_Chelix_1	553	561	PF00786	0.511
LIG_LIR_Apic_2	506	511	PF02991	0.662
LIG_LIR_Gen_1	126	132	PF02991	0.619
LIG_LIR_Gen_1	226	236	PF02991	0.508
LIG_LIR_LC3C_4	296	300	PF02991	0.512
LIG_LIR_Nem_3	126	130	PF02991	0.620
LIG_LIR_Nem_3	226	231	PF02991	0.375
LIG_LIR_Nem_3	276	281	PF02991	0.563
LIG_LIR_Nem_3	440	446	PF02991	0.533
LIG_LIR_Nem_3	77	81	PF02991	0.413
LIG_PCNA_yPIPBox_3	170	181	PF02747	0.449
LIG_PDZ_Class_3	561	566	PF00595	0.498
LIG_Pex14_1	74	78	PF04695	0.517
LIG_PTAP_UEV_1	52	57	PF05743	0.561
LIG_Rb_LxCxE_1	538	560	PF01857	0.556
LIG_SH2_CRK	22	26	PF00017	0.534
LIG_SH2_CRK	508	512	PF00017	0.656
LIG_SH2_NCK_1	508	512	PF00017	0.656
LIG_SH2_PTP2	127	130	PF00017	0.522
LIG_SH2_SRC	145	148	PF00017	0.613
LIG_SH2_STAP1	219	223	PF00017	0.455
LIG_SH2_STAT5	127	130	PF00017	0.477
LIG_SH3_3	112	118	PF00018	0.463
LIG_SH3_3	153	159	PF00018	0.694
LIG_SH3_3	236	242	PF00018	0.500
LIG_SH3_3	296	302	PF00018	0.563
LIG_SH3_3	391	397	PF00018	0.603
LIG_SH3_3	42	48	PF00018	0.572
LIG_SH3_3	50	56	PF00018	0.605
LIG_SH3_3	92	98	PF00018	0.752
LIG_Sin3_3	234	241	PF02671	0.500
LIG_SUMO_SIM_anti_2	296	301	PF11976	0.483
LIG_SUMO_SIM_par_1	211	216	PF11976	0.638
LIG_SUMO_SIM_par_1	444	450	PF11976	0.524
LIG_SUMO_SIM_par_1	453	458	PF11976	0.451
LIG_TYR_ITIM	20	25	PF00017	0.539
MOD_CDC14_SPxK_1	167	170	PF00782	0.648
MOD_CDK_SPxK_1	164	170	PF00069	0.674
MOD_CDK_SPxK_1	467	473	PF00069	0.682
MOD_CK1_1	245	251	PF00069	0.608
MOD_CK1_1	305	311	PF00069	0.420
MOD_CK1_1	324	330	PF00069	0.641
MOD_CK1_1	436	442	PF00069	0.509
MOD_CK1_1	51	57	PF00069	0.685
MOD_CK1_1	560	566	PF00069	0.592
MOD_CK2_1	332	338	PF00069	0.528
MOD_DYRK1A_RPxSP_1	433	437	PF00069	0.599
MOD_GlcNHglycan	111	114	PF01048	0.518
MOD_GlcNHglycan	221	224	PF01048	0.558
MOD_GlcNHglycan	244	247	PF01048	0.655
MOD_GlcNHglycan	304	307	PF01048	0.454
MOD_GlcNHglycan	315	318	PF01048	0.402
MOD_GlcNHglycan	324	327	PF01048	0.610
MOD_GlcNHglycan	343	346	PF01048	0.342
MOD_GlcNHglycan	355	358	PF01048	0.486
MOD_GlcNHglycan	53	56	PF01048	0.567
MOD_GlcNHglycan	67	70	PF01048	0.511
MOD_GlcNHglycan	86	90	PF01048	0.633
MOD_GSK3_1	105	112	PF00069	0.595
MOD_GSK3_1	186	193	PF00069	0.641
MOD_GSK3_1	237	244	PF00069	0.521
MOD_GSK3_1	245	252	PF00069	0.549
MOD_GSK3_1	286	293	PF00069	0.506
