LeishMANIAdb
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MFS_transporter_putative/GeneDB:LmjF.03.0410

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS_transporter_putative/GeneDB:LmjF.03.0410
Gene product:
MFS transporter, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H541_LEIDO
TriTrypDb:
LdBPK_030390.1 , LdCL_030008900 , LDHU3_03.0400
Length:
680

Annotations

LeishMANIAdb annotations

A transporter protein family expanded in Kinetoplastids. Distantly similar to animal hem transporters (human FLVCR).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 17
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

A0A3S5H541
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H541

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 19
GO:0022857 transmembrane transporter activity 2 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 313 317 PF00656 0.648
CLV_C14_Caspase3-7 375 379 PF00656 0.743
CLV_NRD_NRD_1 10 12 PF00675 0.597
CLV_NRD_NRD_1 275 277 PF00675 0.310
CLV_NRD_NRD_1 295 297 PF00675 0.467
CLV_NRD_NRD_1 306 308 PF00675 0.513
CLV_NRD_NRD_1 474 476 PF00675 0.265
CLV_NRD_NRD_1 622 624 PF00675 0.434
CLV_PCSK_KEX2_1 10 12 PF00082 0.502
CLV_PCSK_KEX2_1 295 297 PF00082 0.415
CLV_PCSK_KEX2_1 306 308 PF00082 0.460
CLV_PCSK_KEX2_1 474 476 PF00082 0.275
CLV_PCSK_KEX2_1 608 610 PF00082 0.277
CLV_PCSK_KEX2_1 614 616 PF00082 0.280
CLV_PCSK_KEX2_1 678 680 PF00082 0.563
CLV_PCSK_PC1ET2_1 608 610 PF00082 0.332
CLV_PCSK_PC1ET2_1 614 616 PF00082 0.333
CLV_PCSK_PC1ET2_1 678 680 PF00082 0.442
CLV_PCSK_SKI1_1 477 481 PF00082 0.259
CLV_PCSK_SKI1_1 604 608 PF00082 0.322
DEG_MDM2_SWIB_1 406 414 PF02201 0.478
DEG_SCF_FBW7_1 26 32 PF00400 0.666
DEG_SPOP_SBC_1 546 550 PF00917 0.473
DOC_CKS1_1 200 205 PF01111 0.301
DOC_CKS1_1 26 31 PF01111 0.643
DOC_CYCLIN_RxL_1 471 484 PF00134 0.549
DOC_MAPK_DCC_7 385 395 PF00069 0.630
DOC_MAPK_FxFP_2 272 275 PF00069 0.428
DOC_MAPK_gen_1 471 480 PF00069 0.458
DOC_MAPK_RevD_3 263 277 PF00069 0.428
DOC_PP4_FxxP_1 241 244 PF00568 0.262
DOC_PP4_FxxP_1 272 275 PF00568 0.309
DOC_PP4_FxxP_1 464 467 PF00568 0.354
DOC_PP4_FxxP_1 529 532 PF00568 0.303
DOC_SPAK_OSR1_1 88 92 PF12202 0.473
DOC_USP7_MATH_1 188 192 PF00917 0.389
DOC_USP7_MATH_1 20 24 PF00917 0.656
DOC_USP7_MATH_1 416 420 PF00917 0.284
DOC_USP7_UBL2_3 246 250 PF12436 0.289
DOC_USP7_UBL2_3 327 331 PF12436 0.614
DOC_USP7_UBL2_3 604 608 PF12436 0.549
DOC_WW_Pin1_4 107 112 PF00397 0.311
DOC_WW_Pin1_4 199 204 PF00397 0.301
DOC_WW_Pin1_4 25 30 PF00397 0.783
DOC_WW_Pin1_4 573 578 PF00397 0.319
LIG_14-3-3_CanoR_1 407 413 PF00244 0.563
LIG_14-3-3_CanoR_1 626 633 PF00244 0.688
LIG_AP2alpha_2 85 87 PF02296 0.561
LIG_BRCT_BRCA1_1 190 194 PF00533 0.487
