RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H546_LEIDO

TriTrypDb:

LdBPK_030500.1 , LdCL_030010100 , LDHU3_03.0520

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000243	commitment complex	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0016604	nuclear body	2	1
GO:0016607	nuclear speck	3	1
GO:0032991	protein-containing complex	1	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0089701	U2AF complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H546

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H546

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003727	single-stranded RNA binding	5	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0030628	pre-mRNA 3'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.693
CLV_C14_Caspase3-7	408	412	PF00656	0.563
CLV_C14_Caspase3-7	476	480	PF00656	0.564
CLV_C14_Caspase3-7	8	12	PF00656	0.734
CLV_MEL_PAP_1	336	342	PF00089	0.503
CLV_NRD_NRD_1	291	293	PF00675	0.518
CLV_NRD_NRD_1	297	299	PF00675	0.434
CLV_NRD_NRD_1	325	327	PF00675	0.401
CLV_NRD_NRD_1	420	422	PF00675	0.450
CLV_NRD_NRD_1	44	46	PF00675	0.702
CLV_NRD_NRD_1	57	59	PF00675	0.732
CLV_NRD_NRD_1	669	671	PF00675	0.497
CLV_NRD_NRD_1	704	706	PF00675	0.424
CLV_NRD_NRD_1	77	79	PF00675	0.774
CLV_NRD_NRD_1	80	82	PF00675	0.737
CLV_NRD_NRD_1	824	826	PF00675	0.579
CLV_NRD_NRD_1	9	11	PF00675	0.590
CLV_PCSK_FUR_1	42	46	PF00082	0.747
CLV_PCSK_FUR_1	661	665	PF00082	0.487
CLV_PCSK_FUR_1	78	82	PF00082	0.674
CLV_PCSK_KEX2_1	291	293	PF00082	0.516
CLV_PCSK_KEX2_1	297	299	PF00082	0.437
CLV_PCSK_KEX2_1	325	327	PF00082	0.401
CLV_PCSK_KEX2_1	420	422	PF00082	0.450
CLV_PCSK_KEX2_1	44	46	PF00082	0.691
CLV_PCSK_KEX2_1	57	59	PF00082	0.758
CLV_PCSK_KEX2_1	663	665	PF00082	0.470
CLV_PCSK_KEX2_1	669	671	PF00082	0.478
CLV_PCSK_KEX2_1	77	79	PF00082	0.774
CLV_PCSK_KEX2_1	80	82	PF00082	0.737
CLV_PCSK_KEX2_1	9	11	PF00082	0.619
CLV_PCSK_PC1ET2_1	663	665	PF00082	0.486
CLV_PCSK_PC7_1	40	46	PF00082	0.693
CLV_PCSK_SKI1_1	274	278	PF00082	0.584
CLV_PCSK_SKI1_1	403	407	PF00082	0.482
CLV_PCSK_SKI1_1	435	439	PF00082	0.379
CLV_PCSK_SKI1_1	451	455	PF00082	0.280
CLV_PCSK_SKI1_1	459	463	PF00082	0.323
CLV_PCSK_SKI1_1	478	482	PF00082	0.186
CLV_PCSK_SKI1_1	507	511	PF00082	0.376
CLV_PCSK_SKI1_1	588	592	PF00082	0.550
DEG_APCC_DBOX_1	273	281	PF00400	0.579
DEG_SPOP_SBC_1	259	263	PF00917	0.727
DEG_SPOP_SBC_1	818	822	PF00917	0.761
DOC_CKS1_1	623	628	PF01111	0.486
DOC_CKS1_1	99	104	PF01111	0.667
DOC_CYCLIN_RxL_1	400	409	PF00134	0.494
DOC_CYCLIN_RxL_1	456	464	PF00134	0.564
DOC_CYCLIN_RxL_1	585	594	PF00134	0.608
DOC_MAPK_FxFP_2	761	764	PF00069	0.536
DOC_MAPK_gen_1	375	384	PF00069	0.414