MOD_GSK3_1	302	309	PF00069	0.337
MOD_GSK3_1	320	327	PF00069	0.519
MOD_GSK3_1	428	435	PF00069	0.602
MOD_GSK3_1	463	470	PF00069	0.606
MOD_GSK3_1	47	54	PF00069	0.691
MOD_GSK3_1	85	92	PF00069	0.623
MOD_GSK3_1	93	100	PF00069	0.689
MOD_N-GLC_1	418	423	PF02516	0.543
MOD_N-GLC_1	65	70	PF02516	0.557
MOD_NEK2_1	106	111	PF00069	0.532
MOD_NEK2_1	196	201	PF00069	0.561
MOD_NEK2_1	249	254	PF00069	0.612
MOD_NEK2_1	34	39	PF00069	0.566
MOD_NEK2_1	341	346	PF00069	0.399
MOD_NEK2_1	365	370	PF00069	0.465
MOD_NEK2_1	420	425	PF00069	0.594
MOD_NEK2_1	428	433	PF00069	0.634
MOD_NEK2_1	464	469	PF00069	0.589
MOD_NEK2_1	503	508	PF00069	0.509
MOD_NEK2_1	557	562	PF00069	0.492
MOD_PIKK_1	249	255	PF00454	0.701
MOD_PIKK_1	438	444	PF00454	0.622
MOD_PIKK_1	552	558	PF00454	0.507
MOD_PKA_2	109	115	PF00069	0.535
MOD_PKA_2	183	189	PF00069	0.554
MOD_PKA_2	199	205	PF00069	0.613
MOD_PKA_2	302	308	PF00069	0.454
MOD_PKA_2	332	338	PF00069	0.548
MOD_PKA_2	410	416	PF00069	0.603
MOD_PKA_2	432	438	PF00069	0.586
MOD_Plk_1	428	434	PF00069	0.544
MOD_Plk_1	65	71	PF00069	0.555
MOD_Plk_4	192	198	PF00069	0.672
MOD_Plk_4	360	366	PF00069	0.506
MOD_Plk_4	557	563	PF00069	0.544
MOD_ProDKin_1	164	170	PF00069	0.674
MOD_ProDKin_1	213	219	PF00069	0.447
MOD_ProDKin_1	29	35	PF00069	0.428
MOD_ProDKin_1	358	364	PF00069	0.582
MOD_ProDKin_1	433	439	PF00069	0.663
MOD_ProDKin_1	465	471	PF00069	0.681
MOD_ProDKin_1	93	99	PF00069	0.780
TRG_DiLeu_BaEn_2	394	400	PF01217	0.602
TRG_DiLeu_BaEn_2	76	82	PF01217	0.490
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.497
TRG_ENDOCYTIC_2	127	130	PF00928	0.531
TRG_ENDOCYTIC_2	22	25	PF00928	0.531
TRG_ENDOCYTIC_2	278	281	PF00928	0.443
TRG_ENDOCYTIC_2	78	81	PF00928	0.417
TRG_ER_diArg_1	302	304	PF00400	0.566
TRG_ER_diArg_1	348	350	PF00400	0.569
TRG_ER_diArg_1	42	44	PF00400	0.615
TRG_ER_diArg_1	424	427	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSY5	Leptomonas seymouri	54%	98%
A0A1X0P955	Trypanosomatidae	30%	100%
A0A422NMI0	Trypanosoma rangeli	31%	100%
A4H3M8	Leishmania braziliensis	85%	100%
D0A270	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ACL2	Leishmania major	95%	100%
E9AG56	Leishmania infantum	100%	100%
E9AJV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BXE2	Trypanosoma cruzi	32%	100%