LIG_deltaCOP1_diTrp_1 85 89 PF00928 0.569
LIG_FHA_1 130 136 PF00498 0.309
LIG_FHA_1 193 199 PF00498 0.301
LIG_FHA_1 200 206 PF00498 0.287
LIG_FHA_1 237 243 PF00498 0.312
LIG_FHA_1 493 499 PF00498 0.379
LIG_FHA_1 555 561 PF00498 0.370
LIG_FHA_1 597 603 PF00498 0.426
LIG_FHA_1 66 72 PF00498 0.714
LIG_FHA_2 365 371 PF00498 0.768
LIG_FHA_2 574 580 PF00498 0.280
LIG_FHA_2 608 614 PF00498 0.555
LIG_GBD_Chelix_1 265 273 PF00786 0.302
LIG_GBD_Chelix_1 489 497 PF00786 0.382
LIG_Integrin_RGD_1 83 85 PF01839 0.334
LIG_IRF3_LxIS_1 412 418 PF10401 0.428
LIG_IRF3_LxIS_1 94 101 PF10401 0.349
LIG_LIR_Apic_2 239 244 PF02991 0.259
LIG_LIR_Gen_1 191 201 PF02991 0.412
LIG_LIR_Gen_1 408 417 PF02991 0.465
LIG_LIR_Nem_3 191 197 PF02991 0.464
LIG_LIR_Nem_3 401 406 PF02991 0.519
LIG_LIR_Nem_3 408 413 PF02991 0.492
LIG_LIR_Nem_3 566 572 PF02991 0.324
LIG_MYND_1 61 65 PF01753 0.718
LIG_NRBOX 166 172 PF00104 0.387
LIG_NRBOX 492 498 PF00104 0.405
LIG_Pex14_2 252 256 PF04695 0.267
LIG_Pex14_2 406 410 PF04695 0.605
LIG_PTB_Apo_2 205 212 PF02174 0.459
LIG_SH2_CRK 262 266 PF00017 0.381
LIG_SH2_CRK 476 480 PF00017 0.472
LIG_SH2_PTP2 138 141 PF00017 0.323
LIG_SH2_SRC 134 137 PF00017 0.266
LIG_SH2_STAP1 262 266 PF00017 0.428
LIG_SH2_STAT3 186 189 PF00017 0.303
LIG_SH2_STAT5 119 122 PF00017 0.259
LIG_SH2_STAT5 134 137 PF00017 0.282
LIG_SH2_STAT5 138 141 PF00017 0.304
LIG_SH2_STAT5 186 189 PF00017 0.349
LIG_SH2_STAT5 511 514 PF00017 0.335
LIG_SH2_STAT5 537 540 PF00017 0.549
LIG_SH3_3 23 29 PF00018 0.790
LIG_SH3_3 232 238 PF00018 0.309
LIG_SH3_3 272 278 PF00018 0.277
LIG_SH3_3 457 463 PF00018 0.348
LIG_SH3_4 604 611 PF00018 0.549
LIG_SUMO_SIM_anti_2 484 489 PF11976 0.372
LIG_SUMO_SIM_par_1 195 202 PF11976 0.303
LIG_SUMO_SIM_par_1 413 419 PF11976 0.302
LIG_SUMO_SIM_par_1 490 495 PF11976 0.357
LIG_SUMO_SIM_par_1 536 542 PF11976 0.466
LIG_SUMO_SIM_par_1 96 101 PF11976 0.303
LIG_TYR_ITIM 136 141 PF00017 0.299
LIG_Vh1_VBS_1 478 496 PF01044 0.458
LIG_WRC_WIRS_1 237 242 PF05994 0.348
LIG_WRC_WIRS_1 583 588 PF05994 0.425
LIG_WRC_WIRS_1 591 596 PF05994 0.428
MOD_CK1_1 364 370 PF00069 0.714
MOD_CK1_1 408 414 PF00069 0.514
MOD_CK1_1 665 671 PF00069 0.714
MOD_CK2_1 190 196 PF00069 0.288
MOD_CK2_1 364 370 PF00069 0.714
MOD_CK2_1 378 384 PF00069 0.747
MOD_CK2_1 416 422 PF00069 0.297
MOD_CK2_1 573 579 PF00069 0.321
MOD_CK2_1 607 613 PF00069 0.532
MOD_CK2_1 69 75 PF00069 0.656
MOD_Cter_Amidation 472 475 PF01082 0.349
MOD_GlcNHglycan 20 23 PF01048 0.563
MOD_GlcNHglycan 224 227 PF01048 0.323
MOD_GlcNHglycan 418 421 PF01048 0.303
MOD_GlcNHglycan 549 552 PF01048 0.271
MOD_GlcNHglycan 628 631 PF01048 0.489
MOD_GlcNHglycan 653 656 PF01048 0.581
MOD_GlcNHglycan 664 667 PF01048 0.581
MOD_GSK3_1 188 195 PF00069 0.323