DOC_MAPK_gen_1	658	667	PF00069	0.431
DOC_MAPK_MEF2A_6	237	244	PF00069	0.657
DOC_MAPK_MEF2A_6	377	386	PF00069	0.446
DOC_MAPK_MEF2A_6	512	519	PF00069	0.488
DOC_MAPK_NFAT4_5	237	245	PF00069	0.663
DOC_PP1_RVXF_1	457	464	PF00149	0.564
DOC_PP2B_LxvP_1	280	283	PF13499	0.652
DOC_PP2B_LxvP_1	319	322	PF13499	0.457
DOC_PP2B_LxvP_1	665	668	PF13499	0.413
DOC_PP4_FxxP_1	137	140	PF00568	0.790
DOC_PP4_FxxP_1	56	59	PF00568	0.784
DOC_PP4_FxxP_1	595	598	PF00568	0.573
DOC_PP4_FxxP_1	761	764	PF00568	0.536
DOC_USP7_MATH_1	102	106	PF00917	0.724
DOC_USP7_MATH_1	140	144	PF00917	0.807
DOC_USP7_MATH_1	258	262	PF00917	0.819
DOC_USP7_MATH_1	299	303	PF00917	0.559
DOC_USP7_MATH_1	446	450	PF00917	0.532
DOC_USP7_MATH_1	539	543	PF00917	0.710
DOC_USP7_MATH_1	566	570	PF00917	0.770
DOC_USP7_MATH_1	699	703	PF00917	0.406
DOC_USP7_MATH_1	828	832	PF00917	0.745
DOC_USP7_UBL2_3	528	532	PF12436	0.693
DOC_WW_Pin1_4	156	161	PF00397	0.701
DOC_WW_Pin1_4	192	197	PF00397	0.720
DOC_WW_Pin1_4	622	627	PF00397	0.507
DOC_WW_Pin1_4	98	103	PF00397	0.655
LIG_14-3-3_CanoR_1	325	333	PF00244	0.468
LIG_14-3-3_CanoR_1	375	380	PF00244	0.559
LIG_14-3-3_CanoR_1	718	722	PF00244	0.544
LIG_14-3-3_CanoR_1	755	764	PF00244	0.464
LIG_AP2alpha_2	54	56	PF02296	0.761
LIG_APCC_ABBA_1	631	636	PF00400	0.488
LIG_APCC_ABBAyCdc20_2	842	848	PF00400	0.583
LIG_BIR_III_2	424	428	PF00653	0.605
LIG_BIR_III_4	131	135	PF00653	0.586
LIG_BIR_III_4	778	782	PF00653	0.611
LIG_BIR_III_4	833	837	PF00653	0.591
LIG_BRCT_BRCA1_1	377	381	PF00533	0.518
LIG_BRCT_BRCA1_1	759	763	PF00533	0.525
LIG_Clathr_ClatBox_1	277	281	PF01394	0.747
LIG_Clathr_ClatBox_1	460	464	PF01394	0.523
LIG_eIF4E_1	623	629	PF01652	0.462
LIG_FHA_1	220	226	PF00498	0.753
LIG_FHA_1	355	361	PF00498	0.629
LIG_FHA_1	412	418	PF00498	0.569
LIG_FHA_1	539	545	PF00498	0.723
LIG_FHA_1	623	629	PF00498	0.435
LIG_FHA_1	718	724	PF00498	0.557
LIG_FHA_1	757	763	PF00498	0.459
LIG_FHA_1	845	851	PF00498	0.711
LIG_FHA_2	306	312	PF00498	0.512
LIG_FHA_2	427	433	PF00498	0.519
LIG_FHA_2	516	522	PF00498	0.527
LIG_FHA_2	594	600	PF00498	0.574
LIG_FHA_2	734	740	PF00498	0.440
LIG_FHA_2	768	774	PF00498	0.656
LIG_Integrin_RGD_1	206	208	PF01839	0.728
LIG_LIR_Apic_2	136	140	PF02991	0.722
LIG_LIR_Apic_2	54	59	PF02991	0.772
LIG_LIR_Apic_2	592	598	PF02991	0.585
LIG_LIR_Apic_2	621	626	PF02991	0.516
LIG_LIR_Apic_2	759	764	PF02991	0.528
LIG_LIR_Apic_2	88	94	PF02991	0.680
LIG_LIR_Gen_1	314	324	PF02991	0.481
LIG_LIR_Gen_1	378	389	PF02991	0.384
LIG_LIR_Gen_1	473	480	PF02991	0.480
LIG_LIR_Gen_1	642	652	PF02991	0.443
LIG_LIR_Gen_1	733	741	PF02991	0.447
LIG_LIR_Nem_3	229	234	PF02991	0.665
LIG_LIR_Nem_3	314	320	PF02991	0.427
