Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-Repressible Phosphate Permease-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H545_LEIDO

TriTrypDb:

LdBPK_030480.1 , LdCL_030009900 , LDHU3_03.0500

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A0A3S5H545

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H545

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0015698	inorganic anion transport	6	24
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0009987	cellular process	1	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035435	phosphate ion transmembrane transport	6	3
GO:0055085	transmembrane transport	2	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098661	inorganic anion transmembrane transport	5	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.527
CLV_C14_Caspase3-7	369	373	PF00656	0.375
CLV_NRD_NRD_1	138	140	PF00675	0.504
CLV_NRD_NRD_1	247	249	PF00675	0.217
CLV_NRD_NRD_1	289	291	PF00675	0.221
CLV_NRD_NRD_1	302	304	PF00675	0.177
CLV_NRD_NRD_1	530	532	PF00675	0.223
CLV_PCSK_KEX2_1	246	248	PF00082	0.260
CLV_PCSK_KEX2_1	289	291	PF00082	0.204
CLV_PCSK_KEX2_1	302	304	PF00082	0.177
CLV_PCSK_KEX2_1	530	532	PF00082	0.287
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.325
CLV_PCSK_SKI1_1	140	144	PF00082	0.395
CLV_PCSK_SKI1_1	329	333	PF00082	0.337
CLV_PCSK_SKI1_1	39	43	PF00082	0.304
CLV_PCSK_SKI1_1	533	537	PF00082	0.208
DEG_Nend_Nbox_1	1	3	PF02207	0.327
DEG_ODPH_VHL_1	187	200	PF01847	0.412
DEG_SPOP_SBC_1	508	512	PF00917	0.275
DOC_CKS1_1	482	487	PF01111	0.556
DOC_CYCLIN_RxL_1	172	182	PF00134	0.239
DOC_CYCLIN_RxL_1	329	338	PF00134	0.399
DOC_MAPK_DCC_7	186	196	PF00069	0.412
DOC_MAPK_gen_1	246	254	PF00069	0.508
DOC_MAPK_gen_1	530	538	PF00069	0.432
DOC_MAPK_MEF2A_6	39	48	PF00069	0.491
DOC_MAPK_MEF2A_6	531	540	PF00069	0.554
DOC_MAPK_NFAT4_5	533	541	PF00069	0.551
DOC_MAPK_RevD_3	232	248	PF00069	0.308
DOC_MAPK_RevD_3	518	531	PF00069	0.343
DOC_PP1_RVXF_1	213	219	PF00149	0.284
DOC_PP1_RVXF_1	528	535	PF00149	0.266
DOC_PP4_FxxP_1	157	160	PF00568	0.311
DOC_PP4_FxxP_1	468	471	PF00568	0.239
DOC_SPAK_OSR1_1	175	179	PF12202	0.501
DOC_USP7_MATH_1	110	114	PF00917	0.314
DOC_USP7_MATH_1	144	148	PF00917	0.287
DOC_USP7_MATH_1	278	282	PF00917	0.462
DOC_USP7_MATH_1	413	417	PF00917	0.301
DOC_USP7_MATH_1	418	422	PF00917	0.319
DOC_USP7_MATH_1	508	512	PF00917	0.275
DOC_USP7_MATH_1	568	572	PF00917	0.533
DOC_USP7_MATH_2	317	323	PF00917	0.399
DOC_USP7_UBL2_3	300	304	PF12436	0.412
DOC_WW_Pin1_4	156	161	PF00397	0.312
DOC_WW_Pin1_4	352	357	PF00397	0.513
DOC_WW_Pin1_4	481	486	PF00397	0.475
LIG_14-3-3_CanoR_1	215	225	PF00244	0.310
LIG_14-3-3_CanoR_1	279	286	PF00244	0.588
LIG_14-3-3_CanoR_1	39	44	PF00244	0.513
LIG_BRCT_BRCA1_1	554	558	PF00533	0.367
