Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H548_LEIDO

TriTrypDb:

LdBPK_030540.1 , LdCL_030010500 , LDHU3_03.0560

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H548

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H548

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.656
CLV_NRD_NRD_1	20	22	PF00675	0.476
CLV_NRD_NRD_1	214	216	PF00675	0.511
CLV_NRD_NRD_1	248	250	PF00675	0.517
CLV_NRD_NRD_1	305	307	PF00675	0.574
CLV_NRD_NRD_1	336	338	PF00675	0.526
CLV_NRD_NRD_1	346	348	PF00675	0.591
CLV_NRD_NRD_1	388	390	PF00675	0.489
CLV_NRD_NRD_1	437	439	PF00675	0.629
CLV_NRD_NRD_1	48	50	PF00675	0.443
CLV_NRD_NRD_1	526	528	PF00675	0.712
CLV_NRD_NRD_1	567	569	PF00675	0.492
CLV_NRD_NRD_1	62	64	PF00675	0.511
CLV_NRD_NRD_1	706	708	PF00675	0.487
CLV_NRD_NRD_1	76	78	PF00675	0.441
CLV_PCSK_FUR_1	18	22	PF00082	0.448
CLV_PCSK_FUR_1	565	569	PF00082	0.485
CLV_PCSK_KEX2_1	18	20	PF00082	0.469
CLV_PCSK_KEX2_1	214	216	PF00082	0.507
CLV_PCSK_KEX2_1	247	249	PF00082	0.519
CLV_PCSK_KEX2_1	305	307	PF00082	0.574
CLV_PCSK_KEX2_1	336	338	PF00082	0.526
CLV_PCSK_KEX2_1	346	348	PF00082	0.591
CLV_PCSK_KEX2_1	364	366	PF00082	0.481
CLV_PCSK_KEX2_1	388	390	PF00082	0.489
CLV_PCSK_KEX2_1	436	438	PF00082	0.636
CLV_PCSK_KEX2_1	48	50	PF00082	0.443
CLV_PCSK_KEX2_1	526	528	PF00082	0.712
CLV_PCSK_KEX2_1	567	569	PF00082	0.492
CLV_PCSK_KEX2_1	62	64	PF00082	0.511
CLV_PCSK_KEX2_1	706	708	PF00082	0.458
CLV_PCSK_KEX2_1	76	78	PF00082	0.441
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.515
CLV_PCSK_SKI1_1	113	117	PF00082	0.426
CLV_PCSK_SKI1_1	187	191	PF00082	0.554
CLV_PCSK_SKI1_1	62	66	PF00082	0.501
DEG_ODPH_VHL_1	552	563	PF01847	0.325
DEG_ODPH_VHL_1	636	647	PF01847	0.620
DEG_SPOP_SBC_1	193	197	PF00917	0.829
DEG_SPOP_SBC_1	209	213	PF00917	0.637
DEG_SPOP_SBC_1	530	534	PF00917	0.526
DEG_SPOP_SBC_1	598	602	PF00917	0.629
DEG_SPOP_SBC_1	609	613	PF00917	0.632
DOC_ANK_TNKS_1	52	59	PF00023	0.660
DOC_CKS1_1	147	152	PF01111	0.717
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.369
DOC_MAPK_MEF2A_6	634	642	PF00069	0.583
DOC_MAPK_MEF2A_6	648	656	PF00069	0.495
DOC_PP2B_LxvP_1	418	421	PF13499	0.369
DOC_PP2B_LxvP_1	551	554	PF13499	0.369
DOC_PP2B_LxvP_1	656	659	PF13499	0.602
DOC_USP7_MATH_1	171	175	PF00917	0.730
DOC_USP7_MATH_1	193	197	PF00917	0.675
DOC_USP7_MATH_1	258	262	PF00917	0.761
DOC_USP7_MATH_1	298	302	PF00917	0.834
DOC_USP7_MATH_1	310	314	PF00917	0.673