MOD_GSK3_1 218 225 PF00069 0.270
MOD_GSK3_1 25 32 PF00069 0.766
MOD_GSK3_1 360 367 PF00069 0.752
MOD_GSK3_1 554 561 PF00069 0.379
MOD_GSK3_1 571 578 PF00069 0.290
MOD_GSK3_1 596 603 PF00069 0.432
MOD_GSK3_1 65 72 PF00069 0.701
MOD_N-GLC_1 122 127 PF02516 0.444
MOD_N-GLC_1 364 369 PF02516 0.535
MOD_N-GLC_1 408 413 PF02516 0.331
MOD_N-GLC_2 359 361 PF02516 0.547
MOD_NEK2_1 122 127 PF00069 0.280
MOD_NEK2_1 129 134 PF00069 0.332
MOD_NEK2_1 415 420 PF00069 0.329
MOD_NEK2_1 545 550 PF00069 0.472
MOD_NEK2_1 554 559 PF00069 0.280
MOD_NEK2_1 563 568 PF00069 0.230
MOD_NEK2_1 600 605 PF00069 0.370
MOD_NEK2_1 98 103 PF00069 0.291
MOD_NEK2_2 20 25 PF00069 0.657
MOD_NEK2_2 596 601 PF00069 0.415
MOD_OFUCOSY 345 350 PF10250 0.444
MOD_PIKK_1 122 128 PF00454 0.316
MOD_PKA_1 306 312 PF00069 0.599
MOD_PKA_2 306 312 PF00069 0.721
MOD_Plk_1 122 128 PF00069 0.257
MOD_Plk_1 408 414 PF00069 0.492
MOD_Plk_1 539 545 PF00069 0.467
MOD_Plk_2-3 378 384 PF00069 0.648
MOD_Plk_4 130 136 PF00069 0.302
MOD_Plk_4 218 224 PF00069 0.320
MOD_Plk_4 236 242 PF00069 0.212
MOD_Plk_4 29 35 PF00069 0.714
MOD_Plk_4 428 434 PF00069 0.316
MOD_Plk_4 456 462 PF00069 0.331
MOD_Plk_4 481 487 PF00069 0.341
MOD_Plk_4 492 498 PF00069 0.331
MOD_Plk_4 563 569 PF00069 0.319
MOD_Plk_4 587 593 PF00069 0.287
MOD_Plk_4 596 602 PF00069 0.280
MOD_ProDKin_1 107 113 PF00069 0.311
MOD_ProDKin_1 199 205 PF00069 0.301
MOD_ProDKin_1 25 31 PF00069 0.779
MOD_ProDKin_1 573 579 PF00069 0.319
MOD_SUMO_rev_2 575 583 PF00179 0.246
TRG_DiLeu_BaLyEn_6 201 206 PF01217 0.323
TRG_DiLeu_BaLyEn_6 58 63 PF01217 0.719
TRG_ENDOCYTIC_2 119 122 PF00928 0.273
TRG_ENDOCYTIC_2 138 141 PF00928 0.295
TRG_ENDOCYTIC_2 262 265 PF00928 0.381
TRG_ENDOCYTIC_2 476 479 PF00928 0.476
TRG_ER_diArg_1 295 298 PF00400 0.645
TRG_ER_diArg_1 474 476 PF00400 0.481
TRG_ER_diLys_1 676 680 PF00400 0.644
TRG_NLS_Bipartite_1 608 627 PF00514 0.671
TRG_NLS_MonoCore_2 275 280 PF00514 0.533
TRG_NLS_MonoExtN_4 275 280 PF00514 0.533

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I416 Leptomonas seymouri 27% 96%
A0A0N1IHM9 Leptomonas seymouri 70% 96%
A0A0S4J2T0 Bodo saltans 34% 100%
A0A1X0NWR8 Trypanosomatidae 27% 100%
A0A1X0PA49 Trypanosomatidae 51% 100%
A0A3Q8IBI9 Leishmania donovani 25% 100%
A0A422NQJ7 Trypanosoma rangeli 52% 100%
A4H3K8 Leishmania braziliensis 82% 100%
A4HRV1 Leishmania infantum 100% 100%
A4HYN7 Leishmania infantum 25% 100%
D0A244 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9ACI6 Leishmania major 94% 100%
E9AJS4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AUH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
Q4QD06 Leishmania major 26% 100%
V5BCB7 Trypanosoma cruzi 55% 100%
V5BQV3 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS