Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H551_LEIDO

TriTrypDb:

LdBPK_030610.1 , LdCL_030011200 , LDHU3_03.0650

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H551

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H551

PDB structure(s): 7ane_ak

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.806
CLV_C14_Caspase3-7	310	314	PF00656	0.658
CLV_NRD_NRD_1	138	140	PF00675	0.574
CLV_NRD_NRD_1	191	193	PF00675	0.630
CLV_NRD_NRD_1	213	215	PF00675	0.652
CLV_NRD_NRD_1	269	271	PF00675	0.487
CLV_NRD_NRD_1	274	276	PF00675	0.477
CLV_NRD_NRD_1	288	290	PF00675	0.350
CLV_PCSK_FUR_1	189	193	PF00082	0.622
CLV_PCSK_KEX2_1	138	140	PF00082	0.603
CLV_PCSK_KEX2_1	191	193	PF00082	0.643
CLV_PCSK_KEX2_1	274	276	PF00082	0.529
CLV_PCSK_KEX2_1	288	290	PF00082	0.397
CLV_PCSK_KEX2_1	301	303	PF00082	0.422
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.500
CLV_PCSK_PC7_1	270	276	PF00082	0.570
CLV_PCSK_SKI1_1	126	130	PF00082	0.464
CLV_PCSK_SKI1_1	16	20	PF00082	0.407
CLV_PCSK_SKI1_1	215	219	PF00082	0.433
CLV_PCSK_SKI1_1	251	255	PF00082	0.488
DEG_APCC_DBOX_1	288	296	PF00400	0.578
DEG_SPOP_SBC_1	89	93	PF00917	0.753
DOC_MAPK_gen_1	212	219	PF00069	0.591
DOC_PP2B_LxvP_1	238	241	PF13499	0.476
DOC_PP4_FxxP_1	182	185	PF00568	0.550
DOC_SPAK_OSR1_1	181	185	PF12202	0.578
DOC_USP7_MATH_1	231	235	PF00917	0.415
DOC_USP7_MATH_1	44	48	PF00917	0.481
DOC_USP7_MATH_1	89	93	PF00917	0.743
DOC_USP7_UBL2_3	297	301	PF12436	0.568
DOC_WW_Pin1_4	74	79	PF00397	0.761
DOC_WW_Pin1_4	82	87	PF00397	0.712
LIG_14-3-3_CanoR_1	214	220	PF00244	0.440
LIG_14-3-3_CanoR_1	28	32	PF00244	0.502
LIG_14-3-3_CanoR_1	288	296	PF00244	0.542
LIG_14-3-3_CterR_2	322	325	PF00244	0.587
LIG_Actin_WH2_2	308	324	PF00022	0.698
LIG_APCC_ABBAyCdc20_2	14	20	PF00400	0.505
LIG_BIR_II_1	1	5	PF00653	0.477
LIG_Clathr_ClatBox_1	243	247	PF01394	0.438
LIG_CtBP_PxDLS_1	104	109	PF00389	0.571
LIG_deltaCOP1_diTrp_1	175	182	PF00928	0.574
LIG_FHA_1	214	220	PF00498	0.583
LIG_FHA_1	4	10	PF00498	0.429
LIG_FHA_2	101	107	PF00498	0.615
LIG_FHA_2	308	314	PF00498	0.632
LIG_GBD_Chelix_1	9	17	PF00786	0.445
LIG_LIR_Gen_1	118	127	PF02991	0.541
LIG_LIR_Gen_1	278	287	PF02991	0.515
LIG_LIR_Nem_3	118	122	PF02991	0.530
LIG_LIR_Nem_3	278	284	PF02991	0.474
LIG_LIR_Nem_3	30	34	PF02991	0.496
LIG_LIR_Nem_3	43	48	PF02991	0.380
LIG_Pex14_1	59	63	PF04695	0.442
LIG_PTAP_UEV_1	77	82	PF05743	0.698