DOC_USP7_MATH_1	317	321	PF00917	0.652
DOC_USP7_MATH_1	448	452	PF00917	0.514
DOC_USP7_MATH_1	469	473	PF00917	0.503
DOC_USP7_MATH_1	530	534	PF00917	0.580
DOC_USP7_MATH_1	543	547	PF00917	0.325
DOC_USP7_MATH_1	597	601	PF00917	0.712
DOC_USP7_MATH_1	608	612	PF00917	0.676
DOC_USP7_MATH_1	688	692	PF00917	0.666
DOC_USP7_MATH_1	695	699	PF00917	0.651
DOC_WW_Pin1_4	117	122	PF00397	0.693
DOC_WW_Pin1_4	146	151	PF00397	0.828
DOC_WW_Pin1_4	180	185	PF00397	0.653
DOC_WW_Pin1_4	260	265	PF00397	0.727
DOC_WW_Pin1_4	351	356	PF00397	0.731
DOC_WW_Pin1_4	365	370	PF00397	0.702
DOC_WW_Pin1_4	586	591	PF00397	0.725
DOC_WW_Pin1_4	600	605	PF00397	0.609
DOC_WW_Pin1_4	674	679	PF00397	0.650
DOC_WW_Pin1_4	94	99	PF00397	0.692
LIG_14-3-3_CanoR_1	187	192	PF00244	0.750
LIG_14-3-3_CanoR_1	20	28	PF00244	0.668
LIG_14-3-3_CanoR_1	398	404	PF00244	0.569
LIG_14-3-3_CanoR_1	454	458	PF00244	0.480
LIG_14-3-3_CanoR_1	53	57	PF00244	0.675
LIG_14-3-3_CanoR_1	607	616	PF00244	0.630
LIG_14-3-3_CanoR_1	694	700	PF00244	0.690
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	1	5	PF00533	0.655
LIG_Clathr_ClatBox_1	424	428	PF01394	0.369
LIG_deltaCOP1_diTrp_1	668	673	PF00928	0.685
LIG_eIF4E_1	283	289	PF01652	0.733
LIG_FHA_1	110	116	PF00498	0.656
LIG_FHA_1	142	148	PF00498	0.694
LIG_FHA_1	193	199	PF00498	0.692
LIG_FHA_1	283	289	PF00498	0.686
LIG_FHA_1	415	421	PF00498	0.369
LIG_FHA_1	487	493	PF00498	0.521
LIG_FHA_1	698	704	PF00498	0.697
LIG_FHA_1	88	94	PF00498	0.686
LIG_FHA_2	297	303	PF00498	0.670
LIG_FHA_2	32	38	PF00498	0.693
LIG_LIR_Gen_1	2	12	PF02991	0.663
LIG_LIR_Gen_1	30	40	PF02991	0.625
LIG_LIR_Gen_1	408	419	PF02991	0.324
LIG_LIR_Gen_1	628	638	PF02991	0.605
LIG_LIR_Nem_3	2	8	PF02991	0.656
LIG_LIR_Nem_3	278	282	PF02991	0.796
LIG_LIR_Nem_3	30	35	PF02991	0.630
LIG_LIR_Nem_3	408	414	PF02991	0.324
LIG_LIR_Nem_3	613	619	PF02991	0.658
LIG_LIR_Nem_3	628	633	PF02991	0.605
LIG_LIR_Nem_3	644	649	PF02991	0.638
LIG_PCNA_PIPBox_1	639	648	PF02747	0.597
LIG_PCNA_yPIPBox_3	555	568	PF02747	0.482
LIG_PCNA_yPIPBox_3	632	646	PF02747	0.601
LIG_SH2_STAP1	649	653	PF00017	0.625
LIG_SH3_3	144	150	PF00018	0.776
LIG_SH3_3	178	184	PF00018	0.669
LIG_SH3_3	186	192	PF00018	0.851
LIG_SH3_3	363	369	PF00018	0.782
LIG_SH3_3	398	404	PF00018	0.708
LIG_SUMO_SIM_par_1	381	387	PF11976	0.620
LIG_SUMO_SIM_par_1	583	589	PF11976	0.642
LIG_TRAF2_1	679	682	PF00917	0.797
LIG_TYR_ITIM	647	652	PF00017	0.448
MOD_CDK_SPK_2	146	151	PF00069	0.652