LIG_LIR_Nem_3	378	384	PF02991	0.386
LIG_LIR_Nem_3	455	460	PF02991	0.521
LIG_LIR_Nem_3	473	477	PF02991	0.408
LIG_LIR_Nem_3	642	648	PF02991	0.451
LIG_LIR_Nem_3	657	662	PF02991	0.434
LIG_LIR_Nem_3	733	737	PF02991	0.443
LIG_LIR_Nem_3	760	766	PF02991	0.490
LIG_LYPXL_S_1	607	611	PF13949	0.635
LIG_LYPXL_yS_3	415	418	PF13949	0.548
LIG_LYPXL_yS_3	608	611	PF13949	0.570
LIG_MAD2	435	443	PF02301	0.516
LIG_MYND_1	609	613	PF01753	0.487
LIG_NRBOX	176	182	PF00104	0.673
LIG_NRBOX	505	511	PF00104	0.432
LIG_PCNA_TLS_4	310	317	PF02747	0.479
LIG_Pex14_2	137	141	PF04695	0.760
LIG_Rb_pABgroove_1	628	636	PF01858	0.472
LIG_SH2_CRK	457	461	PF00017	0.564
LIG_SH2_CRK	623	627	PF00017	0.548
LIG_SH2_CRK	645	649	PF00017	0.439
LIG_SH2_CRK	659	663	PF00017	0.437
LIG_SH2_CRK	727	731	PF00017	0.508
LIG_SH2_GRB2like	615	618	PF00017	0.599
LIG_SH2_GRB2like	715	718	PF00017	0.532
LIG_SH2_NCK_1	686	690	PF00017	0.488
LIG_SH2_NCK_1	734	738	PF00017	0.460
LIG_SH2_SRC	469	472	PF00017	0.525
LIG_SH2_SRC	615	618	PF00017	0.657
LIG_SH2_SRC	686	689	PF00017	0.484
LIG_SH2_STAP1	641	645	PF00017	0.478
LIG_SH2_STAT3	103	106	PF00017	0.705
LIG_SH2_STAT5	316	319	PF00017	0.431
LIG_SH2_STAT5	529	532	PF00017	0.642
LIG_SH3_3	193	199	PF00018	0.719
LIG_SH3_3	230	236	PF00018	0.594
LIG_SH3_3	436	442	PF00018	0.506
LIG_SH3_3	495	501	PF00018	0.441
LIG_SH3_3	671	677	PF00018	0.511
LIG_SH3_5	682	686	PF00018	0.578
LIG_SUMO_SIM_anti_2	625	631	PF11976	0.390
LIG_SUMO_SIM_par_1	276	281	PF11976	0.705
LIG_SUMO_SIM_par_1	569	578	PF11976	0.678
LIG_TRAF2_1	227	230	PF00917	0.662
LIG_TRAF2_1	309	312	PF00917	0.560
LIG_TRAF2_1	770	773	PF00917	0.662
LIG_TRAF2_1	792	795	PF00917	0.748
LIG_TYR_ITIM	732	737	PF00017	0.434
LIG_UBA3_1	762	768	PF00899	0.539
LIG_WRC_WIRS_1	758	763	PF05994	0.466
LIG_WW_3	197	201	PF00397	0.773
LIG_WW_3	58	62	PF00397	0.766
MOD_CK1_1	105	111	PF00069	0.592
MOD_CK1_1	21	27	PF00069	0.732
MOD_CK1_1	261	267	PF00069	0.723
MOD_CK1_1	370	376	PF00069	0.445
MOD_CK1_1	618	624	PF00069	0.652
MOD_CK1_1	643	649	PF00069	0.563
MOD_CK1_1	844	850	PF00069	0.691
MOD_CK2_1	224	230	PF00069	0.675
MOD_CK2_1	305	311	PF00069	0.515
MOD_CK2_1	359	365	PF00069	0.530
MOD_CK2_1	377	383	PF00069	0.454
MOD_CK2_1	441	447	PF00069	0.547
MOD_CK2_1	733	739	PF00069	0.440
MOD_CK2_1	767	773	PF00069	0.636
MOD_CK2_1	79	85	PF00069	0.587
MOD_GlcNHglycan	107	110	PF01048	0.714
MOD_GlcNHglycan	142	145	PF01048	0.771
MOD_GlcNHglycan	250	253	PF01048	0.741
MOD_GlcNHglycan	301	304	PF01048	0.499
MOD_GlcNHglycan	31	34	PF01048	0.689
MOD_GlcNHglycan	396	399	PF01048	0.573
MOD_GlcNHglycan	525	528	PF01048	0.512
MOD_GlcNHglycan	540	544	PF01048	0.666