LIG_CaM_NSCaTE_8	452	459	PF13499	0.341
LIG_FHA_1	180	186	PF00498	0.540
LIG_FHA_1	438	444	PF00498	0.300
LIG_FHA_1	465	471	PF00498	0.300
LIG_FHA_1	493	499	PF00498	0.309
LIG_FHA_1	502	508	PF00498	0.210
LIG_FHA_1	510	516	PF00498	0.327
LIG_FHA_1	545	551	PF00498	0.318
LIG_FHA_1	562	568	PF00498	0.360
LIG_FHA_2	375	381	PF00498	0.518
LIG_FHA_2	76	82	PF00498	0.199
LIG_GBD_Chelix_1	493	501	PF00786	0.239
LIG_HP1_1	83	87	PF01393	0.225
LIG_LIR_Apic_2	155	160	PF02991	0.311
LIG_LIR_Apic_2	467	471	PF02991	0.239
LIG_LIR_Apic_2	503	508	PF02991	0.327
LIG_LIR_Gen_1	203	212	PF02991	0.311
LIG_LIR_Gen_1	380	388	PF02991	0.391
LIG_LIR_Gen_1	81	91	PF02991	0.235
LIG_LIR_Gen_1	97	107	PF02991	0.371
LIG_LIR_LC3C_4	495	499	PF02991	0.341
LIG_LIR_Nem_3	147	152	PF02991	0.270
LIG_LIR_Nem_3	203	209	PF02991	0.311
LIG_LIR_Nem_3	380	386	PF02991	0.391
LIG_LIR_Nem_3	401	407	PF02991	0.464
LIG_LIR_Nem_3	526	532	PF02991	0.301
LIG_LIR_Nem_3	97	103	PF02991	0.358
LIG_MYND_1	189	193	PF01753	0.412
LIG_NRP_CendR_1	569	572	PF00754	0.572
LIG_Pex14_2	200	204	PF04695	0.313
LIG_SH2_CRK	342	346	PF00017	0.399
LIG_SH2_CRK	431	435	PF00017	0.212
LIG_SH2_CRK	505	509	PF00017	0.370
LIG_SH2_CRK	88	92	PF00017	0.346
LIG_SH2_NCK_1	431	435	PF00017	0.212
LIG_SH2_SRC	388	391	PF00017	0.412
LIG_SH2_STAP1	431	435	PF00017	0.271
LIG_SH2_STAT5	145	148	PF00017	0.256
LIG_SH2_STAT5	190	193	PF00017	0.427
LIG_SH2_STAT5	295	298	PF00017	0.474
LIG_SH2_STAT5	385	388	PF00017	0.412
LIG_SH2_STAT5	5	8	PF00017	0.303
LIG_SH2_STAT5	541	544	PF00017	0.269
LIG_SH2_STAT5	84	87	PF00017	0.311
LIG_SH3_3	350	356	PF00018	0.405
LIG_SH3_3	479	485	PF00018	0.556
LIG_Sin3_3	166	173	PF02671	0.210
LIG_SUMO_SIM_anti_2	233	238	PF11976	0.353
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.556
LIG_SUMO_SIM_par_1	150	155	PF11976	0.299
LIG_SUMO_SIM_par_1	497	504	PF11976	0.301
LIG_SUMO_SIM_par_1	518	523	PF11976	0.327
LIG_SUMO_SIM_par_1	546	551	PF11976	0.338
LIG_TRAF2_1	317	320	PF00917	0.412
LIG_TYR_ITIM	340	345	PF00017	0.399
LIG_TYR_ITIM	86	91	PF00017	0.301
LIG_UBA3_1	241	246	PF00899	0.301
LIG_UBA3_1	472	479	PF00899	0.499
LIG_ULM_U2AF65_1	530	535	PF00076	0.398
LIG_WRC_WIRS_1	283	288	PF05994	0.412
LIG_WRC_WIRS_1	465	470	PF05994	0.370
LIG_WRC_WIRS_1	76	81	PF05994	0.199
MOD_CDK_SPxK_1	481	487	PF00069	0.475
MOD_CK1_1	217	223	PF00069	0.191
MOD_CK1_1	282	288	PF00069	0.490
MOD_CK1_1	35	41	PF00069	0.573
MOD_CK1_1	500	506	PF00069	0.327
MOD_CK2_1	74	80	PF00069	0.204
MOD_Cter_Amidation	137	140	PF01082	0.412
MOD_GlcNHglycan	146	149	PF01048	0.590
MOD_GlcNHglycan	219	222	PF01048	0.569
MOD_GlcNHglycan	254	257	PF01048	0.309
MOD_GlcNHglycan	389	393	PF01048	0.369
MOD_GlcNHglycan	444	447	PF01048	0.415
MOD_GlcNHglycan	54	58	PF01048	0.389
MOD_GlcNHglycan	554	557	PF01048	0.324