MOD_CDK_SPxxK_3	180	187	PF00069	0.566
MOD_CDK_SPxxK_3	600	607	PF00069	0.601
MOD_CDK_SPxxK_3	94	101	PF00069	0.595
MOD_CK1_1	132	138	PF00069	0.650
MOD_CK1_1	158	164	PF00069	0.617
MOD_CK1_1	196	202	PF00069	0.765
MOD_CK1_1	203	209	PF00069	0.637
MOD_CK1_1	210	216	PF00069	0.581
MOD_CK1_1	24	30	PF00069	0.591
MOD_CK1_1	301	307	PF00069	0.687
MOD_CK1_1	368	374	PF00069	0.643
MOD_CK1_1	375	381	PF00069	0.639
MOD_CK1_1	384	390	PF00069	0.487
MOD_CK1_1	452	458	PF00069	0.614
MOD_CK1_1	486	492	PF00069	0.780
MOD_CK1_1	510	516	PF00069	0.717
MOD_CK1_1	533	539	PF00069	0.728
MOD_CK1_1	600	606	PF00069	0.608
MOD_CK1_1	667	673	PF00069	0.560
MOD_CK1_1	71	77	PF00069	0.546
MOD_CK2_1	180	186	PF00069	0.608
MOD_CK2_1	296	302	PF00069	0.561
MOD_CK2_1	384	390	PF00069	0.721
MOD_CK2_1	609	615	PF00069	0.593
MOD_Cter_Amidation	334	337	PF01082	0.556
MOD_Cter_Amidation	74	77	PF01082	0.614
MOD_DYRK1A_RPxSP_1	365	369	PF00069	0.680
MOD_GlcNHglycan	173	176	PF01048	0.675
MOD_GlcNHglycan	202	205	PF01048	0.716
MOD_GlcNHglycan	218	221	PF01048	0.710
MOD_GlcNHglycan	312	315	PF01048	0.773
MOD_GlcNHglycan	319	322	PF01048	0.610
MOD_GlcNHglycan	332	335	PF01048	0.564
MOD_GlcNHglycan	446	449	PF01048	0.640
MOD_GlcNHglycan	451	454	PF01048	0.785
MOD_GlcNHglycan	485	488	PF01048	0.644
MOD_GlcNHglycan	500	503	PF01048	0.609
MOD_GlcNHglycan	509	512	PF01048	0.647
MOD_GlcNHglycan	515	518	PF01048	0.714
MOD_GlcNHglycan	536	539	PF01048	0.598
MOD_GlcNHglycan	54	57	PF01048	0.632
MOD_GlcNHglycan	65	68	PF01048	0.657
MOD_GlcNHglycan	70	73	PF01048	0.600
MOD_GlcNHglycan	78	81	PF01048	0.515
MOD_GSK3_1	109	116	PF00069	0.543
MOD_GSK3_1	117	124	PF00069	0.742
MOD_GSK3_1	125	132	PF00069	0.636
MOD_GSK3_1	192	199	PF00069	0.623
MOD_GSK3_1	203	210	PF00069	0.683
MOD_GSK3_1	23	30	PF00069	0.571
MOD_GSK3_1	260	267	PF00069	0.683
MOD_GSK3_1	341	348	PF00069	0.588
MOD_GSK3_1	356	363	PF00069	0.601
MOD_GSK3_1	368	375	PF00069	0.613
MOD_GSK3_1	410	417	PF00069	0.369
MOD_GSK3_1	444	451	PF00069	0.643
MOD_GSK3_1	452	459	PF00069	0.568
MOD_GSK3_1	492	499	PF00069	0.594
MOD_GSK3_1	507	514	PF00069	0.627
MOD_GSK3_1	529	536	PF00069	0.693
MOD_GSK3_1	588	595	PF00069	0.617
MOD_GSK3_1	695	702	PF00069	0.602
MOD_N-GLC_1	323	328	PF02516	0.607
MOD_N-GLC_1	483	488	PF02516	0.605
MOD_N-GLC_1	688	693	PF02516	0.659
MOD_NEK2_1	143	148	PF00069	0.611
MOD_NEK2_1	207	212	PF00069	0.730
MOD_NEK2_1	282	287	PF00069	0.609
MOD_NEK2_1	323	328	PF00069	0.661