LIG_SH2_CRK	45	49	PF00017	0.405
LIG_SH2_GRB2like	5	8	PF00017	0.434
LIG_SH2_STAP1	153	157	PF00017	0.454
LIG_SH2_STAP1	304	308	PF00017	0.540
LIG_SH2_STAP1	5	9	PF00017	0.431
LIG_SH2_STAT5	5	8	PF00017	0.434
LIG_SH3_3	181	187	PF00018	0.564
LIG_SH3_3	55	61	PF00018	0.560
LIG_SH3_3	75	81	PF00018	0.743
LIG_SH3_3	83	89	PF00018	0.726
LIG_SUMO_SIM_anti_2	103	109	PF11976	0.578
LIG_SUMO_SIM_anti_2	216	224	PF11976	0.594
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.450
LIG_TRAF2_1	128	131	PF00917	0.489
LIG_TYR_ITSM	41	48	PF00017	0.516
LIG_UBA3_1	243	251	PF00899	0.424
LIG_UBA3_1	263	271	PF00899	0.474
MOD_CDC14_SPxK_1	85	88	PF00782	0.743
MOD_CDK_SPxK_1	82	88	PF00069	0.748
MOD_CK1_1	87	93	PF00069	0.758
MOD_CK1_1	94	100	PF00069	0.688
MOD_CK2_1	311	317	PF00069	0.666
MOD_GlcNHglycan	110	113	PF01048	0.437
MOD_GlcNHglycan	99	102	PF01048	0.660
MOD_GSK3_1	251	258	PF00069	0.606
MOD_GSK3_1	287	294	PF00069	0.579
MOD_GSK3_1	307	314	PF00069	0.356
MOD_GSK3_1	40	47	PF00069	0.368
MOD_GSK3_1	84	91	PF00069	0.762
MOD_GSK3_1	93	100	PF00069	0.685
MOD_N-GLC_1	68	73	PF02516	0.727
MOD_NEK2_1	110	115	PF00069	0.408
MOD_NEK2_1	3	8	PF00069	0.436
MOD_NEK2_1	307	312	PF00069	0.672
MOD_NEK2_1	9	14	PF00069	0.396
MOD_NEK2_2	231	236	PF00069	0.436
MOD_OFUCOSY	35	42	PF10250	0.452
MOD_PIKK_1	287	293	PF00454	0.568
MOD_PKA_2	213	219	PF00069	0.606
MOD_PKA_2	27	33	PF00069	0.439
MOD_PKA_2	287	293	PF00069	0.568
MOD_PKA_2	3	9	PF00069	0.435
MOD_PKA_2	87	93	PF00069	0.761
MOD_Plk_4	44	50	PF00069	0.400
MOD_ProDKin_1	74	80	PF00069	0.760
MOD_ProDKin_1	82	88	PF00069	0.711
MOD_SUMO_for_1	128	131	PF00179	0.489
MOD_SUMO_rev_2	205	213	PF00179	0.719
MOD_SUMO_rev_2	247	253	PF00179	0.453
MOD_SUMO_rev_2	313	319	PF00179	0.610
TRG_DiLeu_BaEn_1	282	287	PF01217	0.449
TRG_ENDOCYTIC_2	304	307	PF00928	0.649
TRG_ENDOCYTIC_2	45	48	PF00928	0.393
TRG_ER_diArg_1	137	139	PF00400	0.610
TRG_ER_diArg_1	190	192	PF00400	0.633
TRG_ER_diArg_1	273	275	PF00400	0.554
TRG_ER_diArg_1	287	289	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B1	Leptomonas seymouri	64%	100%
A0A0S4JDA3	Bodo saltans	31%	100%
A0A1X0P8U5	Trypanosomatidae	44%	100%
A0A422NMF2	Trypanosoma rangeli	46%	100%
D0A266	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ACK8	Leishmania major	96%	100%
E9AG52	Leishmania infantum	97%	100%
E9AJU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5BCA0	Trypanosoma cruzi	44%	100%