MOD_GlcNHglycan	70	73	PF01048	0.457
MOD_GSK3_1	152	159	PF00069	0.323
MOD_GSK3_1	210	217	PF00069	0.180
MOD_GSK3_1	248	255	PF00069	0.551
MOD_GSK3_1	278	285	PF00069	0.577
MOD_GSK3_1	31	38	PF00069	0.431
MOD_GSK3_1	315	322	PF00069	0.438
MOD_GSK3_1	348	355	PF00069	0.518
MOD_GSK3_1	408	415	PF00069	0.246
MOD_GSK3_1	418	425	PF00069	0.300
MOD_GSK3_1	497	504	PF00069	0.239
MOD_GSK3_1	509	516	PF00069	0.327
MOD_GSK3_1	544	551	PF00069	0.343
MOD_GSK3_1	60	67	PF00069	0.329
MOD_GSK3_1	90	97	PF00069	0.346
MOD_NEK2_1	102	107	PF00069	0.204
MOD_NEK2_1	179	184	PF00069	0.536
MOD_NEK2_1	216	221	PF00069	0.310
MOD_NEK2_1	32	37	PF00069	0.476
MOD_NEK2_1	497	502	PF00069	0.327
MOD_NEK2_1	520	525	PF00069	0.239
MOD_NEK2_1	548	553	PF00069	0.364
MOD_NEK2_1	90	95	PF00069	0.285
MOD_PK_1	248	254	PF00069	0.399
MOD_PK_1	279	285	PF00069	0.399
MOD_PKA_2	214	220	PF00069	0.199
MOD_PKA_2	252	258	PF00069	0.568
MOD_PKA_2	278	284	PF00069	0.565
MOD_Plk_1	179	185	PF00069	0.412
MOD_Plk_2-3	348	354	PF00069	0.519
MOD_Plk_4	152	158	PF00069	0.297
MOD_Plk_4	39	45	PF00069	0.404
MOD_Plk_4	94	100	PF00069	0.330
MOD_ProDKin_1	156	162	PF00069	0.312
MOD_ProDKin_1	352	358	PF00069	0.513
MOD_ProDKin_1	481	487	PF00069	0.475
MOD_SUMO_for_1	313	316	PF00179	0.399
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.301
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.446
TRG_ENDOCYTIC_2	342	345	PF00928	0.399
TRG_ENDOCYTIC_2	431	434	PF00928	0.213
TRG_ENDOCYTIC_2	5	8	PF00928	0.303
TRG_ENDOCYTIC_2	84	87	PF00928	0.314
TRG_ENDOCYTIC_2	88	91	PF00928	0.308
TRG_ER_diArg_1	247	249	PF00400	0.420
TRG_ER_diArg_1	529	531	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.212
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	49%	100%
A0A0S4JEW4	Bodo saltans	26%	90%
A0A1X0NXY5	Trypanosomatidae	48%	100%
A0A3Q8I8Y3	Leishmania donovani	49%	87%
A0A3Q8IBK1	Leishmania donovani	48%	95%
A0A3R7K4N2	Trypanosoma rangeli	44%	100%
A0A3R7L5P3	Trypanosoma rangeli	25%	95%
A4H5Y5	Leishmania braziliensis	47%	87%
A4H6C2	Leishmania braziliensis	47%	87%
A4HBH2	Leishmania braziliensis	46%	95%
A4HH06	Leishmania braziliensis	80%	99%
A4HUP5	Leishmania infantum	48%	86%
A4HYJ6	Leishmania infantum	48%	95%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ACJ5	Leishmania major	96%	100%
E9AG39	Leishmania infantum	100%	100%
E9AJT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	86%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	86%
E9AUE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
P15710	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	97%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q08357	Homo sapiens	28%	88%
Q4QH82	Leishmania major	49%	87%
Q4QHL7	Leishmania major	49%	87%
Q5XHF9	Xenopus laevis	28%	88%
V5DS90	Trypanosoma cruzi	44%	100%