MOD_GlcNHglycan	569	572	PF01048	0.791
MOD_GlcNHglycan	66	71	PF01048	0.809
MOD_GlcNHglycan	829	833	PF01048	0.734
MOD_GSK3_1	365	372	PF00069	0.522
MOD_GSK3_1	5	12	PF00069	0.758
MOD_GSK3_1	618	625	PF00069	0.577
MOD_GSK3_1	753	760	PF00069	0.530
MOD_GSK3_1	98	105	PF00069	0.655
MOD_N-GLC_1	406	411	PF02516	0.552
MOD_N-GLC_1	643	648	PF02516	0.566
MOD_NEK2_1	210	215	PF00069	0.661
MOD_NEK2_1	369	374	PF00069	0.489
MOD_NEK2_1	405	410	PF00069	0.551
MOD_NEK2_1	591	596	PF00069	0.546
MOD_NEK2_1	79	84	PF00069	0.588
MOD_NEK2_2	446	451	PF00069	0.532
MOD_PIKK_1	102	108	PF00454	0.727
MOD_PIKK_1	261	267	PF00454	0.723
MOD_PIKK_1	392	398	PF00454	0.462
MOD_PIKK_1	615	621	PF00454	0.610
MOD_PIKK_1	643	649	PF00454	0.576
MOD_PIKK_1	819	825	PF00454	0.761
MOD_PK_1	367	373	PF00069	0.525
MOD_PKA_1	9	15	PF00069	0.586
MOD_PKA_2	3	9	PF00069	0.709
MOD_PKA_2	717	723	PF00069	0.538
MOD_PKA_2	79	85	PF00069	0.683
MOD_Plk_1	406	412	PF00069	0.560
MOD_Plk_1	446	452	PF00069	0.564
MOD_Plk_1	515	521	PF00069	0.507
MOD_Plk_1	539	545	PF00069	0.665
MOD_Plk_1	591	597	PF00069	0.543
MOD_Plk_1	643	649	PF00069	0.513
MOD_Plk_1	753	759	PF00069	0.588
MOD_Plk_2-3	733	739	PF00069	0.440
MOD_Plk_4	235	241	PF00069	0.600
MOD_Plk_4	618	624	PF00069	0.594
MOD_Plk_4	757	763	PF00069	0.459
MOD_ProDKin_1	156	162	PF00069	0.703
MOD_ProDKin_1	192	198	PF00069	0.716
MOD_ProDKin_1	622	628	PF00069	0.497
MOD_ProDKin_1	98	104	PF00069	0.656
MOD_SUMO_for_1	461	464	PF00179	0.564
MOD_SUMO_rev_2	362	369	PF00179	0.494
MOD_SUMO_rev_2	432	437	PF00179	0.460
MOD_SUMO_rev_2	778	787	PF00179	0.667
TRG_DiLeu_BaEn_1	338	343	PF01217	0.517
TRG_ENDOCYTIC_2	116	119	PF00928	0.718
TRG_ENDOCYTIC_2	316	319	PF00928	0.431
TRG_ENDOCYTIC_2	415	418	PF00928	0.548
TRG_ENDOCYTIC_2	457	460	PF00928	0.554
TRG_ENDOCYTIC_2	471	474	PF00928	0.426
TRG_ENDOCYTIC_2	503	506	PF00928	0.402
TRG_ENDOCYTIC_2	608	611	PF00928	0.574
TRG_ENDOCYTIC_2	645	648	PF00928	0.443
TRG_ENDOCYTIC_2	659	662	PF00928	0.428
TRG_ENDOCYTIC_2	727	730	PF00928	0.477
TRG_ENDOCYTIC_2	734	737	PF00928	0.428
TRG_ER_diArg_1	291	294	PF00400	0.545
TRG_ER_diArg_1	324	326	PF00400	0.384
TRG_ER_diArg_1	40	43	PF00400	0.823
TRG_ER_diArg_1	419	421	PF00400	0.435
TRG_ER_diArg_1	56	58	PF00400	0.549
TRG_ER_diArg_1	668	670	PF00400	0.467
TRG_ER_diArg_1	77	80	PF00400	0.710
TRG_NES_CRM1_1	332	346	PF08389	0.508
TRG_NES_CRM1_1	585	599	PF08389	0.596
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWG2	Leptomonas seymouri	57%	100%
A0A0S4IUY1	Bodo saltans	31%	100%
A4H3L4	Leishmania braziliensis	81%	98%
E9ACJ7	Leishmania major	92%	100%
E9AG41	Leishmania infantum	98%	100%
E9AJT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%