MOD_NEK2_1	330	335	PF00069	0.655
MOD_NEK2_1	345	350	PF00069	0.676
MOD_NEK2_1	399	404	PF00069	0.454
MOD_NEK2_1	414	419	PF00069	0.319
MOD_NEK2_1	497	502	PF00069	0.587
MOD_NEK2_1	592	597	PF00069	0.596
MOD_PIKK_1	345	351	PF00454	0.597
MOD_PK_1	381	387	PF00069	0.581
MOD_PKA_1	336	342	PF00069	0.567
MOD_PKA_1	567	573	PF00069	0.644
MOD_PKA_1	76	82	PF00069	0.644
MOD_PKA_2	213	219	PF00069	0.601
MOD_PKA_2	22	28	PF00069	0.576
MOD_PKA_2	336	342	PF00069	0.622
MOD_PKA_2	345	351	PF00069	0.635
MOD_PKA_2	453	459	PF00069	0.617
MOD_PKA_2	52	58	PF00069	0.604
MOD_PKA_2	567	573	PF00069	0.644
MOD_PKA_2	76	82	PF00069	0.737
MOD_PKB_1	19	27	PF00069	0.555
MOD_PKB_1	565	573	PF00069	0.632
MOD_Plk_1	193	199	PF00069	0.616
MOD_Plk_1	252	258	PF00069	0.597
MOD_Plk_1	323	329	PF00069	0.607
MOD_Plk_1	439	445	PF00069	0.620
MOD_Plk_2-3	296	302	PF00069	0.566
MOD_Plk_2-3	31	37	PF00069	0.619
MOD_Plk_2-3	581	587	PF00069	0.582
MOD_Plk_4	143	149	PF00069	0.675
MOD_Plk_4	323	329	PF00069	0.651
MOD_Plk_4	410	416	PF00069	0.304
MOD_Plk_4	543	549	PF00069	0.307
MOD_Plk_4	581	587	PF00069	0.660
MOD_Plk_4	699	705	PF00069	0.543
MOD_ProDKin_1	117	123	PF00069	0.617
MOD_ProDKin_1	146	152	PF00069	0.804
MOD_ProDKin_1	180	186	PF00069	0.564
MOD_ProDKin_1	260	266	PF00069	0.666
MOD_ProDKin_1	351	357	PF00069	0.669
MOD_ProDKin_1	365	371	PF00069	0.628
MOD_ProDKin_1	586	592	PF00069	0.663
MOD_ProDKin_1	600	606	PF00069	0.501
MOD_ProDKin_1	674	680	PF00069	0.558
MOD_ProDKin_1	94	100	PF00069	0.615
MOD_SUMO_rev_2	523	533	PF00179	0.563
MOD_SUMO_rev_2	677	686	PF00179	0.684
TRG_ENDOCYTIC_2	616	619	PF00928	0.558
TRG_ENDOCYTIC_2	630	633	PF00928	0.486
TRG_ENDOCYTIC_2	649	652	PF00928	0.452
TRG_ER_diArg_1	17	20	PF00400	0.569
TRG_ER_diArg_1	176	179	PF00400	0.598
TRG_ER_diArg_1	247	249	PF00400	0.642
TRG_ER_diArg_1	305	307	PF00400	0.678
TRG_ER_diArg_1	345	347	PF00400	0.705
TRG_ER_diArg_1	435	438	PF00400	0.532
TRG_ER_diArg_1	47	49	PF00400	0.542
TRG_ER_diArg_1	525	527	PF00400	0.644
TRG_ER_diArg_1	565	568	PF00400	0.600
TRG_ER_diArg_1	705	707	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	617	622	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	634	639	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4E7	Leptomonas seymouri	30%	100%
A4H3L8	Leishmania braziliensis	60%	97%
E9ACK1	Leishmania major	85%	100%
E9AG45	Leishmania infantum	100%	100%
E9AJT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%